Neuro Blocker = Botox like Results & Reorganizes Aging Dermal Cells

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1 Powerful Peptides Neuro Blocker = Botox like Results & Reorganizes Aging Dermal Cells Every cell needs protein to maintain its life. Peptides are the building blocks of protein and are contained in every living thing. Peptides can be found as hormones, enzymes, antibiotics, and receptors. Peptides are easier to reproduce synthetically than a protein due to their size. This allows better penetration but can also initiate irritation. Irritation is Too much irritation to the skin causes aging. This has been found to be true with numerous people over-using exfoliants as anti-aging measures. More is not better when using an abundance of retinol and AHA s. Your age management must be balanced balance. Lira Clinical s philosophy is: Peel with Heal, a balanced and healthy approach to age management. By utilizing a peptide, plant stem cells, and an exfoliator combination Lira Clincial skin care formulations control the Penetrability into the skin with limited skin irritation Promotes glycosaminoglycan (GAG) production increasing hyaluronic acid synthesis Stimulates microcirculation and capillary repair Encourages natural free radical skin protection Progeline Discovered through understanding the juvenile disease of Progeria: an accelerated aging condition in children Increases collagen production thus a remodeling effect and wrinkle reduction Stimulates a better collagen/elastin bond for an increase of 56% in an anti-sagging effect First peptide to mimic the natural process of skin communication and repair Transmits signals between skin cells and the dermal collagen/elastin matrix Regulate cell proliferation, survival, and cell differentiation through growth factor receptor crosstalk Increases lymphatic circulation around the eye area Decreases dark circles- by up to 60% Strengthens fragile capillary walls Haloxyl and Eyeliss work synergistically together for the best possible result in eye products. Lira Clinical has combined both peptides in our Mystiq Perfecting Eye Crème. Maxi-Lip is a natural peptide stabilized by being coupled to a palmitoyl chain It stimulates collagen and glycosaminoglycan synthesis 19

2 Powerful Peptides Matrixyl (Palmitoyl Pentapeptide-3) Mimics the anti-aging results of retinoic acid without the irritation and wounding of the epidermis Initiates the dermal production of collagen and elastin Collagen synthesis is increased up to 117% Collagen IV synthesis is increased up to 327% strengthens the basal membrane along the epidermal/dermal junction Increased glycosaminoglycan production of hyaluronic acid by up to 267% Snap-8 (Acetyl Octapeptide-3) Reduces the depth of wrinkles caused by muscle contractions SNAP-8 destabilizes the SNARE complex which, in turn, blocks the muscle contraction Reduction in wrinkles by up to 63% when applied twice daily Syn-ake (Palmitoyl Tripeptide) Developed from viper venom research Clinical studies have shown that the frequency of muscle contractions is reduced up to 82%. Argireline (Acetyl Hexapeptide-3) Neuropeptide: associated with neural tissue Referred to as the topical Botox Relaxes facial muscles but allows natural expression and movement Can increase the life of your injections by up to a month when used twice daily topically Myristoyl Pentapeptide 17&16 Both peptides work in conjunction with each other to achieve a 25% increase in eyelash length. Peptides stimulate keratin growth Strengthen keratin for better lash retention TM (Biotinoyl Tripeptide-1) Stimulates hair bulb proliferation Allows for better hair shaft retention Results seen in as little as 2 weeks 20

3 Plant stem cells (PSC) are the plants foundation cells. They are located in the bulb, root or stem of the plant also known as the meristem. They are the origin of the plant s vitality supplying precursor cells forming various plant tissues and organs. These cells also aid in repair and regeneration. PSCs create new cells to grow or replace specialized tissues. You can see PSCs at work when you place a bulb or stem in water. It will begin to root and form a completely new plant or repair its self. Plant stem cells are utilized in cosmetics as they are nature s liposomes that are completely compliant with our skin. energy level in cells for better repair. located in the plant s meristems for cell renewal. Recently, researchers have begun looking to plants as a source for stem cells, and those plant stem cells have proven to be effective in supporting the skin s cellular turnover. Like human stem cells, plant stem cells develop according to the environment they re in. The idea for using plant stem cells in skin care stemmed from an unusual source: an almost-extinct apple tree in Switzerland. Originally bred in the 18th century for their incredible shelf life, Uttwiler Spätlauber apples shrank into long-lasting freshness was its ability to heal itself. If an apple was scratched while still on the tree, the fruit s skin would quickly regenerate and close the wound. Luckily, the Uttwiler Spätlauber, and the plant stem cells that gave it its staying power, caught the attention of researchers just in the nick of time. Researchers found a way to extract stem cells from the bark of the tree and generate new ones in a lab. They then started to investigate how human cells would react to them. The results were astonishing. They found the apple s stem cells could stimulate human stem cell proliferation by 80 percent and could protect human stem cells against UV damage. Today, applications for their cell repair and protection abilities. One exciting area of research for plant stem cells is treating skin problems such as wrinkles, distended capillaries, and photo damage. Like all areas of the body, the skin contains stem cells. In the basal layer of the epidermis, stem cells divide and replace lost or dying cells. They also repair the skin when it suffers injury. The epidermis is in a constant state of renewal so it requires non-stop cell replacement. As we age, it is even more important to continue to renew our skin with healthy cells. The aging process can slow cell turnover down as well as cripple new keratinocytes in reaching the stratum corneum s surface. 21

4 Sea Fennel Stem Cell (Crithmum Maritimum Callus Cell Culture) Key Word: Hyperpigmentation Organic brightener Helps repair melanocyte damage reducing current pigment Brightens skin and lessens the possibilities of pigmentation damage development Improves skin tone and evens color Overall skin renewal Echinacea Stem Cell (Echinacea Angustifolia Meristem Cell Culture) Key Word: Wound Healing Stimulates the immune system and suppresses infection Regenerating and wound healing Anti-stress and anti- Potent antioxidant and skin revitalizer (Syringa Vulgaris Leaf Cell Culture) Key Word: Acne Reduces all acne lesions by up to 40% after 30 days of use for reduction in redness and acne scarring caused by trans epidermal water loss through protective skin properties Potent antioxidants protects skin against free radical invasions Key Word: Elastin 22 Orange Stem Cell (Citrus Sinensis Cell Culture) Recovers elastic skin properties from up to 12 years prior Organizes and re-thickens the dermis matrix giving the skin its velvet touch back Increases keratohylin (glue-like substance) in the epidermis restoring cell adhesion Repairs the skin to its youthful glow improving the appearance of

5 Alpine Rose Stem Cell (Rhododendron Ferrugineum Leaf Cell Culture) Key Word: Barrier Function Increases skin stem cell vitality Boosts epidermal regeneration Improves skin s barrier function Helps skin adapt to extreme climate changes Swiss Apple Stem Cell (Malus Domestica Fruit Cell Culture) Key Word: Trauma Slows skin cell aging process Helps reconstruct traumatized skin Potent antioxidant Enhances UV protection skin (Vitis Vinifera Fruit Cell Extract) Key Word: UV Protection Protects skin stem cells against UV stress Delays natural aging process of essential cells Fights UV photo-aging Edelweiss Stem Cell (Leontopodium Alpinum Meristem Culture) Key Word: Collagen Dermal/epidermal repairing properties through collagen regeneration potent antioxidant Aids skin s adaptability to extreme climates Results are improved when paired with Alpine Rose Stem Cell 23

6 Argan Stem Cell (Argania Spinosa Sprout Cell Culture Extract) Key Word: Growth Accelerates natural repair process Rejuvenates dermal cells initiating new hair bulb growth Protects and awakens dermal skin cells for hair follicle stimulation Cell repair conditioning lashes Stem Cell (Lilium Candidum Leaf Cell Extract) Key Word: Brighten Prevent and decrease chloasma (age spots) Inhibits melanosome transfer brightening skin Evens out skin tone Encourages epidermal regeneration Stimulates collagen and elastin growth These icons let you know which plant stem cells are in which products. You can see these icons on the packaging of Lira Clinical products. 24 Lilac PSC Echinacea PSC Orange PSC Alpine Rose PSC Argan PSC Edelweiss PSC Grape PSC Madonna Lily PSC Sea Fennel PSC Swiss Apple PSC