PureSense. when efficacy meets comfort. PureSense. PureSense INDICATIONS AND SUMMARY TABLE SWISS INNOVATION APPLIED TO BEAUTY.

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1 M GT GT PT 877 Q SWSS VT PP T BT TS SMM TB First ines Global ction eep ines ltra eep 20 mg/g 22 mg/g idocaine eedle 23G 1 ndications orrection of superficial wrinkles: fine lines and wrinkles on thin skin Filling of all moderately pronounced wrinkles on the full face Filling deep wrinkles Superficial dermis Mid dermis eep dermis Volume-creating capability njection area FFTV SF G-STG eep dermis Subcutaneous or pre-periosteal Blister pack 2 x 0.7 m 1 x 3 m stimated duration before touch up* 6 months 9 months 12 months up to 18 months when efficacy meets comfort * verage duration depends on several factors: patient's skin type, severity of the wrinkle to be corrected, type of injection and the volume injected. PTM MFT Subcutaneous tissue reation of volume (cheek bones, cheeks, chin, temporal area) es harmilles - ue de yon, Genève Tél. : +41 (0) Fax : +41 (0) mail : info@teoxane.com F : 0073/02 armonization of edefinition of volume and lip facial contours contour orrection of very deep wrinkles in thick skin

2 GT PT 877 linically proven esults The most complete dermal fillers range with lidocaine the1st barrier Fear of pain Q of patients towards injections MTG Multicentrical study, r Trevidic and r laude (France, 20) 32 patients 63% of patients type (Fitzpatrick skin scale) psos consumer study 2008 Split face design injection of nasolabial folds and lips with vs (ltra eep, et eep ines) ntense volume Pain assessment measured by VS* international scale ltra eep The gentle way to give volume SGFT T F T PTT'S P P SSSSMT ips enhancement VS S eep ines FFTV SF G-STG n-depth filling 40 PTM MFT - 68,7% 30 Global ction Simplified filling PTT STSFT - 66,5% 20 o pain» threshold reached after 5 min First ines Soft lines 0 TS BF eep ines of patients injected with TS are willing to be re-injected*. 1ml syringe injected asolabial folds, marionette lines ltra eep 2x1ml syringes injected TS 5 M FT JT n-vitro test reproducing the action of oxidative stress in the skin When injected in the skin, hyaluronic acid gels suffer from a strong oxidative stress (skin inflammatory response) accelerating the % of remaining elasticity G 96 % deterioration of the product. 95 G 99% 1 MT FT oss of elasticity due to exposition to oxidative stress asolabial folds TS n optimized durability 0% of patients injected satisfied by the aesthetic results of the treatment. G found injection significantly less painful than an injection without lidocaine*. G V TS G JT mmediate and ong-lasting esults G V 9 patients out of (average perceived pain) % Thanks to Teoxane aboratories know-how 80 in the conception of hyaluronic acid based 75 dermal fillers, 70 products offer a better protection against oxidative stress in comparison % with other dermal fillers containing the same monophasic gel ( 24mg/ml biphasic gel ( 20mg/ml of lidocaine ( 25mg/ml *Visual nalogic Scale * Multicentrical study done on 32 patients by octors Trevidic and laude, specialists in Plastic, econstructive and esthetics Surgery. 20.

3 GT PT 877 linically proven esults The most complete dermal fillers range with lidocaine the1st barrier Fear of pain Q of patients towards injections MTG Multicentrical study, r Trevidic and r laude (France, 20) 32 patients 63% of patients type (Fitzpatrick skin scale) psos consumer study 2008 Split face design injection of nasolabial folds and lips with vs (ltra eep, et eep ines) ntense volume Pain assessment measured by VS* international scale ltra eep The gentle way to give volume SGFT T F T PTT'S P P SSSSMT ips enhancement VS S eep ines FFTV SF G-STG n-depth filling 40 PTM MFT - 68,7% 30 Global ction Simplified filling PTT STSFT - 66,5% 20 o pain» threshold reached after 5 min First ines Soft lines 0 TS BF eep ines of patients injected with TS are willing to be re-injected*. 1ml syringe injected asolabial folds, marionette lines ltra eep 2x1ml syringes injected TS 5 M FT JT n-vitro test reproducing the action of oxidative stress in the skin When injected in the skin, hyaluronic acid gels suffer from a strong oxidative stress (skin inflammatory response) accelerating the % of remaining elasticity G 96 % deterioration of the product. 95 G 99% 1 MT FT oss of elasticity due to exposition to oxidative stress asolabial folds TS n optimized durability 0% of patients injected satisfied by the aesthetic results of the treatment. G found injection significantly less painful than an injection without lidocaine*. G V TS G JT mmediate and ong-lasting esults G V 9 patients out of (average perceived pain) % Thanks to Teoxane aboratories know-how 80 in the conception of hyaluronic acid based 75 dermal fillers, 70 products offer a better protection against oxidative stress in comparison % with other dermal fillers containing the same monophasic gel ( 24mg/ml biphasic gel ( 20mg/ml of lidocaine ( 25mg/ml *Visual nalogic Scale * Multicentrical study done on 32 patients by octors Trevidic and laude, specialists in Plastic, econstructive and esthetics Surgery. 20.

4 GT PT 877 linically proven esults The most complete dermal fillers range with lidocaine the1st barrier Fear of pain Q of patients towards injections MTG Multicentrical study, r Trevidic and r laude (France, 20) 32 patients 63% of patients type (Fitzpatrick skin scale) psos consumer study 2008 Split face design injection of nasolabial folds and lips with vs (ltra eep, et eep ines) ntense volume Pain assessment measured by VS* international scale ltra eep The gentle way to give volume SGFT T F T PTT'S P P SSSSMT ips enhancement VS S eep ines FFTV SF G-STG n-depth filling 40 PTM MFT - 68,7% 30 Global ction Simplified filling PTT STSFT - 66,5% 20 o pain» threshold reached after 5 min First ines Soft lines 0 TS BF eep ines of patients injected with TS are willing to be re-injected*. 1ml syringe injected asolabial folds, marionette lines ltra eep 2x1ml syringes injected TS 5 M FT JT n-vitro test reproducing the action of oxidative stress in the skin When injected in the skin, hyaluronic acid gels suffer from a strong oxidative stress (skin inflammatory response) accelerating the % of remaining elasticity G 96 % deterioration of the product. 95 G 99% 1 MT FT oss of elasticity due to exposition to oxidative stress asolabial folds TS n optimized durability 0% of patients injected satisfied by the aesthetic results of the treatment. G found injection significantly less painful than an injection without lidocaine*. G V TS G JT mmediate and ong-lasting esults G V 9 patients out of (average perceived pain) % Thanks to Teoxane aboratories know-how 80 in the conception of hyaluronic acid based 75 dermal fillers, 70 products offer a better protection against oxidative stress in comparison % with other dermal fillers containing the same monophasic gel ( 24mg/ml biphasic gel ( 20mg/ml of lidocaine ( 25mg/ml *Visual nalogic Scale * Multicentrical study done on 32 patients by octors Trevidic and laude, specialists in Plastic, econstructive and esthetics Surgery. 20.

5 M GT GT PT 877 Q SWSS VT PP T BT TS SMM TB First ines Global ction eep ines ltra eep 20 mg/g 22 mg/g idocaine eedle 23G 1 ndications orrection of superficial wrinkles: fine lines and wrinkles on thin skin Filling of all moderately pronounced wrinkles on the full face Filling deep wrinkles Superficial dermis Mid dermis eep dermis Volume-creating capability njection area FFTV SF G-STG eep dermis Subcutaneous or pre-periosteal Blister pack 2 x 0.7 m 1 x 3 m stimated duration before touch up* 6 months 9 months 12 months up to 18 months when efficacy meets comfort * verage duration depends on several factors: patient's skin type, severity of the wrinkle to be corrected, type of injection and the volume injected. PTM MFT Subcutaneous tissue reation of volume (cheek bones, cheeks, chin, temporal area) es harmilles - ue de yon, Genève Tél. : +41 (0) Fax : +41 (0) mail : info@teoxane.com F : 0073/02 armonization of edefinition of volume and lip facial contours contour orrection of very deep wrinkles in thick skin

6 M GT GT PT 877 Q SWSS VT PP T BT TS SMM TB First ines Global ction eep ines ltra eep 20 mg/g 22 mg/g idocaine eedle 23G 1 ndications orrection of superficial wrinkles: fine lines and wrinkles on thin skin Filling of all moderately pronounced wrinkles on the full face Filling deep wrinkles Superficial dermis Mid dermis eep dermis Volume-creating capability njection area FFTV SF G-STG eep dermis Subcutaneous or pre-periosteal Blister pack 2 x 0.7 m 1 x 3 m stimated duration before touch up* 6 months 9 months 12 months up to 18 months when efficacy meets comfort * verage duration depends on several factors: patient's skin type, severity of the wrinkle to be corrected, type of injection and the volume injected. PTM MFT Subcutaneous tissue reation of volume (cheek bones, cheeks, chin, temporal area) es harmilles - ue de yon, Genève Tél. : +41 (0) Fax : +41 (0) mail : info@teoxane.com F : 0073/02 armonization of edefinition of volume and lip facial contours contour orrection of very deep wrinkles in thick skin

PureSense INDICATIONS AND SUMMARY TABLE TEOSYAL. TEOSYAL PureSense First Lines. TEOSYAL PureSense. TEOSYAL PureSense. TEOSYAL PureSense.

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