ANTI-AGEING STEM-CELL SERUM. Lifting, firming & nourishing Serum. FREQUENTLY ASKED QUESTIONS

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1 ANTI-AGEING STEM-CELL SERUM Lifting, firming & nourishing Serum. FREQUENTLY ASKED QUESTIONS

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3 ANTI-AGEING STEM-CELL SERUM is a Blend of Apple Stem Cell technology, Resveratrol and other natural plant extracts that protect skin cells against oxidative stress and combat skin ageing. ANTI-AGEING STEM-CELL SERUM is a combination of extracts derived from the stem cells of green apple, resveratrol and a proprietary blend of natural extracts. By stimulating ageing skin stem cells, ANTI-AGEING STEM-CELL SERUM has been shown to lessen the appearance of unsightly wrinkles and rejuvenate ageing skin. This unique formulation increases the longevity of skin cells, resulting in skin that has a more youthful and radiant appearance. ANTI-AGEING STEM-CELL SERUM works at the DNA Level stimulating the very sources in our skin that we lose as we grow old, Collagen and Fibronectin.

4 INGREDIENT GLOSSARY The apple: The Uttwiler Spätlauber is an old Swiss variety, which is very rare today. It was known for its exceptional capacity to keep for long periods but gradually lost its popularity to sweet apples because of its bitter taste. As the apple could be stored for a long time without becoming shrivelled or losing flavour, it clearly had special ingredients and especially long-lived stem cells. And precisely these longevity factors were of particular interest to the researchers at Mibelle Biochemistry. The effect: Mibelle Biochemistry was able to show in comprehensive studies that Malus Domestica, the active ingredient based on apple stem cells, promotes the vitality and longevity of skin stem cells, protects them from damage due to environmental stress and thus delays the skin ageing processes. Summary: Malus Domestica has opened up entirely new possibilities in the field of cosmetics. Using plant stem cells can slow skin ageing by protecting essential skin stem cells, keeping the skin looking youthful for longer, and giving it a better and more vital appearance. Improves the vitality of stem cells: Cultures of epidermal stem cells were treated with different concentrations of Malus Domestica and their colony-forming efficiency was determined. The investigations showed that Malus Domestica had a clear, positive effect on stem cell characteristics. Preserves the ability to form new epidermal tissue: Young, vital epidermal stem cells can form a complete, multi-layer epidermis in laboratory conditions. When this experiment is conducted on older stem cells, these no longer multiply and no epidermis is formed. These stem cells are depleted and have reached the end of their lifecycle. If, however, Malus Domestica stem cell extract is added to cultivate the stem cells, even old stem cells can still generate a stratified epidermis. Under the influence of Malus Domestica stem cell extract, the epidermal stem cells retain their vitality longer and are capable of forming new tissue and renewing the skin. Anti-wrinkle effect: The anti-wrinkle effect of Malus Domestica was studied in a clinical trial with 20 subjects (aged 37 to 64). An emulsion with 2% Malus Domestica was applied to the crow s feet area over 28 days. The results showed a significant, visible reduction in wrinkles in 100% of the subjects.

5 INGREDIENT GLOSSARY Malus Domestica Fruit Cell Culture is a liposomal preparation based on the stem cells of a rare Swiss apple. Thanks to this technology, plant stem cells can be obtained and is incorporated into our serum to ensure the longevity of skin cells. Malus Domestica Fruit Cell Culture is a revolutionary anti-aging active ingredient based on a high-tech plant cell culture technology. Resveratrol: Resveratrol is a naturally-occuring polyphenols antioxidant that is found in some plant products like grapes and cocoa. It is categorized as a phytoalexin, an antimicrobial compound that is produced by plants to protect them from rough environments like excessive ultraviolet light, infections and climate changes. Because it is primarily an antioxidant, it does what all antioxidants do - it protects the skin, restoring its health and attracts and neutralizes free radicals. Free radicals in the skin can cause premature signs of aging, and are generally created in the skin through too much time in the sun or through environmental pollutants. Antioxidants help to prevent the cells of the skin form becoming oxidized. Resveratrol is also anti-inflammatory. It helps to reduce the appearance of inflammation, which manifests itself as swelling and redness and often accompanies conditions like psoriasis and eczema. By calming this irritation, skin can return to a more balanced state and perform the necessary healing functions. Resveratrol can prolong the lives of healthy skin cells and aid in the regeneration of even healthier, longer-living skin cells, which push dead, dying cells to the surface to reveal a younger-looking, more vibrant skin. It promotes the reduction of fine lines, wrinkles and signs of ageing. This antioxidant can also improve circulation. As skin ages, the veins constrict resulting in impeding blood flow and making it harder for skin to regenerate itself. Some women will see spider veins begin to appear on their cheeks. With improved blood flow, the look of these spider veins will begin to fade. Better circulation also means that there will be more blood in the skin to wash away toxins and impurities, which can give skin a dull look. Better circulation is essential for healthy, young-looking skin. Resveratrol is also used as a sunblock. Lecithin: Lecithin aids to hydrate, replenish and repair the skin due to its essential fatty acid content. It is derived from soybeans with skin protection qualities and acts as a natural moisturiser. Lecithin has the ability to penetrate the epidermis and carry substances right to the cell level. It is an important source of choline and inositol, which are vital components of all cell membranes, as well as playing an important role in cell growth and function. Lecithin promotes the deeper penetration of fat and biologically active substances into the epidermis.

6 FREQUENTLY ASKED QUESTIONS How do stem cells interact with the skin? Plant Stem cells are specialized ingredients that protect the Keratincyte stem cell, improving their potential for self-renewal and adhesion and preserve the capacity of the progenitor cells to build a functional epidermis. The surface of the skin will feel smoother and more radiant, making the skin appear brighter and more toned. KERATINOCYTE A keratinocyte is the predominant cell type in the epidermis, the outermost layer of the skin, constituting 90% of the cells found there.[1] Those keratinocytes found in the basal layer (stratum basale) of the skin are sometimes referred to as basal cells or basal keratinocytes Our Plant Stem-Cell Serum is a combination of extract derived from the stem cells of green apple, resveratrol and a proprietary blend of natural extracts. By stimulating ageing skin stem cells, Plant Stem Cell Serum has been shown to lessen the appearance of unsightly wrinkles and rejuvenate ageing skin. This unique formulation increases the longevity of skin cells, resulting in skin that has a more youthful and radiant appearance. Plant Stem Cell Serum works at the DNA Level stimulating the very sources in our skin that we lose as we grow old Collagen and Fibronectin. When we lose collagen, our skin gets thinner and wrinkles begin to appear. Apple Stem Cell Serum reverses the ageing process. Is BioDermal Anti Ageing Stem Cell Serum suitable for all skin types? Yes. Can BioDermal Anti Ageing Stem Cell Serum be applied after using the BioDermal Cooling Enzymatic Peel? It is recommended.

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