INNOVATIVE TECHNIQUE OR DEVICE & FULL SERVICES FOR YOUR EFFICACY TESTS.

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1 INNOVATIVE TECHNIQUE OR DEVICE & FULL SERVICES FOR YOUR EFFICACY TESTS. You wish to enhance the reliability of your efficiency studies? You need an innovative technique to support the innovation of your product? 1 1 We send you the device all over the world We equip and train you for a project We help you for your protocol and monitoring of the acquisitions We do the analysis and the interpretation of your data in terms of «product effect» We offer you the illustrations and all support Sending of system : from 2 days* Results and interpretations : from 5 Days** Independently we can perform all image analysis, 2D or 3D, from all techniques * depending of the technique ** depending of the study design and technique - See below

2 2 2 CALIBRATED PHOTOGRAPHS 1/2 Validation Status : 1 st Level (Repeat./Reprod.) HEADSCAN DYNAMISC V02 (Visia CR Like Calibrated photographs Crossed, parallel, diffused light, Face and lateral Right/Left 45 ) Post calibration and correction of photographs based on color chart SKIN : Color (CIE L, a, b, ITA ), Multi-area Skin complexion and radiance, homogeneity Homogeneity of pigmentation (White light and UV), density of pigmentation, pigmentary spots analysis (color and morphology) Skin vascularization, acne (counting and inflammation level), facial redness, telangiectasia Skin brightness Skin texture Visibility of wrinkles, calculation of the equivalent age of the skin MAKE-UP : Following of color and stability (Lipsticks, eye shadow, foundation cream, eyeliner, ), Length, width, number, volume, curvature and elevation of lashes (mascara or care products), Matifying aspect of foundation cream, Brightness and of nail polishes HAIR : Brightness, color, homogeneity, volume of hair.

3 3 3 CALIBRATED PHOTOGRAPHS 2/2 Validation Status : 1 st Level (Repeat./Reprod.) Claims : skin radiance and complexion, depigmenting effect, homogenization of complexion, pigmentary spots, whitening & lightening, sensitive skin, rosacea, oily skin, improvement of skin texture, anti-ageing, anti-wrinkles,...etc. Delivery : 2 days (HEADSCAN DYNAMICS for acquisitions of calibrated photographs Depending of the availability) Results and Report : 5 days (Statistics time effect and illustration) Cost with the device : 2800 euros* (Without expedition cost - 1 month) Cost without the device : 2200 euros** ** Complete service of analysis and support without device. Combination of various analysis ; +25% - Supplementary time of measurement or location +25% - Contact us for other request All analysis can be perform on images obtained with other calibrated system for the acquisitions of photographs. Contact us.

4 4 4 CONFOCAL MICROSCOPY OF REFLECTANCE VIVASCOPE (Caliber/Mavig GmbH) Thickness of the Stratum Corneum & epidermis (spinous and granular layers), size of corneocytes, Size and density of epidermal keratinocytes (spinous and granular layers), Height, size, shape and density of papilla, Dermis elastosis and photoaging, calculation of the Age equivalent of the dermis, Basal pigmentation, lentigo, macula, melisma Papillae vascularisation (superficial blood flow into the skin) Claims : skin densification, rejuvenation, anti-ageing, pigmentation, whitening/lightening, lentigo, vascularization...etc Delivery : 8 days (Full system Ready ti use - Depending of the availability from MAVIG GmbH) Results and Report : 7 days (Statistics time effect and illustration) Cost with the device : 5500 euros* (Without expedition cost - 1 month) Cost without the device : 3200 euros** ** Complete service of analysis and support without device. Combination of various analysis ; +25% - All analysis can be perform on images obtained with other calibrated system for the acquisitions of photographs. Contact us.

5 5 5 SKIN BRIGHTNESS : GonioLUX GONIOLUX - (OrionTechnoLab, France) 3D Measurement of the modalities of the skin brightness Specular reflection ( Oily aspect ) Diffused reflection ( Satin aspect ) Total light re-emitted by the skin Homogeneity of the light reflection in the space Claims : Skin complexion/radiance, matifying effect...etc. Delivery : 2 days (Goniolux and computer, ready to use ) Results and Report : 5 days (Statistics time effect and illustration) Cost with the device : 2500 euros* (Without expedition cost - 1 month)

6 6 6 SKIN TRANSPARENCY : TransluDERM TRANSLUDERM - (OrionTechnoLab, France) Measurement of light propagation into the skin Epidermis attenuation of the light propagation Epidermis attenuation of the light propagation Index of the skin transparency Claims : Skin complexion/radiance, whitening/lightening, transparency of the skin, covering or light-blocking effect of a product.. etc. Delivery : 2 days (Goniolux and computer, ready to use ) Results and Report : 5 days (Statistics time effect and illustration) Cost with the device : 2500 euros* (Without expedition cost - 1 month)

7 DERMOSCOPY : ViewSKIN White 7 7 VIEWSKIN White - (OrionTechnoLab, France) Local measurements 60X80 mm - White Crossed Polarized light Other system available Post calibration and correction of dermoscopies based on color chart included Color (CIE L, a, b, ITA ), Skin complexion and radiance, homogeneity of complexion, Homogeneity of pigmentation, density of pigmentation, Pigmentary spots analysis (On cheek or forehead - color and morphology), Skin vascularization, acne (counting and inflammation level), facial redness, telangiectasia. Claims : skin radiance and complexion, depigmenting effect, homogenization of complexion, pigmentary spots, whitening & lightening, sensitive skin, rosacea, anti-ageing...etc. Delivery : 2 days (Goniolux and computer, ready to use ) Results and Report : 5 days (Statistics time effect and illustration) Cost with the device : 2500 euros* (Without expedition cost - 1 month) Cost without the device : 2200 euros** ** Complete service of analysis and support without device. Combination of various analysis ; +25% - Supplementary time of measurement or location +25% - Contact us for other request All analysis 113 can rue be des perform Bordiers on images obtained Tours, with France other calibrated - Phone system +33 for (0)2 the 47 acquisitions of - Mobile photographs +33.(0)6 Contact 10 us

8 8 8 SKIN FIRMNESS : SkinFLEX SKINFLEX - (Standalone system equivalent to the DynaSkin OrionTechnoLab, France) Dynamic measurement in 3D, without contact (air flow) of the mechanical properties of the of the skin and subcutaneous tissues (Face or Body) Firmness (Surface, volume and depth of the airflow deformation) Elasticity (Ue, Uv) Skin ageing (Residue, fatigability of the skin) Claims : Firming effect, Elasticity/Tonicity of the skin, antiageing etc. Delivery : 2 days (Goniolux and computer, ready to use ) Results and Report : 7 days (Statistics time effect and illustration) Cost with the device : 2500 euros* (Without expedition cost - 1 month)

9 9 9 SKIN AGEING : Ultrasound Scanning DSUB SkinScanner 25/50 MHz - (Or other scanner) Skin thichness (Dermis) Density of the dermis Photo-ageing (Sub Epidermal Low Echogenic Band : SELEB) and Depth of the skin damage Calculation of the Age equivalent of the skin Claims : Densification, rejuvenation, improvement of collagen network, anti-ageing...etc Delivery : 8 days (Depending of the availability of th system) Results and Report : 5 days (Statistics time effect and illustration) Cost with the device : 3500 euros* (Without expedition cost - 1 month) Cost without the device : 2200 euros** ** Complete service of analysis and support without device. All analysis can be perform on images obtained with other ultrasound scanner. Contact us. Combination of various analysis ; +25% - Supplementary time of measurement or location +25% - Contact us for other request.

10 10 10 OCT : Optical Coherence Tomography VIVOSIGHT - Michelson Diagnostics, UK Epidermis thichness / Volume Vascular compartment density Claims : Densification, rejuvenation, regulation of the skin vascularization...etc Illustrations : Illustration before/after ; 3D, morphing ; animations before after...etc Delivery : 15 days (Depending of the availability of th system) Results and Report : 7 days (Statistics time effect and illustration) Cost with the device : to define* (depending of the manufacturer) Cost without the device : 3200 euros** ** Complete service of analysis and support without device. Combination of various analysis ; +25% - Supplementary time of measurement or location +25% - Contact us for other request

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