Innovative Preservative Solutions. Dr. Matthias Kunze LANXESS Distribution GmbH Barcelona, 16 April 2015

Transcription

1 Innovative Preservative Solutions Dr. Matthias Kunze LANXESS Distribution GmbH Barcelona, 16 April 2015

2 Innovative Preservative Solutions Bild/Grafik Größe: Topics Status of cosmetic preservation Innovative paraben alternatives 1. paraben-free 2. preservative-free Höhe = 13,06 cm Breite = 10,89 cm 3. renewable Efficacy tests MIC data challenge tests 2

3 Status of Cosmetic Preservation Bild/Grafik Größe: Preservation Market Trends paraben-free formulations paraben-free claims standard alternatives Höhe = 13,06 cm Breite = 10,89 cm 3

4 Status of Cosmetic Preservation Launches of skin care formulations containing parabens SOURCE: MINTEL phase out of parabens continues after stalling in

5 Status of Cosmetic Preservation Launched skin care formulations claiming free from parabens SOURCE: MINTEL paraben-free claim still attractive 5

6 Status of Cosmetic Preservation Summary Parabens under pressure phase-out of parabens continues free from parabens claim increasingly popular Standard paraben alternatives formaldehyde donors not preferred (banned in Japan) isothiazolinones heavily restricted strong need for new alternatives 6

7 Innovative Preservative Solutions Bild/Grafik Größe: Innovative Paraben Alternatives 1. paraben-free 2. preservative-free 3. renewable Höhe = 13,06 cm Breite = 10,89 cm 7

8 Innovative Paraben Alternatives 1. Paraben free: blend composition Typical approach: phenoxyethanol + organic acids organic acids cover weakness of phenoxyethanol vs. bacteria organic acids require acidic environment Solution: replacement of organic acids by triethylene glycol good synergistic effect suitable also for alkaline formulations up to ph 10 brand name: Solbrol TP (INCI: Phenoxyethanol, Triethylene Glycol) 8

9 Innovative Paraben Alternatives 1. Paraben free: MIC data Phenoxyethanol Solbrol TP P. aeruginosa S. aureus C. albicans A. niger Solbrol TP shows good performance against bacteria and fungi Solbrol TP is suitable for both acidic and alkaline environments 9

10 Innovative Paraben Alternatives 2. Preservative free: blend composition Typical approach: caprylyl glycol free from preservatives weakness in particular against bacteria difficult to handle due to high viscosity Solution: combination with phenethyl alcohol well balanced preservation effect suitable also for alkaline formulations up to ph 10 brand name: Solbrol CP (INCI: Caprylyl Glycol, Phenethyl Alcohol) 10

11 Innovative Paraben Alternatives 2. Preservative free: MIC data Caprylyl Glycol Solbrol CP P. aeruginosa S. aureus C. albicans A. niger Solbrol CP is very effective also against bacteria Solbrol CP is suitable for both acidic and alkaline environments 11

12 Innovative Paraben Alternatives 3. Renewable: blend composition Natural extracts: e.g. Bark extract from the white willow tree in propanediol free from preservatives ECOCERT certified suitable for alkaline formulations up to ph 8 brand name: Solbrol SP INCI: Propanediol, Salix Alba (Willow) Bark Extract 12

13 Innovative Paraben Alternatives 3. Renewable: MIC data > 6 > 6 2 Propanediol Solbrol SP P. aeruginosa S. aureus A. niger C. albicans Solbrol SP is very effective against bacteria Solbrol SP is suitable for both acidic and mild alkaline environments 13

14 Innovative Preservative Solutions Bild/Grafik Größe: Höhe = 13,06 cm Breite = 10,89 cm Challenge Tests shampoo wet wipe formulation benchmarked against paraben blend Solbrol Mix P Phenoxyethanol, Methyl-, Ethyl-, Propyl-, Butyl- and Isobutylparabenn according to Ph. Eur Efficacy of Antimicrobial Preservation 14

15 Challenge Test Results Shampoo Formulation INGREDIENT % (weight) Deionised water 57.0 Sodium Lauryl Sulphate 9.0 Propylene Glycol 5.0 Cocamidopropyl Betaine 1.4 C10-30 Alkyl Acrylate Crosspolymer 1.0 Sodium Hydroxide 0.5 ph =

16 Challenge Test Results Shampoo Formulation criteria A criteria B fail paraben blend paraben free preservative free renewable Solbrol type none Mix P TP CP SP Concentration (%) Pseudomonas aeruginosa Staphylococcus aureus Candida albicans Aspergillus niger criteria A achieved by Solbrol TP and Solbrol CP at 0.4 % Solbrol SP achieves criteria A at 0.8 % 16

17 Challenge Test Results Wet Wipes INGREDIENT % (weight) Deionised Water 90.7 Glycerin 5.0 Propylene Glycol 2.0 Polysorbate Cocamidopropyl Betaine 0.5 Aloe Barbadensis 0.2 Tocopheryl Acetate g of solution on 10 g of cotton tissue ph =

18 Challenge Test Results Wet Wipes criteria A criteria B fail paraben blend paraben free preservative free renewable Solbrol type none Mix P TP CP SP Concentration (%) Pseudomonas aeruginosa Staphylococcus aureus Candida albicans Aspergillus niger Solbrol CP achieves criteria B at 0.5 %, criteria A at 1 % Criteria B preservation achieved by Solbrol TP at 1 % Solbrol SP achieves criteria B at 1 % 18

19 Innovative Preservative Solutions Summary Solbrol TP paraben-free blend good alternative also for alkaline formulations (ph 10) Solbrol CP preservative-free blend high and well-balanced efficacy (up to ph 10) Solbrol SP ECOCERT certified blend especially active against bacteria, also works in mild alkaline environments (ph 8) 19

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