Legato Treatment Results Skin Barrier Breakthrough System
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1 Legato Treatment Results Skin Barrier Breakthrough System Maria Claudia Almeida Issa, MD, PhD Associate Professor, Department of Clinical Medicine Fluminense Federal University Rio de Janeiro, Brazil
2 Dr. Maria Claudia Almeida Issa is among the leading dermatologists in Brazil and South America. She has had 9 articles published in dermatology trade journals, and has presented her findings at 15 international conferences. Dr. Issa holds a PhD in Dermatology from the Federal University of Rio de Janeiro (2008) and a MsC in Dermatology from the Fluminense Federal University (1997). Dr. Issa has been registered as a dermatologist with the Brazilian Society of Dermatology since Dr. Maria Claudia Almeida Issa MD, PhD Dr. Issa is currently an Associate Professor within the Department of Clinical Medicine Dermatology, at the Fluminense Federal University. Her research focuses on Photodynamic Therapy, non-melanoma Skin Cancer, Lasers, Photoaging and Dermal Remodeling. In addition, Dr. Issa operates her own clinic called Dermavance Dermatologia, located in Niteroi, Rio de Janeiro. ]2[
3 Introduction: The Legato Skin Barrier Breakthrough System for Trans-Epidermal Delivery. The Legato was developed to overcome the challenge of introducing cosmeceuticals beneath the skin without interference from the stratum corneum (outer layer of skin barrier). The Legato is a dual stage system that uses RF and ultrasound technologies to introduce cosmeceuticals beneath the skin s surface. The protocol first calls for fractional skin ablation and creating microchannels in the skin. The Legato then harnesses the power of acoustic ultrasonic waves, pushing cosmeceuticals into these microchannels directly to the area that will most benefit from the active ingredients. The Legato is designed for the treatment of scars and stretch marks - two indications for which there is no effective solution which is not highly invasive. Other indications that may benefit from the delivery of cosmeceuticals directly beneath the skin include skin whitening and skin rejuvenation. ipixel RF The first step of the Legato solution is to create microchannels in the skin. The Legato uses the ipixel TM RF, a radio wave generator that causes precise and controllable thermal damage and fractional ablation. As the ipixel RF makes contact with the skin, small plasma sparks are released that pierce the epidermis and cause fractional skin ablation - forming the microchannels. Each microchannel is microns in diameter and has a depth of microns, depending on the RF-power settings. Cosmeceuticals The advantage of Trans-Epidermal Delivery compared to topical, oral, and hypodermic injections - is the ability to deliver the appropriate dose of cosmeceuticals directly to the location that will most benefit. When cosmeceuticals are introduced directly to biological tissue, they are more deeply absorbed and provide a stronger therapeutic effect. Until now, the main problem with effective delivery of skin care products/cosmeceuticals, was the fact that the stratum corneum is an effective barrier to outside elements. Cosmeceuticals are applied to the skin following the creation of the microchannels due to the fractional skin ablation. The cosmeceuticals are forced through the microchannels by the Impact Ultrasound unit. Impact Impact is the name of the ultrasound unit that acts as a vibrator, releasing acoustic waves that push the cosmeceuticals into the skin via the microchannels. The acoustic vibrations of the ultrasound leads to radiation pressure that gives the cosmeceuticals greater mobility and reactivity. This increases the amount of cosmeceuticals that enter the body, thereby increasing the affectivity of the cosmeceuticals. ]3[
4 Legato Treatment Settings Face (ipixel RF ) Treated area Power [W] Neck 40 Chin 40 Cheeks 45 Periorbital 40 Forehead 45 Body (ipixel RF ) Treated area Power [W] Hand 40 Abdominals 45 Waist 45 Hip 40 Buttocks 45 (Of note, the skin color was closer to the natural color.) Other noted changes in the appearance of the skin following the use of the Legato include a decrease in skin tension by the scar and the reduction in height or depth of the scar. In addition, using basal blood flow assessment with a Doppler flowmeter, the edema of the adjacent tissue decreased due to improvements of the blood circulation. Conclusions It is the author s belief that the combined use of cosmeceuticals with a delivery system like the Legato is highly effective. In particular, the realized synergies between cosmeceuticals and a delivery system include improved clinical and functional effects. The author is not aware of any alternative solution that is comparable to the Legato. The Legato may be used for mature scars, post acne scars, stretch marks, skin whitening, skin rejuvenation, and immediately following the removal of sutures. Treatment The Legato Skin Barrier Breakthrough System was used on 30 patients with pathologic scars, including 13 patients with atrophic scars and 17 patients with hypertrophic changes. In addition, 27 patients had striatal atrophy of the skin. All of the patients received a minimum of 4, and maximum of 8 sessions. By the 5th session, a partial reduction in the scar tissue was indicated. ]4[
5 Legato Treatment Results Skin Barrier Breakthrough System Scars
6 Scars 1 week after 2 Tx Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio de Janeiro, Brazil RF: 45 W, 3 passes Cosmeceutical: Triancinolona Impact: 60 Hz, 80%, 1 min ]6[
7 Scars After 2 Tx Courtesy of: Dr. Igor Pinson, MD & PhD, Dermatologist, Moscow, Russia RF: 45 w Cosmeceutical: Contractubex Impact: 40 Hz, 50%, 1 min ]7[
8 Scars 10 days after 4 Tx Courtesy of: Dr. Igor Pinson, MD & PhD, Dermatologist, Moscow, Russia RF: 50 w 2-3 passes Cosmeceutical: Contractubex Impact: 40 Hz, 50%, 1 min ]8[
9 Scars 1 week after 2 Tx Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio de Janeiro, Brazil RF: 40W, 2 passes Cosmeceutical: Hyaluronic Acid + Vit C Impact: 60 Hz, 80%, 1 min ]9[
10 Scars After 4 Tx. Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio de Janeiro, Brazil RF: 40W, 2 passes Cosmeceutical: Hyaluronic Acid + Vit C Impact: 60 Hz, 80%, 1 min ]10[
11 Scars After 1 Tx. Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio de Janeiro, Brazil RF: 45W, 3 passes Cosmeceutical: Triancinolona Acetonide Impact: 60 Hz, 80%, 2 min ]11[
12 Scars After 1 Tx. Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio de Janeiro, Brazil RF: 45W, 3 passes Cosmeceutical: Triancinolona Acetonide Impact: 60 Hz, 80%, 2 min ]12[
13 Legato Treatment Results Skin Barrier Breakthrough System Acne Scars
14 Acne Scars After 2 Tx Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio de Janeiro, Brazil RF: 45W, 3 passes Cosmeceutical: Tretinoin 0.05% Impact: 60 Hz, 80%, 2 min ]14[
15 Acne Scars After 3 Tx. Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio de Janeiro, Brazil RF: 45W, 3 passes Cosmeceutical: Tretinoin 0.05% Impact: 60 Hz, 80%, 2 min ]15[
16 Acne Scars After 3 Tx Courtesy of: Maria Angelo-Khattar, PhD, Aesthetica Clinic, Dubai RF: 60 W, stationary and ipixel RF (In Motion), 6 passes Cosmeceutical: Dalacine (Clindamycin) ]16[
17 Acne Scars After 6 Tx Courtesy of: Maria Angelo-Khattar, PhD, Aesthetica Clinic, Dubai RF: W (Treatments 1-5), 100 W (Treatment 6), ipixel RF (IN Motion), 7 passes Cosmeceutical: Locoid (hydrocortisone butyrate) Impact: 40 Hz, 50%, 2 min ]17[
18 Acne Scars 1 week after 1 Tx Courtesy of: Choi Jun, MD, PhD, MayLin Clinic, Seoul, Korea RF: W, 4-5 passes Cosmeceutical: PRP Impact: 60 Hz, 50%, 2 min ]18[
19 Acne Scars After 3 Tx Courtesy of: Dr. Michael Shohat, Dermatologist RF: 45-50W, 2-3 passe Cosmeceutical: Meso anti Wrinkle,1% HA, MicroAcne kit Impact: 60 Hz, 80%, min ]19[
20 Legato Treatment Results Skin Barrier Breakthrough System Strech Marks
21 Stretch Marks After 4 Tx Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio de Janeiro, Brazil RF: 45 W, 3 passes Cosmeceutical: Hyaluronic Acid + Vitamin C Impact: 60 Hz, 80%, 4 min ]21[
22 Stretch Marks After Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio de Janeiro, Brazil RF: 45 W,3 passes Cosmeceutical: Hyaluronic Acid + Vitamin C Impact: 60 Hz, 80%, 4 min ]22[
23 Stretch Marks After 4 Tx Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio de Janeiro, Brazil RF: 45 W 2 crosses (4passes) in motion tip Cosmeceutical: tretinoin 0,05% Impact: 60 Hz 80% ]23[
24 Stretch Marks After 1 Tx Courtesy of: Dr. Michael Shohat, Dermatologist RF: 55W, 2 passes Cosmeceutical: Meso Striae kit Impact: 60 Hz, 50%, 5 min ]24[
25 Stretch Marks After 3 Tx Courtesy of: Dr. Michael Shohat, Dermatologist RF: 55W, 3 passes Cosmeceutical: Meso Striae kit Impact: 80 Hz, 50%, 3 min ]25[
26 Stretch Marks 14 days after 2 Tx Courtesy of: Dr. Igor Pinson, MD & PhD, Dermatologist Moscow, Russia RF: 45 W, 3 passes Cosmeceutical: Hyaluronic Acid + Vitamin C ]26[
27 Legato Treatment Results Skin Barrier Breakthrough System Skin Rejuvenation
28 Skin Rejuvenation 1 week after 2 Tx Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio de Janeiro, Brazil RF: 40 W, 3 passes Cosmeceutical: Retinoic Acid 0,05% Impact: 60 Hz, 80%, 60 sec periocular +120 sec-malar and mandibular ]28[
29 Skin Rejuvenation After 4 Tx Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio de Janeiro, Brazil RF: 40 W, 3 passes Cosmeceutical: Anti-Wrinkle+Retinoic Acid (RA) Impact: 60 Hz, 80%, 1 min ]29[
30 Skin Rejuvenation After 3 Tx Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio de Janeiro, Brazil RF: 45 w Cosmeceutical: Tretinoin 0,05%+ HÁ 5% + VIT C 5% Impact: 60 HZ 80% ]30[
31 Skin Rejuvenation After 4 Tx Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio de Janeiro, Brazil RF: 45 w Cosmeceutical: Glicolic acid 10% + Hydroquinone 4% Impact: 60 Hz 80% ]31[
32 Skin Rejuvenation After 2 Tx Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio de Janeiro, Brazil RF: 40W, 2 passes Cosmeceutical: Vit C + Hyaluronic Acid Impact: 60 Hz, 80%, 1 min ]32[
33 Skin Rejuvenation After 4 Tx Courtesy of: Maria Angelo-Khattar, PhD, Aesthetica Clinic, Dubai RF: 60 W, 2 stationary passes Cosmeceutical: Vitamin C, Alphalipoic acid, Zinc, Silicium and Manganese Impact: 60 Hz, 60%, 2 min ]33[
34 Skin Rejuvenation After 2 Tx Courtesy of: Maria Angelo-Khattar, PhD, Aesthetica Clinic, Dubai RF: 55 W, 3 passes Cosmeceutical: Vitamin C, Alphalipoic acid, Zinc, Silicium and Manganese Impact: 60 Hz, 60%, 2 min ]34[
35 Skin Rejuvenation After 3 Tx Courtesy of: Maria Angelo-Khattar, PhD, Aesthetica Clinic, Dubai RF: 50W, 4 passes stationary Cosmeceutical: Vitamin C, Alphalipoic acid, Zinc, Silicium and Manganese Impact: 60 Hz, 60%, 2 min ]35[
36 Skin Rejuvenation 1 week after 1 Tx Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio de Janeiro, Brazil RF: 40W, 3 passes Cosmeceutical: Meso DMAE Impact: 60 Hz, 80%, 2 min ]36[
37 Skin Rejuvenation After 3 Tx Courtesy of: Maria Angelo-Khattar, PhD, Aesthetica Clinic, Dubai RF: 60W, 3 stationary passes and 2 IN Motion passes Cosmeceutical: Vitamin C, Alphalipoic acid, Zinc, Silicium and Manganese Impact: 60 Hz, 60%, 2 min ]37[
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