# DOC SSL V1 AseptaUS.com MAJ BF 06/2012 AKILEINE BLUE RANGE DRY FEET, CALLUS ASEPTA LABORATORIES - MONACO

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1 # DOC SSL V1 MAJ BF 06/2012 AKILEINE BLUE RANGE DRY FEET, CALLUS ASEPTA LABORATORIES - MONACO

2 AKILEINE BLUE RANGE DRY FEET, CALLUS REMOVING CALLUSES AND SOFTENING THE SKIN CALLUSES AND SEVERE ROUGH SKIN: ROUGH SKIN REMOVER FOR KERATOSIS or PODORASP CALLUSES AND MODERATE ROUGH SKIN, GENERAL CARE : ANTI-CALLUS ROUGH SKIN REMOVAL CREAM MOISTURISING, REPAIRING AND PREVENTING CALLUSES STRONG DEHYDRATION, SENSITIVE SKIN, IMPORTANT CALLUSES HYDRA-DEFENSE BALM STRONG DEHYDRATION, CALLUSES, SENSITIVE SKIN: REGENERATING CREAM FOR DRY FEET MODERATE DRYNESS, CARE : SOFTENING MILK FOR FEET AND LEGS SOFTENING AND RELAXING HYDRA-DEFENSE BATH OIL

3 AKILEINE BLUE RANGE DRY FEET, CALLUS REMOVING CALLUS AND SOFTENING THE SKIN

4 AKILEINE BLUE RANGE CALLUS AND ROUGH SKIN PUMICE STONE Kerato-corrective treatment PRODUCT ADVANTAGES Removes callus and very rough skin Optimises AKILEINE moisturizing care Can be used once a week under a trickle of water For less frequent care, use the anti-callus FOOT PEELING cream ACTIVE SUBSTANCES POLYURETHANE (patented material) REMOVES DEAD SKIN CELLS THANKS TO DIAMOND-SHAPED GRAINS

5 AKILEINE BLUE RANGE SEVERE CALLUS AND ROUGH SKIN PODORASP Kératocorrective PRODUCT ADVANTAGES Removes callus and very rough skin rapidly Double-sided: 1 very rough size to remove heavy callus 1 slightly abrasive side to smooth and soften the skin Optimises the effect of AKILEINE moisturising care Can be used once a day on dry skin For weekly care, use the anti-callus Foot Peeling Cream ACTIVE SUBSTANCES ABRASIVE FILM REMOVES DEAD SKIN CELLS

6 AKILEINE BLUE MODERATE CALLUS & ROUGHNESS ANTI-CALLUS PEELING CREAM Coconut Shells & Grape Seed Oil ADVANTAGES Eliminates easily dead cells responsible for callus and roughness on heels, forefeet and pressure points Smoothes and softens even the most dehydrated feet Ideal before the action of an Akileine moisturizing care To be used once to twice a week Paraben-free formula. New high tolerance fragrance ACTIVE INGREDIENTS COCONUT SHELLS POLYETHYLENE SALICYLIC ACID KERATO-CORRECTIVE COMPLEX MADE WITH EXFOLIATING GRAINS OF DIFFERENT SIZES TO SMOOTHE THE SKIN, AND WITH SALICYLIC ACID WITH KERATOLITIC EFFECT GRAPE SEED OIL SOFTENS AND NOURISHES THE SKIN CELLULOSE CREATES SMALL ROLLS WHICH GET RID OF DEAD CELLS

7 AKILEINE BLUE MODERATE CALLUS & ROUGHNESS EFFICACY TESTED UNDER DERMATOLOGIST CONTROL REDUCES ROUGHNESS, DESQUAMATION AND HYPERKERATOSIS FROM THE VERY FIRST APPLICATION Clinical score * - 34% - 39% - 43% BEFORE APPLICATION AFTER APPLICATION

8 AKILEINE BLUE RANGE DRY FEET, CALLUS MOISTURIZING, REPAIRING, PREVENTING CALLUS Dryness and heavy callus Dryness and moderate callus Dryness and little callus Mature skin

9 AKILEINE BLUE RANGE DEHYDRATION AND STRONG CALLUS HYDRA-DEFENSE BALM With silk lipesters, Cameline oils and grape seeds PRODUCT ADVANTAGES Ideal for severe dehydration, heavy callus and brittle skin. Intense moisturising effect from the very first application. Decreases rough skin, hyperkeratosis after 7 days only. Immediate soothing feeling Reduces risk of infections: protects the skin while the balance is being reestablished ACTIVE SUBSTANCES CAMELINE OILS AND GRAPE SEEDS IMPERATA CYLINDRICA ILK LIPESTERS / SERINE (U, C8, and P) PRO VITAMIN B5 Extremely rich in essential fatty acids (omega 3 and 6). These oils restore the protective function of the skin Plant from the Australian desert, with high moisturising power Protect the skin from microbial attacks, moisturise and help prevent hyperkeratosis

10 AKILEINE BLUE RANGE DEHYDRATION AND STRONG CALLUS HYDRA-DEFENSE BALM With silk lipesters and cameline oils and grape seeds EFFICIENCY TESTED UNDER DERMATOLOGICAL CONTROL MOISTURISING EFFECT 70% Increase in hydratation 30 mins after application: + 66 % 60% 50% Increase in hydratation 3 h after application: + 30 % 40% 30% 20% 66% 30% 26% 43% Increase in hydratation 6 h after application: + 26 % Increase in hydratation24 h after application: + 20 % 10% 0% 20% Deep increase in hydratation after 7 days of application and measured on 8th days: + 43 % VERY GOOD RESULTS FROM THE VERY FIRST APPLICATION: THE IMMEDIATE MOISTURISING EFFECT IS EXCELLENT ( + 66% ) 24 HOURS OF NON-STOP HYDRATION! AFTER 7 DAYS OF DAILY USE THE SKIN RECOVERS ITS LEVEL OF OPTIMUM HYDRATION (43 % INCREASE IN HYDRATION)

11 AKILEINE BLUE RANGE DEHYDRATION AND HEAVY CALLUS HYDRA-DEFENSE BALM With silk lipesters, cameline oils and grape seeds oils EFFICIENCY TESTED UNDER DERMATOLOGICAL CONTROL EFFICIENCY ON DRYNESS AND ON HYPERKERATOSIS (heel) Clinical score * J1 2 J8 A REDUCTION BY ONE POINT CAN BE NOTICED IN 7 DAYS ONLY : DRY SKIN, HYPERKERATOSIS, ROUGH SKIN, AND EXFOLIATION

12 AKILEINE BLUE RANGE DEHYDRATION AND STRONG CALLUS HYDRA-DEFENSE BALM With silk lipesters, cameline oils and grape seeds EFFICIENCY TESTED UNDER DERMATOLOGICAL CONTROL PROTECTION AGAINST PATHOGENIC GERMS PROTECTION AGAINST: TRICHOPHYTON MENTAGROPHYTES TRICHOPHYTON RUBRUM ASPERGILLUS NIGER CANDIDA ALBICANS PROPIONI BACTERIUM TRICHOPHYTON RUBRUM CANDIDA ALBICANS ASPERGILLUS NIGER THE BALM PROTECTS THE SKIN FROM PATHOGENIC STRAINS RESPONSIBLE FOR MYCOSIS OR INFECTIONS THAT ARE FREQUENT ON VERY DEHYDRATED SKIN WITH DIMINISHED NATURAL PROTECTION

13 AKILEINE BLUE VERY DRY SKIN, MATURE SKIN NUTRI-REPAIR CREAM WITH PLANTS Shea Butter Macadamia Horse Chestnut - Arnica - Iparzine -4A BENEFITS Immediate and long-lasting hydration (24h)* In 7 days, fissures and cracks get repaired, roughness and dryness has reduced ** In 2 weeks, the skin is visibly nicer and regenerated, callus has improved *** Revitalizing effect: increase by 134% of collagen III synthesis **** Rich texture, easy to penetrate, non-sticky. Paraben free *Tested by corneometry **Test by clinical scorage ***Tested by volunteers self-evaluation - **** Tested on skin explant ACTIVE INGREDIENTS NATURAL SHEA BUTTER MACADAMIA OIL PLANT GLYCERIN This complex provides the skin with hydration, nutrition and repair. It restores the barrier function and the hydrolipidic film. HORSE CHESTNUT ARNICA OIL IPARZINE -4A Arnica and horse chesnut improve the oxygenation of tissues by stimulating the blood micro-circulation and also soothe inflammation Exclusive ASEPTA patented ingredient to maintain a youthful skin, to enhance the repair action and to fight the inflammation.

14 IPARZINE-4A : ANTI-AGING & ANTI-INFLAMMATORY Zinc anti-inflammatory and healing oligoelement Aspartic Acid stimulating aminoacid Palmitic Fatty Acid skin protector and penetration vector DI - PALMITOYL- ZINC ASPARTATE = IPARZINE-4A

15 IPARZINE -4A : A PROTECTIVE SHIELD FOR THE SKIN PREVENTS SKIN AGING AND HELPS REGENERATION: IPARZINE -4Aprotects the youthfulness of the skin thanks to its inhibition power of MMP9. These enzymes are responsible for the damage of derm main constituents (collagen, elastin, hyaluronic acid). IPARZINE -4A protects derm constituents and helps reshape the tissues. * In vitro Study - Sephra d ANTI-INFLAMMATORY ACTION: Inflammation increases pre-mature ageing. Stress, UV rays, pollution, smoke develop free radicals which stimulate inflammation. Thanks to powerful anti-inflammatory properties, IPARZINE -4A soothes the skin and fights the aging process due to inflammatory stress. ** In vitro Study- Sephra d

16 AKILEINE SOINS BLUE BLEUS PIEDS TRÈS SECS, PEAU MATURE. VERY DRY SKIN, MATURE SKIN NUTRI-REPAIR CREAM WITH PLANTS EFFICACY TESTED UNDER DERMATOLOGICAL CONTROL 1 CLINICAL STUDY ON THE REPAIR ACTION ON DRY FEET WITH ROUGHNESS AND CRACKS 2 STUDY OF THE IMMEDIATE AND LONG-LASTING MOISTURIZING EFFECT 3 STUDY OF THE REGENERATIVE EFFECT

17 AKILEINE BLUE NUTRI-REPAIR CREAM WITH PLANTS VERY DRY SKIN, MATURE SKIN 1 CLINICAL STUDY ON NUTRI-REPAIR CREAM S REPAIR ACTION ON DRY FEET SHOWING ROUGHNESS AND CRACKS 14 days Treated //non-treated foot CONDITIONS OF THE STUDY: Plan: open trial and intraindividual Target: 21 volunteers with dry feet average age: 51 ± 2 years Methodology: Treated area // non-treated area Frequence of use: 2 applications per day for 14 days on one foot only

18 AKILEINE BLUE VERY DRY SKIN, MATURE SKIN NUTRI-REPAIR CREAM WITH PLANTS EFFICACY TESTED UNDER DERMATOLOGICAL CONTROL DECREASE OF CRACKS WITHIN 7 DAYS Score* : 0= no crack 2= heel with cracks, very few cracks 4 = fissures + cracks in a moderate quantity 6 = a large number of fissures + cracks Clinical Score* 6 In 7 days: - 42% In 14 days: - 56 % treated ,1 4,1 4,3 3,9 2,5 1,9 D0 D7 PIED TREATED TRAITE FOOT D14 PIED NON TRAITE NON-TREATED FOOT D14 non-treated Clinical test carried out on 21 volunteers showing fissures and cracks on feet. Tested during 2 weeks. 2 applications per day. Treated // non-treated Foot. Average age 51 ans VOLUNTEER # 16

19 AKILEINE BLUE VERY DRY SKIN, MATURE SKIN NUTRI-REPAIR CREAM WITH PLANTS EFFICACY TESTED UNDER DERMATOLOGICAL CONTROL* DECREASE OF ROUGHNESS WITHIN 7 DAYS Roughness Measurement* : 0= none 1= very few 2= few 3= moderate Clinical score In 7 days: - 56% In 14 days: - 64% D0 7 DAYS D7 TREATED FOOT NON-TREATED FOOT Clinical test carried out on 21 volunteers showing fissures and cracks on feet. Tested during 2 weeks. 2 applications per day. Treated // non-treated Foot. Average age 51 ans VOLUNTEER # 20

20 AKILEINE BLUE VERY DRY SKIN, MATURE SKIN NUTRI-REPAIR CREAM WITH PLANTS EFFICACY TESTED UNDER DERMATOLOGICAL CONTROL* DECREASE OF DRYNESS WITHIN 7 DAYS Roughness Measurement* : 0= none 1= very few 2= few 3= moderate Clinical score In 7 days: - 52% In 14 days: - 56% J0 J7 TREATED FOOT NON-TREATED FOOT Clinical test carried out on 21 volunteers showing fissures and cracks on feet. Tested during 2 weeks. 2 applications per day. Treated // non-treated Foot. Average age 51 ans VOLUNTEER # 16

21 AKILEINE BLUE NUTRI-REPAIR CREAM WITH PLANTS VERY DRY SKIN, MATURE SKIN EFFICACY REPORTED BY VOLUNTEERS AFTER 14 DAYS OF USE, THE SKIN IS VISIBLY NICER AND REGENERATED* 100 % THE SKIN IS NICER, SOFTER, SUPPLE AND MOISTURIZED 90 % THE SKIN IS VISIBLY REGENERATED 100 % CALLUS HAS REDUCED 100 % FISSURES AND CRACKS HAVE REDUCED 100 % PAINFUL SENSATIONS ARE SOOTHED Clinical test carried out on 21 volunteers showing fissures and cracks on feet. Tested during 2 weeks. 2 applications per day. Treated // non-treated Foot. Average age 51 ans

22 AKILEINE BLUE NUTRI-REPAIR CREAM WITH PLANTS VERY DRY SKIN, MATURE SKIN EFFICACY TESTED UNDER DERMATOLOGICAL CONTROL 2 STUDY OF THE IMMEDIATE AND LONG-LASTING MOISTURIZING EFFECT CONDITIONS OF THE STUDY: Plan: open trial and intraindividual Targeted: 10 volunteers with dry skin Methodology: treated area // non-treated area Measurement Device: Cornéomètre CM 825 Cinetic: t0, t1h, t8h, t24h

23 AKILEINE BLUE NUTRI-REPAIR CREAM WITH PLANTS VERY DRY SKIN, MATURE SKIN EFFICACY TESTED UNDER DERMATOLOGICAL CONTROL IMMEDIATE AND LONG-LASTING HYDRATION (24H) FROM THE VERY FIRST APPLICATION* % of hydration gain * Tested by corneometry on 10 volunteers with very dry skin

24 AKILEINE BLUE NUTRI-REPAIR CREAM WITH PLANTS VERY DRY SKIN, MATURE SKIN EFFICACY TESTED UNDER DERMATOLOGICAL CONTROL 3 STUDY OF THE REGENERATIVE ACTION AIM OF THE STUDY: Highlighting the REGENERATIVE and REVITALIZING effects of the Cream on DRY FEET: Study of fibroblast stimulation with the measurement of the densification of collagen III & IV OPERATING PROCEDURE: Study of Skin Explants. Evaluation of the regenerative effect of the NUTRI REPAIR CREAM compared with a regenerative reference and non-treated explants. Examination of the general morphology of dermic and epidermic structures Immunohistochemistry : collagen III and collagen IV Half-quantification of results by image analysis.

25 AKILEINE BLUE VERY DRY SKIN, MATURE SKIN NUTRI-REPAIR CREAM WITH PLANTS Evaluation of the REGENERATIVE EFFECT THE NUTRI-REPAIR CREAM FOR DRY FEET LEADS TO THE DENSIFICATION OF THE DERMAL RIDGE AND A SIGNIFICANT INCREASE OF COLLAGEN III BY 134% Non-treated skin DAY 10 % of collagen III % With the Nutri-Repair Cream, Collagen III is denser and the skin is revitalized Non-treated Regenerative Reference Treated with AKILEÏNE Skin treated with AKILEÏNE Nutri-Repair Cream DAY 10 PJ10_ E2206 Coll III 50 µm

26 AKILEINE BLUE VERY DRY SKIN, MATURE SKIN NUTRI-REPAIR CREAM WITH PLANTS Evaluation of the REVITALIZING EFFECT THE NUTRI-REPAIR CREAM DENSIFIES SIGNIFICANTLY COLLAGEN IV OF THE DERMO-EPIDERMIC JUNCTION Non-treated Skin DAY 10 % of collagen III % With the Nutri-Repair Cream, Collagen IV is denser and the skin is revitalized Skin treated with AKILEÏNE DAY 10 Non-treated Treated with regenerative reference Treated with AKILEÏNE