FACIAL ARTS. Manufacturer: naturelize GmbH Kasseler Straße Bad Emstal Germany Phone: +49 (0)

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1 Manufacturer: naturelize GmbH Kasseler Straße Bad Emstal Germany Phone: +49 (0) Fax: +49 (0) Mail: customer supporting esthetic visions

2 An attractive smile takes more than just good teeth. naturelize natural treatment of wrinkles. To make it as easy and convenient as possible for you to meet this desire, we have developed naturelize, an innovative range of products based on nature-identical hyaluronic acid. Our naturelize fillers provide you with a diverse range of treatment options, which deliver highly persuasive results and are natural and gentle to use something your patients will definitely appreciate! naturelize products permit extremely gentle esthetic treatments and a long-lasting effect. To ensure that our products always live up to this claim, naturelize products are manufactured in accordance with the most stringent requirements: the latest production technology for the restoration of natural esthetics made in Germany for the best possible product quality, guaranteeing optimum treatment outcomes innovative products for individual patient expectations

3 naturelize restore This biphasic filler guarantees a long-lasting effect and is frequently used for medically-indicated reconstruction of concave deformities. The product s core in shell technology permits a long-lasting volume effect of up to 18 months to be achieved with the same small amount of material. naturelize inline & maxface naturelize inline and maxface fillers provide the option of a simple, easy to perform injection for almost all indications, including moderate lip augmentation. These monophasic fillers enable you contingent on individual patient-related factors to achieve the volumizing effect desired and persistence of the product in the skin. They exhibit a more lasting persistence in the tissues than inline soft and maxface soft. The effects of these products last for up to 10 months. naturelize inline soft & maxface soft naturelize fillers inline soft and maxface soft belong to the latest generation of fillers, containing fully-hydrated particles. Because they are well tolerated biologically and have a soft, fullyhydrated texture, they are easy to inject and encounter minimal resistance. A special manufacturing process is used in which insoluble particles, produced by cross-linking linear hyaluronic acid chains, are then fully-hydrated, with the result that each individual particle is surrounded by a stable aqueous shell. The soft particles do not absorb water from the surrounding tissue after injection, so that swelling is avoided. The soft particles are also perfectly prepared for enzymatic degradation by hyaluronidases. naturelize soft fillers permit rapid, uncomplicated, generally side-effect free treatment of wrinkles. Depending on the concentration used, the effects last for 5 6 months. naturelize pearl This hyaluronic acid gel smoothes fine wrinkles and is used for rejuvenation and for treating large areas of skin.

4 a visible leap forward in the art of esthetic wrinkle correction and volume augmentation A high level of product safety Linear: Monophasic: Monophasic soft: Biphasic: All naturelize hyaluronic acid filers are manufactured from high purity, protein-free hyaluronic acid produced through fermentation, are endotoxin-free and contain no animal components. Our products are CE and GMP certified and meet the most stringent German and international quality requirements. In addition, naturelize fillers offer all the advantages of hyaluronic acid treatment: fully degradable no unwanted long-term effects extremely well tolerated requires no allergy testing Facial Arts can be used to underline or restore the patient s natural esthetic. A range of products is available covering the full spectrum of treatments, from mesotherapy, to filling fine lines, to facial contouring.

5 Hyaluronic acid forms the basis, Facial Arts the next stage of evolution! non-cross-linked hyaluronic acid cross-linked hyaluronic acid pearl is a monophasic, non-cross-linked hyaluronic acid gel for rejuvenation and mesotherapy. Mesotherapy denotes the treatment of large areas of skin with linear hyaluronic acid (almost identical in structure and effect to the body s own hyaluronic acid) which helps to counteract transepidermal water loss. Following injection, naturelize pearl rapidly spreads within the tissues to smooth out fine wrinkles. rejuvenation, vitalization and hydration of the face, neck, décolletage and hands for touching up after treatment with naturelize maxface naturelize pearl is injected into the upper to mid dermis using a 32 G needle. inline is a monophasic, hyaluronic acid gel with a low degree of cross-linking for injection of fine to medium lines and wrinkles. The homogeneous gel is easy to inject and distributes itself rapidly within the tissue. With the exception of treatment of the glabella, for which it is contraindicated, inline is an all-round filler for all standard treatments. fine to medium wrinkles perioral wrinkles forehead wrinkles gentle lip augmentation lip contouring for touching up after treatment with naturelize maxface naturelize inline is injected into the upper to mid dermis using a 30 G needle.

6 cross-linked hyaluronic acid cross-linked hyaluronic acid maxface is a highly concentrated, monophasic hyaluronic acid gel with a highly homogeneous structure. It permits more substantial volumization and is suitable for treating medium to deep wrinkles. It is also ideal for correcting scars and for cheek and chin augmentation. When augmenting large areas, e.g. cheek or neck augmentation, we recommend using a blunt-tipped cannula. maxface is contraindicated for the treatment of the glabella or forehead wrinkles. medium to deep wrinkles nasolabial folds corner of the mouth perioral wrinkles chin and cheek augmentation acne scars enhancement of the nasal bridge (smaller dose recommended) Procedure: Due to the delay in volumization with this product (after around 1 week), it is generally recommended that a smaller dose is used. After 14 days, an optimum treatment outcome can be achieved by touching up the treatment site with naturelize inline. This results in a long-lasting effect. naturelize maxface is injected into the mid to lower dermis using a 27 G needle. inline soft is a soft hyaluronic acid filler, which has been specifically developed for smaller augmentations. The fully-hydrated gel possesses excellent handling characteristics. Following a gentle injection, it distributes itself evenly within the tissue and produces a fresh, youthful appearance, preserving a natural look. fine lines and wrinkles laughter lines forehead wrinkles glabellar lines crows feet mild nasolabial folds and marionette lines vermilion border hand augmentation Due to its excellent tissue compatibility, side-effects such as swelling are extremely rare. naturelize inline soft is injected into the upper to mid dermis using a 27 G needle.

7 cross-linked hyaluronic acid cross-linked hyaluronic acid maxface soft is a fully-hydrated gel suitable for almost all applications. Its soft texture ensures that injected wrinkles are evenly filled and that it produces an immediate, visible effect. It is contraindicated for treatment of the glabella. medium lines and wrinkles nasolabial fold marionette lines mild scarring severe perioral wrinkles neck wrinkles décolletage Due to the excellent flow characteristics of the gel, injecting maxface soft is gentle and atraumatic. It is injected into the upper to mid dermis using a 27 G needle. restore is a strong, biphasic filler for volumization of the face. Its high degree of efficacy means that restore should be used in small volumes only. The optimum volume is about 1/3 of the normal volume for a monophasic filler. To achieve optimum results, restore is injected into the lower dermis/subcutaneously. Practitioners are advised to explain to patients that use of restore can cause swelling lasting several days (maximum 4 days). deep wrinkles significant volumization, e.g. cheeks facial deformities mandibular line liquid lifting lipoatrophy treatment of deep scarring restore is injected using a 27 G needle. The volumization effect lasts for up to 18 months.

8 Overview of main indications References Forehead wrinkles 2 Glabellar lines 3. Crows feet 4 Cheekbone augmentation 5 Nasolabial fold 6 Philtrum and perioral wrinkles 7 Lip contouring 8 Lip volume 9 Marionette lines 10 Chin augmentation 11 Cheek augmentation (1) Jean Carruthers MD, Steven R Cohen MDb, John H. Joseph MDc, Rhoda S. Narins MDd, Mark Rubin MDc The Science and Art of Dermal Fillers for Soft-Tissue Augmentation, Journal of Drugs in Dermatology, Vol. 8, Issue 4 (April 2009) (2) Doris J. Day, Curt M. Littler, Richard W. Swift and Scott Gottlieb The Wrinkle Severity Rating Scale Am J Clin Dermatol (2004:5) (3) Jefrey Kablik, Gary D. Monheit, MD, LiPing Yu, PhD, Grace Chang, Julia Gershkovich Comparative Physical Properties of Hyaluronic Acid Dermal Fillers Dermatol Surg 2009;35; (4) Larsen NE, Pollak CT, Reiner K, Leshchiner E, Balaz EA. Hylan Gel biomaterial: dermal and immunologic compatibility J Biomed Mater Re 1993; 9; (5) Marina Landau, MD Combination of chemical peelings with botulinum toxin injections and dermal fillers Journal of Cosmetic Dermatology, 2006:5,

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