BASF. Product Catalogue Actives 2017

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1 BASF Product Catalogue Actives 2017

2 PRODUCT OVERVIEW Application fields Product Anti-Aging Anti-Wrinkle Barrier Regulation & Func-tional Support Body Care Deodorant Efoliation Hair Care / Scalp Care Microcirculation Regulation Moisturization / Hydraregulation Natural Oil Problem Skin / Sebum Regulation Sensitive Skin Skin energizing / Cell revitalization Skin Lightening / Whitening / Anti-Age Spots Skin Protection / Anti-Pollution / Lipo Structure Slimming / Shaping Soothing / Anti-irritation / Anti-inflammatory Sun Care Tightening / Firming Preservative ACTIWHITE TM PW LS 9860 ADVANCED MOIST COMPLEX TM NP R11016 AH CARE TM L-65 ANASENSYL LS 9322 AQU ACTIV TM LS 9856 ARGANYL TM LS 9781 ARGANYL TM PW LS 9830 ARGASSENTIAL TM BC09959 ARGATENSYL TM PW BIO LS 9902 ASEBIOL TM LS 9853 BETA HYDROXYDE TM AC SD G00011 BETAPUR TM A00067 BIOPHYTEX TM LS 9832 COBIALIFT TM 18 BC COLLGUARD TM A00263 COLLREPAIR TM DG A00331 DANSONYL TM LS 9715 DELINER TM A00199 DERMAGENIST TM PW BC DERMAWHITE TM WF BC09993 DERMICAN TM PW LS 9838 DERMICAN TM SPB LS 9837 DN-AGE TM LS 9547 DN-AGE TM PW LS 9827 D-STRIA TM A00259 DULCEMIN TM PW BIO LS 9903 ELESTAB TM HP 100 ELESTAN TM LS 9913 ELESTAN TM PW LS 9879 EPERULINE TM PW LS 9627 EPIGENIST TM LS FRESHAXYL TM LS 9980 GENEROL TM R 2

3 PRODUCT OVERVIEW Application fields Product Anti-Aging Anti-Wrinkle Barrier Regulation & Func-tional Support Body Care Deodorant Efoliation Hair Care / Scalp Care Microcirculation Regulation Moisturization / Hydraregulation Natural Oil Problem Skin / Sebum Regulation Sensitive Skin Skin energizing / Cell revitalization Skin Lightening / Whitening / Anti-Age Spots Skin Protection / Anti-Pollution / Lipo Structure Slimming / Shaping Soothing / Anti-irritation / Anti-inflammatory Sun Care Tightening / Firming Preservative HIBISCIN TM HP LS 9198 HYALUFIXT TM GL A00102 HYALURONIC FILLING SPHERES TM C00498 HYALUROSMOOTH TM LS 8998 HYALUROSMOOTH TM PW LS 8997 HYDRASENSYL SPB LS 9938 IRWINOL TM LS 9890 LACTOLAN TM LS 5879 LARICYL TM LS 8865 LINEFACTOR TM C A00314 LIPOFRUCTYL TM ARGAN LS 9779 LIPOFRUCTYL TM CYPERUS LS 9892 LIPOFRUCTYL TM MO LS 9305 LITCHIDERM TM LS 9704 LOX-AGE TM A00327 LYS'LASTINE TM V A00077 LYS SUN TM BC10006 MARINE FILLING SPHERES TM C00468 MARIPONICS TM PSR R11009 MAT-XS TM CLINICAL A00098 MELHYDRAN TM LS 9876 MELLIDYN TM LS 9834 MYOXINOL TM LS 9736 NEUROBIOX TM A00112 OLIGOLIN TM BC OSMHYDRAN TM LS 8453 OSMOGELINE TM R10979 OXYGEN TM COMPLEX LS 9641 PA REVIVISCENCE TM LS 9562 PATCH 2 O TM A00297 PERLAURA TM A00316 PHOTOTAN TM LS 2261 E PHYTOKINE TM A

4 PRODUCT OVERVIEW Application fields Product Anti-Aging Anti-Wrinkle Barrier Regulation & Func-tional Support Body Care Deodorant Efoliation Hair Care / Scalp Care Microcirculation Regulation Moisturization / Hydraregulation Natural Oil Problem Skin / Sebum Regulation Sensitive Skin Skin energizing / Cell revitalization Skin Lightening / Whitening / Anti-Age Spots Skin Protection / Anti-Pollution / Lipo Structure Slimming / Shaping Soothing / Anti-irritation / Anti-inflammatory Sun Care Tightening / Firming Preservative PHYTOLIGHT TM BG A00043 PHYTOSOOTHE TM LS 9766 PILISOFT TM LS 9760 PROTEASYL TM PW PSE LS 8951 PROTEASYL TM TP POE LS 9818 PURICARE TM POE LS 9727 PURISOFT TM POE LS 9726 PURISOFT TM PW PSE LS 9836 RADIANSKIN TM PW LS 9918 RELIPIDIUM TM A00265 SANICAPYL TM BC SEBARYL TM FL 9088 SHADOWNYL TM R11026 SKINASENSYL TM LS 9749 SKINASENSYL TM PW LS 9852 SLIM-EXCESS TM A00073 SPECI MEN TM BC10001 SPHINGOCERYL TM VEG LS 9948 SQISANDRYL TM LS 9905 SVELTINE TM ST BC10032 SYMBIOCELL TM BC10015 SYMBIOCELL TM A00110 SYNIORAGE TM PW LS 9847 TRICHOGEN TM VEG UL LS 9922 TRICHOLASTYL TM LS 9912 ULTRA FILLING SPHERES TM VEGESERYL TM HGP LS 9874 VITACELL PW LS 7979 VIT-A-LIKE TM PW LS 9898 VIT-A-LIKE TM SPB LS 9793 VITAPLEX TM LS 9799 X-PRESSIN TM C R

5 Product INCI in-vitro / e-vivo ACTIWHITE TM PW LS 9860 ADVANCED MOIST COMPLEX TM NP R11016 AH CARE TM L-65 ANASENSYL LS 9322 Maltodetrin (and) Sucrose Dilaurate (and) Sodium Cocoyl Glutamate (and) Pisum Sativum Etract Glycerin (and) Aqua (and) Sodium PCA (and) Urea (and) Trehalose (and) Heylene Glycol (and) Polyquaternium-51 (and) Triacetin (and) Caprylyl Glycol (and) Sodium Hyaluronate Lactic Acid (and) Aqua (and) Arginine Mannitol (and) Ammonium Glycyrrhizate (and) Caffeine (and) Zinc Gluconate (and) Aesculus Hippocastanum Seed Etract AQU ACTIV TM LS 9856 Behenyl Alcohol (and) Glyceryl Oleate (and) Cocamide MIPA (and) Calcium Citrate ARGANYL TM LS 9781 ARGANYL TM PW LS 9830 ARGASSENTIAL TM BC09959 ARGATENSYL TM PW BIO LS 9902 Aqua (and) Glycerin (and) Argania Spinosa Etract Argania Spinosa Etract (and) Maltodetrin Dicaprylyl Ether (and) Sorbitol (and) Lauryl Glucoside (and) Polyglyceryl-2 Dipolyhydroystearate (and) Aqua (and) Argania Spinosa Fruit Etract (and) Glycerin Argania Spinosa Kernel Etract (and) Sodium Cocoyl Glutamate Inhibition of melanosome maturation, Inhibition of melanogenesis, Tyrosinase-inhibition Reduction of LDH, PGE2, IL-alpha release Increase of Involucrin, Transglutaminase and Thight junctions protein levels, Increase of lipid neo-synthesis, Inhibits ceramidase activity Anti-collagenase activity (in-tubo), Anti-collagenase activity (e-vivo), Anti-MMP activity, Anti-free radical activity, Cell protection against pollution stress (PM2.5 + PAH, B[a]P + UVA) Anti-collagenase activity (in-tubo), Anti-collagenase activity (e-vivo), Anti-MMP activity, Anti-free radical activity, Cell protection against pollution stress (PM2.5 + PAH, B[a]P + UVA) Increase type I collagen synthesis, Stimulation of pre-adipocyte differentiation, Increase of lipid storage in mature adipocytes Whitening (1.7%, W6, W12), Anti-age spots efficacy (2%, D56), Reduction of number, size and color intensitiy of dark spots (2%, D56; Evaluation by a dermatologist), More even and brighter skin compleion (2%, D56; Panelist s evaluation) Water binding capacity (10%), More hydrating than HA (5%, 0.5h, 2h, 4h, 6h, 8h), Reinforcement of the cutaneous barrier (10%, 2h, 6h), Immediate and all day moisture (3%, 2 min, 4min, 6min, 8h), Longterm moisture (10%, D15) Increase of cell turnover (14.7%, D21), Reduction of acute irritation (Stinging) (14.7%, 2min, 4min, 6min, 8min), Reduction of cumulative irritation (14.7%, D1-14) Soothing and calming after capsaicin application (1%, 30min), Reduction of erythema after shaving (1%, D7, D14) Skin moisturization (3%, D14), Increase of skin elasticity (3%, D14) Skin is more elastic, skin teture is smoother and skin is softer (3%, D56; panelist s evaluation), Anti-oidative potential vs placebo and vs 1% tocopheryl acetate (3%, D15) Skin is more elastic, skin teture is smoother and skin is softer (0.21%, D56; panelist s evaluation), Anti-oidative potential vs placebo and vs 1% tocopheryl acetate (0.21%, D15) Face firming (2%, D56), Face plumping (2%, D56), Lips plumping (2%, D28 Immediate lifting / wrinkle smoothing (test on crow s feet area (0.6%, 15Min, 60Min), Long term wrinkle smoothing in crow s feet area (0.6%, D28) None 2% None 3-10% None 5-10% None % None 2-3% Phenoyethanol 1-3% None % None 1-2% Hydrodispersible & lipodispersible None %; 1.25% for flash serums potentially NaTrue Cosmos approved CHINA approved 5

6 Product INCI in-vitro / e-vivo ASEBIOL TM LS 9853 BETA HYDROXYDE TM AC SD G00011 BETAPUR TM A00067 Aqua (and) Pyridoine HCl (and) Niacinamide (and) Glycerin (and) Panthenol (and) Hydrolyzed Yeast Protein (and) Threonine (and) Allantoin (and) Biotin Acacia Senegal Gum (and) Salicylic Acid Peumus Boldus Leaf Etract (and) Pentylene Glycol (and) Xanthan Gum BIOPHYTEX TM LS 9832 Panthenol (and) Escin (and) Glycerin (and) Ruscus Aculeatus Root Etract (and) Ammonium Glycyrrhizate (and) Centella Asiatica Leaf Etract (and) Hydrolyzed Yeast Protein (and) Calendula Officinalis Flower Etract COLLALIFT TM 18 BC10014 COLLGUARD TM A00263 COLLREPAIR TM DG A00331 DANSONYL TM LS 9715 Glycerin (and) Aqua (and) Khaya Senegalensis Bark Etract (and) Maltodetrin Water (and) Butylene Glycol (and) Davilla Rugosa Leaf Etract (and) Pentylene Glycol (and) Xanthan Gum Aqua (and) Niacin (and) Heylene Glycol (and) Caprylyl Glycol (and) Xanthan Gum (and) Salvia Miltiorrhiza Leaf Etract Hydrolyzed Adansonia Digitata Etract Transcutaneous penetration (e-vivo) Stimulation of the production of β-defensins, Inhibition of the production of inflammatory cytokines and IL8 and MIP3-α Anti-oily hair effect (5%, D28) Skin renewal (0.4%, 2%, D15), Pore size reduction (0.4%; 3%, D28), Reduction of number of pore (0.4%; 3%, D28), Shine reduction (0.4%; 3%, D28), General improvement of oily skin: Refined pores, Compleion eveness, Brightness, blackheads, Inflammatory lesions (0.4%;3%; D14, D30 Clinician evaluation), Less oily skin, matified skin, less visible pores, removed blemishes, comfort (0.4%; 3%; D14, D30 Panelist s evaluation) Reduction of skin redness (2%, D28), Purification of the skin (2%, D28), Purified compleion, refined skin teture, compeion eveness, pores less visible (2%, D28; panelist s evaluation), Decrease of inflammatory aspect and improvement of the skin s overall appearance (4%, D28) Anti-inflammatory (e-vivo) Soothing (5%, D21), Anti-eye dark circle effect (3%, D28), Anti-couperose (3%, D14) Stimulation of collagen XVIII synthesis in keratinocytes, Stimulation of collagen XVIII synthesis in adipocytes, Improvement of biomechanical properties (3D Mimeskin) Inhibition of glycation, Boost of collagen synthesis, Radical scavenging activity, Inhibition of collagenase, Increase of collagen I deposition Etracellular deglycation activity (in-tubo), Intracellular deglycation activity, Intracellular cytoskeleton morphology, Cellular resilience improvement, Breaking the viscous cycle of glycation propagation (in-tubo) Moisture retention Improvement of skin s surface homogeneity, Smoothing of wrinkles (crow s feet area), Improvement of skin elasticity, (1%, D28, D56) Decrease of AGEs (3%, D112), Skin tone improvement (3%, D112), Improvement of skin elasticity (5%, D28) Tightening (10%, D21), Sensorial improvement (5%, 5min, 45min) Phenoyethanol, Potassium Sorbate 3-5% None 0.4-5% None 0.5-5% None 2-5% None 1% None 3-5% Phenoyethanol 3-10% potentially NaTrue Cosmos approved CHINA approved 6

7 Product INCI in-vitro / e-vivo DELINER TM A00199 DERMAWHITE TM WF BC09993 DERMICAN TM PW LS 9838 DERMICAN TM SPB LS 9837 DERMAGENIST TM PW BC10004 DN-AGE TM LS 9547 DN-AGE TM PW LS 9827 D-STRIA TM A00259 DULCEMIN TM PW BIO LS 9903 Pentylene Glycol (and) Zea Mays Etract (and) Xanthan Gum Aqua (and) Tartaric Acid (and) Disodium EDTA (and) Glycerin (and) Butylene Glycol (and) Psidium Guajava Fruit Etract (and) Carica Papaya Fruit Etract (and) Saifraga Sarmentosa Etract Mannitol (and) Acetyl Tetrapeptide-9 Aqua (and) Glycerin (and) Acetyl Tetrapeptide-9 Maltodetrin (and) Origanum Majorana Leaf Etract Aqua (and) Glycerin (and) Cassia Alata Etract Cassia Alata Etract (and) Maltodetrin Butylene Glycol (and) Pentylene Glycol (and) Alcohol (and) Serenoa Serrulata Fruit Etract Prunus Amygdalus Dulcis Protein Activation of fibronection synthesis (e-vivo), Activation of tissue repair (e-vivo) Inhibition of melanin synthesis Stimulation fibroblast cell growth and structural proteins (gene epression), Stimulation of lumican synthesis (on aged fibroblasts and pseudo-dermis), Stimulation of collagen I (gene epression and on fibroblasts) Stimulation fibroblast cell growth and structural proteins (gene epression), Stimulation of lumican synthesis (on aged fibroblasts and pseudo-dermis), Stimulation of collagen I (gene epression and on fibroblasts) Reinforce fibroblast intracellular structures and contractility, Re-activating cells machinery through epigenetic regulation, Re-building of collagen network, Strengthening of cell-matri interactions Nuclear DNA protection from UV-B, mitochondrial DNA protection from UV-A, Support of DNA repair Nuclear DNA protection from UV-B, mitochondrial DNA protection from UV-A, Support of DNA repair Relaing of myofibroblast, Elastin gene epression, Stimulation of collagen I Skin: Cell vitalization by ATP boosting, Hair: Film forming, Sensorial improvement Wrinkle reduction (3%, D56), Redensification of the skin (3%, D120) Skin lightening vs placebo on indian volenteers (2%, D84), Skin lightening vs kojic acid on indian volenteers (2%, D56) Skin is fairer, lighter and looks brighter (2%, vs placebo D56, vs kojic acid D14); Panelist s evaluation), Lightening effect of a facial rinse off soap bar (1.5%, D14, D28), Made my skin fairer, Helps to lighten my skin, Makes my skin tone even, Makes my skin look brighter (1.5%, D28) (Panelist s evaluation) Structuring by increasing dermis s thickness, firming (0.9%, D112) Structuring by increasing dermis s thickness, firming (0.9%, D112) Improvemnet of skin density and firmness (0.4%, D28, D56, D84) Improvement of skin microrelief after UV irradiation (preventive application) (3%, Pre-treatment D6, treatment & irradiation D4, Microrelief alterations after D6) Improvement of skin microrelief after UV irradiation (preventive application) (0.25%, Pre-treatment D6, treatment & irradiation D4, Microrelief alterations after D6) Improvement of stretch marks (3%, D84), Skin is more supple, the stretch mark is smoother, appearance of stretch marks is reduced (3%, D84, Panelist s evaluation Cumulative moisturization (0.3%, D28), Wrinkle smoothing (0.3%, D28), Improvement of skin s tonicity and tensor effect (0.3%, D28) None 3% Sodium Sulfite, Sodium Metabisulfite 2% None 0.3-1% Water dispersible None 0.3-1% None 0.40% Phenoyethanol 1-3% None % None 0.2-1% potentially NaTrue Cosmos approved CHINA approved 7

8 Product INCI in-vitro / e-vivo ELESTAB TM HP 100 Heamidine Diisethionate Anti dandruff (0.1%, D28), Anti-disquamation (0.1%, D28), Improvement in: state of hair, itching, dandruff and regresing (0.1%, D28; Panelist s evaluation) ELESTAN TM LS 9913 ELESTAN TM PW LS 9879 EPERULINE TM PW LS 9627 EPIGENIST TM LS FRESHAXYL TM LS9980 GENEROL TM R Glycerin (and) Manilkara Multinervis Leaf Etract (and) Aqua Manilkara Multinervis Leaf Etract (and) Maltodetrin Detrin (and) Eperua Falcata Etract Maltodetrin (and) Voandzeia Subterranea Seed Etract Glyceryl Laurate (and) Moringa Oleifera Seed Etract Brassica Campestris (Rapeseed) Sterols Anti-elastase activity on skin sections, Anti-glycation performance (in-tubo), Stimulation of tropoelastin gene epression, Stimulation of (tropo) elastin protein synthesis, Stimulation of fibulin-5 synthesis, Stimulation of emilin-1 synthesis, Type I collagen synthesis (e-vivo), GAGs synthesis (e-vivo), Elastin synthesis (e-vivo) Anti-elastase activity on skin sections, Anti-glycation performance (in-tubo), Stimulation of tropoelastin gene epression, Stimulation of (tropo) elastin protein synthesis, Stimulation of fibulin-5 synthesis, Stimulation of emilin-1 synthesis, Type I collagen synthesis (e-vivo), GAGs synthesis (e-vivo), Elastin synthesis (e-vivo) Reduction UVB induced of cytokine epression, Inhibition of plasmin, Inhibition of release of pro-inflammatory neuropeptide CGRP by sensory neurons, Anti-oidative effect, Decrease of IL-8 release in kerotinocytes eposed to PM2.5/UVA, Decrease of IL-8 release in kerotinocytes eposed to VOC (Formaldehyde) Boosts the neuritogenesis, Increase of epidermal thickness Inhibition of the growth of dermal microflora Anti-Neurodermitis/Anti-itching effect (Lit.), UV-Erythema (Lit.), Diaper Dermatitis (Lit.), Anti-pruritic, Anti-inflammatory effect (Lit.) Skin suppleness, skin tonicity (3%, D56; cutometer), Skin suppleness, skin tonicity (3%, D56; Dynaskin method), Anti-stretch mark (3%, D84) Skin suppleness, skin tonicity (0.5%, D56; cutometer), Skin suppleness, skin tonicity (0.5%, D56; Dynaskin method), Anti-stretch mark (0.5%, D84) Improvement of skin biomechanical properties and barrier function (1%, D28) Increases of epidermal thickness (0.5%, D56), Increase of skin luminocity and radiance (0.5%, D56), Decrease of roughness (0.5%, D56) Reduction of odor caused by perspiration upto 24hrs after application (0.4%, 6h, 24h), Effective long-term odor control (0.4%, 6h, 24h; Panelist s evaluation) None % None 2-3% None % None 1% None 0.5% None 0.4% None 1-2% potentially NaTrue Cosmos approved CHINA approved 8

9 Product INCI in-vitro / e-vivo HIBISCIN TM HP LS 9198 HYALUFIX TM GL A00102 HYALURONIC FILLING SPHERES TM C00309 HYALURO-SMOOTH TM LS 8998 HYALURO-SMOOTH TM PW LS 8997 Aqua (and) Esculentus Seed Etract Alpina Galanga Etract (and) Pentylene Glycol (and) Xanthan Gum (and) Caprylic/Capric Triglyceride Ethylheyl Palmitate (and) Trihydroystearin (and) Sodium Hyaluronate Aqua (and) Cassia Angustifolia Etract Cassia Angustifolia Etract Boosts the synthesis of HAS-2, Doubles the production of hyaluronic acid, Restores densitiy to the dermis Water binding properties, No unwanted pre-swelling in formulations Immediate and long-term moisturization Moisturization (5%, D28), (immediate (5%, 15min, 30min, 60min)) Lifting (5%, D28), Tightening (5%, D28) Reduction of nasogenian folds (3 %, D84), Increasingly radiant skin, greater density, fewer wrinkles (3%, D30; Panelist s evaluation) Skin penetration (tape stripping), Thickening of stratum corneum (5%), Anti-wrinkle (2%, 1h, 6h), Reduced epression lines (3%, 1h, 6h; Panelist s evaluation) Improvement of skin compleion (3%, 3min, 15min, 30min), Improvement of skin s suppleness, softness and moisturized sensation (10%; Panelist s evaluation) Improvement of skin compleion (0.075%, 3min, 15min, 30min), Improvement of skin s suppleness, softness and moisturized sensation (0.25%, Omin, 45Min; Panelist s evaluation) Phenoyethanol 2-5% None 0.5-3% Oil dispersible Immediate and long-term moisturization Phenoyethanol 2.5-5% None % HYDRASENSYL SPB LS 9938 IRWINOL TM LS 9890 Aqua (and) Glycerin (and) Butylene Glycol (and) Serenoa Serrulata Fruit Etract (and) Hydrolyzed Adansonia Digitata Etract Octyldodecanol (and) Irvingia Gabonensis (and) Hydrogenated Coco-Glycerides Skin: Moisturizing activity compared to shea butter (e-vivo), Sensorial properties compared to jojoba oil and shea butter Hair: Conditioning effect, improvement of hair sensorial properties LACTOLAN TM LS 5879 Hydrolyzed Milk Protein ATP-boosting, vitalizing Hair: UV color and structure protection, improvement of combability, conditioning, repairing, reduction of electrostatic charge, hydro retaining Skin: Immediate and long-term moisturization (e-vivo), Elasticity (e-vivo) LARICYL TM LS 8865 Butylene Glycol (and) Fomes Officinalis Etract Astringent, pore tightening, immediate and long-term moisturizing (e-vivo) Skin: Repairing activity on damaged lips (3%, D7), Softening, smoothing and soothing (2%, 5min) Skin: Softness/tolerance on babies (7%, D21) Astringent and pore tightening (3%) None Phenoyethanol Phenoyethanol Skin care: 1-3% Lip care: 0.5-3% Hair care: 0.5-1% 1-10% 2-5% and soluble in diluted ethanol potentially NaTrue Cosmos approved CHINA approved 9

10 Product INCI in-vitro / e-vivo LINEFACTOR TM C A00314 LIPOFRUCTYL TM ARGAN LS 9779 LIPOFRUCTYL TM CYPERUS LS 9892 LIPOFRUCTYL TM MO LS 9305 LITCHIDERM TM LS 9704 LOX-AGE TM A00327 LYS LASTINE TM V A00077 LYS SUN TM BC10006 MARINE FILLING SPHERES TM C00468 Pentylene Glycol (and) Hibiscus Abelmoschus Etract (and) Xanthan Gum FGF-2 protection, Cell proliferation, Stimulation of collagen synthesis, Stimulation of total and sulphated GAGs synthesis, Stimulation of Aquaporine-3 synthesis, Recovery of skin barrier function (e-vivo), Stimulation of fillagrin epression (e-vivo) Wrinkle reduction (3%, D42), Improvement of skin teture and elasticity (3%, D42) Argania Spinosa Oil None 1-5% Cyperus Esculentus Oil Moisturizing activity on skin, Hair: Sensorial evaluation Moringa Oleifera Seed Oil None 2-10% Butylene Glycol (and) Litchi Chinensis Pericarp Etract Aqua (and) Cichorium Intybus (Chicory) Leaf Etract (and) Heylene Glycol (and) Caprylyl Glycol (and) Xanthan Gum Peucedanum Graveolens Etract (and) Pentylene Glycol (and) Xanthan Gum Aqua (and) Pentylene Glycol (and) Hamamelis Virginiana Leaf Etract (and) Xanthan Gum (and) Caprylyl Glycol Pentaerythrityl Tetraisostearate (and) Silica Dimethyl Silylate (and) Butylene Glycol (and) Pentylene Glycol (and) Sodium Chondroitin Sulfate (and) Atelocollagen Anti-free radical (in-tubo), Anti-inflammatory induced by UV-A and -B, Anti-MMP-1 induced by UV-A and -B (e-vivo), Moisturizing Stimulation of the gene epression of LOX, Increase of LOX protein synthesis, Increase of differentiation and cohesion of keratinocytes, Stimulation of Collagen-I synthesis Stimulation of LOXL synthesis, Activity only after percutaneous absorption, Decrease of progerin accumulation (= reduction of replicative senescence), Stimulation of Khloto production (= Delay of metabolic senescence), Improvement of elasticity (reconstructed dermis) Increase of LOX-L gene epression under UV radiation, Inhibition of elafin synthesis under UV-eposion (e-vivo), Radical scavenging (in-tubo), Anti-MMP-12 and -MMP-2 (in-tubo) Water binding properties Anti-free radical (5%, 10nin), Improvement of skin compleion (5%, D28, D56) Reduces skin blemishes (2%, D28, D56), Reduces the appearance of pores (2%, D28, D56), Increases the skin elasticity (2%, D28, D56), Reduction of lines and fine lines (2%, D28, D56), Restoration of youthful skin appearance (2%, D56; Panalist s evaluation) Improvement of elasticity and stretchability (1%, D56), Anti-wrinkle (1%, D56), Restructuring of face contour (1%), Skin teture is improved, skin is more elastic, facial architecture is improved and satisfied (1%; Panelist s evaluation), Improvement of skin tonicity on the decolette (1%, D84) Reduaction of wrinkles and skin roughness vs. Placebo (1%, D56), Increase of skin firmness vs. Placebo (1%, D84), Cutaneous penetration (1%, 1h, 5h), Anti-Wrinkle (1%, 1h), Longterm hydration (1%, D3), Lips plumping (3%, 1h) None 2-5% None 2% None 1-2% None 1% None 0.5-4% potentially NaTrue Cosmos approved CHINA approved 10

11 Product INCI in-vitro / e-vivo MARIPONICS TM PSR R11009 MAT-XS TM CLINICAL A00098 MELHYDRAN TM LS 9876 MELLIDYN TM LS 9834 Aqua (and) Pentylene Glycol (and) Butylene Glycol (and) Algae Etract (and) Fae Water (and) Butylene Glycol (and) Pentylene Glycol (and) Sarcosine (and) Xanthan Gum Mel Etract (and) Glycerin (and) Urea (and) Sodium Lactate (and) Arginine HCI (and) Lysine HCI (and) Ornithine HCI Aqua (and) Propylene Glycol (and) Mel Etract (and) Glycerin (and) PEG-40 Hydrogenated Castor Oil (and) Royal Jelly (and) Mel (and) Propolis MYOXINOL TM LS 9736 Hydrolyzed Hibiscus Esculentus Etract (and) Detrin NEUROBIOX TM A00112 OLIGOLIN TM BC Pentylene Glycol (and) Achillea Millefolium Etract (and) Xanthan Gum Hydrolyzed Linseed Etract Gene epression of Superoid Dismutase 1, Gene epression of Cytochrome P450, Gene epression of Prostaglandin-endoperoide synthase 2 Inhibition of 5α-reductase type I, Decrease of squalane production (a component of sebum) Mel Etract (and) Glycerin (and) Urea (and) Sodium Lactate (and) Arginine HCI (and) Lysine HCI (and) Ornithine HCI Anti-inflammation, Immediate to long-term moisturization (e-vivo) Inhibition of muscle cell contraction, Anti-oidant Stimulation of the synthesis of POMC-related receptors, Stimulation of epidermal differentialtion (e-vivo), Improvement of epidermal thickness (e-vivo) Increase of the epression of involucrin, filaggrin, loricrin, Synthesis of collagen IV, Fibroblast proliferation and migration, Increase of collagen I, collagen III and lumican, Inhibition of heparanase and hyaluronidase activity (in-tubo), improvement of epidermal thickness (e-vivo), Increase of the filaggrin epression (e-vivo), Improvement of the level of collagen I and III (e-vivo), Increase of the GAGs epression (e-vivo) Skin feels clean, non-greasy but still moistured (3%, D28, D56; Panelist s evaluation), Reduction of wrinkles on forehead (3%, D56), Pore refining on forehead (3%, D56), Improvement of skin tone evenness (3%, D56) Decrease in skin shine and sebum secretion (2%,, D14, D28), Pore refining (2%, D14, D28), Skin is less oily, skin compleion is more even, no quick re-greasing and pores are tightened (2%, D28; Panelist s evaluation) Improvement of skin micro relief (5%, D28), Hydro-retention on hair (2%, 5%, D28) None 0.5-3% None 1-5% None 3-5% Anti-wrinkle (1%, D21) None 0.5-2% Acceleration of epidermal renewal (2%, D56), Wrinkle smoothing (2%, D56), Pore refining (2%, D56), Skin softening (2%), Improvement of the skin radiance vs placebo and glycolic acid (2%, D56), Brightening (2%, D56), Blurring effect: The product improves my skin clarity, The product makes my compleion look renewed, The product smoothes my skin surface, The product refines the appearance of pores (2%, D56; panelist s evaluation) Improvement of skin firmness (Dynaskin) and skin hydration (Corneometer) (1%, D28) None 1-5% None 1% potentially NaTrue Cosmos approved CHINA approved 11

12 Product INCI in-vitro / e-vivo OSMHYDRAN TM LS 8453 OSMOGELINE TM R10979 OXYGEN COMPLEX TM LS 9641 PA REVIVI-SCENCE TM LS 9562 PATCH 2 O TM A00297 PERLAURA TM A00316 PHOTOTAN TM LS 2261 E Mannitol (and) Arginine (and) Serine (and) Sucrose (and) PCA (and) Citrulline (and) Glycogen (and) Histidine HCl (and) Alanine (and) Threonine (and) Glutamic Acid (and) Lysine HCl Aqua (and) Algae Etract (and) Citric Acid Mannitol (and) Fae Etract (and) Glycogen (and) Magnesium Ascorbyl Phosphate Aqua (and) Glycerin (and) Trehalose (and) Tamarindus Indica Seed Polysaccharide (and) Myrothamnus Flabellifolia Leaf Etract Aqua (and) Glycerin (and) Trehalose (and) Urea (and) Serine (and) Pentylene Glycol (and) Glyceryl Polyacrylate (and) Algin (and) Caprylyl Glycol (and) Sodium Hyaluronate (and) Pullulan (and) Disodium Phosphate (and) Potassium Phosphate Aqua (and) Polygonum Bistorta Root Etract (and) Heylene Glycol (and) Caprylyl Glycol (and) Xanthan Gum Sorbitol (and) Arginine HCI (and) Ornithine HCI (and) Tyrosine (and) Silica Hydro-retaining/ osmo-regulation (e-vivo) Reduction of UV-B-mediated TNF-α secretion, Prevention of cellular lipoperoidation (in-tubo), Stimulation of involucrin synthesis, Protection of the dermal matri, Stimulation of gene epression of the proteins coding for skin barrier function, Increase of ceramide synthesis (e-vivo) Stimulation of protein synthesis, ATP-boosting, Control of lactic acid release, Stimulation of oygen consumption, Control of ROS Cell protection from UV-A and -B, DNA protection, Heat- and cold-shock protection, Osmotic shock protection, Immediate and long-term moisturization (e-vivo) Reduction of water evaporation, Immediate and long-term moisturization (e-vivo), Recovery of cellular ATP level impaired by PAH loaded PM2.5 under UVA, Reduction of MDA release induced by B[a]P under UVA Increase of perlecan and dystroglycan protein epression in keratinocytes, Increase of perlecan and dystroglycan protein epression in endothelial cells, Stimulation of Claudin-5 epression in endothelial cells, contribution to compensate the decrease of perlecan and dystroglycan with aging (e-vivo) Stimulation of melanin synthesis, Stimulation of tyrosinase activity Improvement of skin microrelief and sensory properties of skin (2%, D21) Skin feels moistured, smooth and soft (10%, D3, D7; Panelist s evaluation) Skin looks more radiant and luminous (3%, D3; Panelist s evaluation) Immediate (30min, 60min) and long term moisturization (e-vivo and in-vivo (5%, D7)), Softening and anti-drying (5%, 60Min) Immediate and long-termin moisturization, Sustained hydration (3%, 30min, 48h), Skin is more hydrated, soft, visibly elastic and visibly nourished (3%, D21; Panelist s evaluation), (2%, Immediate increase of scalp hydration (2%, 4h), Scalp moisturizing effect (during and after treatement) (2%, D21, D24), Reduces itchiness on my scalp, Allows my scalp skin to feel more relaed (cumulative and sustained effect) (2%, D21, D24) (Panelist s evaluation) Improvment of skin radiance, evenness and smoothness and wrinkle (crow s feet, length and surface) reduction (1%, D14, D28) None 2-5% / Phenoyethanol 1-10% / None 1% / Phenoyethanol 3-5% / / / None 3-5% / potentially NaTrue Cosmos approved CHINA approved 12

13 Product INCI in-vitro / e-vivo PHYTOKINE TM A00287 PHYTOLIGHT TM BG A00043 PHYTOSOOTHE TM LS 9766 PILISOFT TM LS 9760 PROTEASYL TM PW PSE LS 8951 PROTEASYL TM TP POE LS 9818 Hydrolyzed Soy Protein (and) Butylene Glycol (and) Pentylene Glycol (and) 1,2-Heanediol (and) Caprylyl Glycol Cucumis Sativus (Cucumber) Fruit Etract (and) Pyrus Malus (Apple) Fruit Etract (and) Camellia Sinensis Leaf Etract (and) Disodium EDTA (and) Scutellaria Baicalensis Etract Brassica Campestris (and) Cetearyl Alcohol Aqua (and) Pentylene Glycol (and) Gymnema Sylvestre Etract Pisum Sativum Etract (and) Cyclodetrin Aqua (and) Glycerin (and) Pisum Sativum Etract Increase of collagen neo-synthesis and deposition, Increase of GAGs neo-synthesis, Increase of elastin neo-synthesis, Improvement of collagen fibrillogenesis and organization of collagen fibers, Recovery of epidermal thickness, Activation of lipids synthesis (e-vivo) Anti-tyrosinase activity, Dose-effect on the tyrosinase activity of B16 cells Anti-inflammation Anti-proliferation effect, Anti-hair growth on hair follicles in culture Plasmin inhibition, Stimulation of Collagen III-, elastin- and GAG-synthesis, Anti-elastase (e-vivo), Moisturizing (e-vivo), Immediate and long-term moisturization (e-vivo) Plasmin inhibition,stimulation of collagen III-, elastin- and GAG-synthesis, Anti-elastase (e-vivo), Moisturizing (e-vivo), Immediate and long-term moisturization (e-vivo) Synthesis of dermal collagen (2.5%, D28), Synthesis of dermal glycosaminoglycans (2.5%, D28) Hair: Improvement of the clinical symptoms on the scalp and hair beautifying effect (3%, D16) skin: Moisturizing and skin barrier strengthening effect with 1% GenerolTM 122 N PRL None 1-4 % None 1-4% Anti-hair growth (1%, D28) None 0.5-1% Improvement of skin elasticity (0.14%, 15h, 24h), Improvement of skin firmness (0.23%, D42) Improvement of skin elasticity (3%,12h, 24h), Improvement of skin firmness (5%, D42) None % Phenoyethanol 3-5% PURICARE TM POE LS 9727 Aqua (and) Glycerin (and) Moringa Oleifera Seed Etract Hair: Anti-pollution, Anti-odor, Conditioning and repairing, Photo protective activity, Hair strengthening, Anti-free radical activity, Anti-greasy hair effect Phenoyethanol 2-4% PURISOFT TM POE LS 9726 Aqua (and) Glycerin (and) Moringa Oleifera Seed Etract Cyto-protection against heavy metals, Protection against cigarette smoke (e-vivo), Cell protection against pollution stress (PM2.5 + PAHs) Purification, cleansing enhancement (1.5 %) Phenoyethanol 1-3% PURISOFT TM PW PSE LS 9836 Moringa Oleifera Seed Etract (and) Maltodetrin Cyto-protection against heavy metals, protection against cigarette smoke (e-vivo), Cell protection against pollution stress (PM2.5 + PAHs) Purification, cleansing enhancement (0.03 %) None % potentially NaTrue Cosmos approved CHINA approved 13

14 Product INCI in-vitro / e-vivo RADIANSKIN TM PW LS 9918 RELIPIDIUM TM A00265 SANICAPYL TM BC SEBARYL TM FL 9088 SHADOWNYL TM R11026 SKINASENSYL TM LS 9749 SKINASENSYL TM PW LS 9852 SLIM-EXCESS TM A00073 SPECI MEN TM BC10001 Hydroyphenoy Propionic Acid Hydrolyzed Yeast Protein (and) Butylene Glycol (and) Pentylene Glycol Butylene Glycol (and) Sodium Lauroyl Lactylate (and) Sodium Caproyl Lactylate (and) Piper Nigrum Fruit Etract (and) Inga Alba Bark Etract Aqua (and) Niacinamide (and) Fae Etract (and) Aesculus Hippocastanum Seed Etract (and) Ammonium Glycyrrhizate (and) Panthenol (and) Propylene Glycol (and) Zinc Gluconate (and) Caffeine (and) Biotin Aqua (and) Algae Etract (and) Heylene Glycol (and) Caprylyl Glycol (and) Xanthan Gum Aqua (and) Glycerin (and) Coco-Glucoside (and) Acetyl Tetrapeptide-15 Mannitol (and) Sodium Citrate (and) Acetyl Tetrapeptide-15 Pentylene Glycol (and) Sodium Chloride (and) Hydrolyzed Rhodophycea Etract (and) Xanthan Gum Glycerin (and) Aqua (and) Hydrolyzed Adansonia Digitata Etract Melanogenesis inhibition on B16 melanocytes, Protection against damages caused by UV-B on keratinocytes Anti-age spots on face (asian population) (1%, D14, D28, D56), Anti-age spots on hand (caucasian population) (1%, D14,D28, D56), Skin lightening on forearm (asian population) (1%, D14, D28, D56) Activation of lipids synthesis Visible relipiding effect (3%), Skin is less dry (3%; Panelist s evaluation), Evaluation of skin barrier improvemnet through TEWL (1%, D14), Effect on skin microbiota and skin hydration (2%, D14) Anti-microbial activity, Anti-inflammatory activity, Moisturizing Inhiition of 5α-reductase Stimulation of heme oygenase-1 gene epression, Increase of HO-1 protein, Stimulation of collagen-1 synthesis, Anti-oidation, Inhibition of IL-8 CGRP release from cultured sensory neurons, Mechanism of action CGRP release from cultured sensory neurons, Mechanism of action Activation of the lipolysis, Inhibition of adipocytes proliferation, Inhibition of lipogenesis Versican mrna epression of normal human dermal fibroblasts from aged male, Inhibition of MMP-12 enzymatic activity (in-tubo) Reduction of dandruff and sebum (1%, D14, D28), Health of scalp and hair (1%, D14, D28) Seboregulation (5%, D28), Anti-seborrhea activity on scalp (3%, D28) Decrease of the dark color under the eyes (2%, D14), Decrease of the area of the dark circles under the eyes (2%, D14), Decrease of the crow s feet wrinkles in length, surface and volume (2%, D7), Eye area has smoother teture and is visibly refreshed (2%, D7, D14; Panelist s evaluation) Soothing: Reduction of cutaneous over-sensitivity against capsaicin (3%, D4), Reduction of cutaneous thermal over-sensitivity (2%, 60min, 120min) Soothing: Reduction of cutaneous over-sensitivity against capsaicin (1%, D4), Reduction of cutaneous thermal over-sensitivity (0.67%, 60min, 120min) Reduction of cellulite (3%, D14, D28), Slimming of the tights (3%, D28, D56), Boost of the activity of caffeine (3%), Face contour correction (2%, D28, D56, D84), Reduction of the double chin (2%, D28, D56, D84), Improvement of the skin elasticity (2%, D84), Cellulite has diminished and figure is reshaped (3%; panelist s evaluation) Skin tonicity recovery (Cutometry measurement on the cheekbones) (3%, D28, D56), Anti-wrinkle effect on nasogenian fold (3%, D56), Decrease of the eyebag volume & lower eyelid slackening (3%, D28, D56), The wrinkles are softened, The skin is more radiant, The skin is toner, The product helps to feel my skin healthier, The skin aspect is improved, The pores are less visible, The fine lines are smoothed (3%, D28, D56; panelist s evaluation) None 0.5-1% None 0.3-1% Phenoyethanol 3-5% and soluble in diluted ethanol None 1-2% Sorbic Acid 1-3% None 0.3-1% potentially NaTrue Cosmos approved CHINA approved 14

15 Product INCI in-vitro / e-vivo SPHINGOCERYL TM VEG LS 9948 SQISANDRYL TM LS 9905 SVELTINE TM ST BC10032 Octyldodecanol (and) Hydrogenated Coco-Glycerides (and) Helianthus Annuus Seed Etract Schisandra Chinensis Fruit Etract Maltodetrin (and) Lythrum Salicaria Etract Increase of COL17A1 MRNA epression, Increase of collagen XVII synthesis, Increase of LAD-1 mrna epression, Increase of ladinin-1 synthesis Increase of fibroblast-populated collagen lattices (dermis tightening), Reduction of lipid storage, hypodermis and adipocytes thickness (hypodermis thinning) Repair of cutaneous micro relief (5%, D21), Strengthening of corneocytar cohesion (5%, D21) Improvement of the skin resilience, elasticity and firmness (0.3%, D56) Buttock push-up effect (0.25%, D14, D28, D56), Tigh shaping (0.25%, D14, D28, D56) None Skin Care: 2-5% Hair Care: 1-3% None % None 0.25% SYMBIOCELL TM BC10015 SYMBIOCELL TM A00110 SYNIORAGE TM PW LS 9847 TRICHOGEN TM VEG UL LS 9922 TRICHOLASTYL TM LS 9912 Pentylene Glycol (and) Cestrum Latifolium Leaf Etract (and) Xanthan Gum Pentylene Glycol (and) Cestrum Latifolium Leaf Etract (and) Xanthan Gum Mannitol (and) Acetyl Tetrapeptide-11 Aqua (and) Arginine (and) Acetyl Tyrosine (and) PEG-12 Dimethicone (and) Calcium Pantothenate (and) Zinc Gluconate (and) Niacinamide (and) Ornithine HCI (and) Polyquaternium-11 (and) Citrulline (and) Hydrolyzed Soy Protein (and) Glucosamine HCI (and) Arctium Majus Root Etract (and) Pana Ginseng Root Etract (and) Biotin Glycerin (and) Aqua (and) Sorbitol (and) Pterocarpus Marsupium Bark Etract (and) Disodium Succinate (and) Glutamic Acid Regulation of dentritic cells activation Regulation of dentritic cells activation Overall gene epression profile of keratinocytes, Repression of DDR1 gene, Stimulation of keratinocytes growth, Stimulation of syndecan-1 synthesis (test on keratinocytes), Stimulation of syndecan-1 synthesis (test on human reconstructed skin), Stimulation of the epression of collagen XVII gene Stimulation of cell metabolism, Substantivity effect on hair tress, Conditioning and repairing on dry hair, Photo-protection on hair tress, Strengthening on hair Anti-glycation on collagen, Anti-free radical (in-tubo), Anti-inflammatory Skin homogenity (2 %), Reduction of skin redness (2 %), Skin is less sensitive to irritation, feels more comfortable, increasingly radiant, skin is better adapted to the environment (2 %; Panelist s evaluation) Skin homogenity (2%), Reduction of skin redness (2%), Skin is less sensitive to irritation, feels more comfortable, increasingly radiant, skin is better adapted to the environment (2%; Panelist s evaluation) None 1-2% None 1-2% Increase of firmness and elasticity (1%, D28, D56) None % Anti-hair loss activity and improvement of aesthetic qualities of hair (10%, 8W, 16W), Improvement of appearance and sensorial qualities scalp/hair, decrease of hair loss and increase in hair growth (10%, 8W, 16W; Panelist s evaluation) Phenoyethanol 5-10% Anti-hair loss preventive activity (10%, 6M) None 2-5% potentially NaTrue Cosmos approved CHINA approved 15

16 Product INCI in-vitro / e-vivo ULTRA FILLING SPHERES TM C00487 VEGESERYL TM HGP LS 9874 Ethylheyl Palmitate (and) Trihydroystearin (and) Sodium Hyaluronate (and) Amorphophallus Konjac Root Powder Aqua (and) Glycine Soja Protein Water absorbtion capacity, Thickening of stratum corneum (e-vivo) Nutritive, vitalizing and protective effect, Preventive cytoprotection against a surfactant VITACELL PW LS 7979 Mannitol (and) Fae Etract Stimulation of cell vitality, Stimulation of cell metabolism on epidermal keratinocytes, Stimulation of O 2 consumption of epithelial cells, Stimulation of the epidermal ATP synthesis (e-vivo) VIT-A-LIKE TM PW LS 9898 VIT-A-LIKE TM SPB LS 9793 VITAPLEX TM LS 9799 X-PRESSIN TM C R11021 Vigna Aconitifolia Etract (and) Maltodetrin Aqua (and) Vigna Aconitifolia Etract (and) Sodium Cocoyl Glutamate Mannitol (and) Chondrus Crispus Powder (and) Xanthan Gum (and) Laminaria Digitata Etract (and) Glycogen Aqua (and) Papain (and) Carbomer (and) 1,2-Heanediol (and) Caprylyl Glycol (and) Algin Stimulation of epidermal cellular renewal, Enhancement of type I collagen gene epression, Increase of collagen synthesis Stimulation of epidermal cellular renewal, Enhancement of type I collagen gene epression, Increase of collagen synthesis Revitalizing activity on human keratinocytes Hair: Evaluation of sensory properties on human hair Effect of crosslinker on thermostability on X-Pressin C (in-tubo), Comparison of thermostability of X-Pressin C vs free proteases (in-tubo), Thermostability of X-Pressin C in formulations (in tubo) Anti-wrinkle (10%, D28), Improvement of cutaneous elasticity, Silky and softening effect (10%, D42), Hydroretaining effect (10%, D42) None 0.5-3% Liposolbule Sodium Benzoate, Potassium Sorbate 3-10% Stimulation of metabolic activity (TcpO 2 ) (2 %) None 1-2% Stimulation of epidermal cellular renewal (0.21%; 0.35%, D15), Anti-wrinkle (crow s feet area) (0.35%, D56) Stimulation of epidermal cellular renewal (3%;5%, D15), Anti-wrinkle (crow s feet area) (5%, D56) None % Phenoyethanol 3-5% Sensorial evaluation after a single application (2 %) None 2-4% Efoliation activity (1%; 3%, D14), Increase of brightness with better skin tolerance (1%, D28), Reduction of skin imperfections (1%, D28), Skin softening and smoothing (1%, D21), Skin is soft and smooth, gentle, has an even skin tone and refined (1%, D21; Panelist s evaluation) potentially NaTrue Cosmos approved CHINA approved Distributed by IMPAG AG Räffelstrasse Zürich Switzerland Tel.: Fa: Web: IMPAG Group Country Offices Austria/Vienna France/Nancy Germany/Offenbach Poland/Warsaw Switzerland/Zurich 05/ 2017

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