Anti-aging eye contour serum SEMBLANCE: An impressive look in one touch. The look of the eyes transmits beauty and attractiveness and it is essential in interpersonal communication. As we age, the delicate skin around the eyes becomes even thinner and therefore more susceptible to age-related changes. Eye puffiness appears due to liquid retention as a consequence of higher permeability of blood vessels, which when added to bilirubin accumulation (from hemoglobin breakdown) induces vascular pigmentation and therefore dark circles. In addition, the deterioration of skin support proteins, like collagen and elastin, contributes to an increased visibility of such signs, besides the development of wrinkles. Eye contour serum SEMBLANCE is a regenerating serum, used to correct and repair lines of expression and signs of aging in this sensitive area. Provides multiple benefits: deep nourishes moisturizes and moisturizes even the driest skins. BIOACTIVE ingredients in SEMBLANCE Eye contour serum: 1) SQUALENE: Natural water balance It is a terpene with antioxidant properties naturally present in our skin, binding to the cell membrane, helping to eliminate toxins and disabling free radicals. On the skin, it acts as an oxygen radical scavenger, thereby protecting the skin from lipid peroxidation due to exposure to UV rays and other sources of ionizing radiation. With age, the production of this compound decreases and since it is one of the main constituents of our lipids, (25% approx), this reduction causes over the years that skin gets dehydrated more easily and become dryer. It is an extraordinary emollient, keeps the skin hydrated also is non-comedogenic and quickly absorbed.
2) LACTIC ACID: Natural moisturizing factor Lactic acid is an alpha hydroxy acid used as a softener. It is a natural component of the hydrolipidic layer of the skin and, consequently, plays a physiological activity, belongs to the hydrophilic components that make up the protective mantle of the skin. It is mainly used to improve the texture of the skin. Lactic acid is also a natural moisturizing factor (NMFs) of the skin, which favors the water-binding ability of the stratum corneum. In dermatology has been used since the time of Cleopatra, who legend, bathed in sour milk (lactic acid) to keep his skin soft and smooth. It favors the skin regeneration and has keratolytic activity, exerting a gentle exfoliative effect that favors the regeneration of the horny layer. 3) SESAFLASH: Hydrolyzed sesame protein Sesaflash is a non-sensitizing cosmeceutical derived from sesame which has been shown to have an immediate tensing and straightening effect. Tense and softens wrinkles with deep moisturizing and long lasting effect. In-vivo clinical study: In order to demonstrate its properties, several in-vivo clinical studies were carried out, in which the tensile and anti-wrinkling effect was evaluated by means of light-strip techniques, taking measurements of the skin relief at 5 minutes after application:
In an in-vivo clinical trial with 20 women, deep wrinkles were reduced by 13% after use for 30 minutes. Images of before and 5 minutes after the application of Sesaflash and microscopic appearance of the skin. 4) EYESERYL : Tetrapeptide with Anti-puffins and Anti-edema activity With age, the skin around the eye contour loses elasticity. The periocular muscles also weaken. As a result, this aged and loose skin ends up forming puffins around the eyes, which accumulate fat or water, characterized by a swelling in the lower eyelid. Either because the bags have an aqueous or fatty origin, in both cases there is a congestive origin common to both situations. The approach should aim at improving lymphatic circulation in the area and to reduce the edema. EYESERYL Is an Acetyl-tetrapeptide (Acetyl tetrapeptide-5) with anti-edema properties with proven efficacy in the reduction of ocular puffiness. It is an anti-aging, firming and decongestant complex.
In-vivo clinical study with 0.01% EYESERYL: To demonstrate the claimed properties, the manufacturer performed an in-vivo clinical study on 20 volunteers aged 18-65 years. A cream containing 0.01% EYESERYL was applied twice a day for 60 days. Images were taken at 0, 15, 30, 45 and 60 days. Instrumental, visual and physical parameters were taken, under dermatological evaluation and supervision. Ocular congestion was significantly reduced after 15 days of use in 70% of volunteers. By the end of the trial, 95% of the volunteers experienced an improvement: 30% showed slight improvement (grade 2) 30% showed a fairly good improvement (grade 3) 35% showed a good improvement (grade 4) Imágenes del Día 1 y Día 15 después de la aplicación de EYESERYL dos veces al día
Improvement of the elasticity and hydration of the skin: Both the elasticity and hydration of the skin increased considerably. Specifically, skin elasticity increased by 30% after 30 days. Skin s elasticity improvement Skin s hydration improvement In-vivo clinical study with 0.001% of EYESERYL: The trial was performed on 17 people, aged 34 to 54 years, using a cream containing 0.001% EYESERYL, applied twice daily for 28 days. Evolution of the ocular bag volume after 15 days The volume of the ocular sac was measured using a technique called Fringe Projection where 3D images of the areas studied were obtained by FaceScanner and later processed with the Optocat Software (Breuckman, Germany - EoTech, France). After 14 days, 63% of the volunteers had reduced their bags. - EoTech, Francia). Evolution of the ocular bag volume after 15 days
Anti-Dark circles Effect: In order to perform this study, highresolution photographs of the area under dark circles under polarized light were taken and chromametric studies were performed. Both results (eye volume and dark circles) were significant. Evolución de las ojeras tras 15 días The above tests demonstrated the extraordinary efficacy of EYESERYL even at extremely low concentrations. 5) EYEDELINE: Marine ingredient extracted from Plankton EYEDELINE is a marine ingredient of biotechnological origin. It is a new cosmetic active which provides complete care of the eye contour area by reducing fluid extravasation and increasing the degradation of bilirubin. It also boosts collagen and elastin synthesis and decreases the formation of advanced glycation end products (AGEs), for a brighter and younger look. It is part of Lipotec's new BIOINTEC blue biotechnology line of biotechnological ingredients. Isolated from a naturally-occurring marine microorganism (E. crustaceum) isolated in Playa Paraiso, Tenerife Island in Spain, it is produced through biotechnology, so there is no harvesting or extracting from nature.
In-vivo clinical studies: A panel of 21 females (22-65 years old) with dark circles applies a placebo cream on one side of the eye contour area, and a cream with 1% EYEDELINETM marine ingredient on the other side, twice a day for 28 days. The vascular component (red color) of dark circles was then calculated from high-resolution photographs taken under cross polarized light. The active ingredient reduced the vascular component of dark circles by 1.5% and was 35.7% more effective than the placebo. A group of 20 female subjects (aged 41-66) showing eyebags used a cream with 4% EYEDELINE marine ingredient on half of the face around the eye and a placebo cream on the other half, twice a day, for 28 days. Fringe projection technique was used to evaluate the eyebags volume. The results were already evident after 14 days, reducing them by 8.2% after 28 days. A panel of 18 females (40-54 years old) applied a placebo cream or a cream with 2% EYEDELINE marine ingredient on crow's feet wrinkles of one eye or the other, twice a day and for 14 days. Measurement of in vivo skin topometry of crow's feet was performed by fringe projections. EYEDELINETM provided a general smoothing effect by reducing roughness by 9.0%, mean wrinkle depth by 8.75% and Maximum wrinkle depth by 9.8%.
Elastin levels stimulation: Elastin synthesis increase (%) Human dermal fibroblasts were incubated for 48 h with 0.1 or 1 μg / ml EYEDELINE and 0.4 μg / ml dexamethasone (positive control). Elastin levels were measured by a dyebinding method. Elastin levels increased 51.6% Collagen type I levels stimulation: Collagen I increase (%) Dermal fibroblasts were treated with 5 μg / ml of EYEDELINE for 48 h. The concentration of type I collagen was measured by an immunoassay (ELISA). Collagen I levels increased by 61.8%. Anti-aging eye contour serum SEMBLANCE activity: Decreases vascular permeability to ameliorate eye bags and dark circles Enhances bilirubin degradation to reduce the vascular pigmentation that causes dark coloration under the eyes Promotes the production of type I collagen and elastin by dermal fibroblasts Diminishes glycation of collagen to maintain strength and elasticity of the dermis In vivo, it improves the appearance of all signs of aging in the eye contour area, including dark circles, puffiness, and wrinkles Lighter looking thanks to a correct hydration of the skin Strengthened skin Smooth appearance in the delicate area of the eye contour Anti-oxidant properties, non-irritating, perfect for sensitive skin.