NYDA hävitab. täid ja tingud
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1 NYDA hävitab täid ja tingud
2 Peatäi (Pediculus humanus) Tiivutu putukas Seesamiseemne suurune (2-3 mm) Eluks vajab verd, mida imeb inimese peanahast Ilma verd imemata ei suuda elada kauem kui 55 tundi Ei kanna edasi viirusi Sigimisvõimelise täi eluiga on kuni 30 päeva Täi elab eranditult vaid inimese peas. Kuna väikelastel ja koolilastel on omavaheline sotsiaalne kontakt tihedam, siis levivad peatäid eelkõige laste seas Põhjustab peanaha tugevat sügelust ja põletikku. Verd imedes eritavad peatäi süljenäärmed vere hüübimist takistavat sekreeti. Haavale sattunud sülje suhtes tekivad inimesel immuunreaktsioonid, mis omakorda põhjustavad peanahal tüüpilise sügeluse.
3 Täi elutsükkel Täiskasvanud täi eluiga on max 30 päeva päevad Ting Munast koorub noortäi ehk nümf Täiskasvanud täi päev päev Surm 50 päev Täi muneb oma elu jooksul muna (tingu)
4 Täitõve diagnoosimine Esimeseks tunnuseks on peanaha sügelemine. Kuna peatäid on väikesed ja hästi varjatud, on neid sageli keeruline märgata. Eriliselt tuleb jälgida kõrvataguseid ja kuklapiirkonda. Lõpliku diagnoosi saab panna elusate ja liikuvate täide põhjal. 1-cm-reegel : juuksed kasvavad umbes 1cm kuus. Täi kinnitab muna (tingu) juuksekarvale peanaha ligidal. Munemisest vastsete koorumiseni kulub umbes nädal. Munad, mis asuvad peanahast kaugemal kui 1 cm, on peaaegu alati tühjad. Ainult tühjad täimunad ei tõenda, et inimene on nakatunud. Siiski võib tegemist olla ka täis munadega, ent sellisel juhul on munas olev vastne juba surnud (ka peale edukat täiravi võivad surnud tingud jääda juuste külge, ainult munade olemasolu ei pruugi tähendada, et inimene on täidega püsivalt nakatunud) Igaühte, kelle peas on elus täid, vastsed või munad (juuksekarva küljes peanahale lähemal kui 1cm), tuleb ravida.
5 Täitõve ravimeetodid Keemiline (neurotoksiline) Permetriin, malatioon Probleem: võimalik toksilisus, resistentsus Taimsed vahendid Kookosõli, teepuu õli Probleem: ebaefektiivsus, kaheetapiline manustamine, ebapiisavad kliinilised uuringud Mehhaaniline Kammid, vaakum Probleem: ebaefektiivsus Füüsikaline Dimetikoon (NYDA )
6 Hea täitõrjevahendi parameetrid Efektiivne kõigi täi arengustaadiumite korral ting, noortäi, täi Ühekordne annustamine Ohutu, mittetoksiline Ei teki resistentsust Hästi talutav Kliiniliselt uuritud Mõistlik hind
7 NYDA Neile kõigile parameetritele vastab täivastane vahend NYDA
8 NYDA - kahekomponendiline dimetikoon NYDA koosneb kahekomponendilisest (dual formula) dimetikoonist ehk dimetikoonide segust, mille koostises on erineva ahela pikkuse ja viskoossusega dimetikoonid: Dimetikoon 1 lühema-ahelaline komponent Madala viskoossusega, väga hea voolavusega, kannab dimetikoon 2 kõigi täide ja tingudeni. Dimetikoon 2 pikemaahelaline komponent Viskoossem, hea voolavusega, tungib täi ja tingu hingamisavadesse ning lämmatab täid ja tingud.
9 NYDA : Füüsikaline toimemehhanism NYDA toimeaineks on dimetikoon, täpsemalt kahe erineva molekulmassiga dimetikooni segu. Toimemehhanism on kahefaasiline Nn kandurdimetikoon viib segu sihtkohta Dimetikoon tungib sügavale täi hingeavadesse (vt joonis) Asendab õhu Lämmatab täi, vastse ja tingu Resistentsust ei teki
10 NYDA : Füüsikaline toimemehhanism NYDA tungib sügavale täi hingeavadesse Enne NYDA t Pärast NYDA manustamist (siniselt)
11 NYDA hävitab ka tingud! Tingudel on samuti hingeavad aerofülid (ing kl aerophyles). NYDA tungib tingude hingeavadesse ja lämmatab tingud! Tõestatud toime: Laboratory Testing on Lice Eggs: NYDA is highly effective in killing lice eggs, both at young and mature stages of development. Sonnberg S. et al. (2008): Monatsschr. Kinderheilkd., Band 156, suppl. 1, S Heukelbach J. et al. (2011): Ovicidal efficacy of high concentration dimeticone: A new era of head lice treatment. J Am Acad Dermatol 64; 4, e61-e62. Strycharz J.P. et al. (2012): Ovicidal Response of NYDA Formulations on the Human Head Louse (Anoplura: Pediculidae) Using a Hair Tuft Bioassay. J Med Entomol. 2012; 49(2):
12 NYDA : Efektiivsus 100% efektiivne täide 1) ja tingude 2) suhtes Kliiniliselt tõestatud 3) Hävitab täi kõik kolm arenguastet (täi, noortäi ja tingu) Toime esimese kasutuskorraga Ei teki resistentsust NYDA ei ole neurotoksiline putukamürk NYDA - l ei ole spetsiifilisi kõrvaltoimeid Mõistlik hind 1) Fabíola A.S. Oliveira, Rick Speare, Jorg Heukelbach: High in vitro efficacy of Nyda L, a pediculicide containing dimeticone Journal of the European Academy of Dermatology and Venereology, DOI: /j x. 2) Data on file, ) Heukelbach J. et al.: High efficacy of a pediculicide based on dimeticone in a population with high intensity of infestation: a randomised controlled trial. Trop. Med. Int. Health, 12 suppl. 1, , 2007
13 NYDA -ga ei ole täidel pääsu!
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