850 Lincoln Centre Drive Foster City, CA 94404 U.S.A. T 650.570.6667 F 650.572.2743 www.appliedbiosystems.com Dear Valued Customer: In an effort to better serve you, Applied Biosystems is revising the look and feel of our Material Safety Data Sheets, (MSDSs). In addition, we will now be supplying MSDSs for materials which are classified as nonhazardous as defined by the Dangerous Substances and Dangerous Preparations Directives, 67/548/EEC and 88/379/EEC respectively, (EU), and the OSHA Hazard Communication Standard, 29 CFR 1910.1200 (U.S.). As always, MSDSs will be available in multiple languages. In the coming months, we will be implementing a system whereby you will be able to choose your preferred method for MSDS delivery. Your delivery options are as follows: By E mail By FAX Please take a few minutes to send an e-mail to: MSDS_Inquiry_CCRM@appliedbiosystems.com to let us know your preference. Type MSDS Delivery in the subject line and include your preference in the body of the letter along with your full name, Company or Institution, and your preferred E-mail address or FAX number as applicable. Please choose only one option. Alternatively, you may print out this letter, circle your preference from the list above, and mail it to the address below. Please include your full name, Company or Institution, and E-mail address or FAX number as applicable on this letter. In the meantime, you will continue to receive your document(s) along with your order if it is the first order of the calendar year, or when the MSDS has undergone a major revision. MSDSs are also available on our website. For AB products, please visit: http://docs.appliedbiosystems.com/msdssearch.html. For Ambion products, please visit: http://www.ambion.com/techlib/msds If you are a Distributor or Dealer of Applied Biosystems Products: As the last supplier in the chain who provides hazardous substances to a place of work, you have the responsibility to provide a Material Safety Data Sheet (MSDS) and any updated hazard information from our company to your customers. You are required to send the MSDS to your downstream users prior to or with the initial delivery of a hazardous substance. When an MSDS is revised, a copy of the revised MSDS should be sent to the purchaser as soon as it is revised. Should you have any questions, feel free to contact us via email at: MSDS_Inquiry_CCRM@appliedbiosystems.com or call 650-638-5635 (USA) Thank you for your continued business. Vergine Furniss Global Chemical Compliance and Risk Management Applied Biosystems 850 Lincoln Centre Drive Foster City, CA 94404 1-800-327-3002 x5635 (USA) Revision Date: 5-Jan-07 Version 1.0
MATERIAL SAFETY DATA SHEET 1 PRODUCT AND COMPANY IDENTIFICATION Product Name: Tropix GALACTON-Star Product No.: T2255 Manufacturer Name: Applied Biosystems 850 Lincoln Centre Drive Foster City, CA 94404, USA Phone: (650) 638-5800 (USA) www.appliedbiosystems.com Emergency Telephone: 1-800-424-9300 (NORTH AMERICA); +1-703- 527-3887 (INTERNATIONAL, REVERSE CHARGES) Intended Use: For Research Use Only. Not for Use in Diagnostic Procedures 2 HAZARDS IDENTIFICATION Emergency Overview Physical State: Liquid Color: No data available. Odor: No data available. WARNING! Causes eye irritation. May cause central nervous system effects. Prolonged or repeated contact may dry skin and cause irritation. Flammable liquid and vapor. Potential Health Effects Inhalation: May cause central nervous system effects. Vapors may cause drowsiness and dizziness. Eye Contact: Causes eye irritation. Exposed individuals may experience eye tearing, redness, and discomfort. Skin Contact: Prolonged or repeated contact may dry skin and cause irritation. Ingestion: May cause discomfort if swallowed. Chronic Health Effects: May cause central nervous system effects. Prolonged skin contact may cause dermatitis. Target Organ(s): Eye Central nervous system Skin US MSDS 1 / 8
Potential Physical / Chemical Effects: The product is flammable, and heating may generate vapors which may form explosive vapor/air mixtures. OSHA Regulatory Status: This product is hazardous according to OSHA 29CFR 1910.1200. Environment: The product components are not classified as environmentally hazardous. However, this does not exclude the possibility that large or frequent spills can have a harmful or damaging effect on the environment. 3 COMPOSITION / INFORMATION ON INGREDIENTS General Information: The product contains: Organic solvent. Chemical Name CAS-No. Concentration* 67-63-0 30-60% 111-42-2 0-1% * All concentrations are percent by weight unless ingredient is a gas. Gas concentrations are in percent by volume. This chemical is hazardous according to OSHA criteria. 4 FIRST AID MEASURES General: Thermal burns: Flush with water immediately. While flushing, remove clothes which do not adhere to affected area. Call an ambulance. Continue flushing during transport to hospital. Inhalation: Move to fresh air. Get medical attention if any discomfort continues. Eye Contact: Immediately flush with plenty of water for at least 15 minutes. If easy to do, remove contact lenses. Get medical attention. Skin Contact: Wash skin with soap and water. Get medical attention if irritation persists after washing. Ingestion: Rinse mouth thoroughly. Get medical attention if any discomfort continues. 5 FIRE-FIGHTING MEASURES Extinguishing Media: Extinguish with foam, carbon dioxide, dry powder or water fog. Unsuitable Extinguishing Media: Not applicable. Special Fire Fighting Procedures: Use standard firefighting procedures and consider the hazards of other involved materials. Unusual Fire & Explosion Hazards: During fire, gases hazardous to health may be formed. Solvent vapors may form explosive mixtures with air. Hazardous Combustion Products: Carbon Dioxide, Carbon Monoxide Protective Measures: Selection of respiratory protection for fire fighting: follow the general fire precautions indicated in the workplace. US MSDS 2 / 8
Flammability Class: NFPA Rating Fire = 3. Liquids and solids that can be ignited under almost all ambient temperature conditions. 6 ACCIDENTAL RELEASE MEASURES Personal Precautions: Extinguish all ignition sources. Avoid sparks, flames, heat and smoking. Ventilate. Avoid inhalation of vapors and contact with skin and eyes. Wear suitable protective clothing. See Section 8 of the MSDS for Personal Protective Equipment. Spill Cleanup Methods: Smaller quantities of residue may be collected by an absorbent. For waste disposal, see section 13 of the MSDS. Environmental Precautions: Avoid discharge into drains, water courses or onto the ground. Notification Procedures: Inform authorities if large amounts are involved. 7 HANDLING AND STORAGE Handling: Avoid inhalation of vapors and contact with skin and eyes. The product is flammable, and heating may generate vapors which may form explosive vapor/air mixtures. Ground container and transfer equipment to eliminate static electric sparks. Wear approved safety goggles. Wear protective gloves and appropriate clothing to prevent skin contact. See Section 8 of the MSDS for Personal Protective Equipment. Observe good industrial hygiene practices. Storage: Follow rules for flammable liquids. Store in closed original container in a dry place. Keep away from heat, sparks and open flame. Keep away from food, drink and animal feedingstuffs. Store away from incompatible materials. 8 EXPOSURE CONTROLS / PERSONAL PROTECTION Exposure Limits: Chemical Name Source Type Exposure Limits Notes US. ACGIH TLV STEL 400 ppm US. ACGIH TLV TWA 200 ppm US. NIOSH Guide IDLH 2000 ppm US. OSHA Z-1 PEL TWA 980 mg/m³ 400 ppm US. ACGIH TLV TWA 2 mg/m³ Skin Engineering Controls: Provide adequate ventilation. Observe Occupational Exposure Limits and minimize the risk of inhalation of vapors. Provide easy access to water supply or an emergency shower. Use explosion-proof ventilation equipment. Respiratory Protection: If engineering controls do not maintain airborne concentrations below recommended exposure limits (where applicable) or to an acceptable level (in countries where exposure limits have not been established), an approved respirator must be worn. In the United States of America, if respirators are used, a program should be instituted to assure compliance with OSHA Standard 63 FR 1152, January 8, 1998. Seek advice from local supervisor. US MSDS 3 / 8
Eye Protection: Wear approved safety goggles. Hand Protection: Wear protective gloves. Be aware that the liquid may penetrate the gloves. Frequent change is advisable. Suitable gloves can be recommended by the glove supplier. Skin Protection: Wear suitable protective clothing. Hygiene Measures: Always observe good personal hygiene measures, such as washing after handling the material and before eating, drinking, and/or smoking. Routinely wash work clothing and protective equipment to remove contaminants. 9 PHYSICAL AND CHEMICAL PROPERTIES Color: No data available. Odor: No data available. Odor Threshold: No data available. Physical State: Liquid ph: No data available Melting Point: No data available. Freezing Point: No data available. Boiling Point: No data available. Flash Point: No data available. Evaporation Rate: No data available. Flammability Limit - Upper (%): No data available. Flammability Limit - Lower (%): No data available. Vapor Pressure: No data available. Vapor Density (Air=1): No data available. Specific Gravity: No data available. Solubility in Water: Miscible with water. Solubility (Other): No data available. Partition Coefficient (n-octanol/water): No data available. Autoignition Temperature: No data available. Decomposition Temperature: No data available. Viscosity: No data available. 10 STABILITY AND REACTIVITY Stability: This product is stable under expected conditions of use. Conditions to Avoid: Heat, sparks, flames. Incompatible Materials: Strong oxidizing agents. Strong bases. Hazardous Decomposition Products: At Elevated Temperatures: Carbon Dioxide, Carbon Monoxide 11 TOXICOLOGICAL INFORMATION Specified Substance(s) US MSDS 4 / 8
Acute Toxicity: Chemical Name Test Results Dermal LD50 (Rabbit): 7640 ul/kg Inhalation LC50 (Rat): 200 ppm Oral LD50 (Rat): 620 ul/kg Dermal LD50 (Rabbit): 12800 mg/kg Inhalation LC50 (8 hour(s), Rat): 16000 ppm (v) Oral LD50 (Rat): 5045 mg/kg Listed Carcinogens: Chemical Name IARC NTP OSHA ACGIH Not Listed Not Listed Not Listed A4 3 Not Listed Not Listed Not Listed IARC: 1 = Carcinogenic to Humans; 2A = Probably Carcinogenic to Humans; 2B = Possibly Carcinogenic to Humans; 3 = Not classifiable as to carcinogenicity to humans; 4 = Probably not carcinogenic to humans; Not listed = Not evaluated by IARC. ACGIH: A1 = Confirmed Human Carcinogen; A2 = Suspected Human Carcinogen; A3 = Confirmed Animal Carcinogen; A4 = Not classifiable as a human carcinogen; A5 = Not suspected to be a human carcinogen; Not listed = Not evaluated by ACGIH. Product Information Acute Toxicity: Test Results: No test data available for the product. Other Acute: Causes eye irritation. May cause central nervous system effects. Chronic Toxicity: Prolonged skin contact may cause dermatitis. May cause central nervous system effects. 12 ECOLOGICAL INFORMATION Ecotoxicity: The product components are not classified as environmentally hazardous. However, this does not exclude the possibility that large or frequent spills can have a harmful or damaging effect on the environment. Specified Substance(s) Chemical Name Test EC50 (24 hour(s), Daphnia): 5102 mg/l LC50 (96 hour(s), Oryzia latipes): 9640 mg/l EC50 (48 hour(s), Daphnia magna): 55 mg/l LC50 (96 hour(s), Fish): 600 mg/l Mobility: The product is water soluble and may spread in water systems. The product contains organic solvents which will evaporate easily from all surfaces. Persistence and Degradability: No data available. Bioaccumulation Potential: No data available. Other Adverse Effects: No data available. 13 DISPOSAL CONSIDERATIONS US MSDS 5 / 8
General Information: Dispose of waste and residues in accordance with local authority requirements. Disposal Methods: No specific disposal method required. Container: Since emptied containers retain product residue, follow label warnings even after container is emptied. 14 TRANSPORT INFORMATION DOT UN No.: UN1993 Proper Shipping Name: Flammable liquids, n.o.s. () Class: 3 Packing Group: III Label(s): 3 IATA UN No.: UN1993 Proper Shipping Name: Flammable liquid, n.o.s. () Class: 3 Packing Group: III Label(s): 3 IMDG UN No.: UN1993 Proper Shipping Name: Flammable liquid, n.o.s. () Class: 3 Packing Group: III EmS No.: F-E, S-E 15 REGULATORY INFORMATION Inventory Status: US TSCA inventory Status: All the components of this substance are listed on or are exempt from the inventory. For purposes of 40 CFR 720.36, this product is for Research and Development (R&D) Use Only. US Regulations CERCLA Hazardous Substance List (40 CFR 302.4): Chemical Name RQ 100 lbs SARA Title III Section 302 Extremely Hazardous Substances (40 CFR 355, Appendix A): Not regulated. Section 311/312 (40 CFR 370): X Acute (Immediate) X Chronic (Delayed) X Fire Reactive Pressure Generating Section 313 Toxic Release Inventory (40 CFR 372): Chemical Name CAS-No. Reporting threshold Reporting threshold US MSDS 6 / 8
for other users for manufacturing and processing 67-63-0 10000 lbs 25000 lbs For reporting purposes: the De Minimis Concentration for a toxic chemical in a mixture is 0.1% for carcinogens as defined in 29 CFR 1910.1200(d)(4) or 1% for others. Clean Air Act (CAA) Section 112(r) Accidental Release Prevention (40 CFR 68.130): Not regulated. Clean Water Act Section 311 Hazardous Substances (40 CFR 117.3): Not regulated. Drug Enforcement Act: Not regulated. TSCA TSCA Section 4(a) Final Test Rules & Testing Consent Orders: Not regulated. TSCA Section 5(a)(2) Final Significant New Use Rules (SNURs) (40CFR 721, Subpt. E): Not regulated. TSCA Section 5(e) PMN-Substance Consent Orders: Not regulated. TSCA Section 12(b) Export Notification (40 CFR 707, Subpt. D): Not regulated. State Regulations California Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65): Not regulated. Massachusetts Right-To-Know List: Michigan Critical Materials List (Michigan Natural Resources and Environmental Protection Act (Act. 451 of 1994)): Not regulated. Minnesota Hazardous Substances List: New Jersey Right-To-Know List: Pennsylvania Right-To-Know List: ; Rhode Island Right-To-Know List: 16 OTHER INFORMATION HAZARD RATINGS Health Hazard Fire Hazard Instability Special Hazard NFPA 2 2 0 -- Hazard rating: 0 - Minimal; 1 - Slight; 2 - Moderate; 3 - Serious; 4 - Severe NFPA Label colored diamond code: Blue - Health; Red - Flammability; Yellow - Instability; White - Special Hazards US MSDS 7 / 8
Health Hazard Flammability Physical Hazard Personal Protection HMIS 2* 2 0 G Hazard rating: 0 - Minimal; 1 - Slight; 2 - Moderate; 3 - Serious; 4 - Severe *- Chronic Health Effect Personal Protection codes: G - Safety Glasses, Gloves, Vapor Respirator HMIS Label colored bar code: Blue - Health; Red - Flammability; Orange - Physical Hazards; White - Special Issue Date: Supercedes Date: SDS No.: 1018625 Disclaimer: This MSDS has been prepared using information from sources considered technically reliable. It should not be relied upon as a product specification. The company makes no warranty of any kind, express or implied, concerning the safe use of this material in your process or in combination with other chemical substances. Every user of the product is responsible for evaluating its own processes and conditions of use and selecting appropriate protective measures for employee exposure. US MSDS 8 / 8