Raising the Bar for Skin Health

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1 is Zein Obagi, MD Raising the Bar for Skin Health Under the guidance of Dr. Zein Obagi, ZO Skin Health, Inc., has developed a wide spectrum of therapeutic treatment protocols, effectual products and daily skincare solutions that create and maintain healthy skin. Based on the latest scientific advances in skin therapy technologies, these products and protocols help physicians provide continuous skin health for all skin types, genders, and ages Raising the Bar for Skin Health Introducing New Products and Solutions for Creating Healthy Skin ZO Skin Health Circle Comprehensive & Continuous Solutions ZO Skin Health, Inc., and Dr. Obagi have no business relationship with Obagi Medical Products, and Obagi Medical Products does not sell or endorse using any ZO product. ZO is a registered trademark of ZO Skin Health, Inc /12

2 Comprehensive and Continuous Solutions for Skin Health Under the guidance of Dr. Zein Obagi, ZO Skin Health, Inc., has developed a wide spectrum of therapeutic treatment protocols, effectual products and daily skincare solutions that create and maintain healthy skin. Based on the latest advances in skin therapy technologies unique delivery systems, bioengineered complexes, and exclusive formulations these products and protocols help physicians provide continuous skin health for all skin types, genders, and ages. ZO Therapeutic Solutions ZO Medical ZO Medical therapeutic treatments, effectual products and protocols have been optimized to treat a wide range of skin disorders and chronic conditions. ZO Daily & Preventive Skincare ZO Skin Health A wide range of products, regimens, and programs help maintain the results of therapeutic treatments, and provide effective daily skincare and protection from the environment. Dr. Zein Obagi, Medical Director Innovative Science for Healthy Skin ZO Skin Health, Inc. identified new bioengineered complexes and utilized plant stem cell components with antioxidants to create unique formulations in multi-therapy delivery systems that have not been available until now. ZO Commitment to Education and Training For more than 35 years, Dr. Zein Obagi s progressive ideas have defined the science of skin health. Today, his innovative new protocols, guidelines, and treatments for creating and maintaining healthy skin are available through lectures, personal consultation, and comprehensive ZO training programs.

3 ZO Medical Products New Protocols and Products for Creating Healthy Skin ZO Medical ZO Medical Therapeutic treatments, effectual products and protocols are optimized to treat a wide range of skin disorders and chronic conditions including: Pigmentation disorders Sebum (oily skin) Sun damage Pilosebaceous unit disorders Other inflammatory disorders The Ideal Protocol for Healthy Skin Creating healthy skin always begins with skin stabilization prior to procedures to assure the effectiveness of the treatment. 1. Evaluation of skin condition 2. Determining a treatment plan 3. Stabilization and treatment regimens 4. Therapeutic procedures 5. Maintenance, daily skincare, and protection ZO Medical Skin Health Solutions Based on the latest advancements in skincare technology and Dr. Zein Obagi s extensive clinical experience, ZO Medical solutions include new protocols, prescription pharmaceuticals, and enhancing products that treat a wide range of medical skin conditions. These therapeutic treatments, effectual products and protocols represent Dr. Obagi s new thinking on how to create and maintain healthy skin. Guidelines for evaluation of skin quality Optimized treatments and regimens for effective results Products with high concentrations of active topical agents Solutions for a wide range of patients regardless of skin type Continuous skin health programs after therapeutic treatments Effective and Economical for Your Practice ZO Medical supports healthcare professionals practices in many ways. ZO Medical products are sold exclusively to healthcare professionals Diversion and third-party Internet sales are forbidden Airless pumps with precise dispensing Larger-sized products are more convenient and economical Superior in formulation and technology Patient-friendly skin health maintenance ZO Skin Health products build loyalty to the practice following therapeutic treatments

4 ZO Medical ZO Medical Products BRIGHTENEX Skin Brightener & Correcting Crème Non-Hydroquinone Bioengineered to target all three stages of skin discoloration through a patented, biovectored, microsphere delivery system. It is formulated to even skin color and tone, and recommended as a first course in treating skin discoloration. Synergistic Retinol Formulation A blend of potent retinol (1.0%) and antioxidants is released to rapidly brighten and even skin tone quality. Additionally, this comprehensive multi-action formulation minimizes skin redness caused by environmental factors and helps maintain an even and restored skin tone. BRIGHTENEX Multi-Action System Vitamin A and vitamin C work on contact in the uppermost skin layers Natural stachys officinalis antioxidants soothe and mediate the appearance of skin redness Triple-action glutathione, soy isoflavones, and N-acetyl glucosamine minimize the appearance of age spots and uneven color The new alternative to hydroquinone treatments (75 ml, 2.5 fl. oz.) RETAMAX Active Vitamin A Micro Emulsion Multi-action formula potent retinol (1.0%), blended with plant stem cell antioxidants and biomimetic proteins reduces the signs of aging and aids in the prevention of future damage. Stimulating Collagen Formation and Skin Barrier Function Vitamin A aids in skin rejuvenation by supporting the natural production of hyaluronic acid the skin s most vital natural hydrating factor and the formulation of collagen. Antioxidants and Free-Radical Scavenging This biocellular antioxidant system serves to block free-radical damage and helps protect vulnerable cellular DNA, and addresses the root cause initiators of future skin aging, while ensuring the maintenance of new, healthy skin. RETAMAX Micro Emulsion System High-potency vitamin A aids the skin s natural rebuilding process Vitamins C and E, and buddleja plant stem cells support free-radical scavenging Biomimetic protein activation aids skin regeneration Micro emulsion technology supports rapid delivery of key ingredients (75 ml, 2.5 fl. oz.) MELAMIN Skin Bleaching & Correcting Crème Hydroquinone USP, 4% Prescription Only A highly effective Rx solution to lighten hyperpigmentation with 4% hydroquinone. Recommended following use of BRIGHTENEX. This formulation alters the essential subcellular metabolic processes that cause cytolysis. It inhibits melanin production to even skin color and tone. 4% hydroquinone acts as a gradual bleaching agent Reduces the appearance of chloasma, melasma, freckles, and sun damage Vitamin E helps repair damaged skin cells (Net Wt. 80 g, 2.8 oz.) MELAMIX Skin Lightener & Blending Crème Hydroquinone USP, 4% Prescription Only A 4% hydroquinone bleaching cream penetrates the skin and effectively delivers the active ingredients of the system to the melanocytes. It alters the essential subcellular metabolic processes that cause cytolysis and inhibit melanin production. 4% hydroquinone acts as a gradual bleaching agent Reduces the appearance of chloasma, melasma, and freckles Optimizes delivery of active ingredients (Net Wt. 80 g, 2.8 oz.) OILACLEANSE Cleanser for Normal to Oily Skin Dual-action cleanser exfoliates and cleanses skin, targeting excess oil. Removes oil and other impurities to clean the skin and help clear acne. Reduces the factors that contribute to skin redness Helps decrease the level of bacteria on skin surface Promotes exfoliation (240 ml, 8 fl. oz.)

5 ZO Medical Products NORMACLEANSE Cleanser for Normal to Dry Skin Its advanced surfactant gently removes impurities and oil, and prepares the skin to receive therapeutic treatments. This unique formulation gently cleans and conditions the skin. Highly advanced surfactant matrix removes impurities Peptide and collagen-boosting complex helps firm the skin Moisturizing complex nourishes and calms the skin (240 ml, 8 fl. oz.) GLYCOGENT Exfoliation Accelerator An innovative exfoliation accelerator engineered to help reduce skin redness and prevent future damage. Active ingredients enhance mitosis and help correct skin discoloration. Potent glycolic and lactic acid complex provides skin surface renewal Active complexes help minimize the appearance of irritated skin Proven antioxidants help prevent future skin damage (75 ml, 2.5 fl. oz.) BALATONE Calming Toner ph Balancer This unique toner optimizes the penetration of therapeutic treatments by removing impurities and balancing the ph of weak skin. It invigorates dry, sensitive and irritated skin with its proprietary technology. Unique combination of solvents, astringents, and exfoliants thoroughly clears and cleanses the skin Exclusive blend of conditioners, moisturizers, and hydrators soothes treated skin Gentle cooling action adds comfort to reduce irritation (180 ml, 6 fl. oz.) CEBATROL Oil Control Pads An invigorating acne medication to treat and prevent outbreaks. Its proven exfoliants effectively remove dead skin cells. These pads also contain an emollient complex to help soothe skin and reduce redness. Maximum-strength 2% salicylic acid acne treatment Mandelic acid helps resurface skin for a smoother appearance Triclosan provides additional antibacterial benefits (60 pads/75 ml, 2.5 fl. oz.) ZO CONTROLLED DEPTH PEEL Kit Professional Use Only The ZO CONTROLLED DEPTH PEEL Kit for use with TCA 30% (trichloracetic acid) is used to medically treat the various skin conditions of acne, wrinkles, fine lines, skin pigmentation disorders, and sun damage. This kit includes an innovative Base, Cleanser, and accessories. Preconditioning skin with ZO Medical products is required before performing this peel. (Kit does not include TCA.) The Next Generation of ZO Peels Controlled absorption and penetration Easily mixed with TCA Excellent anti-inflammatory properties Resurfacing Damaged Skin with TCA TCA (trichloracetic acid) is a non-toxic chemical that is used by medical professionals to perform therapeutic skin peels. When TCA is applied to skin it causes surface skin cells to dehydrate and then peel off over a period of several days to one week. When the surface skin peels away, it exposes a new layer of undamaged skin, which has a smoother texture and a more even skin tone. Physicians utilize TCA peels today as a preferred remedy for treating various skin disorders. Reduce brown spots, age spots, uneven skin pigmentation, and the appearance of melasma Improve the texture of leathery, sun-damaged skin and impart more glow Treat certain types of acne conditions and post-inflammatory hyperpigmentation Reduce fine lines and wrinkles ZO CONTROLLED DEPTH PEEL Base Guides the Systemic Application TCA treatments must be applied in an even and continuous application over the entire treatment area with an effective visual guidance system. ZO custom-designed a ph-balanced peel base that complements the use of TCA. The ZO CONTROLLED DEPTH PEEL Base, when proportionally prepared with TCA, is a highly effective method to aid in systemic application guidance over the entire treatment area. Enriched with skin lipid supplements, skin redness modulators, and antioxidants, this ZO Base minimizes skin redness, replenishes skin barrier function, and minimizes newly exposed skin cells from post-peel damaging oxidative stress. ZO CONTROLLED DEPTH PEEL Cleanser This ZO Cleanser emulsifies and lifts most colorant staining and residue on the skin following application of the ZO Base. During the foaming action, an ultra-mild beta-hydroxy acid exfoliant deposits on skin for secondary removal of any remaining dead surface skin cells. In addition, vitamin B3 -niacinamide penetrates the upper layers of skin to help aid the skin s natural cellular renewal processes that accelerate replenishment of new skin cells and help maintain healthy skin. Tretinoin Tretinoin USP available in 0.1% and 0.05% cream in 20 g tubes. Prescription Only

6 ZO Skin Health Products Daily and Preventative Skincare Solutions Now all patients can experience continuously healthy skin whether or not they require a therapeutic skincare procedure. Featuring powerful ingredients and effective delivery systems, ZO Skin Health products and programs make it possible for healthcare professionals to recommend a home-care regimen that enables patients to experience healthy skin every day. The Power of Retinol from ZO ZO Skin Health has developed a wide range of delivery systems that maximize the effectiveness of vitamin A (retinol) to reduce the signs of aging fine lines, wrinkles, sun damage, and age spots. ZO Skin Health Anyone. Anytime. Anywhere. ZO Skin Health products provide effective daily skincare and protection from the environment for every patient at every age and stage of their life. Delivering clinically proven results, these programs create and maintain healthy skin that is strong, smooth and firm, evenly toned and free of disease. Continuously Healthy Skin for Patients and Practices The ZO Skin Health Circle expands the breadth of solutions for creating healthy skin beyond therapeutic treatments and procedures so patients can experience continuous skin health. This continuity of care increases patient loyalty and referrals to everyone seeking healthier and younger appearing skin. Stabilization and Correction Stabilization and correction is the process of improving barrier function to increase skin tolerance and eliminate weakness through: Restoring the normal balance of the stratum corneum Increasing epidermal thickness Improving circulation Minimizing irritation Enhancing cellular function Controlling overactive melanocytes Maintaining integrity of pilosebaceous units Stimulating collagen and elastin production Stimulating Dermal Cellular Function Retinol, a vitamin A derivative, is one of the few substances with small enough molecules to penetrate the epidermis and reach skin receptors to stimulate the natural production of collagen and elastin. Collagen and elastin are the core building blocks of healthy skin. Ossential Radical Night Repair Plus Addresses Signs of Aging Using a high concentration of retinol, sequestered in a patented, time-released microdelivery system, Ossential Radical Night Repair Plus is designed to deliver rapid results to address multiple signs of skin aging. Patients will initially experience short-term redness, stinging, and peeling of the superficial skin layers. This assists the new, healthy, underlying skin cells to emerge to the surface for a more even tone, smoother texture and restoration of a radiant appearance. With repeated use, patients will notice dramatic reductions of wrinkles and lines, increased skin firmness and density, and supple, elastic derma. Stabilized Retinol for Effectiveness Utilizing advanced formulations, ZO delivery systems serve to minimize retinol hydrolysis and degradation, and to ensure full-strength delivery to the stratum corneum. These highly stable retinol formulations are used in Ossential Daily Power Defense, Olluminate Intense Eye Repair, Ommerse Renewal Crème, and Ommerse Overnight Recovery Crème.

7 Three Programs for Specific Skin Conditions ZO Skin Health ZO Skin Health makes it easy for skincare specialists and their patients to understand and execute the benefits of a healthy skin program, based on a three-tiered approach that targets specific skin conditions using the most effective combination of products for treatment. Daily Skincare Program Aggressive Anti-Aging Skincare Program Condition: Youthful Skin Little or no apparent signs of chronological or photo-aging. Daily Skincare Program Provides the essential tools to help achieve healthier skin using retinol, specialized enzymes, and antioxidants to promote cellular function and restore and maintain youthful, healthy-looking skin. Offects Exfoliating Cleanser (1.5 oz.) Offects Exfoliating Polish (0.5 oz.) Ossential Daily Power Defense (1.0 oz.) Oclipse Sunscreen + Primer SPF 30 (0.5 oz.) Anti-Aging Skincare Program Condition: Mature Skin Early signs of intrinsic aging fine lines, uneven skin tone, loss of firmness. Anti-Aging Skincare Program Uses higher concentrations of active ingredients including growth factors, retinol, and enzymes, to prevent and help repair moderate skin damage at the cellular level. Offects Exfoliating Cleanser (1.5 oz.) Offects Exfoliating Polish (0.5 oz.) Ossential Daily Power Defense (1.0 oz.) Ossential Growth Factor Serum (0.66 oz.) Oclipse Sunscreen + Primer SPF 30 (0.5 oz.) Condition: Aging Skin Definite signs of aging skin wrinkles, brown patches, skin laxity, large pores, significant sun damage. Aggressive Anti-Aging Skincare Program Delivers the highest concentrations of retinol, helping patients with aging and photo-damaged skin to radically reduce wrinkles, uneven skin tone, fine lines, rough texture, and sagging skin. Offects Hydrating Cleanser (1.5 oz.) Offects Exfoliating Polish (0.5 oz.) Ossential Daily Power Defense (1.0 oz.) Ommerse Renewal Crème (1.7 oz.) Ossential Radical Night Repair Plus (1.0 oz.) Oclipse Sunscreen + Primer SPF 30 (0.5 oz.)

8 ZO Skin Health Products Offects Exfoliating Cleanser Gently exfoliates and cleanses skin, reduces excess oil, and neutralizes free radicals. Encapsulated vitamin E provides antioxidant protection and hydration for healthy skin. (150 ml, 5.0 fl. oz.) Ossential Growth Factor Serum Growth Factor Serum uses two proprietary peptides to support collagen production for increased skin density. Combining retinol and amino acids, cellular function is stimulated, collagen degradation reduced, and elasticity restored. (30 ml, 1.0 fl. oz.) Olluminate Intense Eye Repair Stabilized retinol and advanced peptides aid in strengthening skin and minimizing fine lines and wrinkles. Optical diffusers highlight the eye area to reduce the appearance of dark circles. Olluminate Intense Eye Repair helps reduce puffiness and discoloration with antioxidants and anti-irritation ingredients. (15 ml, 0.5 fl. oz.) Offects Hydrating Cleanser Hydrates and rejuvenates without disrupting the moisture barrier. Using panthenol and allantoin to soothe, repair, and restore skin, it cleans away dead skin cells and supports cellular renewal. (150 ml, 5.0 fl. oz.) Ossential Radical Night Repair Plus A full 1% concentration of retinol stimulates new cell activity and collagen formation in aged and UV-damaged skin faster and more effectively than most anti-aging treatments. (30 ml, 1.0 fl. oz.) Oraser Microderm Hand Renewal Oraser Microderm Hand Renewal makes a dramatic and immediate improvement in the appearance of hands. Retinol, an active form of vitamin A, helps restore and maintain a youthful appearance. Sugar crystals exfoliate the skin, gently scrubbing away rough, dull skin, leaving it smooth. Shea butter moisturizes, hydrates, and softens the skin to make hands look and feel younger. (30 ml, Net Wt. 1.0 oz.) Offects TE-Pads Acne Pore Treatment Reduces sebum production, removes dead skin cells, and deep-cleans congested pores using 2% salicylic acid. Botanical extracts calm and soothe irritation. Recommended for prevention and treatment of oily skin and breakouts. (60 pads) Ommerse Renewal Crème This functional hydrator contains encapsulated retinol, powerful antioxidants, and an antiirritation agent to calm, replenish, rejuvenate, and repair the skin s moisture barrier. (50 ml, 1.7 fl. oz.) Oraser Daily Hand Repair SPF 20 Applied daily, Oraser Daily Hand Repair helps erase the signs of aging hands. Using powerful antioxidants, brightening and amino acid complexes, it helps minimize age spots, fine lines, and wrinkles. Broad-spectrum UVA/UVB sunscreen helps prevent future damage. (100 ml, 3.4 fl. oz.) Offects Exfoliating Polish Ultra-fine magnesium crystals exfoliate dead skin cells and increase epidermal turnover for a cleaner, smoother, more even-toned complexion. Vitamins A, C, E, and C-Esters provide antioxidant benefits to help maintain skin barrier function. (65 g, Net Wt. 2.0 oz.) Ommerse Overnight Recovery Crème Calming agents help prevent irritation as retinol and other ingredients work more actively overnight to repair and regenerate skin cells to help reduce fine lines and wrinkles. (50 ml, 1.7 fl. oz.) Oraser Overnight Hand Recovery A unique, proprietary combination of retinol, powerful antioxidants, and rich emollients give ZO Skin Health s Oraser Overnight Hand Recovery cream the ability to help reduce pigmentation and the incidence of fine lines and wrinkles. (100 ml, 3.4 fl. oz.) Ossential Daily Power Defense Highly stable retinol, antioxidants, and specialized DNA-repairing enzymes work around the clock to help minimize UV oxidative damage and uneven pigmentation, while restoring skin function and elasticity. (30 ml, 1.0 fl. oz.) Oclipse Sunscreen + Primer SPF 30 Using natural melanin, titanium dioxide, and zinc oxide to provide broad-spectrum UVA/UVB protection, Oclipse is also used to smooth and prime skin for a more even makeup application. (30 ml, 1.0 fl. oz.) Oraser Body Emulsion Oraser Body Emulsion uses lactic acid to soften skin and allow it to retain its youthful appearance, texture, and tone. Specially formulated retinol, ceramides, and emollients help to prevent moisture loss and create an antioxidant-rich complex that perfectly hydrates, exfoliates, and nourishes skin from head to toe. (240 ml, 8.1 fl. oz.)

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