Skin Active Texture Preservation

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1 Skin Active Texture Preservation Temporary version

2 Active complex to stimulate skin hydration and improve its texture. Unichondrin ATP is an optimized mix between energetic and moisturizing molecules, that revitalize the skin: Rapid and intense hydration; Improvement of its texture in only one cycle of skin renewal. Stress and environmental factors Trans-epidermal water loss Degradation of the connective tissue Unichondrin ATP is an active complex consisting of chondroitin sulfate, an intense skin moisturizer; ATP, as energy source; hydrolyzed vegetable protein and butylene glycol. Dry and rough skin

3 Active complex to stimulate skin hydration and improve its texture. Unichondrin ATP is an optimized mix between energetic and moisturizing molecules, that revitalize the skin: Rapid and intense hydration; Improvement of its texture in only one cycle of skin renewal. Stress and environmental factors Unichondrin ATP Better regeneration of the connective tissue + - Chondroitin sulfate moisture retaining biopolymer that occurs in the connective tissue Adenosine Triphosphate cell energy for a long term effect Unichondrin ATP is an active complex consisting of chondroitin sulfate, an intense skin moisturizer; ATP, as energy source; hydrolyzed vegetable protein and butylene glycol. Improved texture and hydrated skin Hydrolyzed vegetable protein Stabilize ATP Reinforce the hydrating properties of chondroitin sulfate

4 Enhancement of skin texture (Clinical efficacy) Protocol: Unichondrin ATP was tested to enhance skin texture. This clinical study was run on 4 women (aged between 35 and 65), who applied either a placebo or the cream containing 2.5% of the product, twice a day, for 4 weeks on half of the face. Silicone replicas were then analyzed using computer aided image analysis. Result: Unichondrin ATP shows an overall enhancement of skin texture: -67% wrinkles decrease in number and -46% reduction of wrinkles depth, compared to placebo. % change vs T Assessment of skin surface topography -35% -46% Average amplitude (RZ) -29% -67% Number of peaks (RN) -54% -58% Residual length (RS) -25% -42% Primary wrinkle (RT) -30% Placebo Unichondrin ATP - 2.5% -42% Roughness

5 Enhancement of skin texture (Clinical efficacy) Protocol: Unichondrin ATP was tested for its ability to enhance skin texture. This clinical study was run on 4 women (aged between 35 and 65), who applied on half of the face either a placebo or the cream containing 2.5% of the product, twice a day, for 4 weeks. 3-D representation of the silicone replicas were then analyzed done. Result: Unichondrin ATP shows an overall enhancement of skin texture, compared to placebo. 3-D representation 3-D representation with 2-D projection Digitized image analysis of silicone replicas Before Peaks Transitions Valleys After 4 weeks

6 Improvement of skin moisturization (Clinical efficacy) Protocol: Unichondrin ATP was tested for its ability to increase skin moisturization. This clinical study was run on 4 volunteers (aged of 43 & 44), who applied on their forearm a placebo and a cream containing 2.5% of the product, twice a day, for 29 days. Measurement were done using the electrical conductivity of the skin. Skin moisturization (% vs T0) Measurement of skin moisture content +12% +62% Result: Unichondrin ATP increases skin moisturization by 62%, after 4 weeks of application, compared to placebo days 29 days Placebo Unichondrin ATP - 2.5%

7 TECHNICAL INFORMATION INCI: Origin: Preservation: Appearance: Solubility: Dosage: Processing: Regulatory status: Claims: Water, Butylene Glycol, Hydrolyzed Vegetable Protein, Adenosine Triphosphate, Sodium Chondroitin Sulfate Organic synthesis Preservative free Clear to slightly opalescent, brownish liquid Water-soluble 2.5% - 5% Can be incorporated in any formula in liquid form at ph below 6.5 and temperature below 45 C CN, JP, KR*, HK, AU, ASEAN, USA, CA, South-Am., Mid-East, EU Skin revitalization, skin texture enhancement, smoothing, moisturization SAFETY ASSESSMENT * Registration pending Ocular irritation: Skin irritation: Mutagenicity: Advanced Tissue Sciences Customer Testing - non irritant at 100% Closed epicutan patch test - non irritant at 20% Ames assay - OECD non mutagenic

8 Thank you Induchem AG Industriestrasse 8A CH-8604 Volketswil Induchem USA, Inc. 535 Fifth Avenue, Floor 23 New-York, NY10017 Induchem France SAS 171 Bis Avenue Charles de Gaulle FR Neuilly Sur Seine

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