RHA (Resilient Hyaluronic Acid) 10 YEARS OF RESEARCH INTERNATIONAL PATENT SWISS ANTI-AGING EXPERTISE

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1 RHA (Resilient Hyaluronic Acid) 10 YEARS OF RESEARCH INTERNATIONAL PATENT SWISS ANTI-AGING EXPERTISE ADV TEOXANE COSME GB.indd 1 09/04/14 12:50

2 TEOXANE LABORATORIES EXPERTS IN HYALURONIC ACID s SWISS DESIGNER and MANUFACTURER of hyaluronic acid-based dermal fillers s MARKET LEADER in the field of AESTHETIC MEDICINE TEOXANE PATENTED TECHNOLOGY RHA (Resilient Hyaluronic Acid) 10 YEARS OF RESEARCH INTERNATIONAL PATENT ADV TEOXANE COSME GB.indd 2 09/04/14 12:50

3 TEOXANE COSMECEUTICALS A UNIQUE OFFER ON THE MARKET Today, Teoxane Laboratories makes the benefits of its INTEGRATED R&D DEPARTMENT and IN-HOUSE INNOVATIONS available to everyone, in a GLOBAL ANTI-AGING COSMECEUTICAL RANGE, MADE IN SWITZERLAND. TEOXANE INNOVATIONS s RHA Resilient Hyaluronic Acid The same technology as the one used in TEOXANE dermal fillers s Dermo-Restructuring Complex (CDR) Complex of active ingredients also present in TEOSYAL PureSense Redensity I and II dermal fillers (medical devices of class III, CE 0086) TEOXANE COSMECEUTICALS TECHNICAL PRODUCTS with tangible results & proven efficacy LUXURY PRODUCTS with high quality standards & luxury codes A DAILY SOLUTION that meets the HIGHEST DEMANDS in terms of BEAUTY and GLOBAL SKIN HEALTH ADV TEOXANE COSME GB.indd 3 09/04/14 12:50

4 CORE FORMULA* RHA Resilient Hyaluronic Acid Hydrating layer prevents transepidermal water loss moisturizes tightens the skin active ingredients gradually released Dermo-Restructuring Complex (CDR) Powerful antioxidants Amino-acids, minerals vitamin B6 NovHyal Biotech-G GAG s synthesis Dermal-Epidermal junction strengthener AN EFFICIENT RESPONSE TO SKIN AGING ANTIOXIDANT ACTION** EPIDERMAL REGENERATION** DERMAL-EPIDERMAL JUNCTION RESTRUCTURING** 2 3 DERMAL CELL ACTIVITY STIMULATION** ADV TEOXANE COSME GB.indd 4 09/04/14 12:50

5 RHA Resilient Hyaluronic Acid TEOXANE PATENTED TECHNOLOGY - TEOXANE INNOVATION Unlike traditional Hyaluronic Acid, TEOXANE RHA Resilient Hyaluronic Acid forms a Hyaluronic Acid mesh on the application zone, like a second skin. This mesh gives RHA a specific, additional action: it smoothes, plumps and firms skin as well as acting globally as a matrix rich in active ingredients that are gradually released for a targeted anti-aging solution. CDR - Dermo Restructuring Complex TEOXANE INNOVATION 8 amino acids, 3 antioxidants, 2 minerals, Vitamin B6 Known for their synergistic activities on the dermis*: Cellular defense Hydration regulation Collagen synthesis *D. Gerard-Monnier, J. Chaudiere, «Metabolism and antioxidant function of glutathion», Path. Biol.1996, 44, L. Packer, E. H. Witt, H. J. Tritschler, Alpha-lipoic acid as a biological antioxidant, Free Rad. Biol. Med. 1995, 19, N. Morley, A. Curnow, L. Salter, S. Campbell, D. Gould, N-Acetyl-L-cysteine prevents DNA damage induce by UVA, UVB and visible radiation in human fibroblasts, J. Photochem. Photobiol. B: Biology 2003, 72, P. M. Elias, Stratum corneum defensive functions: an integrated view, J. Invest Dermatol. 2005, 125, D. J. Prockop, K. I. Kivirikko, Collagens: molecular biology, diseases, and potentials for therapy, Annu. Rev. Biochem. 1995, 64, K. Mizuno, T. Hayashi, H. P. Bächinger, Hydroxylation-induced stabilization of the collagen triple-helix, J. Biol.Chem. 2003, 278, N. Jiravanichanun, K. Mizuno, H. P. Bächinger, K. Okuyama, Threonine in collagen triple-helical structure, Polymer J. 2006, 38, NovHyal Biotech-G - Pro Filler Molecule N-Acetyl Glucosamine-6-Phosphate NovHyal Biotech-G SKIN CELLS Glucose glucose-6-p Fructose-6-P Glucosamine-6-P N-acetyl-glucosamine-6-P NAG6P UDP- UDP-glucoronic acid Hyaluronic Acid -UDP Cellular Regeneration (1) Skin Cells Mediation (2) Hyaluronic Acid Production (3) Dermal-Epidermal Junction Reinforcement (1) NovHyal Biotech-G, operating mode figure (1) Ex-vivo tests, performed by an independent laboratory (2) In-vivo tests, performed by an independent laboratory (3) In-vitro tests, performed by an independent laboratory ADV TEOXANE COSME GB.indd 5 09/04/14 12:50

6 ADV TEOXANE COSME GB.indd 6 09/04/14 12:50

7 TEOXANE COSMECEUTICALS A COMPLETE RANGE AT PRACTITIONER'S OFFICE POST PROCEDURE Soothing Aftercare Fluid 100 ml KIT POST PROCEDURE DEEP REPAIR BALM - 2ml RHA SERUM - 2ml ADVANCED FILLER Dry Skin - 2ml DAY CARE RHA TM PRIME SOLUTION Prep Cleansing Solution 200 ml RHA TM SERUM Regenerative Skin Concentrate 30 ml ADVANCED FILLER Derma-Restructuring Anti-Wrinkle Cream - Normal to Combination Skin - Dry Skin 50 ml NIGHT CARE PERFECT SKIN REFINER (10% AHA) Skin Renewal Cream 50 ml TARGETED SKINCARES DEEP REPAIR BALM Ultra Comfort Soothing Balm 30 ml RADIANT NIGHT PEEL (15% AHA) «New skin» effect Treatment Class I Medical Device 40 ml ADV TEOXANE COSME GB.indd 7 09/04/14 12:50

8 POST PROCEDURE ml SOOTHING FLUID FOR MEDICAL USE FOR PROFESSIONAL USE Arnica extract with soothing and anti-inflammatory properties Antarticine helps the skin healing process Neutrazen helps skin regeneration Chlorexidine Digluconate recognized for its bacteriostatic properties USE Apply POST PROCEDURE generously to the target areas immediately after the aesthetic procedure. We recommend that patients use DEEP REPAIR BALM for 5 days at home after the aesthetic procedure to help skin recover its integrity. KIT POST PROCEDURE FOLLOW-UP CARE FOR PATIENTS AFTER AESTHETIC PROCEDURE ENSURES OPTIMAL RELIEF AND COMFORT* PRODUCTS DEEP REPAIR BALM - 2ml RHA SERUM - 2ml ADVANCED FILLER DRY SKIN - 2ml *Results specific to DEEP REPAIR BALM. Assessment and self-assessment carried out on 20 volunteers during 28 days, by an independent laboratory. ADV TEOXANE COSME GB.indd 8 09/04/14 12:50

9 RHA PRIME SOLUTION ml PREP CLEANSING SOLUTION - FACE AND EYES DAY CARE RHA + CDR + NOVHYAL G CORE FORMULA Soothing Rose water Cleansing agent GENTLY CLEANSES ALL SKIN TYPES, EVEN SENSITIVE SKIN FIRST STEP OF ANTI-AGING ROUTINE PREPARE THE SKIN TO RECEIVE BENEFITS OF RHA SERUM USE Apply with a cotton pad, morning and evening to the face to cleanse skin and remove make up. Do not rinse. ADV TEOXANE COSME GB.indd 9 09/04/14 12:50

10 RHA SERUM - 30 ml VISIBLY TRANSFORMS THE SKIN WITHIN 14 DAYS DAY CARE RHA + CDR + NOVHYAL G CORE FORMULA plant extract powerful moisturizing agent THE HIGHEST CONCENTRATION OF RHA + CDR + NOVHYAL G FOR A REINFORCED ANTIOXIDANT PROTECTION* RESULTS AFTER 14 DAYS** MOISTURISES PROTECTS REACTIVATES THE NATURAL DEEP SKIN REGENERATION MECHANISMS: cell renewal, tissue restructuring FIRMING EFFECT 97% 94% 91% 91% Skin is more HYDRATED Complexion is BRIGHTER Skin is SMOOTHER Skin appears MORE RESISTANT USE Apply to clean skin, morning and evening, before applying ADVANCED FILLER. * Ex-vivo test, model closest to human skin, performed by an independent laboratory ** Self assessment carried out on 31 volunteers by an independent laboratory. ADV TEOXANE COSME GB.indd 10 09/04/14 12:50

11 ADVANCED FILLER - 50ml INTENSE FILLING TREATMENT Normal to Combination Skin / Dry Skin DAY CARE RHA + CDR + NOVHYAL G CORE FORMULA Matrixyl 3000 matrikines based anti-wrinkles active ingredient LONG-LASTING HYDRATION** RESTRUCTURING** WRINKLE FILLING** Exceptional instrumental analysis results Lasting skin hydration: +25%* Increased elasticity: +10%* Diminished wrinkle depth: -17%* Tolerance: 100%* 45 T0 Corneometric unit (a.u.) ,6 41,6 40,0 40,8 T28 20 D0 D1 D14 D28 Instrumental measurements of skin hydration* IMMEDIATE RESULTS** 100% - Skin is HYDRATED 97% - Skin is MATTIFIED Exceptional skin smoothing effect after 28 days, confirmed using profilometry* RESULTS** AFTER 28 DAYS 97% - Wrinkles and fine lines are SMOOTHED 93% - Skin tone is MORE EVEN 97% - Skin is REGENERATED USE Apply to clean skin in the morning, after RHA SERUM. *Assessment of ADVANCED FILLER, Normal to Combination skin carried out on 30 volunteers by an independent laboratory. Results evaluated after 28 days. **Self-assessment of ADVANCED FILLER, Normal to Combination skin carried out on 30 volunteers by an independent laboratory. ADV TEOXANE COSME GB.indd 11 09/04/14 12:50

12 PERFECT SKIN REFINER - 50 ml REVEAL "PERFECT SKIN" - NIGHT CARE NIGHT CARE RHA + CDR + NOVHYAL G CORE FORMULA Resurfacing ingredients including Glycolic Acid (10%) SMOOTHES THE SKIN* INCREASES THE QUALITY OF THE SKIN* CORRECTS PIGMENTATION IMPERFECTIONS* RESULTS* AFTER 15 DAYS complexion is EVEN and MORE LUMINOUS pores are REFINED pigmentation spots are CORRECTED USE Apply 2 or 3 doses to thoroughly cleansed face and neck in the evening. Avoid contact with the eyes and lips. *Assessment results of a multicentrical study conducted on 24 volunteers by 2 independent aesthetic practitioners and 2 dermatologists. Results after 15 days. ADV TEOXANE COSME GB.indd 12 09/04/14 12:50

13 DEEP REPAIR BALM - 30ml ULTRA-COMFORT SOOTHING BALM TARGETED SKINCARE RHA provides specific hydration Arnica extract with soothing and anti-inflammatory properties Neutrazen promotes skin regeneration Helichrysum extract, recognized for its anti-hematoma properties RESULTS* HELPS RESTORE altered skin protection functions SOOTHES MOISTURISES DIMINISHES REDNESS characteristic of localized skin disorders 95% 100% 95% Skin is SOOTHED** Skin is REPAIRED** The product restores IMMEDIATE COMFORT** USE Apply to dry or sensitized areas by massaging gently as often as necessary. DEEP REPAIR BALM can also be used as a night care, a deep moisturizing mask, an after sun care or accompany professional aesthetic procedures (injections, laser treatments, peeling...). *In-vivo test carried by an independent laboratory **Self-assessment carried on 20 volunteers during 28 days, by an independent laboratory. ADV TEOXANE COSME GB.indd 13 09/04/14 12:50

14 RADIANT NIGHT PEEL - 40ml SKIN RENEWAL TREATMENT Class I Medical Device - 15% Glycolic Acid TARGETED SKINCARE RHA providing specific hydration 15% Glycolic Acid accelerates the skin renewal process SPEEDS UP CELL RENEWAL* EVENS OUT SKIN TONE AND TEXTURE* DIMINISHES PIGMENTED AREAS* RESULTS* AFTER 15 DAYS 85% effectiveness on the markers of PERFECT SKIN THE COMPLEXION IS RADIANT PORES ARE REFINED PIGMENTATION SPOTS ARE DIMINISHED USE Apply a thin and even layer to thoroughly cleansed face in the evening, avoiding the eye and lip contours. To be used as 21-day intensive care, 3 times a year. RADIANT NIGHT PEEL can also be used as 15-day intensive care to prepare skin for an aesthetic procedure as part of a medical peeling protocol. *Assessment results of a multicentrical study conducted on 24 volunteers by 2 independent aesthetic practitioners and 2 dermatologists. Results after 15 days. ADV TEOXANE COSME GB.indd 14 09/04/14 12:51

15 For more information, contact us at ADV TEOXANE COSME GB.indd 15 09/04/14 12:51

16 TEOXANE Ceuticals Rue de Lyon, 105 CH 1203 Genève - SWITZERLAND Ref /02 - CONCEPTION : LEMAHIEU DESIGN ADV TEOXANE COSME GB.indd 16 09/04/14 12:51

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