Dear Valued Customer:

Transcription

1 850 Lincoln Centre Drive Foster City, CA U.S.A. T F Dear Valued Customer: In an effort to better serve you, Applied Biosystems is revising the look and feel of our Material Safety Data Sheets, (MSDSs). In addition, we will now be supplying MSDSs for materials which are classified as nonhazardous as defined by the Dangerous Substances and Dangerous Preparations Directives, 67/548/EEC and 88/379/EEC respectively, (EU), and the OSHA Hazard Communication Standard, 29 CFR (U.S.). As always, MSDSs will be available in multiple languages. In the coming months, we will be implementing a system whereby you will be able to choose your preferred method for MSDS delivery. Your delivery options are as follows: By E mail By FAX Please take a few minutes to send an to: MSDS_Inquiry_CCRM@appliedbiosystems.com to let us know your preference. Type MSDS Delivery in the subject line and include your preference in the body of the letter along with your full name, Company or Institution, and your preferred address or FAX number as applicable. Please choose only one option. Alternatively, you may print out this letter, circle your preference from the list above, and mail it to the address below. Please include your full name, Company or Institution, and address or FAX number as applicable on this letter. In the meantime, you will continue to receive your document(s) along with your order if it is the first order of the calendar year, or when the MSDS has undergone a major revision. MSDSs are also available on our website. For AB products, please visit: For Ambion products, please visit: If you are a Distributor or Dealer of Applied Biosystems Products: As the last supplier in the chain who provides hazardous substances to a place of work, you have the responsibility to provide a Material Safety Data Sheet (MSDS) and any updated hazard information from our company to your customers. You are required to send the MSDS to your downstream users prior to or with the initial delivery of a hazardous substance. When an MSDS is revised, a copy of the revised MSDS should be sent to the purchaser as soon as it is revised. Should you have any questions, feel free to contact us via at: MSDS_Inquiry_CCRM@appliedbiosystems.com or call (USA) Thank you for your continued business. Vergine Furniss Global Chemical Compliance and Risk Management Applied Biosystems 850 Lincoln Centre Drive Foster City, CA x5635 (USA) Revision Date: 5-Jan-07 Version 1.0

2 SAFETY DATA SHEET 1 IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND OF THE COMPANY/UNDERTAKING Product name: Tropix GALACTON-Star Supplier: Applied Biosystems, UK 7 Kingsland Grange, Woolston Warrington, Cheshire, WA1 4SR, United Kingdom Intended use: For research use only. Not for Use in Diagnostic Procedures Product No.: T2255 Emergency telephone: CHEMTREC (International, Reverse Charges) Contact person: furnisvc@appliedbiosystems.com 2 HAZARDS IDENTIFICATION The product has been classified according to the legislation in force. Classification: R10 Xi; R36 R67 The full text for all R-phrases is displayed in Section 16. Potential health effects Inhalation: May cause central nervous system effects. May cause irritation to the respiratory system. Vapours may cause drowsiness and dizziness. Eye contact: Irritating to eyes. Exposed may experience eye tearing, redness, and discomfort. Skin contact: May cause irritation. Defats the skin. Ingestion: May cause discomfort if swallowed. Other health effects: May cause central nervous system effects. Potential physical / chemical effects: The product is flammable, and heating may generate vapours which may form explosive vapour/air mixtures. Environment: The product components are not classified as environmentally hazardous. However, this does not exclude the possibility that large or frequent spills can have a harmful or damaging effect on the environment. 3 COMPOSITION/INFORMATION ON INGREDIENTS GB SDS 1 / 7

3 General information: The product contains: Organic solvent. Chemical name EC No. CAS-No. Concentration * Classification Notes % F;R11, Xi;R36, R % Xn;R22, Xi;R38, Xi;R41, Xn;R48/22 - * All concentrations are percent by weight unless ingredient is a gas. Gas concentrations are in percent by volume. The full text for all R-phrases is displayed in Section FIRST-AID MEASURES General: Burns: Flush with water immediately. While flushing, remove clothes which do not adhere to affected area. Call an ambulance. Continue flushing during transport to hospital. Inhalation: Move to fresh air. Get medical attention if any discomfort continues. Eye contact: Immediately flush with plenty of water for up to 15 minutes. Remove any contact lenses and open eyes wide apart. Get medical attention. Skin contact: Wash skin with soap and water. Get medical attention if irritation persists after washing. Ingestion: Rinse mouth thoroughly. Get medical attention if any discomfort continues. 5 FIRE-FIGHTING MEASURES Extinguishing media: Extinguish with foam, carbon dioxide, dry powder or water fog. Inappropriate extinguishing media: Not applicable. Special fire fighting procedures: Use standard firefighting procedures and consider the hazards of other involved materials. Unusual fire & explosion hazards: During fire, gases hazardous to health may be formed. Solvent vapours may form explosive mixtures with air. Hazardous combustion products: Carbon dioxide, Carbon monoxide Protective measures: Selection of respiratory protection for fire fighting: follow the general fire precautions indicated in the workplace. 6 ACCIDENTAL RELEASE MEASURES Personal precautions: Extinguish all ignition sources. Avoid sparks, flames, heat and smoking. Ventilate. Avoid inhalation of vapours and contact with skin and eyes. Wear suitable protective clothing. See Section 8 for personal protective equipment. Spill cleanup methods: Smaller quantities of residue may be collected by an absorbent. For waste disposal, see section 13. GB SDS 2 / 7

4 Environmental precautions: Avoid discharge into drains, water courses or onto the ground. Notification procedures: Inform authorities if large amounts are involved. 7 HANDLING AND STORAGE Handling: Avoid inhalation of vapours and contact with skin and eyes. The product is flammable, and heating may generate vapours which may form explosive vapour/air mixtures. Ground container and transfer equipment to eliminate static electric sparks. Wear approved safety goggles. Wear protective gloves and appropriate clothing to prevent skin contact. See Section 8 for personal protective equipment. Observe good industrial hygiene practices. Storage: Follow rules for flammable liquids. Keep away from heat, sparks and open flame. Store in closed original container in a dry place. Keep away from food, drink and animal feeding stuffs. Store away from incompatible materials. 8 EXPOSURE CONTROLS/PERSONAL PROTECTION Exposure limit values: Make sure to provide adequate control by applying the "COSHH Essentials" procedure. Chemical name Source Type Workplace exposure limits Notes EH40/2005 STEL 1250 mg/m³ 500 ppm EH40/2005 TWA 999 mg/m³ 400 ppm Engineering controls: Use explosion-proof ventilation equipment. Provide adequate ventilation. Observe Occupational Exposure Limits and minimise the risk of inhalation of vapours. Provide easy access to water supply or an emergency shower. Respiratory protection: In case of inadequate ventilation or risk of inhalation of vapours, use suitable respiratory equipment with combination filter (type A2/P2). Personal protection equipment should be chosen according to the CEN standards and in discussion with the supplier of the personal protective equipment. Eye protection: Wear approved safety goggles. Hand protection: Wear protective gloves. Nitrile gloves are recommended, but be aware that the liquid may penetrate the gloves. Frequent change is advisable. Suitable gloves can be recommended by the glove supplier. Skin protection: Wear suitable protective clothing. Hygiene measures: Always observe good personal hygiene measures, such as washing after handling the material and before eating, drinking, and/or smoking. Routinely wash work clothing and protective equipment to remove contaminants. 9 PHYSICAL AND CHEMICAL PROPERTIES Physical state: Liquid Colour: No data available. Odour: No data available. Odour threshold: No data available. GB SDS 3 / 7

5 ph: No data available Melting point: No data available. Freezing point: No data available. Boiling Point: No data available. Relative density: No data available. Vapour pressure: No data available. Vapour density (air=1): No data available. Evaporation rate: No data available. Volatile: No data available Solubility in water: Miscible with water. Solubility (other): No data available. Partition coefficient (n-octanol/water): No data available. Viscosity: No data available. Flash point: No data available. Autoignition temperature: No data available. Flammability limit - lower(%): No data available. Flammability limit - upper (%): No data available. 10 STABILITY AND REACTIVITY Stability: This product is stable under expected conditions of use. Conditions to avoid: Heat, sparks, flames. Incompatible materials: Strong oxidising agents. Strong bases. Hazardous decomposition products: At elevated temperatures: Carbon dioxide, Carbon monoxide 11 TOXICOLOGICAL INFORMATION Specified substance(s) Acute toxicity: Chemical name Test results Inhalation LC50 (Rat): 200 ppm Dermal LD50 (Rabbit): 7640 ul/kg Oral LD50 (Rat): 620 ul/kg Inhalation LC50 (8 hour(s), Rat): ppm (v) Oral LD50 (Rat): 5045 mg/kg Dermal LD50 (Rabbit): mg/kg Inhalation: May cause irritation to the respiratory system. May cause central nervous system effects. Vapours may cause drowsiness and dizziness. Eye contact: Irritating to eyes. Exposed may experience eye tearing, redness, and discomfort. Skin contact: May cause irritation. Defats the skin. Ingestion: May cause discomfort if swallowed. GB SDS 4 / 7

6 Sensitisation: No data available. Listed carcinogens: Chemical name IARC NTP OSHA ACGIH Not listed Not listed Not listed A4 3 Not listed Not listed Not listed IARC: 1 = Carcinogenic to Humans; 2A = Probably Carcinogenic to Humans; 2B = Possibly Carcinogenic to Humans; 3 = Not classifiable as to carcinogenicity to humans; 4 = Probably not carcinogenic to humans; Not listed = Not evaluated by IARC. ACGIH: A1 = Confirmed Human Carcinogen; A2 = Suspected Human Carcinogen; A3 = Confirmed Animal Carcinogen; A4 = Not classifiable as a human carcinogen; A5 = Not suspected to be a human carcinogen; Not listed = Not evaluated by ACGIH. Mutagenesis: Not known. Reproductive toxicity: Not known. Other effects: May cause central nervous system effects. 12 ECOLOGICAL INFORMATION Ecotoxicity: The product components are not classified as environmentally hazardous. However, this does not exclude the possibility that large or frequent spills can have a harmful or damaging effect on the environment. Specified substance(s) Chemical name Test EC50 (48 hour(s), Daphnia magna): 55 mg/l LC50 (96 hour(s), Fish): 600 mg/l EC50 (24 hour(s), Daphnia): 5102 mg/l LC50 (96 hour(s), Oryzia latipes): 9640 mg/l Mobility: The product is water soluble and may spread in water systems. The product contains organic solvents which will evaporate easily from all surfaces. Persistence and degradability: No data available Bioaccumulation potential: No data available Other adverse effects: No data available 13 DISPOSAL CONSIDERATIONS General information: Dispose of waste and residues in accordance with local authority requirements. Disposal methods: No specific disposal method required. European waste codes Used product: * 14 TRANSPORT INFORMATION ADR/RID GB SDS 5 / 7

7 UN No.: UN1993 Proper shipping name: Flammable liquid, n.o.s. () Class: 3 Packing group: III Label(s): 3 IMDG UN No.: UN1993 Proper shipping name: Flammable liquid, n.o.s. ( ) Class: 3 Packing group: III EmS No.: F-E, S-E IATA UN No.: UN1993 Proper shipping name: Flammable liquid, n.o.s. ( ) Class: 3 Packing group: III Label(s): 3 15 REGULATORY INFORMATION Irritant. R10; Flammable. R36; Irritating to eyes. R67; Vapours may cause drowsiness and dizziness. S25; Avoid contact with eyes. S26; In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S60; This material and its container must be disposed of as hazardous waste. 16 OTHER INFORMATION Wording of the R-phrases in sections 2 and 3: R10; Flammable. R11; Highly flammable. R22; Harmful if swallowed. R36; Irritating to eyes. R38; Irritating to skin. R41; Risk of serious damage to eyes. R48/22; Harmful: danger of serious damage to health by prolonged exposure if swallowed. R67; Vapours may cause drowsiness and dizziness. Inventory status: All ingredients are either listed or exempt from listing on EINECS/ELINCS. Issue date: Supercedes date: SDS No.: Disclaimer: This MSDS has been prepared using information from sources considered technically reliable. It should not be relied upon as a product specification. The company makes no warranty of any kind, express or implied, concerning the safe use of this material in your process or in combination with other chemical substances. Every user of the product is responsible for evaluating its own processes and conditions of use and selecting appropriate protective measures for employee exposure. GB SDS 6 / 7

8 GB SDS 7 / 7