NIOSKIN ULTRA-FLEXIBLE NIOSOME. The latest generation of skin delivery system. easy to formulate total natural compound preservative free

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NioSkinTM Innovative Solution for Dermal Delivery Nioskin niosomes are a new and effective delivery system designed to improve skin penetration of natural ingredients.

2 NioSkinTM Innovative Solution for Dermal Delivery Nioskin niosomes are a new and effective delivery system designed to improve skin penetration of natural ingredients. NIOSKIN ULTRA-FLEXIBLE NIOSOME The latest generation of skin delivery system. easy to formulate total natural compound preservative free Nioskin Active Ingredients are patented.

3 NIOSKIN TM ULTRA-FLEXIBLE NIOSOME The latest generation of skin delivery system NIOSKIN TM ARE NIOSOMES SPECIFICALLY DESIGNED TO ENCAPSULATE PHYTOACTIVES NIOSKIN TM TECHNOLOGY Biologically active molecules of natural origin are included in special natural vesicles to pursue an optimal bioavailability, enhancing skin penetration through the stratum corneum. The clinically tested positive effects of NioSkin are related to the high rate of absorption through the skin. A vesicle of O nm, composed of amphiphilic molecules + an aqueous cavity suitable to incorporate large molecules as natural active compunds lipophilic active compounds can be associated with the bilayer hydrophilic active compunds can be entrapped in the acqueous cavity HIGH ELASTICITY AND DEFORMABILITY Nioskin vesicles are elastic and can squeeze through the pores in the stratum corneum performing penetration along intercellular routes. Flexible Niosome ( nm) Lipid regions (20-40 nm) The bilayer of the ULTRA-FLEXIBLE NIOSOME is made by polyglycerols single-chain surfactant being elastic to maximized the penetration throught the skin. Corneocyte Epidermis Stratum Corneum (15 µm) 2015 The vesicle shape to size the pore and then return to the original shape in the deeper epidermis stratum. Small size < 200 nm and maximum flexibility enhance skin and mucosal absorption The active compound is directly driven into the epidermis cells = maximum efficacy. Liposomes Conventional Niosome Ethosomes Ultra-flexible Niosomes NIOSKIN TM Nioskin niosomes are highly hydrophilic and when applied on the skin help to secure an additional hydration, migrating into the water-rich deeper stratum of the skin.

NIOSKIN TM TECHNICAL SUPPORT ADVANTAGES FOR COSMETIC FORMULATION Easy to formulate by introduction in the water or lipid phase of emulsion Direct use in cold phase Application Self-preservative

Documentation Total natural components Allergen free Gluten free Paraben free Clinical tests Skin barrier and hydration Trans Epidermal Water Loss (TEWL) Skin pigmentation Preservative free GMO free

4 NIOSKIN TM TECHNICAL SUPPORT ADVANTAGES FOR COSMETIC FORMULATION Easy to formulate by introduction in the water or lipid phase of emulsion Direct use in cold phase Application Self-preservative Soluble in water and dispersible in lipid Stable at a wide range of ph Solvent free NioSkin is suitable to formulate a wide range of dermocosmetics for face and body care. Documentation Total natural components Allergen free Gluten free Paraben free Clinical tests Skin barrier and hydration Trans Epidermal Water Loss (TEWL) Skin pigmentation Preservative free GMO free Dermatologically tested (Patch Test and Repeated Patch Test) Skin aging (Ultrasound Skin-Imaging) Skin inflammation Skin elasticity Emulsion W/O Emulsion O/W Balm and Lipstick Lotion BB creams Serum and day base creams Eye care serum Facial mask Recommended usage dosage: 2% w/w

5 NIOSKIN TM ACTIVE INGREDIENTS PLATFORM COSMETIC APPLICATION NioSkin RCL40 Red Clover Isoflavone Aglycones Extract AQUA, OLIVE OIL POLYGLYCERYL-6 ESTERS, POLYGLYCERYL-6 LAURATE, GLYCERIN, TRIFOLIUM PRATENSE LEAF EXTRACT, MAGNOLOL, HONOKIOL NioSkin HMRLignan Picea Abies Purified Lignan 7-Hydroxymataresinol Extract AQUA, OLIVE OIL POLYGLYCERYL-6 ESTERS, POLYGLYCERYL-6 LAURATE, GLYCERIN, PICEA ABIES WOOD EXTRACT, MAGNOLOL, HONOKIOL NioSkin Ginkgo Ginkgo Biloba 24/6 Extract AQUA, OLIVE OIL POLYGLYCERYL-6 ESTERS, POLYGLYCERYL-6 LAURATE, GLYCERIN, GINKGO BILOBA LEAF EXTRACT, MAGNOLOL, HONOKIOL NioSkin Bilberry European Bilberry Anthocianins Extract AQUA, OLIVE OIL POLYGLYCERYL-6 ESTERS, POLYGLYCERYL-6 LAURATE, GLYCERIN, VACCINIUM MYRTILLUS FRUIT EXTRACT, MAGNOLOL, HONOKIOL NioSkin MedCan Cannabis sativa CBD Extract (THC free) AQUA, OLIVE OIL POLYGLYCERYL-6 ESTERS, POLYGLYCERYL-6 LAURATE, GLYCERIN, CANNABIS SATIVA EXTRACT, MAGNOLOL, HONOKIOL RCL40 HMRLIGNAN GINKGO Anti-aging in mature skin (+40) Hyperpigmentation in aging Dryness of skin and mucosae Anti-wrinkle at any age Anti-aging in young skin (+30) High hydration and eye-lines recover Skin irritation and sensitive skin Anti-aging sunscreen formula Anti-aging, moisturizing High hydration and fine lines recover Local tissue microcirculation Body care Produced with GMP certified active ingredients and in compliance with the highest quality standards. NioSkin Active Ingredients fulfil the requirements of the European Cosmetic Regulation 1223/2009 and its amendments and the Guidelines for Safety Evaluation of Cosmetic Ingredients. BILBERRY Antioxidant & antiaging Capillary protection & couperose Dark eye circle serum MEDCAN Anti-inflammatory Dermatosis Contact dermatitis Immunological related skin disorders

NIOSKIN TM RCL40 A UNIQUE CONCENTRATED NATURAL PHYTOACTIVE FROM RED CLOVER NioSkin RCL40 demonstrates a superior improvement of skin elasticity providing a younger appearance and a firming tone

antiaging effects have been proven through clinical trials with significance evidence in skin elasticity, hydration and derma re-modelling for long term repairing effect.

6 NIOSKIN TM RCL40 A UNIQUE CONCENTRATED NATURAL PHYTOACTIVE FROM RED CLOVER NioSkin RCL40 demonstrates a superior improvement of skin elasticity providing a younger appearance and a firming tone INDICATION ANTI-AGING Firming action on mature skin (+40) Skin elasticity Increases dermal density Increases skin thickness Moisturizes aged skin Repairs the skin barrier CLINICAL TESTS Overall antiaging effects have been proven through clinical trials with significance evidence in skin elasticity, hydration and derma re-modelling for long term repairing effect. SKIN ELASTICITY A study on skin elasticity was carried out on 12 subjects by evaluating the reduction of the Young s elastic modulus (E), Time Retention (R) and VE Viscoelasticity. The volunteers were required to apply a 2% O/W cream twice a day for a period of 4 consecutive weeks, on the forearm inner side and on the face. A formulation without NioSkin was used as control. Results show that topical application of 2% NioSkin RCL40 produces a significant increase in skin elasticity after 2 weeks, reaching the maximum value after 28 days. DERMASCAN A study on skin thickness and dermal density was carried out on 18 subjects by Dermascan Ultra-sound High Resolution Image Analysis, a new non-invasive methodology for the in-vivo study of the skin aging process. The volunteers were required to apply a 2% O/W emulsion twice a day for a period of 8 consecutive weeks, on the forearm inner side. A formulation without NioSkin was used as control. Results show that topical application of 2% NioSkin RCL40 produces a significant increase in skin thickness and dermal density. Significant reduction of the elastic Young s modulus E % Significant reduction of the skin Time Retraction (R) % Significant reduction of VE Viscoelasticity % Significant increase of Dermal Density % Red clover is the preferred natural source of isoflavones as free aglycones. Nioskin RCL40 has been formulated with the superior concentrated and standardized Red Clover Extract 40% isoflavones in their readyactive form. OTHER ANTI-AGING TESTS NIOSKIN RCL40 has been tested on TEWL and Corneometric Skin Hydration showing significant improvement Day 0 Day 28 Day 56 Nioskin RCL40 Placebo

NIOSKIN TM HMRLIGNAN A ULTIMATE NATURAL AND PURIFIED LIGNAN FOR COSMETIC USE NioSkin HMRlignan demonstrates a rapid improvement of skin wrinkle lines, showing a superior hydration and protecting

CLINICAL TESTS Antiaging effects have been proven through clinical trials with significance evidence in restoring the skin barrier and hydration, being the first answer to wrinkles and lines at any

7 NIOSKIN TM HMRLIGNAN A ULTIMATE NATURAL AND PURIFIED LIGNAN FOR COSMETIC USE NioSkin HMRlignan demonstrates a rapid improvement of skin wrinkle lines, showing a superior hydration and protecting effects on sensitive skin INDICATION ANTI-AGING Anti-wrinkle Repairs the skin barrier Long term Moisturizing Prevents skin aging by increasing dermal density & skin thickness Ideal for sensitive skin CLINICAL TESTS Antiaging effects have been proven through clinical trials with significance evidence in restoring the skin barrier and hydration, being the first answer to wrinkles and lines at any age, with an overall evidence of derma re-modelling for long term repairing effect. Effective on sensitive skin. SKIN BARRIER AND FAST HYDRATION A study on skin barrier and restoring hydration was carried out on 12 subjects by evaluating the Trans Epidermal Water Loss (TEWL). The volunteers were required to apply a 2% O/W cream twice a day for a period of 4 consecutive weeks, on the forearm inner side and on the face. A formulation without NioSkin was used as control. Results show that topical application of 2% NioSkin HMRlignan produces a significant increase in skin barrier and hydration after 2 weeks, reaching the maximum value after 28 days. DERMASCAN A study on skin thickness and dermal density was carried out on 18 subjects by Dermascan Ultra-sound High Resolution Image Analysis, a new non-invasive methodology for the in-vivo study of the skin aging process. The volunteers were required to apply a 2% O/W emulsion twice a day for a period of 8 consecutive weeks, on the forearm inner side. A formulation without NioSkin was used as control. Results show that topical application of 2% HMRLignan produces a significant increase in skin thickness and dermal density. Significant reduction of TEWL % Significant variation of Short-Term Skin Moisturizing Index Significant increase of Dermal Density % minutes 15 minutes 30 minutes 60 minutes Day 0 Day 28 Day 56 Significant increase of Skin Thickness % OTHER ANTI-AGING TESTS HMRlignan is a unique patented extract from Picea Abies knots, rich in a particular type of lignans. 7-hydroxymatairesinol is the purified lignan with superior antioxidant and anti- inflammatory properties in NioSKin HMRlignan NIOSKIN HMRlignan has been tested on Skin Elasticity and Corneometric Hydration showing significant improvement. NIOSKIN HMRlignan has been specifically tested on sensitive skin, showing significant rapid improvement of skin conditions Day 0 Day 28 Day 56 Nioskin HMRLignan Placebo

NIOSKIN TM BILBERRY A CONCENTRATE BLUE PHYTOACTIVES FROM BILBERRY FRUITS FOR COSMETIC USE NioSkin Bilberry demonstrates an improvement of skin elasticity, showing antiaging and protecting effects

significance evidence on skin elasticity and hydration for an antioxidant repairing effect.

8 NIOSKIN TM BILBERRY A CONCENTRATE BLUE PHYTOACTIVES FROM BILBERRY FRUITS FOR COSMETIC USE NioSkin Bilberry demonstrates an improvement of skin elasticity, showing antiaging and protecting effects INDICATION ANTI-AGING Skin moisturizing Repairs Skin Barrier Increases Skin Elasticity Antiaging & Antioxidant CLINICAL TESTS Overall antiaging effects have been proven through clinical trials with significance evidence on skin elasticity and hydration for an antioxidant repairing effect. SKIN ELASTICITY A study on skin elasticity was carried out on 12 subjects by evaluating the reduction of the Young s elastic modulus (E), Time Retention (R) and VE Viscoelasticity. The volunteers were required to apply a 2% O/W cream twice a day for a period of 4 consecutive weeks, on the forearm inner side and on the face. A formulation without NioSkin was used as control. Results show that topical application of 2% NioSkin Bilberry produces a significant increase in skin elasticity after 2 weeks, reaching the maximum value after 28 days. CORNEOMETRIC SKIN HYDRATION A study on skin hydration was carried out on 12 subjects by evaluating the Corneometric Hydration Index at Short-Term and Long-Term. The volunteers were required to apply a 2% O/W cream on the face, for the 24 hours test and twice a day for a period of 4 consecutive weeks. A formulation without NioSkin was used as control. Results show that topical application of 2% NioSkin Bilberry produces an extremely significant rapid increase in skin hydration after 15 minutes, with evidence of high significant efficacy on long term treatment. Significant reduction of the elastic Young s modulus E % Significant reduction of VE Viscoelasticity % Significant reduction of the Skin Time Retraction (R) % Significant increase of Long Term Skin Moisturizing Index Bilberry is the most famous fruit and concentrated source of antioxidant poliphenol pigments, the blue anthocyanins. Nioskin Bilberry contains the superior concentrated and standardized extract from Bilberry fruits 36% anthocyanins, totally stabilized. OTHER ANTI-AGING TESTS NIOSKIN Bilberry has been tested on Dermascan and Corneometric Hydration showing positive improvement Day 0 Nioskin Bilberry Placebo

NIOSKIN TM GINKGO A CONCENTRATED PHYTOACTIVES FROM THE ANCIENT GINKGO TREE FOR COSMETIC USE NioSkin Ginkgo demonstrates an improvement of skin moisturizing and skin firmness showing a superior

been proven through clinical trials with significance evidence on skin hydration and skin barrier, improving skin firmness, contrasting fine lines and wrinkles, and offering a superior antioxidant

9 NIOSKIN TM GINKGO A CONCENTRATED PHYTOACTIVES FROM THE ANCIENT GINKGO TREE FOR COSMETIC USE NioSkin Ginkgo demonstrates an improvement of skin moisturizing and skin firmness showing a superior protecting effects from oxidative stress INDICATION ANTI-AGING Skin moisturizing Anti-wrinkle Protecting the skin from oxidative stress and inflammation CLINICAL TESTS Overall antiaging effects have been proven through clinical trials with significance evidence on skin hydration and skin barrier, improving skin firmness, contrasting fine lines and wrinkles, and offering a superior antioxidant protecting effect. Ginkgo biloba is the oldest tree. The leaves of Ginkgo contain unique flavonoids and terpenes not found in any other plants, being an elective source of antioxidant compounds. Nioskin Ginkgo has been formulated with the standardized Ginkgo Biloba extract 24-6% flavonoids & terpenes recognized for their radical scavenging properties that protect tissue against oxidative stress which leads to aging and inflammation. Ginkgo helps to eliminate toxins, strengthen the skin s defenses, improving the dermal microcirculation and lymphatic drainage and stimulate fibroblast for an overall antiaging effect. SKIN MOISTURIZING AND BARRIER A study on skin barrier and moisturizing was carried out on 12 subjects by evaluating the trans Epidermal Water Loss (TEWL). The volunteers were required to apply a 2% O/W cream twice a day for a period of 4 consecutive weeks, on the forearm inner side and on the face. A formulation without NioSkin was used as control. Results show that topical application of 2% NioSkin Ginkgo produces a significant increase in skin barrier and hydration after 2 weeks, reaching the maximum value after 28 days. Aging and related changes of epidermal structure can affect skin capacity to maintain water inside the stratum corneum. Measurements of skin hydration are of great importance in evaluating skin barrier and anti-aging protecting effects. SKIN HYDRATATION A study on skin hydration was carried out on 12 subjects by evaluating the Corneometric Hydration Index at Short-Term and Long-Term. The volunteers were required to apply a 2% O/W cream on the face, for the 24 hours test and twice a day for a period of 4 consecutive weeks. A formulation without NioSkin was used as control. Results show that topical application of 2% NioSkin Ginkgo produces an extremely significant rapid increase in skin hydration after 15 minutes, with evidence of high significant efficacy on long term treatment. OTHER ANTI-AGING TESTS NIOSKIN Ginkgo has been tested on Dermascan and Skin Elasticity showing positive improvement. Significant reduction of TEWL % Significant increase of Long-Term Skin Moisturizing Index Significant increase of Short-Term Skin Moisturizing Index % Significant variation of Short-Term Skin Moisturizing Index Day minutes 15 minutes 30 minutes 60 minutes Nioskin Ginkgo minutes 15 minutes 30 minutes 60 minutes Placebo 1.56

NIOSKIN TM MEDCAN AN INNOVATIVE CONCENTRATE PHYTOACTIVES FROM CANNABIS FOR TOPICAL USE Linnea Nioskin Cannabis contains a concentrated total cannabis extract standardized

related skin disorders Cannabis phytocomplex and its phytocannabinoids may have a relevant medicinal value for certain diseases.

10 NIOSKIN TM MEDCAN AN INNOVATIVE CONCENTRATE PHYTOACTIVES FROM CANNABIS FOR TOPICAL USE Linnea Nioskin Cannabis contains a concentrated total cannabis extract standardized in cannabidiols (CBD) NioSkin INDICATION The result of a balanced combination of Nature and Science Skin Anti-inflammatory Dermatosis Contact dermatitis Immunological related skin disorders Cannabis phytocomplex and its phytocannabinoids may have a relevant medicinal value for certain diseases. Cannabis phytocomplex has a role in the control of epidermal physiology and skin differentiation genes, anti-inflammatory and immunological related skin disorders, neurodermitis, contact eczema, hitching dermatosis, rosacea.

11 About Linnea Located in the Swiss canton of Ticino, Linnea is a high-quality manufacturer of Botanical Extracts and Active Pharmaceutical Ingredients of Natural Origin in Bulk form. Linnea Ingredients are suitable for the use in the Pharmaceutical, Health-Food and Cosmetic Industries. The company employs a team of experienced professionals specialized in the extraction and purification of plant materials and in the synthesis of fine chemicals. Best solutions, everywhere Linnea s service is tailored to the needs of its customers. With our extensive knowledge of international requirements and dispatch procedures, prompt efficient delivery is guaranteed just about anywhere in the world. Thanks to the company s competence and reliability, Linnea exports its products to more than 60 countries across 5 continents and supplies more than 200 clients per year. Headquarters Linnea SA Via Cantonale CH-6595 Riazzino (TI) Switzerland Tel: +41 (0) Fax: +41 (0) info@linnea.ch US office Linnea Inc. 435 McCartney Street Easton, PA USA Tel: (US) or Fax: dstanek@linnea.ch

effect. Application studies show that the treatment with 4% Beraclay Gold in a shampoo promotes hair cuticle repair.

effect. Application studies show that the treatment with 4% Beraclay Gold in a shampoo promotes hair cuticle repair. Class Beraclay Amazonian White Clay Beraclay Black Beraclay Crude Beraclay Gold Beraclay Light Green Beraclay Purple Natural clay is collected from the Marajo shore in the Brazil Amazon river mouth. This