Marine Molecules as Nanofibres. Seafood Innovation Conference

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Stanley Pearson
6 years ago
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1 Marine Molecules as Nanofibres Seafood Innovation Conference

2 Design functional nanofibre Air filtration Develop. Superior products Manufacture. Specialised to Industrial scale Commercialise. innovation Skincare and Medical Composite reinforcement Acoustics Anti-allergy bedding

3 Sonic Electrospinning Technology The Komodo: Winner of New Zealand Engineering Excellence Award (Manufacturing) 2012

4 Nanofibre Customisation Services

Extraordinary Nanofibres Unique Properties Van

level Biomimicry and biomaterials Conductive,

Easy to integrate into production lines Safe

points of bonding and functionality High

Thickness Low weight Micron thickness High

breathability Adjustable packing density Ideal

5 Extraordinary Nanofibres Unique Properties Van der Waals attractive forces at the molecular level Biomimicry and biomaterials Conductive, piezoelectric Non-woven textile Rolled goods Easy to integrate into production lines Safe to handle Huge surface area 3D scaffold Many points of bonding and functionality High loadings of actives Negligible weight & Thickness Low weight Micron thickness High strength to weight ratio Porous structure High breathability Adjustable packing density Ideal filtration media Selective filtration Platform Technology Wide range of materials New functionality in textiles Many commercial uses ripe for commercialization

6 skin performance skin repair An active delivery platform for skin care

Technology 1. A completely new, patented delivery system for skin care an alternative to creams and dressings 2. Simple application delivering a controlled dose each and every time 3.

7 Technology 1. A completely new, patented delivery system for skin care an alternative to creams and dressings 2. Simple application delivering a controlled dose each and every time 3. All natural - no carriers, no preservatives, no emulsifiers 4. Clinically proven skin performance and skin repair extracts and marine collagen - nothing else % pure, 100% natural, 100% New Zealand

8 Simple Delivery Simply apply to wet skin Convenient Quick and easy to use A controlled dose

9 Collagen fibre being applied onto skin activlayr: Collagen nanofibre being applied onto skin

10 Electrospinning collagen Collagen fibers nm

11 The complex collagen fiber ascorbate ascorbate

Unique source of marine collagen Hoki (Macruronus novaezelandiae) skins were obtained from a commercial fish processing factory (Sealord Group Ltd, Nelson, New Zealand).

100 g skins per L acid) to extract the collagen.

12 Unique source of marine collagen Hoki (Macruronus novaezelandiae) skins were obtained from a commercial fish processing factory (Sealord Group Ltd, Nelson, New Zealand). The skins are cleaned of adhering scales, muscle, fat and pigment. After thorough rinsing in water the skins are mixed with 0.5 M acetic acid (approx. 100 g skins per L acid) to extract the collagen. Hoki skin collagen has a low imino acid (proline and hydroxyproline) content (147 residues/ 1000 residues) compared with collagen from skin of calf (Bostaurus) (232/1000) and that from the temperate fish, carp (Cyprinus carpio) Extraction process provides α-chains, electrospinning forms Type I&II collagen fibrils

13 Simple Ingredients Pure New Zealand Marine Collagen Fibres Water soluble Sustainably sourced from waste hoki skins No religious connotations Vinanza Skin Performance and Skin Repair Proprietary blends of New Zealand sourced kiwifruit, grape and berry extracts 100% water extracted Water soluble High bioactivity

14 Absorbance FTIR Spectra - ingredients 4.00E E E-01 Pure SPP powder Pure Collagen fibre 2.50E E E E-01 (C-O) stretch (C=O) stretch 5.00E E E E E E E+03 Wave number ( cm -1 )

15 Absorbance FTIR spectra - activlayr 4.00E E E-01 collagen + SPP collagen only fibre 2.50E E E E-01 (C-H) rock of benzene (C-O) stretch of ester (C=O) stretch of ester or amide 5.00E E E E E E E E+03 Wave number ( cm -1 )

16 Cosmetic patches activlayr supporting fabric Magnified 200x

17 Clinically proven Anti-aging formulation. In seven days: Improved elasticity (17%) Moisturizes decreased TEWL (16%) Skin whitening (6%) Proven to stimulate growth of type I and III collagen Bean shape, fits contours of the face - target problem areas around eyes, mouth, etc Suitable for daily use No fragrances, no preservatives, no emulsifiers Patent protection Skin Performance

18 Skin Performance clinical results After 7 days use Decreased TEWL (water loss from skin) by 17% Increased elasticity by 16% Reduced skin redness by 7% Improved skin whitening (decreased melanin) by 4% Different blends would give targeted results; for example more kiwifruit extract would improved skin whitening effect

growth (phase 2 enzymes) Antibacterial Skin whitening Alternative to ointments

19 Skin Repair Skin repair formulation - blend of plant extracts selected specifically for repairing damaged or inflamed skin Anti-inflammatory Cell growth (phase 2 enzymes) Antibacterial Skin whitening Alternative to ointments and dressings A natural remedy Pain free application Clean delivery no rubbing, no peeling

20 Skin Repair clinical results Reduced skin reddening (inflammation) by over 50% Plant extracts specifically targeted at wound care (scrapes, grazes) Use on inflamed and damaged skin

21 100% Natural No additives No carriers No preservatives No harsh chemicals No residues No colours No fragrance

22 100% New Zealand 100% pure - no added chemicals, pesticides or preservatives 100% natural 100% sustainable 100% New Zealand ingredients

Limitless Possibilities in seafood molecules Active patches, New formulations: successfully carried manuka honey, bee venom, proteins, TiO2, other phenolic compounds Skin moisture and elasticity face

23 Limitless Possibilities in seafood molecules Active patches, New formulations: successfully carried manuka honey, bee venom, proteins, TiO2, other phenolic compounds Skin moisture and elasticity face masks algae, alginate and carrageenan from seaweed Encapsulation of oils Omega3, etc Other fish/jellyfish collagens for cosmetic applications Wound dressing or Burn treatment composite dressings using chitosan or collagen Dermal drug delivery

24 Interlaminar reinforcement for carbon fibre composites Toughening resin and improving mechanical performance Negligible impact on size or weight Localized reinforcement Increased fatigue resistance, impact strength, crack and delamination resistance

25 Up to 100% extra load strength Virtually no added weight

26 New developments

27 Thanks for listening Further information:

Product Information. Bringing new life to your skin naturally

Product Information. Bringing new life to your skin naturally Product Information Bringing new life to your skin naturally Natural New Zealand BeeBio Anti-Aging Skincare is proudly New Zealand owned and made, with our ingredients sourced from within New Zealand.