NELUPURE TM. The sebum balancer inspired by lotus purity, with immediate effect SEBOREGULATING

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Solomon Short
5 years ago
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1 The sebum balancer inspired by lotus purity, with immediate effect SEBOREGULATING

2 The sebum balancer inspired by lotus purity, with immediate effect Lotus is an exquisite plant that always looks clean. It is a symbol that trascends time and is associated to purity, serenity and beauty. Lotus position used in yoga keeps mind calm and balanced. Lotus flowers are associated with the sun and the Creation by ancient Egyptians, because they close at night and sink beneath the water, rising in the morning, perfectly clean. Nelupure is an alliance of pink and blue lotus, that transfers these benefits to the skin for a flawless complexion, by: balancing sebum secretion diminishing skin shine reducing blemishes and imperfections HUGE TARGET Oily skin and its consequences (blemishes, dilated pores) are not only one of the main skin care concerns for youngers, but also for adult population particularly in Asian countries, where porcelain glowing complexion is a must. With Nelupure they all will show radiant not shiny in their selfies.

Its blue color is associated with the victory of the spirit over wisdom.

3 Nelupure is a synergistic alliance of: Egyptian lotus (Nymphaea caerulea) Flower distinctive of the river Nile, appreciated by the pharaohs of ancient Egypt and represented in its architectural ornaments. Its blue color is associated with the victory of the spirit over wisdom. + Sacred lotus (Nelumbo nucifera) Flower cultivated in Asia for more than 7,000 years, used as food and in traditional medicine. Considered as the true lotus of Buddha.

The sebum balancer inspired by lotus purity, with immediate effect IN VITRO EFFICACY Different in vitro studies were performed to test the effect of Nelupure on sebum production in sebocytes.

In addition, to check the anti-inflammatory effect of Nelupure, the gene expression of the cytokine IL-8 was measured too.

4 The sebum balancer inspired by lotus purity, with immediate effect IN VITRO EFFICACY Different in vitro studies were performed to test the effect of Nelupure on sebum production in sebocytes. Modulation of gene expression Leptin, CIDEA, PLIN2 and PLIN3 are proteins involved in sebum synthesis and their gene expression was measured. In addition, to check the anti-inflammatory effect of Nelupure, the gene expression of the cytokine IL-8 was measured too. For the first time in cosmetics we use the mechanism of Leptin-receptor blocking Ob-Rb CIDEA PLIN2 PLIN3 IL-8 (Leptin receptor) -102% -85% -90% -269% -300% Reduction in sebum synthesis in sebocytes A sebocyte incubation with Nelupure was performed for 3 days to analyze lipid variation versus control. 44% Decreased synthesis of lipids 47% Decreased area of lipid droplets CONTROL NELUPURE TM Fluorescence images of sebocytes: green color for lipid droplets and blue color for nucleus. Nelupure TM reduces the activity of key factors in sebum overproduction

5 IN VIVO EFFICACY 3 different panels: 25 Asian women, 27 Caucasian women and 26 Asian men. Twice daily application with a mist containing 2% of Nelupure on one side of the face and a placebo mist on the other side. Instrumental measurements were performed at D0, 8 hours, D14 and D28. GLOSSARY Comedos Blemishes Non-inflammatory Inflammatory Any irregularity, spots. Blackheads Whiteheads Pustules / Papules Values are D28 or D14 vs D0 of product with Nelupure. TARGET 1: Asian women Shine is a great concern for asian women. IN ONLY 8 HOURS 14% Shine reduction 15% Active sebaceous glands reduction Just one application is enough to see results of Nelupure TM after only 8 hours

The sebum balancer inspired by lotus purity, with immediate effect IN 28 DAYS D0 D28 12% Shine reduction 25% Sebum reduction In asian skins inflammatory lesions are prevalent.

6 The sebum balancer inspired by lotus purity, with immediate effect IN 28 DAYS D0 D28 12% Shine reduction 25% Sebum reduction In asian skins inflammatory lesions are prevalent. The less porphyrins, the less oxidation of squalene, which results in less inflammation and imperfections in the skin. D0 D28 37% Porphyrins reduction 65% Inflammatory lesions reduction Images of porphyrins (white dots) reduction.

TARGET 3: Asian men D0 D28 29% Sebum reduction in only 2 weeks 17% Active sebaceous glands reduction in 28

7 TARGET 2: Caucasian women (in 28 days) In caucasian skins non-inflammatory lesions are prevalent. D0 D28 47% Non-inflammatory lesions reduction 41% Blemishes reduction Imperfections reduction is very clear. TARGET 3: Asian men D0 D28 29% Sebum reduction in only 2 weeks 17% Active sebaceous glands reduction in 28 days The images show an obvious reduction of skin shine. Nelupure TM is the active for getting oily skin under control

8 The sebum balancer inspired by lotus purity, with immediate effect Cosmetic applications Oily skin Skin with imperfections Mattifying products Specific makeup Technical specifications Formulation NELUPURE TM PROPERTIES ACTIVE MOLECULES APPEARANCE SOLUBILITY RECOMMENDED DOSE INCI Balances sebum excess on the skin Polyphenols and ellagic acid Transparent liquid - slightly turbid liquid Pale brown - brown color Soluble in aqueous solutions 1-2% Propanediol, glycerin, nymphaea caerulea flower extract, nelumbo nucifera flower extract. MOUSSE-MASK OIL BALANCER GOMMAGE MODE INCI / PCPC %(W/W) A B C Hamamelis Rain (Provital) Aloe Vera Gel - ECO (Provital) Aqua (Water) Tetrasodium Glutamate Diacetate, Sodium Hydroxide, Aqua (Water) Xanthan Gum, Lecithin, Sclerotium Gum, Pullulan Edelweiss - ECO (Provital) Nelupure TM (Provital) Maltooligosyl Glucoside, Hydrogenated Starch Hydrolysate Magnolia Officinalis Bark Extract 1,2-Hexanediol Titanium Dioxide, Aluminum Hydroxide, Stearic Acid, Oleth-10, Polysorbate 20, Phenoxyethanol, Caprylyl Glycol, Aqua (Water) 24, Let your mind be undisturbed, like a lotus leaf in murky water. D E F Lavender Oil (Provital) Palmitoyl Proline, Magnesium Palmitoyl Glutamate, Sodium Palmitoyl Sarcosinate Butyrospermum Parkii (Shea) Butter Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer Aqua (Water), Sodium Hydroxide HDI/Trimethylol Hexyllactone Crosspolymer, Silica G Dehydroxanthan Gum

ANTI-WRINKLES. homeostatine TM. Epidermic homeostasis for an anti-wrinkle effect

ANTI-WRINKLES. homeostatine TM. Epidermic homeostasis for an anti-wrinkle effect ANTI-WRINKLES Epidermic homeostasis for an anti-wrinkle effect Epidermic homeostasis for an anti-wrinkle effect ANTI-WRINKLES Wrinkles: alterations in the ECM homeostasis Keratinocytes release cytokines