Technology. HydroSal. Formulated for suspension in. water and hydro-alcoholic. environments, HydroSal. provides long lasting effects and

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1 Technology Technology specialized for the cosmeceutical and pharmaceutical industries. Solutions for the household, industrial, food and beverage industries. Partner with us to create custom encapsulations that fit your needs. SalSphere Designed specifically for the cosmetic and personal care industries, SalSphere technology delivers functional where they will most effective. Submicron particles range in size from.1 to 5 microns. HydroSal Formulated for suspension in water and hydro-alcoholic environments, HydroSal provides long lasting effects and is capable of burst-like releases. Functional are infused into the core and locked inside a polymeric shell. MultiSal Perfect for providing an additional protective layer or encapsulating more than one active in a single formula, MultiSal technology features a water-sensitive microsphere. The microsphere contains SalSphere particles loaded with functional.

2 Prolonged Product Shelf Life Highly compatible water or Protection of Ingredients and Improved Stability of functional alcohol based delivery system Sensory markers against Sustained release of functional oxidation Targeted delivery of functional A consecutive release of two or to desired site Controlled moisture trigger more functional Reduced reapplication release system - release upon Taste Making occurrences and improved need in response to body High retention of volatile treatment effect moisture or upon rewetting the Extended release of functional target surface Targeted delivery of functional Heat triggered and controlled release system Bioadhesiveness to tissue (e.g. skin, hair care and oral cavity) Enhanced bioavailability by improving cell absorption and increasing intracellular accumulation Prolonged release to target site Capable to perform a burst-like and rapid depletion release small in particle size- idea for spray application Improved stability of functional Prolonged Shelf Life Moisture, heat, or ph triggered control release system Enhanced bioavailability by improving cell absorption and increasing inter-cellular accumulation Consists of sub-micron particles ideal for spray, water-based, triggered, or ph-triggered ranging in size from 0.1 to 5 alcoholic and gel products. release. Product formulated with microns. This technology was HydroSal provides longer MultiSal may have enhanced designed specifically for the lasting effects and in some bioavailability. The microspheres cosmetic and personal care cases water triggered release. may contain nanospheres industries. SalSphere is not The release rate is controlled by (SalSphere ) loaded with one defined as nanotechnology per the choice of polymers used to or various functional the FDA due to its larger particle construct the system. and be adjusted to release one size range (over 0.1 microns). Spheres suspended in water and in hydro-alcoholic environments, Water-sensitive microspheres containing hydrophobic nanoparticles for targeted, heat- functional ingredient following another. MultiSal is also a way to transport SalSphere in a dry form.

3 The Trademarks of Salvona's Solutions 1. LONG LASTING RELEASE Sustain the release of active in use so that the active is released for a longer duration of time. The technology maintains the effective level of the active for a longer time, resulting in better utilization of active. Actives applied normally experience an immediate, high concentration, short burst followed by a rapid decline, whereas actives released from a controlled release delivery system experience a prolonged concentration at the effective level (threshold). This reduces the number of applications necessary for longer-lasting results and also reduces toxicity. The crystalline structure of the SalSphere technology better protects Resveratrol from oxidation thereby helping it to retain its effectiveness over time. Free resveratrol will quickly lose its potency as it oxidizes. The graph above shows that after 2 hours, approximately 25% of the original level of resveratrol is left on the skin as opposed to approximately 75% of resveratrol from SalSphere. This graph demonstrates that SalSphere Resveratrol retains a higher level of the functional ingredient on skin vs. free, or non-encapsulated, resveratrol. Resveratrol content was analyzed via HPLC after skin was extracted with ethanol. Long Lasting Efficacy Water-Triggered Release HydroSal Hairoma Therapy technology maximizes the efficacy of the product by releasing the fragrance at the time it is needed most, such as during excessive sweating generated by exercise. This graph shows the effect of moisture on fragrance intensity from HydroSal Hairoma Therapy in a hair spray application.

4 2. TRIGGERED RELEASE Water-Triggered Release HydroSal Hairoma Therapy technology maximizes the efficacy of the product by releasing the fragrance at the time it is needed most, such as during excessive sweating generated by exercise. This graph shows the effect of moisture on fragrance intensity from HydroSal Hairoma Therapy in a hair spray application. Releasing active on demand, triggered by environmental factors or by consumer action or physiological factors, is a more intelligent and smart form of controlled release systems In a passive control system, the release kinetics from the technology cannot be altered once applied. Triggered delivery systems, however, are initially dormant. Upon triggering, the release is activated to discharge the content at a much higher release rate than in a nonencapsulated scenario. The dormant effect (no or slow release) is beneficial to enhance and protect stability of unstable actives in the formulation until the product is triggered environmentally, physiologically, or by the consumer. The active remain encapsulated and protected up to time of activation. This beneficial tool can be used in many applications, such as the delivery of an anti-bacterial response to bacterial activity (i.e. acne) or an anti-inflammatory response in the case of inflammation 3. TARGETED DELIVERY/VECTOR Release the active materials at a desired location for localized and targeted release from a rinse-off or leave-on application. Targeted, controlled release systems assist in targeting the active to reach a specified site location, where it will release its contents. This improves deposition on skin and scalp in rinse-off applications and enhances the efficacy of anti-cancer drugs used in cancer therapy to target cancerous cells. Another example is deposition and penetration of a hair regrowth agent into the hair follicles or the release of anti-aging agent deep within the skin dermis, where it truly becomes effective, from rinse-off applications. Long Lasting Efficacy The crystalline structure of the SalSphere technology better protects Resveratrol from oxidation thereby helping it to retain its effectiveness over time. Free resveratrol will quickly lose its potency as it oxidizes. The graph above shows that after 2 hours, approximately 25% of the original level of resveratrol is left on the skin as opposed to approximately 75% of resveratrol from SalSphere. This graph demonstrates that SalSphere Resveratrol retains a higher level of the functional ingredient on skin vs. free, or non-encapsulated, resveratrol. Resveratrol content was analyzed via HPLC after skin was extracted with ethanol.

5 Endless Possibilities Salvona Technologies are being used by leading health care, diagnostic, personal care, household, food, and nutraceutical companies across the globe. Below are just a few examples of possible uses for Salvona technologies in the health and personal care markets. Technology Health Care Personal Care HydroSal Pharmaceuticals sunscreens skin treatment products Skin moisturizers body splash fine fragrance sprays body lotions and creams aftershave products hair sprays, styling products, and leave-on conditioners foot antiseptic, antibacterial, anti-fungal, and other treatment products underarm deodorants and antiperspirants anti aging lotions and creams cosmetic applicators SalSphere Delivery of active which exert a local physiological effect and systematic effects IV injectables oral drug delivery oral care topical applications x-ray contrast agents ultrasound contrast agents enhancement agents for MRI and Tomography positron emission agents delivery of monoclonal antibody markers for tumors Oral care products hair care products scalp treatment products liquid soaps body washes lotions and creams skin treatment products cosmetics sunscreens non-woven products MultiSal Delivery of active which exert a local physiological effect and systemic effects Oral care products hair care products body washes silicon lotions and creams lipsticks lip balms cosmetics non-woven products body powders soap bars underarm products Our three main technology platforms only scratch the surface! Contact us for other delivery systems and solutions.