Ingredient Glossary S TRATA

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1 NEO S TRATA C O M P A N Y NeoStrata Company, Inc., 307 College Road East, Princeton, New Jersey 08540, USA Phone (609) Fax (609) Ingredient Glossary POLYHYDROXY AND BIONIC ACIDS Gluconolactone, a polyhydroxy acid, is a cell nutrient and antioxidant found naturally occurring in skin. It works on all of the levels of the skin, from the inside out, to smooth the surface, even skin tone, plump and hydrate. Gluconolactone is made up of multiple hydroxyl groups (as opposed to a single hydroxyl group like other AHAs, such as glycolic acid) that attract water, providing enhanced moisturization. Even though it is gentler than traditional AHAs, it has been found to provide the same textural improvements when used over the same period of time. This includes skin smoothing, improved clarity and brightness, a reduction in the appearance of fine lines and wrinkles, and a more even skin tone. In addition, gluconolactone conditions and builds the skin s barrier function, which increases protection against irritants and helps to retain moisture. This gentle, yet highly effective ingredient is suitable for all skin types. Because of its polyhydroxy acid structure, it penetrates into the skin gently so that patients/clients will not experience stinging, itching, burning or redness that may occur with other AHA use. Lactobionic Acid, a polyhydroxy bionic acid derived from milk sugar, is a potent antioxidant with humectant properties that strongly attracts and binds water. Its unique hydra-film delivers moisture and provides softness and a velvety smoothness to the skin. Lactobionic acid formulations reduce the appearance of fine lines and wrinkles, and plump the skin layers. In addition to helping reverse signs of aging, lactobionic acid works to protect the skin against photoaging by inhibiting destructive enzymes (MMP enzymes) that degrade the skin s structure and strength. This ingredient is suitable for all skin types. Maltobionic Acid is a plant derived polyhydroxy bionic acid that is a potent humectant and antioxidant. Clinical data has shown this ingredient to have significant anti-aging benefits, including visual improvements in skin texture, clarity and roughness, plus self-assessed improvements in skin firmness, elasticity and hydration. This ingredient provides similar antiaging, conditioning and hydrating benefits to lactobionic acid and is suitable for all skin types. 6/03/10 Page 1 of 6

2 ALPHA HYDROXYACIDS Glycolic Acid is found in its natural state in sugar cane. It is the smallest molecule of the AHA family and therefore is optimally absorbed into the skin. Clinical studies have shown that sustained daily treatment with low concentrations of glycolic acid brings about a normal stratum corneum with increased resiliency, and enhanced cell renewal, as well as a plumper, firmer skin matrix. The result is healthier, younger looking skin, with a smoother texture and visually fewer fine lines and wrinkles. Citric Acid is an antioxidant alpha and beta hydroxy acid that is used in both foods and skin care products. Its antioxidant benefits help minimize the damaging effects of the sun and pollution. Studies have shown citric acid to provide significant anti-aging benefits like other AHAs. Lactic Acid, an alpha hydroxyacid occurring in milk, is a component of the skin s natural moisturizing factor. Similar to glycolic acid, lactic acid is an exfoliant and moisturizer that also provides anti-aging benefits including smoother, softer, more even toned skin with a reduction in the appearance of fine lines and wrinkles. Mandelic Acid, found naturally in almonds, is an oil-controlling alpha hydroxyacid with reported antibacterial benefits that may be helpful for oily and acne prone skin. Mandelic acid provides anti-aging benefits that are comparable to other well known AHAs. 6/03/10 Page 2 of 6

3 AMINOSUGARS are non-acid, anti-aging ingredients. NeoGlucosamine, is NeoStrata s patented aminosugar (acetyl glucosamine), a non-acid antiaging alternative for topical skincare. This potent powerhouse is clinically proven to help reduce the look of discolorations and dark spots from aging and acne, while smoothing and evening out the skin s texture and tone. Cellular turnover is increased, improving skin clarity and brightness gently, without irritation. A building block of the skin s gel matrix, NeoGlucosamine provides enhanced skin plumping and firming, and visibly diminishes fine lines and wrinkles. Visually improves skin s clarity and evens color and texture Exfoliation and cell renewal improve texture and tone for smoother, brighter skin Clinically proven to help reduce the look of discoloration and dark spots from aging and acne Enhances skin s youthful fullness and firmness Increases skin plumping, strength and hydration as a component of hyaluronic acid, it helps to build the skin s dermal matrix for full, firmer and more resilient skin Fine lines and wrinkles are visibly diminished Plumping and firming the skin reduces the appearance of facial lines Provides all skin types with the benefits of more youthful looking skin without irritation PEPTIDE BLENDS Matrixyl 3000, a registered trademark of Sederma, Inc., enhances the natural process of extracellular matrix renewal, building the skin s matrix (structure) for a smoother, more lifted and contoured look. Plumps the skin (increased GAGs), visibly reducing lines and wrinkles Signals an increase in collagen production strengthening the skin for a more lifted appearance and reinforcing firmness and tone for a more contoured look Haloxyl, a registered trademark of Sederma, Inc, provides a visual reduction in the appearance of dark circles. Enhances the efficacy of the natural elimination process of dark circle pigments Helps build the skin s matrix (structure), reinforcing firmness and tone of the eye area to make circles less apparent 6/03/10 Page 3 of 6

4 VITAMINS Pro-Vitamin A (Pro-Retinol), an antioxidant, has been shown to enhance epidermal cell turnover, the shedding of corneocytes, to create a smoother skin surface, even the skin tone and diminish the appearance of fine lines and wrinkles. Pro-Vitamin B5 (Panthenol) is a humectant that improves hydration and helps soften and soothe the skin. Vitamin C (L-ascorbic acid) is an antioxidant that protects the skin against UV induced free radicals. Pro-Vitamin E, an antioxidant and skin conditioner, helps protect against the formation of free radicals and to smooth and soften the skin and improve overall skin health. Vitamin K builds the strength of blood vessels, reducing the appearance of dark under eye circles. CONDITIONERS, HUMECTANTS, MOISTURIZERS Beeswax and skin conditioning oils reduce skin roughness on contact and provide a longlasting effect. Hyaluronic Acid (sodium hyaluronate), a natural component of the skin s dermis, attracts and binds water to the skin helping to keep it smooth and resilient. When applied topically, this hydrating macromolecule delivers moisture to skin. Panthenol (Pro-Vitamin B5) is a humectant that improves hydration and helps soften and soothe the skin. Polyhydroxy and Bionic Acids Shea Butter is a skin conditioner that leaves the skin soft and hydrated. 6/03/10 Page 4 of 6

5 ANTIOXIDANTS help protect against the formation of free radicals, which cause oxidative damage to the cells that in turn ages skin. Free radicals are produced by pollution and UV radiation. Citric Acid (an AHA) Crodarom Chardonnay L, developed by Croda, Inc., is a grape seed extract solution utilizing chardonnay grapes from Burgundy, France. Studies have shown it to be a potent antioxidant that is 36% more effective than vitamin C and 85% more effective than vitamin E. Green Tea Polyhydroxy and Bionic Acids (gluconolactone, lactobionic acid and maltobionic acid chelate oxidation promoting metals in skin and help capture free radicals.) Pro-Vitamin A Pro-Vitamin E Vitamin C SUNSCREENS Butyl Methoxydibenzoylmethane (Avobenzone) is an organic and chemical sunscreen, which absorbs a wide spectrum of UVA rays. Ethylhexyl Methoxycinnamate (Octinoxate) is an organic and chemical sunscreen, which absorbs UVB rays. Ethylhexyl Salicylate (Octisalate) is an organic and chemical sunscreen, which absorbs UVB rays. Octocrylene is an organic and chemical sunscreen, which absorbs UVA and UVB rays for broadspectrum protection. Titanium Dioxide is an inorganic and physical sunscreen, which blocks or scatters UVA and UVB rays for broad-spectrum protection. Zinc Oxide is an inorganic and physical sunscreen, which blocks or scatters UVA and UVB rays for broad-spectrum protection. 6/03/10 Page 5 of 6

6 SKIN LIGHTENERS help to inhibit the formation of melanin, the dark pigment in skin. Arbutin is a naturally occurring derivative of HQ. Hydroquinone Kojic Acid Licorice, bearberry and mulberry root extracts are botanical brightening agents. OTHER INGREDIENTS Acetyl Mandelic Acid (or O-Acetyl Mandelic Acid), in its unhydrolyzed form, is an AHA antagonist, which promotes nail retention and strengthens and protects nails that are prone to splitting and peeling. When applied to the skin, acetyl mandelic acid is hydrolyzed producing Mandelic Acid, which provides AHA benefits to oily and acne prone skin. Phytotal, a registered trademark of Croda, Inc., is a botanical blend derived from burdock and margosa (neem) that helps control oily skin. With continued use, Phytotal lessens oily shine, leaving skin looking fresher, healthier and more evenly toned. Salicylic Acid is a keratolytic used to treat acne due to its ability to loosen and shed excess skin and unplug pores. Triclosan is a broad-spectrum anti-bacterial agent. 6/03/10 Page 6 of 6

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