you NEWS Your body s health and beauty protein WHAT YOU LL FIND The Collagen Connection April 2011

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1 April 2011 W S WHAT YOU LL FIND omen s NEWS health & beauty Your body s health and beauty protein The Collagen Connection Find out collagen s overwhelmingly positive effects on skin, hair, nails and bones and learn how you can generate lost collagen naturally. The truth about collagen supplements Generate collagen don t eat it! Know the facts about collagen and you ll certainly benefit from its multitude of health, beauty, and rejuvenating properties. Increase your body s hair bulking protein Grow thicker, stronger hair from the inside out Discover how to increase the diameter of each hair shaft, and create stronger, more break-resistant hair. Create the medically ideal condition of bone Add bone flexibility to bone strength Increase your bones calcium binding sites Learn how collagen creates calcium binding sites inside your bone increasing BMD by 200% over the clinical threshold. Plus you ll see how collagen gives your bones both the strength and flexibility they need to withstand impact. 6 Re-build your skin s structural support Reduce wrinkles add moisture Learn how generating new collagen plumps out skin and smoothes out wrinkles. P E C I A L C O L L A G E N I S S U E The Collagen Connection Your body s health and beauty protein you H e a lt h and Beauty Sta f f want to be healthier and look younger. Who doesn t? Fortunately, you now have advantages your mother and grandmother could not even imagine. Molecular biologists have pinpointed the key structural protein integrally involved in creating smooth skin, thick and strong hair, strong flexible bones, and bone mineral density. Its name? Collagen. Surprised? You re not alone. Say the word collagen to most people, and you conjure up images of Goldie Hawn s lips in the movie The First Wives Club. Collagen and plastic surgeons seem to go together like ham and eggs. But the medical effects of generating your body s own collagen are quite profound. In fact, scientists call collagen the most important building block in the human body. It makes up 70% of your skin and 30% of your bone. Collagen prevents wrinkles from forming. It is integrally involved in vital skin elasticity. Collagen, along with keratin helps create thick, strong hair. Inside your bones, collagen acts as the binding sites for calcium. In fact, clinical trials now show that one specific collagen-generating compound, known as ch-osa, increases bone mineral density by 2.00% compared to placebo. This was an actual increase in bone formation, not just a reduction in loss. New research has even related the condition of youth and beauty to your body s collagen content. But in humans, collagen production begins to diminish by age 21. By age 30 the signs of aging become visible.

2 ch-osa COLLAGEN GENERATOR Look at the staggering statistics on collagen loss. u Collagen production decreases 1% per year, starting at age 21 u A woman s skin decreases in thickness (created by collagen) by 7% every ten years Clinical Results: Clinically proven to u Reduce fine lines and wrinkles u Increase skin elasticity u Create smoother skin u Increase the diameter of hair shafts u Strengthen hair u Increase bone mineral density Following Menopause u Skin thickness declines as much as 1.13% annually. u In the first 5 years, women lose as much as 30% of their skin collagen. u The decrease in skin collagen correlates with decreases in bone mineral density. u Skin elasticity declines 0.55% per year. Astounding statistics, for sure. Yet few Americans can recite even one of them. But clinical trials now prove that ch-osa, can indeed generate collagen. ch-osa produced genuine end point benefits such as reducing existing fine lines and wrinkles, thickening and strengthening hair, increasing bone mineral density, and promoting stronger more flexible (impact resistant) bones. I have been researching collagen for years. I m happy to tell you that there s one company that makes a collagen-generating product with the clinically-proven ingredient ch-osa. It s called BioSil. You can find it at your local health food store. you DID KNOW Skin is comprised of 70% collagen Bone is made up of 30% collagen Joints contain 70% collagen The truth about collagen supplements Generate collagen, don t eat it! What they may not want you to know Cosmetic companies instruct you to rub it on. Plastic surgeons simply say inject it. It s easy to understand how neither of these choices helps your body generate the collagen it needs to support genuine health and beauty. But there s a third option floating in the market now. That is, eating collagen in the form of powders and pills. The story is that if you ingest collagen, you ll increase collagen. But the truth is, your body breaks the collagen down and uses it as food. By contrast, BioSil s clinically-proven patented ch-osa complex, helps your body to generate its own collagen. Through the natural collagen-generating pathways. Yours from the marketplace, Jeff Kob NOTE: If you feel this type of product could benefit you, be sure to look for products containing ch-osa not plain OSA. All the clinical trials I have seen were with ch-osa. 2 Women s health & beauty news

3 Grow thicker, stronger hair from the inside out hair bulking Increase your body s protein let s face it. Everybody wants achieved from the inside thicker, shinier, more luxurious-looking out. Meaning it can t wash hair. It s no wonder. Hair is a symbol of away. It s yours to keep, your overall health and vitality. It also through rain, shine, and gives your face the ideal frame. Plus, hotel shampoos. But it s it s glamorous and sexy. Why else do not magic. It s real science you think Americans spend billions of at work. Here s how BioSil dollars on hair care products every works to thicken your hair: year? You ve got spray on s. Leave in s. And rinse out s. But the truth is, no externally applied hair care product can genuinely change the basic quality of your hair. Not one. Real improvements in your hair happen from the inside out. And, as you ll see, BioSil s ch-osa is clinically proven to do that. You ve got 100,000 hair follicles on your head. You can t add more. But you can make each hair follicle thicker, Increase your hair-bulking protein Have you heard of keratin? Keratin is the hair bulking protein. You see, your hair is made up of 97% keratin. That s why keratin, like collagen, is considered one of Nature s Beauty Proteins. And like collagen, keratin begins to diminish by the time we re 21. Why? The answer is simple. The gene responsible for producing collagen, it increases blood flow delivering a greater amount of healthy nutrients to your hair. I know from personal experience. I found that styling becomes a breeze. But unlike the spray on thickeners you purchase at the cosmetic counter, this thickness will not shampoo out. But there s even better news about your hair and each hair strand stronger. And keratin begins working slower and you can increase blood flow to your slower. Over time, there s less and less hair roots to ensure a healthy flow of keratin to fill up the hair shaft. Here s nutrients. For the women participating a way to look at it. Think of your hair in a clinical trial that s exactly what shaft as an un-inflated balloon, and air BioSil s ch-osa did. And can do for as the keratin. More air means a larger you too. balloon. By the time we re 45, some In fact, the individual diameter of scientists believe we may have only half each hair grew dramatically thicker after the keratin we used to. But that may not taking BioSil products. be a problem any longer. That adds up to You see, BioSil s ch-osa turns on the much greater cells that produce keratin (called keratinoblasts). volume and far Day after day, your hair gets more body. And thicker and thicker. It looks healthier it s bonafide too. Plus, as ch-osa generates more thickness b y Sarah Derby S ta f f Writer BULKING UP YOUR HAIR FROM THE INSIDE Stronger hair clinically proven You ve seen it in your sink. On the shower floor. Tangled up in your brush. It s hair that was not strong enough to withstand simple brushing or shampooing. Sure, some of that lost hair is part of the natural growth cycle. But some was prematurely removed for your head. And ladies, I can absolutely tell you this is where BioSil products really help. A tug of war with hair? Yes. That s exactly what the researchers did in the BioSil clinical trial on hair. They were testing for what they call break load. In other words, how many pounds of pressure does it take to snap the hair in two. It s the scientific measure of the hair s tensile strength. What did they find? The hair on the women taking BioSil s ch-osa was significantly stronger making it virtually breakresistant. April

4 Create the medically ideal condition of bone Add bone flexibility to bone strength Increase your bones calcium binding sites what you re about to hear is bound to change the way you care for your bones from this day on. Until recently, the focus of bone health centered strictly on strength. That s why you heard a lot about calcium and its ability to increase bone mineral density (BMD). And rightly so. But today, the word in the medical community is ideal condition of bone. That means creating both bone strength (BMD) and bone flexibility (ability to withstand impact). And clinical trials now prove one compound, called ch-osa, can do both. MORE BONE CALCIUM BINDING SITES MEANS HIGHER BONE MINERAL DENSITY you DID KNOW Calcium along with Figure A: Before BioSil s ch-osa Figure B: After BioSil s ch-osa Inside your bones, calcium binds to collagen. See Figure 6a. It shows you how with fewer collagen strands, there s less surface area for calcium to attach itself. This causes diminished bone mineral density. Now look at Figure 6b. BioSil s ch-osa increases the collagen strands providing calcium more binding sites. This results in greater bone mineral density. other bone minerals, is the inorganic part of your bone, and accounts for 70% of total bone Collagen is the organic part of your bone, and makes up 30% of bone Increase your BMD by creating more bone calcium binding sites Have you ever seen a cross-section of your bones? Take a look at the bone figure. Notice how the calcium binds to collagen strands (core posts) inside your bone. But as we age, our bone collagen production diminishes. There become fewer and fewer of these bone calcium binding sites. That s when BMD declines. You can easily see why continuously pumping in more and more calcium may accomplish little 4 Women s health & beauty news or nothing. But when you increase the formation of collagen (calcium binding sites) you increase your bones calcium content. This fact was demonstrated in a 12-month clinical trial conducted at the University of London, Research and Genetic Epidemiology Unit, St Thomas Hospital, Department of Pharmaceutical Sciences. In the study, women who were already supplementing with 1000 mg of Calcium and 800 IU of vitamin D, added 6 mg of ch-osa daily. The result was an increase in their bone mineral density by a statistically significant 2.00% compared to placebo, measured at the critical thigh bone. That s 200% over the mark of clinical relevance established by leading bone researchers. It s important to note that the 2.00% rise in BMD was the result of an actual increase in bone formation not merely a lessening of bone loss. But there s an even greater reason why ch-osa is the focus of such intense research today.

5 Increase your resistance to impact by adding bone flexibility Preventing fractures requires bone flexibility. Or as bone researchers like to say, bone toughness. Here the brittle calcium in bone can do little. But this is where the collagen content of your bone takes over. Bone collagen is extremely flexible. Something like rubber. When collagen receives a blow it simply bends slightly and returns to its form. That s why collagen gives your bones their ability to withstand impact reducing the risk of fracture. So how do you increase your bones collagen content? Unfortunately, you cannot eat collagen the way you do calcium. Your body uses the ingested collagen as just another protein source such as chicken, fish, or eggs. The good news is that you can increase bone collagen formation by stimulating your body s own collagen producing cells. And that is exactly what ch-osa was clinically proven to do. And keep in mind, increasing bone collagen has two separate and distinct benefits for you: 1 increases BMD by creating more bone calcium binding sites 2 decreases risk of fracture by adding flexibility or bone toughness As you can see, it takes both bone collagen and bone calcium to create the ideal condition of bones. Think of it like this: Calcium without collagen = Strong, but brittle bones Collagen without calcium = Flexible, but jelly-like bones Collagen plus calcium = Ideal condition of bone ch-osa: Generate collagen with your own DNA fingerprint The women I speak with today are quite conscious about the ingredients they put into their body. I m sure you are too. I often get questions like How do I know the collagen that ch-osa generates is natural? That s a very thoughtful question. The answer is a very comforting one. ch-osa works through your body s natural pathways. So the collagen you generate has your own BioSil: Unprecedented clinical results Your Skin The clinical trial recruited fifty women between 40 and 65 years old with symptoms of aging facial skin. They were divided into two groups, one taking a placebo and the other taking 10 mg BioSil per day for the 20-week period (Barel et al., 2005). No other anti-aging treatment was followed. The results demonstrated that subjects taking BioSil experienced a 19% reduction in fine lines, wrinkles, and skin roughness. Similarly, the skin of the BioSil group exhibited improved elasticity compared with those taking the placebo. Your Hair The ch-osa in BioSil, was clinically shown in another clinical trial to significantly increase the diameter of each hair shaft adding fullness and body to your hair. Plus, BioSil helps make your hair stronger, more elastic, and more break resistant (Wickett et al., 2007). Your Nails Women participating in the clinical trial reported that BioSil strengthened their nails, making them more break resistant (Barel et al., 2005). The BioSil nail phenomenon has given birth to an new expression: Unbreakable Beauty. Your Bone Mineral Density DNA fingerprint on it. Today, you can find two products that contain ch-osa: BioSil Skin Hair Nails, and BioSil Beauty Bones Joints. On their label it shows you the actual results of the ch-osa clinical trial. I still recommend you do some research for yourself. But studies on ch-osa have been published in peer reviewed medical journals and I believe you can find the clinical results on Wikipedia. This may be the most important finding about BioSil. It concerns your bone mineral density in both full-length thigh bone and hip region of thigh bone. In a clinical trial (Spector et al., 2005), subjects were divided into two groups: BioSil and placebo. The BioSil groups took BioSil, calcium, and vitamin D. The placebo group took only calcium and vitamin D. Placebo subjects lost 1.22% in bone mineral density at the hip region whereas the BioSil subjects gained 0.78 %. That s a significant difference of 2.00% twice the clinically relevant threshold. Your Joints Collagen is essential for maintaining articular cartilage in your joints, as well as ensuring the integrity of your ligaments. BioSil provides you with patented choline-stabilized orthosilicic acid to stimulate collagen sybthesis in bone and joints. April

6 Re-build your Multi-directional collagen Smooth youthful skin Reduce wrinkles and add elasticity 6 Women s health & beauty news

7 IMPORTANT note You can find clinically-proven ch-osa in BioSil products. They offer you the same dosage used in the clinical trials skin s structural support you never even considered it back then but when you were a kid, you d wake up in the morning with rosy moisture-drenched skin. Without the fine lines and wrinkles. It looked and felt smooth and flawless. No matter how the pillow scrunched your cheeks. It all happened without makeup. Without creams. Without lotions. The reason is simple: Collagen. You had lots of this skin-plumping, wrinkle-eliminating, moisture-attracting collagen. That s why collagen is called a beauty protein. But starting at age 21, collagen begins to break down. That s when fine lines and wrinkles form. But don t worry. Now, thanks to a clinically-proven compound, ch-osa, you can regenerate the collagen. Dominant-directional collagen Aged skin Plumping your skin from the inside out Take a look at the skin diagram. Notice how the younger skin contains a youthful abundance of collagen fibers. Millions of fibers pushing out the skin at every point along the way. This is what gives skin its firm, smooth appearance. It also prevents wrinkling. Now look at the ageing skin. See how the collagen fibers are few and far between. These gaps between the fibers are exactly where wrinkles form. Skin literally caves in. What can you do about it? A lot, actually. The key is to turn on your body s own collagen-producing cells (called fibroblasts). In a clinical trial, a compound called ch-osa (found in BioSil products) did just that. Week by week, for the women taking ch-osa, more and more collagen fibers began to form. The wrinkle-causing gaps started filling in. The end result was a statistically significant reduction in fine lines and wrinkles. You might be asking But is there a way to prevent or slow down the formation of new wrinkles? The answer seems to be yes. Bounce back the wrinkle preventer Think about it. You laugh. You frown. You raise your eyebrows in surprise. Yet your face doesn t crack. That s elasticity at work. Elasticity gives your skin the ability to bounce back after a crease or fold. Like smiling. Not surprisingly, the quality of your skin s elasticity today is a predictor of the wrinkles that may form in the future. Stated in a positive way, when you increase your skin s elasticity, you give it greater resistance to wrinkling. That s why some researchers call elasticity the great wrinkle preventer. So how do you increase elasticity? In a word, collagen. But it s not just the quantity of collagen you have, but also the direction the collagen fibers run. In wonderfully elastic skin, you find the collagen fibers running in all directions. The scientific name is isotropic (multi-directional). In wrinkled skin, however, the collagen fibers tend to go in one direction, known as anisotrophic (single directional). It s sort of like the difference between linen and silk. Pinch linen, it stays creased. Pinch silk, it bounces back. Now here s the encouraging part. In a clinical trial conducted with women, a compound called ch-osa was shown to increase skin elasticity by creating a rich matrix of multidirectional collagen. It s important to note that the women did not change their daily diet, exercise, or supplement routine. They simply added 10 mg of ch-osa daily. April

8 The Beauty of Authentic BioSil Advanced Collagen Generator Reduces fine lines and wrinkles Thickens and strengthens hair Fortifies nails Promotes healthy bones Clinically proven and patented * The Only Choline-Stabilized Orthosilicic Acid Complex 2011 Bio Minerals NV. Manufactured by Bio Minerals NV, Belgium. Packaged and distributed by : Natural Factors. ch-osa and BioSil are registered trademarks of Bio Minerals NV and the ch-osa logo is a trademark of Bio Minerals NV These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. *Based upon clinical testing on the forearm and forehead