Personal Care. Industrial & Consumer Specialties. A unique solution for complete skin repair. Vitipure TM

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1 Industrial & Consumer Specialties Personal Care A unique solution for complete skin repair Vitipure TM

2 Formulating with VITIPURE TM VITIPURE can be formulated into O/W and W/O emulsions as well as aqueous gels. It is most conveniently incorporated after preservatives have been added to the formulation. Various aesthetic properties can be achieved with VITIPURE TM depending on addition order: Water phase aqueous & light touch Oil phase caring feel At the end rich and substantive feel The addition of VITIPURE could lead to moderately higher viscosities. It is best to incorporate the product below 50 C, although temperatures of 80 C are tolerated for a brief period. VITIPURE is stable over a wide ph range. Recommended Use Levels VITIPURE can be used in the range of %. Studies conducted on the anti-aging and skin repair benefits of VITIPURE included 1.5% VITIPURE TM Feeling in test formulations. VITIPURE can be used in the range of % for a sensory effect. Compatibility There are no known incompatibilities for VITIPURE in cosmetic products. For Deco-Cosmetics the use of VITIPURE Sensation is recommended due to its smaller particle size. Solubility VITIPURE is easily dispersible in water, oil and hydroalcoholic solutions.

3 VITIPURE TM VITIPURE TM is a novel biotech innovation that benefits consumers of all age groups by providing the advantages derived from natural products without sacrificing product performance or aesthetics. VITIPURE TM has been shown to enhance skin elasticity and firmness, while making it feel luxuriously smooth to the touch. The unique complex provides superior benefits for skin repair and anti-aging. The unique, patented biopolymer, VITIPURE TM, consists of a covalently linked chitin-glucan polysaccharide complex. It is of vegetal origin, derived from bio-fermentation of Aspergillus Niger. This novel approach to vegetal chitin provides a unique solution for healthy, youthful skin. Beta (1,3)-glucan Key Functions Skin barrier function restoration Immune-stimulating properties Improvement in skin elasticity and firmness Skin surface micro relief organization Skin hydration Chitin Which VITIPURE TM fits your formulation needs? VITIPURE TM Feeling Larger particle size: 95 % are 125 µm Ideal for use in skin, hair and sun care formulations VITIPURE TM Sensation Finer particle size: 95 % are 30 µm Ideal for use in color cosmetics and lip care formulations VITIPURE at a Glance Specification Source & Process Toxicity Regulatory INCI: Chitin, Beta-Glucan Fine, off-white powder Odorless >90% Dry matter Renewable, Inexhaustible, Traceable Consistent quality Non-GMO ISO & HAACP compliant Non-irritating Hypoallergenic Non-phototoxic Non-ecotoxic Considered a polymer under the EU REACH legislation

4 Anti-Aging Benefits Multi-dimensional wrinkle reduction using cream with 1.5% VITIPURE TM Feeling had a significant reduction in the number and depth of skin microreliefs, as determined using image analysis. The total wrinkled surface area was reduced by 24% after only 8 weeks. 90% of panelists observed a positive effect in the 16 week study. Cream Efficacy According to a subjective questionnaire, the panelists perceived Softer skin: 90% More lifted skin: 77% Smoother complexion: 75% More hydrated skin: 71% Instrumentation N=20, Age 57-60, Women Moisturizing cream containing 1.5% VITIPURE Feeling vs. control Twice daily to the crow s feet region for 16 weeks Image analysis of skin replica Reduced appearance of fine lines and wrinkles Significant smoothing of skin microrelief was achieved in just 4 weeks with a cream containing 1.5% VITIPURE TM Feeling, in comparison to the control cream. Consistent improvement occurred throughout the 16 week study. Optical Profilometry Fine lines, wrinkles, and deep microreliefs due to aging, were quantified using optical profilometry. A lower Rz value indicates smoother skin. Smoother skin provides a more healthy, radiant appearance. N=20, Age 54-62, Men Time (weeks) Instrumentation Moisturizing cream containing 1.5% VITIPURE Feeling vs. control Twice daily to forearm for 16 weeks Optical profilometry of skin surface replicas Mean Depth Measurement, Rz (µm) Cream with VITIPURE TM Feeling 1.5% Control Statistical Significance: * p < 0.05, ** p < 0.01 vs. control

5 Skin Repair Benefits Improved skin hydration with prolonged use Skin hydration significantly increased for panelists using a cream with 1.5% VITIPURE Feeling throughout the 16 week study. Short-term and long-term hydration benefits were observed in comparison to the control cream. Time (weeks) VITIPURE is an excellent water-binding biopolymer, capable of retaining 10 times its own weight in water. It forms an efficient, nonocclusive barrier that limits water loss through evaporation. A higher electrical capacitance value indicates greater water retention capacity of the stratum corneum Smooth skin Electrical Capacitance Measurement, arbitrary units Cream with VITIPURE TM Feeling 1.5% Control Statistical Significance: * p < 0.05, ** p < 0.01 vs. control Instrumentation N=20, Age 54-62, Men Moisturizing cream containing 1.5% VITIPURE Feeling vs. control Twice daily to forearm for 16 weeks Corneometer Measurement 10h post-application Enhanced overall health of compromised skin VITIPURE TM Feeling reduced the physical parameters associated with Atopic Dermatitis and the need for steroid cream in just 1 week. Initial benefits observed were maintained over 4 weeks. Evaluation N=13, Exhibiting atopic dermatitis; 4 adults, 9 children (6 children < 3yrs) Moisturizing cream containing 1.5% VITIPURE Feeling Following 2-day steroid cream initiation period, twice daily to 10 precise regions (front and back) for 4 weeks Dermatologist evaluation: Average score = sum of SCORAD scores for all 10 regions, average of all 13 panelists Panelist evaluation: Average number of sites = number of sites panelists needed to apply steroid cream; average score Clinical Signs of Atopic Dermatitis Dermatologist evaluation Average SCORAD Improved Skin Health Score Need for Steroid Cream Panelist evaluation -50% -62% Average Number of Improved Skin Health Sites

6 Clariant Corporation Industrial & Consumer Specialties 625 E. Catawba Avenue Mount Holly, NC Phone: Fax: This information corresponds to the present state of our knowledge and is intended as a general description of our products and their possible applications. Clariant makes no warranties, express or implied, as to the information s accuracy, adequacy, sufficiency or freedom from defect and assumes no liability in connection with any use of this information. Any user of this product is responsible for determining the suitability of Clariant's products for its particular application. Nothing included in this information waives any of Clariant s General Terms and Conditions of Sale, which control unless it agrees otherwise in writing. Any existing intellectual/industrial property rights must be observed. Due to possible changes in our products and applicable national and international regulations and laws, the status of our products could change. Material Safety Data Sheets providing safety precautions, that should be observed when handling or storing Clariant products, are available upon request and are provided in compliance with applicable law. You should obtain and review the applicable Material Safety Data Sheet information before handling any of these products. For additional information, please contact Clariant. * For sales to customers located within the United States and Canada the following applies in addition: NO EXPRESS OR IMPLIED WARRANTY IS MADE OF THE MERCHANTABILITY, SUITABILITY, FITNESS FOR A PARTICULAR PURPOSE OR OTHERWISE OF ANY PRODUCT OR SERVICE. 9/2010 Copyright Clariant Corporation, 2012

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