MESO-NEEDLING. A new technique for new indications. Rejuvenation Alopecia

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1 MESO-NEEDLING A new technique for new indications Rejuvenation Alopecia

2 REJUVENATION

3 New indications New business opportunities 1. To treat large areas such as neck and decolleté, in a fast and efficient procedure 2. To ease the implementation of a solution for skin quality in doctors 'office 3. For doctors who do not practise mesotherapy, and thus have not mastered the procedure : they can combine with filling injections 4. For doctors who practice mesotherapy and complement the procedure with a superficial technique that can easily be combined with the others 5. A procedure that can be easily delegated to a nurse

4 An innovative technique: Meso-needling Pioneers of mesotherapy and bio-revitalisation, Filorga Laboratories have perfected meso-needling, a new rejuvenating procedure, which is effective, quick and does not entail downtime. This short procedure (3 sessions) rapidly enhances the quality of facial skin and particularly the skin of difficult-to-treat areas of the neck and décolleté. It combines, in one simple and effective procedure, NCTF and a sterile single-use medical roller, which is endowed with CE marking. - NCTF, the best poly-revitalising complex, with a formulation based on free hyaluronic acid with a molecular weight identical to that of the skin and on 53 nutritive elements, stimulates cellular metabolism - Its penetration into the skin is facilitated by the several microperforations made using micro-needles. Moreover, these needles induce a process of skin repair, which stimulates collagen production and micro-circulation, producing a Fraxel-like effect. Result: from the very 1st session, a lifting effect and an immediate glow, without any bruising and without downtime. After 3 sessions spaced 2-3 weeks apart, the skin is firmer, clearer, and more radiant.

5 Principle of Meso-Needling CELLULAR REGENERATION RESULTING FROM A SYNERGY OF ACTIONS: 1. ACTIVATES THE TISSUE REPAIR SYSTEM - Stimulates the production of endogenous elastin and collagen - Improves firmness, elasticity, and hydration - Improves the appearance of residual scars 2. MAXIMISES THE PENETRATION OF REVITALISING ACTIVES - Penetration ti of the actives applied on the skin thanks to the thousands of micropores that are created 3. ACCELERATES CELL RENEWAL - Immediately imparts radiance - Helps eliminate dark spots - Refines skin texture

6 Principle and working of Meso-Needling

7 Micro-needles on a sterile replacement head very fine micro-needles mounted on 10 independent rotating disks Filorga Others Number Length 1 mm Thickness 0.15 mm mm Fixing Disk Insertion - Single-use head: the handle is retained and the rotating head is replaced Single-use: 1 rotating head = 1 session = 1 patient

8 Technical characteristics of the roller MAXIMUM SAFETY - Medical roller: A medical device with CE marking class IIb - Sterile roller and sterile replacement head in blister packs - Sterilisation using Gamma rays - Vacuum-packed blister packs - Micro-needles made of surgical stainless steel micro-pores/cm² more than 125,000 micro-pores created on the face

9 Advantages of the Filorga roller - A very delicate and very effective treatment, thanks to the large number of needles and their sharpness - Fewer scratches and marks, thanks to independent rotating disks - A lower risk of allergies, thanks to the absence of adhesive chemicals - No risk of the loss or dislodgement of a needle, thanks to the disk - Safer due to the replacement head - Excellent value for money

10 The Meso-Needling protocol Session 1 Session 2 Session days days 3 sessions conducted with a gap of 15 days to 1 month 3 sessions conducted with a gap of 15 days to 1 month between each of them according to the skin and indications

11 The application of Meso-needling 1. Carefully disinfect the skin with chlorhexidine, with at least 2 rinsings 2. Apply the NCTF solution on a small patch using a syringe, and then use the roller on it. Treat the face, with one area at a time. The entire face is treated, with particular emphasis on the crow s-feet, the naso-labial folds, and the oval of the face. 3. Move the roller with multi-directional movements until an erythema appears. The pressure should be slightly lower over areas with bony prominences and on the forehead in order to avoid bleeding. 4. Massage using a glove (preferably sterile) to spread the product evenly and help it penetrate 5. Apply a sterile healing product based on hyaluronic acid on the skin once the entire NCTF solution is absorbed

12 Recommendations and tips for meso-needling > One 3ml-vial for one face 2 vials for face, neck and decolleté > It is possible to carry out a peeling 1 week before the 1st meso-needling session, to refine the epidermis. Do not combine peeling and meso-needling in a single session > Local anaesthesia: It is most comfortable for the patient if an anaesthetic cream such as EMLA is applied beforehand, or if the first pass of the roller is extremely light and uses 2% non-adrenalised Lidocaine. Let it take effect for 8-10 min before beginning the meso-needling. > Recommend an SPF50+ screen for the entire duration of the treatment > The inner side of the arms can also be treated. Do not apply on the hands.

13 Launch Package Revitalisation: code ACT sessions Roller 1mm Heads with 10 disks Needles 1mm 1 box of 10 NCTF 135HA (new box without needles and syringes) + 1 roller (10 disks 1mm) + 3 boxes of 3 heads(10 disks 1mm)

14 Launch-related tools > Meso-Needling Leaflet > Meso-Needling demonstration and training video

15 Advantages of Meso-needling - A simple technique to learn - A procedure that does not consume too much clinic time - It can be easily combined with other injections in the same session: - the solution for skin quality, as a complement to fillers - the superficial step in meso injections - A short procedure of 3 sessions - Results that are visible immediately - Lasting results: the stimulation of collagenesis peaks after 6 months - Ideal for large surface areas (neck, décolleté)

16 ALOPECIA

17 New indication New business opportunities Concerns 70 to 80 % of men and 42 % of women Important psychological aspect Few really efficient treatments 1. A new solution to treat patients suffering from hair loss (androgenic alopecia) 2. Reach new patients that would not consult for anti-ageing ageing solutions first (men) 3. Very high loyalty of patients one they see the concrete results of the treatment 4. A way to target dermatologists

18 Factors of alopecia 1. Genetic factors Gene of the receptor to androgenes on the chromosome X, one of the gene for probability to alopecia Normal root, well irrigated Augmentation of the activity of 5-α α reductase enzyme Transforms testosterone into DHT, provoking inhibition of cell proliferation and VEGF supply Augmentation of the sensibility of the receptor to DHT 2. Environmental factors Oxidative stress provoked by tobacco, UV, emotional stress Inflammation and fibrosis Androgenetic root, with poor nutrition, suffering Consequence: micro-circulation nutriments supply Atrophy and miniaturisation of hair Hair fall

19 A complete answer with NCTF Micronutriments supply Boosts cell metabolism Anti-oxidative action Improvement of microcirculation > A complete formula for hair regrowth Vitamins B Gluthation Vitamin C Vitamin E Vitamin B3 Renewal of pilous follicle B8 : biotine, B5 : pantothenic acid, B9 : folic acid, B1, B2, B3 : nicotinamide, B6, B7, B12 Powerful antioxidants Fights the damages of oxidative stress Vasodilatator Improves micro-circulation and helps the supply of micro-nutriments

20 Protocol with Meso-needling Roller 0,5mm 0 1M 2M 3M 4M 5M 6M 7M Treatment of alopecia with NCTF135HA, applied using a roller (published study by Dr. Boisnic) i Procedure of 11 sessions: - disinfection with chlorhexidine - application of NCTF135HA on the scalp - application of the roller using low pressure with multi-directional movements 6 times over each treated area - 1 meso-needling session every 15 days for 3 months - 1 session every month for 5 months

21 Results of Meso-needling Roller 0,5mm Day 0 After 6 meso-needling sessions

22 Launch Package Alopecia: code ACT sessions Roller 0,5mm 1 box of 10 NCTF 135HA (new box without needles and syringes) + 1 roller (10 disks 0,5mm) + 2 boxes of 3 heads (10 disks 0,5mm) + 1 box of 3 heads (4 disks 0,5mm) Heads with 10 disks Needles 0,5 mm For large areas with sparse hair Head with 4 disks Needles 0,5mm For denser hair, allowing a ray after ray treatment (women)

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