AKOTT BIOGENICO LINE. The Art of Chemistry

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1 AKOTT BIOGENICO LINE The Art of Chemistry

2 Emulsifiers GenioCare Series Hydrocolloids BioCol Series Super Mild Surfactants GenioTens M Pearling Agents GenioPearl Sun Care Dispersions UVSperse Series

3 Emulsifiers GenioCare Series Key to Successful Cosmetics Texture Stability Efficacy Appearance GEL NETWORK STRUCTURE Independent from the HLB of the oil phase

4 CLASSIC O/W EMULSION Oil phase droplet with emulsifier Emulsifier Water Oil Emulsifiers GenioCare Series dependent to the Hidrophilic Lipophilic Balance (HLB) of the oil phase

5 Emulsifiers GenioCare Series Gel Network Structures of Oil-in in-water Emulsifiers oil Interlamellar water Interlamellar water bulk water INDEPENDENT FROM THE HLB: will work with VEGETABLE OIL, MINERAL OIL, ESTERS, SILICONS OR ANY BLEND OF THESE.

6 GEL NETWORK STRUCTURE LAMELLAR EMULSION The key to a successful Gel Network Structure is the optimal balance of each component, developed through intense lab testing by Dr. Masato Tagawa,, internationally acclaimed chemist and creator of the line. The result is an ingredient: Easy to formulate, eliminates the need for trial-and-error optimization. Enhancing emulsion stability by slowing down movement of droplets. Facilitating transport of active ingredients and the slow release of water soluble drugs.

7 Emulsifiers GenioCare Series COMPETITIVE ADVANTAGES 1. high skin affinity 2. exceptional texture 3. barrier function 4. long-lasting moisturizing effect 5. high stability of emulsion 6. water-resistance 7. extremely safe (RIPT tested)

8 Emulsifiers GenioCare Series GenioCare E-1 E (100 % natural)* Cetearyl alcohol (and) Sorbitan stearate (and) Sodium lauroyl lactylate (and) Caprylic/Apric Triglycerid (and) Hydrogenated Lecithin GenioCare CES (anionic) GenioCare SY (non ionic) GenioCare SB (siliconic) GenioCare Q/1 (cationic) * Ecocert approved

9 Emulsifiers GenioCare Series Clinical Evaluation of the moisturizing power and TEWL of Geniocare E-1 (4% O/W Emulsion) versus Benchmark (Montanov, 4% O/W Emulsion) M oisturizing Power (Corneometry) 50 % Increase Geniocare E-1 BenchMark* Time (minutes) TEWL-Trans Epidermal Water Loss % Reduction Time (minutes) Geniocare E-1 BenchMark*

10 Emulsifiers GenioCare Series Applications GenioCare E1: Natural and Organic Milks, Lotions, Eye creams GenioCare CES: Creams, Sunscreens GenioCarec SY: Lotions, Sprayables GenioCare SB: Creams, Lotions, Sunscreens GenioCare Q/1: Sun Care, Hair Care, Baby products

11 Hydrocolloids BioCol Series Biocol: much more than thickeners. Modulate the rheology of an emulsion Improve film formation of the emulsion on skin Reduce droplet size in the final formulation Increase heat stability of the formulation Increase degree of pigment dispersion

12 Viscosity [ mpas ] Hydrocolloids BioCol Series Hydrocolloid Surfactant layer Oil droplet ,2 0,4 0,6 0,8 1 1, Concentration BioCol AX [ % w/w ] Impact of BioCol on Viscosity Log Viscosity [Pas] with BioCol AX without BioCol AX Temperature [ C ]

13 Hydrocolloids BioCol Series GENIOCARE THE IMPORTANCE OF HYDROCOLLOIDS OIL PHASE H 2 O C Without BIOCOL VESSEL

14 GENIOCARE (E1, CES, SB, SY, Q/1) H 2 O BIOCOL (AX, LG, LF, ASHG, ASG) OIL PHASE (OILS, ESTERS, SILICONS.) C With BIOCOL 0.5% VESSEL

15 Hydrocolloids BioCol Series BioCol AX (100% natural) Pectin, Xanthan gum BioCol LG (100% natural) Ceratonia siliqua gum, Pectin, Sodium Alginate

16 Super Mild Surfactants GenioTens M The mildest possible cleansing agent Leads to fast and controlled re-fattening of the skin Excellent creamy foam Superior skin feeling after cleansing High compatibility with other ingredients

17 Super Mild Surfactants GenioTens M Natural and Controlled Re-fattening Properties Squalene Content on Skin [%] , Time after Treatment [ Minutes ] GenioTens M Cocoamidopropyl Betain

18 Super Mild Surfactants GenioTens M (1) GenioTens M Superior Foam Formation (2) Cocoamide DEA Immediate After 2 Minutes After 5 Minutes After

19 Super Mild Surfactants GenioTens M Encapsulation of Amphiphilic Actives 3 % Ceramide-III in Sodium Laureth-2 Sulfate polarized light 100 times magnification Multi lamella liposomes containing 3 % Ceramide-III in Geniotens M polarized light 600 times magnification

20 Super Mild Surfactants GenioTens M High Tolerance to Ester Oils in Cleansing Formulations Foam structure immediate after preparation GenioTens M 45.00(%) Cetearyl Isononanoate Water Foam structure 2 minutes after preparation

21 Super Mild Surfactants GenioTens M Effect on the viscosity of the system without GenioTens M with GenioTens M Viscosity [mpa*s] ,0 1,0 2,0 3,0 4,0 5,0 6,0 7,0 Concentration NaCl [%]

22 Pearling Agents GenioPearl MULTI LAMELLAR LIQUID CRYSTAL DELIVERY SYSTEM GenioPearl SERIES

23 Pearling Agents GenioPearl The term pearl gloss is used to describe a soft glossy effect produced by the multiple reflection achieved by the parallel arrangement of highly refractory wafers.

24 Pearling Agents GenioPearl Advantages of Formulating GenioPearl unique brilliant appearance emollient effect by forming a thin lipid layer onto the skin oil components/actives can be incorporated reducing the potential for irritation

25 Pearling Agents GenioPearl Encapsulation of Active Substances facilitates solubilization of hard-to to-dissolve active substances in detergent systems increases the activity of the active substances enhances their affinity for skin and hair.

26 Pearling Agents GenioPearl

27 Sun Care Dispersions UVSperse Series UVSperse Series (T40/BG, T50/LV, T50/MCT/LV and more). Highly efficient micropigment dispersions. Easy to use, safe, and with reduced whitening effect.

28 Sun Care Dispersions UVSperse Series 1. It provides extensive UVB and UVA protection (contributes high SPF values to the sunscreen formulation). 2. It is easy to formulate in o/w and w/o sunscreen emulsions even without preservatives and surfactants 3. It is highly photostable,, thus safe on skin ADVANTAGES not interacting with sensitive raw materials (ascorbic acid, tocopherol and organic UV filters)

29 Sun Care Dispersions UVSperse Series UVSperse Series Excellence in photostability Commonly used TiO2 micropigment products always cause oxidizing effects in the final sunscreen formulation due to insufficient surface treatment. This can be visualized by the method of observing a significant color change when adding the sensitive Vitamin E (D-Alpha Tocopherol) or Vitamin C Palmitate to TiO2 dispersions.

30 Sun Care Dispersions UVSperse Series UVSperse Series Excellence in photostability Biogenico UVSperse dispersions guarantee a state of the art level of surface coating, thus UVSperse does not form radicals under UV radiation.. Consequently maximum skin protection can be guaranteed.

31 Sun Care Dispersions UVSperse Series UVSperse Series Excellence in photostability To proof the high level of quality,, we compared UVSperse T40/TN with a similar predispersed market leaders dispersions based on commonly used TiO2. To those dispersions Vitamin E has been added and the discoloration of the Tocoperol has been documented after 5 min on the following scheme:

32 Sun Care Dispersions UVSperse Series UVSperse Series Excellence in photostability Discoloration of different micropigment dispersions containing 4o%wt TiO2 observed 5 min after the addition of Vitamin E Biogenico T40/TN Tayca MT100T Eusolex T 2000 Solaveil / Tioveil FIN

33 Sun Care Dispersions UVSperse Series UVSperse Series Excellence in photostability We re-produced the test with the most sensitive Vitamin we know Vitamin C. The same experiment was done with the oil soluble Vitamin C Palmitate and once again UVSperse T40/TN did not show any change in color in contrary to the compared other qualities.

34 Sun Care Dispersions UVSperse Series Excellence in photostability Dispersions containing 40% TiO 2 with added Vitamin C after 5 min observation Biogenico T40/TN Tayca MT100T Eusolex T 2000 Tioveil FIN

35 Thank you for your attention!

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