Preservative and Protection Systems
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1 Personal Care Consumer Care Preservative and Protection Systems Selecting systems that effectively protect cosmetic formulations and are consistent with consumers desires, country regulations and technical requirements is critical. Lonza is the world leader in microbial control providing innovative, chemistry-based and related solutions to destroy or to selectively inhibit the growth of harmful microorganisms. Lonza s Personal Care portfolio offers a comprehensive range of preservation and protection systems.
2 Personal Care Preservative and Protection Systems Keeping consumers safe from product contamination through the duration of product use is a priority and is also essential for brand and product success. The specifics of each formulation dictate which kind of preservative or protection system can be used. Lonza s portfolio of Preservative and Protection Systems offers solutions such as: Broad spectrum activity Traditional as well as next-generation and natural technologies Robust data packages supporting toxicology clearance Cost efficiency and wide acceptance in major markets Chemistries that are accepted for use in global formulations FormulaProtect FormulaProtect is a new interactive, online application that allows formulators to save time and easily identify preservatives that best suit their specific needs. By simply selecting specific formulation criteria such as ph, required spectrum, formulation type, regulatory and organizational approvals, amongst other criteria, the user will be presented with a selection of recommended preservative options along with detailed information on each of them. This tool will help provide guidance for the preservatives that meet formulator s marketing needs and that provide the efficacy required throughout the lifetime of the cosmetic product. Find the preservative or protection system that is right for you at 2 Personal Care Preservative and Protection Systems
3 Traditional Preservation Lonza s traditional preservatives are efficacious chemistries that have been used in the personal care industry for decades. They include standalone or blended synthetic chemistries of which many are listed on the Annex V to Regulation EC/1223/2009 formerly Annex VI to Council Directive 76/768/EEC. Each solution offers unique benefits for optimal protection of a variety of formulations. PHMB Technology Cosmocil CQ Cosmocil CQ Polyaminopropyl Biguanide (PHMB) Liquid Solution Bacteria % PHMB % IPBC Technology Glycacil Glycacil L Glycacil 2000 Iodopropynyl Butylcarbamate (IPBC) Iodopropynyl Butylcarbamate (IPBC) Liquid Solution Yeast & mold % IPBC % Liquid Solution and % of active matters * It is the responsibility of the finished good manufacturer to ensure their product is compliant with the applicable regulations. Our regulatory specialists are available for questions surrounding specific requirements and restrictions of these substances. Recommended product use level varies depending on country. Check local regulations. Yeast & mold % IPBC % Preservative and Protection Systems Personal Care 3
4 DMDM Hydantoin Technology Glydant Glydant 2000 DMDM Hydantoin Liquid Solution Bacteria <0.6% DMDMH % Glydant DMDM Hydantoin Liquid Solution Bacteria <0.6% DMDMH % Glydant Ltd (EU only) DMDM Hydantoin Liquid Solution Bacteria <0.6% DMDMH % Glydant Plus Glydant Plus Liquid DMDM Hydantoin & Iodopropynyl Butylcarbamate (IPBC) DMDM Hydantoin & Iodopropynyl Butylcarbamate (IPBC) Solid Broad <0.6% DMDMH; % IPBC % Liquid Solution Broad <0.6% DMDMH; % IPBC % Additional Traditional Preservative Technologies Isocil PC, Lonzagard, Lonzaserve, Mikrokill COS and Spectradyne Isocil PC Lonzagard Benzethonium Chloride Lonzaserve PC Mikrokill COS Methylchloroisothiazolinone & Methylisothiazolinone Liquid Solution Broad % CMI/MI % Benzethonium Chloride Powder Bacteria, mild fungicide DMDM Hydantoin & Methylchloroisothiazolinone & Methylisothiazolinone Phenoxyethanol & Caprylyl Glycol & Chlorphenesin % Benzethonium Chloride Liquid Solution Broad <0.6 % DMDMH; % CMI/MI Liquid Solution Broad 1.0 % Phenoxyethanol; 0.3 % Chlorphenesin % % % Spectradyne Chlorhexidine Digluconate Liquid Solution Bacteria % Chlorhexidine % * It is the responsibility of the finished good manufacturer to ensure their product is compliant with the applicable regulations. Our regulatory specialists are available for questions surrounding specific requirements and restrictions of these substances. Recommended product use level varies depending on country. Check local regulations. 4 Personal Care Preservative and Protection Systems
5 Next-generation Preservation and Natural Protection Systems Many of Lonza s next-generation preservative and protection systems are based on natural, nature-identical or eco-friendly materials. These products show efficacy in a variety of formulation types and have excellent safety packages. The product line contains offerings which could be ideal for formulations that require natural or ECOCERT / COSMOS ingredients. Protection Systems Biovert and Rômacil V Biovert Glucose & Lactoperoxidase & Glucose Oxidase Liquid Solution Broad 1.05 % Biovert % Rômacil V Fragrance (Parfum) Liquid Solution Broad N/A % Eco-Friendly Preservation, including ECOCERT and COSMOS permitted Geogard Geogard 111 A Dehydroacetic Acid Powder Yeast & mold <0.6 % DHA % Geogard 111 S Sodium Dehydroacetate Powder Yeast & mold <0.6 % DHA % Geogard 221 Geogard ECT Geogard LSA Geogard Ultra Dehydroacetic Acid & Benzyl Alcohol Benzyl Alcohol & Salicylic Acid & Glycerin & Sorbic Acid Butylene Glycol & Benzyl Alcohol & Sorbic Acid & Caprylic/Capric Triglyceride & Lauryl Alcohol & Myristyl Alcohol Gluconolactone & Sodium Benzoate Liquid Solution Broad <0.6 % DHA; <1.0 % Benzyl Alcohol % Liquid Solution Broad <1.0% Benzyl Alcohol; < % Sorbic Acid; < % Salicylic Acid Liquid Solution Broad <1.0% Benzyl Alcohol, <0.5% Sorbic Acid % % Powder Broad % Benzoic Acid % * It is the responsibility of the finished good manufacturer to ensure their product is compliant with the applicable regulations. Our regulatory specialists are available for questions surrounding specific requirements and restrictions of these substances. Recommended product use level varies depending on country. Check local regulations. Preservative and Protection Systems Personal Care 5
6 Lonza Personal Care Anti-Dandruff Actives Lonza s Zinc Omadine highly effective bactericide-fungicide anti-dandruff agent establishes the market standard for any active ingredient solutions in anti-dandruff shampoos. Its high antimicrobial efficacy combined with the acceptability for human use has made it the agent of choice for anti-dandruff shampoo manufacturers worldwide. 6 Personal Care Preservative and Protection Systems
7 Zinc Omadine Product Name INCI Name Details Maximum Use Level of Active* ph Zinc Omadine 48% Dispersion (Fine Particle Size) Zinc Omadine 48% Aqueous Dispersion UFPS (Ultra Fine Particle Size) Zinc Omadine Enhanced CP Dispersion Zinc Pyrithione Zinc Pyrithione Aqua (Water) & Zinc Pyrithione & Elaeis guineensis Aqueous mixture of very fine particles of zinc pyrithone, with a dispersant, and viscosity control agent. This is listed in FDA s monograph of approved over-the-counter drug active ingredients for the treatment of anti-dandruff and seborrheic dermatitis. Zinc Omadine 48% Dispersion is a broad spectrum active with excellent efficacy against Malassezia spp., one of the primary causes of the dandruff, and activity against Gram positive and Gram negative bacteria as well as other yeasts and molds. Zinc Pyrithione aqueous mixture with particles milled to a smaller size, making it easier to suspend. Patent-pending advancement with an oil coating which provides a way to target the delivery of the Zinc Omadine to the Malassezia spp. yeast, one of the primary factors in the development of dandruff on the scalp. * It is the responsibility of the finished good manufacturer to ensure their product is compliant with the applicable regulations. Our regulatory specialists are available for questions surrounding specific requirements and restrictions of these substances. Recommended product use level varies depending on country. Check local regulations % % % Preservative and Protection Systems Personal Care 7
8 The Lonza toxicology team comprises global regulatory experts based in the United States, Europe and China. The team is highly involved in the solutions offered to ensure that products are suitable for use and have the regional approvals in the countries to which Lonza sells. The experts capture all restrictions for use in finished formulations to ensure that the necessary requirements for protection of human safety of the consumers are in place. The extensive, global Lonza microbiology staff works every day on testing existing and new preservative and protection systems to best support our customers. This includes combinations of specialized Lonza protocols for microbial testing as well as CTFA challenge testing as required. Lonza s fully-equipped applications laboratories support formulation requests during development. The labs are operated by formulators with extensive experience. This team is happy to assist with technical support by answering customers queries as they relate to finished product formulation, including preservation. Checking the efficacy of all preservation and protection systems or products in the specific formulation in normal use conditions and under the user s stability protocols remains the responsibility of the manufacturer. Testing in the final packaging is encouraged. It remains the responsibility of the customer to check that all regulatory aspects are compliant with their country s specific requirements. Use preservatives safely. Always read the label and product information before use. USA Lonza Consumer Care 70 Tyler Place South Plainfield, NJ Tel Switzerland Lonza Ltd Muenchensteinerstrasse Basel Tel Review and follow all product safety instructions. All product information corresponds to Lonza s knowledge on the subject at the date of publication, but Lonza makes no warranty as to its accuracy or completeness and Lonza assumes no obligation to update it. Product information is intended for use by recipients experienced and knowledgeable in the field, who are capable of and responsible for independently determining the suitability of ingredients for intended uses and to ensure their compliance with applicable law. Proper use of this information is the sole responsibility of the recipient. This information relates solely to the product as an ingredient. It may not be applicable, complete or suitable for the recipient s finished product or application; therefore republication of such information or related statements is prohibited. Information provided by Lonza is not intended and should not be construed as a license to operate under or a recommendation to infringe any patent or other intellectual property right. No claims are made herein for any specific intermediate or end-use application Lonza Personal Care Preservative and Protection Systems 5/15
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