Technical ingredient data sheet

Transcription

1 Powerful Safe Targeted Indication Effective cosmeceutical that provides a lightening effect on melasma and freckles through inhibition of melanin synthesis. Prevents the appearance of new pigment spots and freckles from appearing. Excellent for post acne scars and hormonal hyperpigmentation. Treats hyperpigmentation and blemishes and scars. This complex contains micro vitamin molecules designed to produce and drive in high concentrations of oxygen molecules to the skin. Oxygenating and hydrating whilst dramatically reducing dark marks and evening the skin tone. Combats the effects of the environmental ageing, reducing the signs of dryness, roughness and fine lines as it rehydrates. Fortified with anti-oxidants, amino acids to fight aging free radicals, provides moisture and extended continuous hydration. Glutathione provides extreme dark spot deactivation effect with super concentrated azelaic natural acid to enhance the whitening effect of glutathione Active Ingredients 5% m Tranexamic Acid Acetyl Hexapeptide 3 (Argireline) Renovage Hyaluronic Acid L Glutathione Azelaic Acid Thiotic (Alpha Lipoic) Acid Ubiquinone (Co Enzyme Q10) LIGHT OXYGENATING COMPLEX R Retail Inclusive VAT 30ml White Opal Glass Bottle w/pump Scinderm Category: Renew and Boost Technical ingredient data sheet Full Ingredient Listing: Water (Aqua), m-tranexamic Acid 5%, Acetyl Hexapeptide-3 (Argireline), Caprylic/Capric Triglyceride / Teprenone (Renovage ), Hyaluronic Acid, Cetearyl Alcohol, L-Glutathione, (Gamma-L-Glutamyl-L-Cysteinyl- Glycine), Retinyl Acetate (Vitamin A oil), Azelaic Acid, D-alpha-Tocopheryl Acetate, Ubiquinone (Co enzyme Q10), Thiotic (Alpha Lipoic) Acid, Caprylic/Capric Triglyceride, Sodium Benzoate (Benzoic Acid), Phenoxyethanol PRECAUTION: To ensure compatibility we recommend a patch test for three (3) consecutive days. Protect product from light and heat, as it is photosensitive. Store in a cool dark place. Directions for use: 1. This lightweight silky skin treatment is a slight 2 phase molecular appearance. 2. Please shake before use. Apply a few drops onto a clean skin, concentrating on the dark marks. Apply twice daily. Follow with a moisturizer of your choice.

2 m - Tranexamic Acid Function: Inhibits tyrosinase activity Specially formulated with 5% of m - Tranexamic Acid. m-tranexamic Acid inhibits melanin synthesis in melanocytes by interfering with the interaction of melanocytes and keratinocytes through inhibition of the plasminogen/plasmin system. m-tranexamic Acid is a powerful pigment-lightening ingredient that dissolves pigment spots and inhibits the activities of melanocytes. m-tranexamic Acid has proven to reduce melanin generation caused by acne inflammation by as much as 32% in the laboratory tests, making it one of the most efficient ingredients to the solution for skin pigmentation and discoloration up to date It proves to be highly effective in counteracting melanin growth, removing pigment spots, and brightening skin complexion. Being able to fight chronic mild inflammation, this ingredient is also ideal for lightening acne scars. Acetyl Hexapeptide 3 (Argireline) Function: Anti Ageing Peptide Argireline from Lipotec S.A. is a unique new peptide that both reduces the degree of existing facial wrinkles and has been demonstrated effective against their development. It s been shown to inhibit the formation of the SNARE complex as well as catecholamine release. These inhibitions confer anti-aging activity on Argireline; they closely relate to the basic biochemical mechanisms of wrinkle formation. Controlled studies have also demonstrated that facial wrinkle depth can be reduced, especially in the forehead and around the eyes, and that Argireline can prevent apparent facial skin aging. Skin topographic analysis performed on healthy female volunteers confirmed the validation of the proposed biochemical mechanism of action. Skin topography images before (left) and after a 30 day treatment with a cream containing 10% ARGIRELINE Solution (right).

3 Renovage Function: Pluripotent anti-ageing active ingredient Renovage is an anti aging serum that works on the DNA levels of the origin of youth and targets the cell actors which guarantee lifespan and youth. Usual anti-age skin care treatments which only fight wrinkles cannot restore a youthful appearance to the face. They do not treat loss of tone (sagging), age spots, redness, dry skin, dilated pores, and the irregularities of the skin surface. Indeed, all of these cutaneous dysfunctions are related to less efficient cell physiology. This leads to a tissue composed of "ageing cells" entering the senescence phase more rapidly than necessary. It's due to a successive accumulation of DNA damages over time which are less effectively repaired and less well protected by their telomeres. In order to treat these various skin-ageing symptoms, Sederma launched RENOVAGE a pluripotent active ingredient able to act as a cell facilitator and corrector. In vitro studies showed several properties of RENOVAGE as cutaneous functional and structural recovery, and above all, it avoids premature entry into cell senescence. A clinical study showed that RENOVAGE used at 3% on a panel of 24 volunteers with a mean age of 58 & plus, exerts a significant and visible activity on both functional and structural signs of ageing. Skin functions are improved with an increase of hydration and a reinforcement of the barrier function. Pigmented spots were lessened by -56% after 6 months. Skin recovers its structure with +35% of firmness and +45% of tone in only 1 month, isotropy increased and roughness decreased. Lines, wrinkles and erythrosis were also reduced. What exactly are the clinical signs of aging Renovage focuses on? The signs of aging that Renovage is proven to work on, are: 1. Function loss. Clinical tests proved that the use of Renovage replenished 60% of the functions your skin performs, that it has been lacking in, due to mature age. 2. Cell resistance. Clinical tests improved 75 to 100% the skins ability to regenerate itself, and combat on its own the toxins and forces of age that cause redness, enlarged poors, sun spots, and wrinkles. 3. Self-defence. Clinical tests showed an improvement of 100% in the skins ability to fight off signs of aging, on a continued basis after treatment with Renovage was begun. 4. Wound healing capacity. Your skin's ability to heal itself, not only from things like cuts and scars, but what are actually "wounds" like wrinkles, lines and sun spots. What are the problems on my skin that Renovage can fix? Overall Anti-aging effect on appearance: Wrinkles, Redness, and Scarring all reduced. Notice how the circled brown spots are substantially less noticeable after only 3 months of using a product containing Renovage

4 Hyaluronic Acid The principal skin matrix fillers are glycans, a class of glucose-based polymers that includes glycosoaminoglycans and proteoglycans. As far as skin rejuvenation is concerned, the most important glycan may be hyaluronic acid (a.k.a. hyaluronan, hyaluronate or HA). Chemistry of hyaluronic acid Hyaluronic acid is a polymer whose unit consits of D-Glucuronic acid and N-Acetyl Glucosamine. Hyaluronic acid chains can be up to 25,000 units long or even longer; their molecular weight ranging from about 5,000 to 20,000,000 Da. Hyaluronic acid is synthesized by the enzymes called hyaluronan synthases. Humans have at least three types of hyaluronic acid synthases: HAS1, HAS2, and HAS3. Hyaluronic acid has many functions throughout the body, especially in the connective tissue. In the skin, some of its known roles are the following: Holding moisture Increasing viscosity and reducing permeability of extracellular fluid Contributing to mechanical resilience and suppleness of the skin Regulation of tissues repair Regulation of movement and proliferation of cells Regulation of immune and inflammatory responses It is important to note that physiological effects of hyaluronic acid depend to a large degree on the size (molecular weight) of its chains. In particular, relatively small HA molecules (weighing less than about 20,000 Da) appear to trigger the early phases of wound healing, including activation of various types of immune cells and inflammatory responses L Glutathione Function: Glutathione Tripeptide The Master Anti-oxidant L glutathione can be synthesised from the amino acids glycine, L-glutamic acid and L-cysteine. GSH exists in two forms namely, glutathione disulfide (GSSG) and glutathione (GSH) with former being the common form. The presence of GSH induces the production of pheomelanin (light coloured pigment for skin whitening and fairness) and suppresses the production of eumelanin (darker brown/black pigment). Being an ingredient of skin whitening products it inhibits melanin synthesis by interrupting L-DOPA s abilility to bind to enzyme Tyrosinase (monophenol monooxygenase). Glutathione induces inhibition of tyrosinase glycosylation. This blocks the maturation as well as transfer of tyrosinase from Golgi-endoplasmic recticulum-lysosome (GERL) - coated vesicles to the premelanosome. GSH is believed to direct tyrosinase inactivation within the enzyme s active site by chelating copper. As glutathione takes part in the conversion of dopaquinone to pheomelanin, it mediates in the transformation of eumelanogenesis to pheomelanogenesis. Its antioxidant properties help to neutralyze the peroxides and free radicals which induce melanin synthesis. GSH modulates the capabilities of melanocytotoxic

5 Azelaic Acid A naturally occurring, saturated dicarboxylic acid originally isolated from Pityrosporum ovale, azelaic acid is a rather weak competitive inhibitor of tyrosinase in vitro. In addition, azelaic acid has an antiproliferative and cytotoxic effect on melanocytes. The latter effect occurs because of a rather potent inhibition of thioredoxin reductase, an enzyme involved in mitochondrial oxidoreductase activation and DNA synthesis. Although azelaic acid was initially prescribed for the treatment of acne, it has been successfully used in the treatment of lentigines, rosacea and post inflammatory hyperpigmentation. It is prescribed topically as a 20% cream and has been combined with glycolic acid (15% and 20%). Its efficacy has been compared with hydroquinone 4% in the treatment of facial hyperpigmentation in dark-skinned patients. Thiotic (Alpha Lipoic) Acid Lipoic acid is a unique free radical protector. It is fat and water soluble. Once lipoic acid crosses the cell membrane, it is broken down into dihydrofolic acid, which is also an antioxidant. Alpha lipoic acid also recycles other key antioxidants, such as vitamin C, vitamin E, and glutathione. Ubiquinone (Co Enzyme Q10) Ubiquinone, also known as coenzyme Q10, is a lipid-soluble quinone derivative that is present in the mitochondria and is used to generate adenosine triphosphate (ATP), enhancing energy. It has been shown to decrease peroxidation of the low-density lipoproteins better than vitamin E.