Exfo-Bio. Intelligent exfoliation
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1 Intelligent exfoliation
2 Chemical Peel 5 th Most popular non-surgical procedure in the world 44% increase of cosmetic peel launches since 2013 Alpha hydroxyacids (AHA) are the most used active ingredient in formulations Source: International Society of Aesthetic Plastic Surgery (ISAPS), / Mintel GNPD.
3 Traditional AHAs Main ingredients: Glycolic, malic, citric, lactic, mandelic and tartaric acids Controlled therapeutic peeling that promotes: Whitening Increased cellular turn over Stimulation of MEC Rejuvenation Pain, redness, irritation, sensitization and desquamation
4 Intelligent biological exfoliator and wrinkle filler, composed by carbohydrates and alpha-hydroxy acids Synergistic combination of the glycerin extracts from Cajá, Mango and Banana pulp INCI: Water (and) Glycerin (and) Spondias Mombim Pulp Extract (and) Mangifera Indica (Mango) Pulp Extract (and) Musa Sapientum (Banana) Pulp Extract.
5 Cajá Rich in vitamins A, B1, B2, C, calcium, iron and phosphorus Astringent and emetic properties Mango Banana Rich in ascorbic acid, carotenoids and polyphenols Anti-oxidant activity Rich in fructose, flavonoids and AHA as malic acid Anti-oxidant properties * compositions as described in scientific literature
6 Mechanism of action Epidermis Transglutaminase Key enzyme for formation of the cornified envelope Reduces resistance of the stratum corneum Cornified envelope cross-linked protein structure of the corneocytes
7 Mechanism of action Epidermis Claudin-I Essential protein of the tight junctions Improves the barrier effect of viable layers Protein complex
8 Mechanism of action Epidermis Flaking corneocytes Cell renewal Basal layer of the epidermis Accelerates the desquamation younger-looking skin Basal keratinocyte
9 Mechanism of action Dermis Pro-collagen Collagen type 1 Elastin Redensification Firmness Elasticity
10 Mechanism of action Subcutaneous tissue SREBP-1 Stimulation of lipogenesis NEFA Local fat accumulation Skin filling SREBP-1 sterol regulatory element binding proteins NEFA non-esterified fatty acids
11 In vitro Keratolytic effect and protection of the lower layers of the skin Human keratinocytes treated with 0.04% Exfo-Bio and incubated for 48 h % in relation to control -14% Transglutaminase Claudin-I 65%
12 Ex vivo Protection of the lower layers of the skin Human skin fragments treated with Exfo-Bio and incubated for 6 hours Control 0.04% Exfo-Bio claudin-i nucleus Increased cell adhesion in layers just below the stratum corneum
13 Ex vivo Keratolytic effect and cell renewal Human skin fragments treated with 3% Exfo-Bio and incubated for 72 hours Control Placebo 3% Exfo-Bio increase of 16% In relation to placebo Ki-67 Nucleus Stimulation of cell renewal and desquamation of the stratum corneum
14 Ex vivo Keratolytic effectand cell renewal Human skin fragments treated with Exfo-Bio and incubated for 6 hours Control 0,04% Exfo-Bio Increase the number of cells in epidermis
15 Gene expression in relation to control Exfo-Bio In vitro Skin firmness Human fibroblasts treated with Exfo-Bio and incubated for 48 hours 10,00 8,00 6,00 4,00 2,00 4,4 Pro-collagen 5,3 7,6 0,00 0,01% 0,02% 0,04%
16 Elastin Collagen type I Exfo-Bio Ex vivo Wrinkle filling and skin firmness Fragments of human skin treated with 3% Exfo-Bio and incubated for 72 hours Control Placebo 3% Exfo-Bio 175% * 62% * *in relation to placebo
17 Gene expression in relation to control % in relation to control Exfo-Bio In vitro Wrinkle filling Human adipocytes treated with Exfo-Bio and incubated for 48 hours 2,00 1,60 SREBP-1 1,6 1,6 1,7 Quantification of free fatty acids NEFA 0 0,01% 0,02% 0,04% 30% 1,20 0,80 0,40 0,00 0,01% 0,02% 0,04% ,5-18,0-30,3 SREBP-1 sterol regulatory element binding proteins NEFA non-esterified fatty acids
18 In vivo Clinical efficacy Panel 35 volunteers from 35 until 55 years old Phototypes I to IV With signs of aging and wrinkles Application Face 2x a day For 28 days 3% of Exfo-Bio Evaluation From volunteers From dermatologist
19 In vivo Dermatologist evaluation (Improvement) Luminosity 24% Smothness 14% Moisturization 10% Eye wrinkles Firmness 7% 7% Fine wrinkles Skin whitening 3% 4%
20 In vivo Volunteer evaluation (Improvement) Smothness 94% Moisturization Wrinkles and expression lines Luminosity Tone and firmness 87% 84% 84% 81% Eye wrinkles 75% Skin whitening 69% Filling 63%
21 Benefits Gentle peeling through biological exfoliation Keratolytic effect/intelligent biological exfoliation when removing superficial dead cells and protecting the lower layers of the epidermis Increase of cell renewal in 16% Wrinkle-filling effect: stimulus of lipogenesis in up to 30% and extracellular matrix synthesis: collagen type 1 by 175% and elastin by 62% Improvement of the general characteristics of cutaneous micro-relief Younger skin, 94% softer, 84% more luminous and 81% firmer
22 Application Cream, gel, gel-cream and serum for mild exfoliation Stability and Compatibility Stable at ph 5-7 It can be heated up to 50ºC Water soluble Concentration of Use %
23 Thank you!
24
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