Unimoist U-125 G. The NMF. (natural moisturizing factor) like active. Temporary version

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1 The NMF (natural moisturizing factor) like active Temporary version

2 The NMF-like moisturizing ingredient to recover a perfect moisturization of skin. Unimoist U-125 G is a complete combination of active substances which are very similar to the natural moisturizing factor (NMF): Restore moisture retaning capacity... for a natural hydration of the skin. Unimoist U-125 G contains, in addition to natural saccharides, an ideal combination of various high grade amino acids such as creatine, alanine, aspartic acid, glycocol, with supplementary components include urea and a polycarbinol to compensate the loss of NMF upon aging. NMF composition 1 : 40% Free amino acids 17% Ammonia, uric acid, glucosamine, creatine and other organic substances 7% Urea 1.5% Magnesium 34.5% Other substances such as pyrrolidone carboxylic acid (12%), lactates, chlorides, phosphates, citrates and formiates (12%),... Skin has a natural capacity to retain water thanks to the natural moisture factor (NMF) 1 Composition quoted from Eckstein, R.A. Kosmetologie - Aus Forschung, und Praxis, pp. 95. (1971)

3 The NMF-like moisturizing ingredient to recover a perfect moisturization of skin. Unimoist U-125 G is a complete combination of active substances which are very similar to the natural moisturizing factor (NMF): Restore moisture retaning capacity... for a natural hydration of the skin. Unimoist U-125 G contains, in addition to natural saccharides, an ideal combination of various high grade amino acids such as creatine, alanine, aspartic acid, glycocol, with supplementary components include urea and a polycarbinol to compensate the loss of NMF upon aging. NMF composition 1 : 40% Free amino acids 17% Ammonia, uric acid, glucosamine, creatine and other organic substances 7% Urea 1.5% Magnesium 34.5% Other substances such as pyrrolidone carboxylic acid (12%), lactates, chlorides, phosphates, citrates and formiates (12%),... Skin has a natural capacity to retain water thanks to the natural moisture factor (NMF) Environmental factors : extreme climatic conditions, sunlight, pollution,... 1 Composition quoted from Eckstein, R.A. Kosmetologie - Aus Forschung, und Praxis, pp. 95. (1971)

4 The NMF-like moisturizing ingredient to recover a perfect moisturization of skin. Unimoist U-125 G is a complete combination of active substances which are very similar to the natural moisturizing factor (NMF): Restore moisture retaning capacity... for a natural hydration of the skin. Unimoist U-125 G contains, in addition to natural saccharides, an ideal combination of various high grade amino acids such as creatine, alanine, aspartic acid, glycocol, with supplementary components include urea and a polycarbinol to compensate the loss of NMF upon aging. NMF composition 1 : 40% Free amino acids 17% Ammonia, uric acid, glucosamine, creatine and other organic substances 7% Urea 1.5% Magnesium 34.5% Other substances such as pyrrolidone carboxylic acid (12%), lactates, chlorides, phosphates, citrates and formiates (12%),... Skin has a natural capacity to retain water thanks to the natural moisture factor (NMF) Natural hydration Unimoist U-125 G > 65% of NMF components 1 Composition quoted from Eckstein, R.A. Kosmetologie - Aus Forschung, und Praxis, pp. 95. (1971)

5 Improvement of skin hydration (clinical efficacy) Protocol: Unimoist U-125 G was tested for its moisture retaining effect on live human skin. Creams containing a range fo concentration of the product (0 to 5%) were applied on the inside forearm of each test subject. Measurement were done every 30 min, for 6 hrs. Result: Unimoist U-125 G improves skin moisture content with an increasing lasting effect according to the concentration of product. Number of hours of hydration Moisture content of the skin Measurement of the dielectric constant Placebo 1% 2% 3% 4% 5% Percentage of Unimoist U-125 G n% of Unimoist U-125 n hours of hydration

6 Improvement of skin hydration (clinical efficacy) Protocol: Unimoist U-125 G was tested for its moisture retaining effect on live human skin. Creams containing a range fo concentration of the product (0 to 5%) were applied on the inside forearm of each test subject. Measurement were done every 30 min, for 6 hrs. 80 Reading Moisture content of the skin Measurement of the dielectric constant A B C D G F E n% of Unimoist U-125 n hours of hydration Result: Unimoist U-125 G improves skin moisture content with an increasing lasting effect according to the concentration of product. A = B = C = D = E = untreated skin cream O/W cream with 0% witunimoist U-125 cream with 1% Unimoist U-125 cream with 2% Unimoist U-125 D = E = F = G = hours cream with 2% Unimoist U-125 cream with 3% Unimoist U-125 cream with 4% Unimoist U-125 cream with 5% Unimoist U-125

7 TECHNICAL INFORMATION INCI: Origin: Preservation: Appearance: Solubility: Dosage: Processing: Regulatory status: Claims: Glycerin (or Butylene Glycol for Unimoist BG-125 NP), Urea, Saccharide Hydrolysate, Magnesium Aspartate, Glycine, Alanine, Creatine Organic synthesis Preservative free (except Unimoist U-125 NP, Unimoist BG-125 NP) Clear, slightly yellow liquid Water-soluble, ethanol/water up to 60/40 1-3% Can be incorporated in any formula in liquid form at ph between 5.0 and 8.0 and temperature below 50 C CN, JP, KR, HK, AU, ASEAN, USA, CA, South-Am., Mid-East, EU Moisturizing SAFETY ASSESSMENT Ocular irritation: Skin irritation: Mutagenicity: Eye irritation test - OECD non irritant at 100% Closed epicutan patch test - non irritant at 20% Ames assay - OECD non mutagenic

8 Thank you Induchem AG Industriestrasse 8A CH-8604 Volketswil Induchem USA, Inc. 535 Fifth Avenue, Floor 23 New-York, NY10017 Induchem France SAS 171 Bis Avenue Charles de Gaulle FR Neuilly Sur Seine

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