Athens November Redensyl. The hair growth galvanizer
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1 Athens November 2015 Redensyl The hair growth galvanizer TECHNICAL MARKETING PRESENTATION V
2 Hair loss Market in Numbers
3 45 million 35 million 21 million Men suffering from hair loss in India Men suffering from hair loss in the USA Women suffering from hair loss in the USA
4 6,200$ in Average cost of one hair transplantation surgery % Hair loss sufferers would spend their life savings to regain a full head of hair 1 1 Source : International Society of Hair Restoration Surgery, report of 2013
5 Inspired from Regenerative Medicine
6 How does your body repairs itself???? Thanks to stem cells Human stem cells enable our body to self repair itself. Stem cell research is the Holly Grail for Eternal Youth (stem cells enable the creation and reparation of new organs). More than 500 clinical trials have been initiated for human body repairing in 2013 (brain, pancreas, skin, muscles, ). More information on: Hair follicle stem cells give birth to new hairs on the scalp.
7 Redensyl acts like a switch: it wakes up hair stem cells Real hair loss happens when hair stem cells stay asleep in the scalp. Redensyl wakes up the hair stem cells to generate a new growth phase of all the hair REDENSYL ACTS AS A MOLECULAR SWITCH TO TURN ON HAIR GROWTH AGAIN More information on:
8 Redensyl : the secret of patented molecules Gly Zn DHQG (dihydroquercetin glucoside) EGCG2 (epigallocatehcin gallate glucoside) EPIDERMIS Interleukin 8 1. The scalp is soothed to prepare the action of the other molecules sebaceous gland Hair stem cells reservoir DERMIS sweat gland 2. Stem cells are woken up They migrate down to create a new matrix HYPODERMIS Matrix (keratinocytes) Dermal papilla (fibroblasts) 3. Hair cells are boosted They are ready to produce a new hair 4. Zinc and Glycine nourish the matrix and favor a faster hair growth
9 DHQG: Dihydroquercetin-Glucoside Origin: Larch tree MW: 466 g/mol Biotechnology optimization (glycosylation)
10 EGCG2: Epigallocatechin-gallate-Glucoside Origin: Green tea leaves MW: 604 g/mol Biotechnology optimization (glycosylation)
11 2x better results than Minoxidil
12 Hair growth in μm compared to T0 Hair follicles growth test (Philpott test) Protocol: 24 hair follicles from men suffering from alopecia were maintained alive with either 1% of Minoxidil or 1% of Redensyl during 10 days. Hair growth was measured in µm at D7 and D10. Hair growth after 7 and 10 days %** % * 400 Day Day 7, 1% Redensyl 0 D7 D10 D7 D10 D7 D10 Control untreated Minoxidil 1% Redensyl Neocapyl 1% *p<0.1, **p<0.001 compared to untreated, Student t-test Redensyl increases hair growth by +214% compared to untreated Redensyl shows almost two times better results than Minoxidil, the benchmark reference.
13 Outstanding clinical results
14 Clinical assessment VOLUNTEERS 26 men aged 18 to 70 years old Brown to dark hair Qualified for a grade 3 to 4 alopecia (Norwood scale) With minimum 150 hair/cm 2 and 40 telogen hair/cm 2 I II PROTOCOL Double blind clinical trial versus a placebo 50% of volunteers received the placebo 50% received the formula with 3% Redensyl Applying the formula once a day Under the control of a dermatologist. Period of the test: autumn III IV VI III vertex V VII Clinical formula : AQUA, ALCOHOL DENAT., BUTYLENE GLYCOL, GLYCERIN, XANTHAN GUM, DISODIUM EDTA, CITRIC ACID, (+/-) Redensyl 3%
15 % of hair in anagen phase Increasing growing hair (anagen hair) Protocol: analysis on the volunteers scalp of the number of hair in anagen phase Relaunch of growing (anagen) hair % * 68 NS T0 1 month 3 months T0 1 month 3 months Placebo Neocapyl 3% Redensyl *p<0.01 compared to untreated, Student s t-test Slight non significant placebo effect up to D84 (activation of micro-circulation) Redensyl stimulates by +9% hair in anagen phase
16 % of hair in telogen phase Reduction of hair loss (telogen hair) Protocol: analysis on the volunteers scalp of the number of hair in telogen phase 38 Reduction of falling (telogen) hair % * 34 NS T0 1 month 3 months T0 1 month 3 months Placebo Redensyl Neocapyl 3% *p<0.01 compared to untreated, Student s t-test Slight non significant placebo effect up to D84 (activation of micro-circulation) Redensyl reduces hair in telogen phase by -17%
17 Density of anagen/density of telogen Follow up of the anagen/telogen ratio Protocol: analysis on the volunteers scalp of the ratio of anagen versus telogen hair 2,4 2,3 2,2 2,1 2,0 1,9 1,8 1,7 1,6 1,5 Improved anagen/telogen ratio % T0 1 month 3 months T0 1 month 3 months Placebo Redensyl Neocapyl 3% After 3 months, Redensyl improves the ratio of anagen/telogen by +29%, reaching 2.37 from the initial 1.83
18 Pictures of volunteers BEFORE D84 Increased density 52 years old Reduction of the vortex 38 years old Reduction of the bald area diameter 42 years old
19 Pictures of volunteers BEFORE D84 Increased density 46 years old Reduction of the vortex 36 years old Increased density 29 years old
20 Details - before/after Analysis area - Day 0 Criteria #3 Age 52 years old % of new anagen hair % % of density of hair increase + 17% Number of new hairs / cm hairs/ cm 2 Total number of new hairs on the scalp + 28,200 hairs (600 cm 2 ) Analysis area - Day 84 BEFORE Number of new hair per month on the scalp + 9,400 hairs AFTER Visible redensification of the scalp
21 Details - before/after Analysis area - Day 0 Criteria #6 Age 42 years old % of new anagen hair % % of density of hair increase + 17% Number of new hairs / cm hairs / cm 2 Analysis area - Day 84 BEFORE Total number of new hairs on the scalp (600 cm 2 ) + 25,800 hairs Number of new hair per month on the scalp + 8,600 hairs AFTER Hair loss stopped, a visible increase of hair density is noticeable.
22 Details - before/after Analysis area - Day 0 Volunteer #26 Age 29 years old % of new anagen hair + 9.2% % of density of hair increase + 17% Number of new hairs / cm hairs / cm 2 Analysis area - Day 84 BEFORE Total number of new hairs on the scalp (600 cm 2 ) + 17,400 hairs Number of new hairs per month on the scalp + 5,800 hairs AFTER Hair looks thicker with a visible improvement of the density
23 Self assessment A self-evaluation run by the volunteers after 84 days. Testers claim to see reduced hair loss, improved capillary density, stronger and thicker hair after three months of treatment. After 3 months, my hair loss is diminished 65% After 3 months, my capillary density is visibly enhanced 64% After 3 months, my hair are strengthened After 3 months, my hair is strengthened 71% After 3 months, my hair are thicker After 3 months, my hair is thicker 64% 0% 20% 40% 60% 80%
24 Self assessment A self-evaluation run by the volunteers after 84 days. 71% of the testers are satisfied by the product, and 71% of them would like to buy the product. Satisfaction rate Intent to buy Unsatisfied 29% NO 29% Satisfied 71% YES 71%
25 Summary of Redensyl clinical performances Within 84 days on grade 3 to 4 alopecic volunteers: 85% of volunteers showed clinical improvements: +9% of anagen hair -17% of telogen hair +29% of improvement in the anagen/telogen ratio Hair look thicker 71% of buying intention An average +8% increase in hair density corresponding to +10,000 new hairs Up to +28,200 new hairs
26 Uniqueness
27 Targeting existing hair follicle stem cells A reactivation of the bulge stem cells A metabolic boost of dermal papilla cells A shut down of inflammatory reactions Excellent results on grade 3 to 4 alopecic volunteers: Hair are denser Hair look thicker Increase in hair growth Decrease in hair loss A better ratio anagen/telogen Visible results in 84 days
28 Better results than hair transplantation surgery One hair transplantation = +8,000 new hair 65% of the patients undergo a single hair transplantation 1 for cost reasons But up to 3 hair grafts sessions can be needed to get the appropriate hair density 1 Redensyl gives an average: +10,000 new hairs in less than 3 months, with up to +28,200 new hairs 1 International Society of Hair Restoration Surgery: 2013 Practice Census Results 2 Bernstein Medical center
29 Redensyl - examples of product opportunities MEN Hair care (thin hair, hair loss, sparse hair) WOMEN Hair care (damaged hair, hair loss, sparse hair) Eyelashes growth mascara or primer
30 HAIR GROWTH TONIC Hair loss treatment for men Foam (more easy to apply) which converts into a lotion Evaporates quickly no residues Application once to twice a day HAI : Hair Actives Inside Redensyl 1,5% Bio-vectorized pro-panthenol (DPTA) 1% HAIR GROWTH TONIC Redensifying Recharging Reducing hair thinning - Soothing
31 ALL DAY HAIR PROTECTION Women with damaged thin hair Spray to apply on hair and scalp Evaporates quickly nice fragrance Application in the morning before combing Hair Beauty Technology: Redensyl 2% Anti ozone (Unicontrozon) 1% Silicone alternative (Unitamuron) 1% All-Day Hair Protect Protect dyed hair Prevent hair loss - Facilitate combing Reduce static electricity
32 HYPERCURE HAIR TREAMENT WEEK 1 WEEK 2 WEEK 3 WEEK 4 REDENSIFYING SCALP TREATMENT Men / women with hair loss Intensive cure to apply on scalp Favors the massage of the scalp Application everyday Hair Care Complex: Redensyl 3% Bio-vectorized panthenol (DPTA) 1% Sebum control (Unitrienol) 2% HYPERCURE Prevention of hair loss Soothe scalp Regenerate hair roots Dynamize hair growth Prevent oily hair
33 EVERLASHES EYELASH ENHANCER Women with sparse eyelashes Mascara primer Compatible with all type of make up Application before your mascara Redensyl 3% Long lasting, color enhancer, waterproof booster (Unimer U-1946) 5% Volumize Intensify the look Increase the length and diameter of eyelashes
34 Conclusion
35 Redensyl : the cosmetic alternative to hair surgery 3 years of fundamental research 2 patented molecules (DHQG and EGCG2) 1 green chemistry manufacturing process 1 full set of genetic analysis to decipher the mode of action 1 research collaboration with the world reference laboratory of Dr Philpott Pharma like purity >95% Perfectly safety at 100% Silver award of the best innovation ingredient in cosmetics 2014
36 Redensyl technical information INCI : WATER, GLYCERIN, SODIUM METABISULFITE, GLYCINE, LARIX EUROPAEA WOOD EXTRACT, ZINC CHLORIDE, CAMELLIA SINENSIS LEAF EXTRACT SUGGESTED RANGE OF USE : 1% to 3% FORMULATION : SHELF LIFE : STORAGE: COLOR : ODOR : SOLUBILITY : PACKAGING : OTHER : Add at the end of the formulation process under stirring below 50 C. Can be heated for a short time with the oil phase of formulation. 2 YEARS IN A FRIDGE FOR LONG TERM STORAGE IN A FRIDGE ONCE OPEN CLEAR YELLOW SOLUTION TYPICAL WATER SOLUBLE 1KG, 5 KG AND 25KG SOLVENT FREE (GREEN CHEMISTRY - BIOTECHNOLOGY) SAFETY PROFILE PATCH TEST, NEGATIVE AT 100% EYE IRRITATION, NEGATIVE AT 100% AMES TEST, NEGATIVE HRIPT, NEGATIVE AT 100% BIODEGRADABLE DHQG and EGCG2 are patented molecules from induchem companies
37 What can we do for you? Dr. Nicola Garuccio Global Sales Manager Induchem AG Industriestrasse 8A CH-8604 Volketswil Induchem USA, Inc. 535 Fifth Avenue, Floor 23 New-York, NY10017 Induchem France SAS 171 Bis Avenue Charles de Gaulle FR Neuilly Sur Seine
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