Intelligent exfoliation
Chemical Peel 5 th Most popular non-surgical procedure in the world 44% increase of cosmetic peel launches since 2013 Alpha hydroxyacids (AHA) are the most used active ingredient in formulations Source: International Society of Aesthetic Plastic Surgery (ISAPS), 2016. / Mintel GNPD.
Traditional AHAs Main ingredients: Glycolic, malic, citric, lactic, mandelic and tartaric acids Controlled therapeutic peeling that promotes: Whitening Increased cellular turn over Stimulation of MEC Rejuvenation Pain, redness, irritation, sensitization and desquamation
Intelligent biological exfoliator and wrinkle filler, composed by carbohydrates and alpha-hydroxy acids Synergistic combination of the glycerin extracts from Cajá, Mango and Banana pulp INCI: Water (and) Glycerin (and) Spondias Mombim Pulp Extract (and) Mangifera Indica (Mango) Pulp Extract (and) Musa Sapientum (Banana) Pulp Extract.
Cajá Rich in vitamins A, B1, B2, C, calcium, iron and phosphorus Astringent and emetic properties Mango Banana Rich in ascorbic acid, carotenoids and polyphenols Anti-oxidant activity Rich in fructose, flavonoids and AHA as malic acid Anti-oxidant properties * compositions as described in scientific literature
Mechanism of action Epidermis Transglutaminase Key enzyme for formation of the cornified envelope Reduces resistance of the stratum corneum Cornified envelope cross-linked protein structure of the corneocytes
Mechanism of action Epidermis Claudin-I Essential protein of the tight junctions Improves the barrier effect of viable layers Protein complex
Mechanism of action Epidermis Flaking corneocytes Cell renewal Basal layer of the epidermis Accelerates the desquamation younger-looking skin Basal keratinocyte
Mechanism of action Dermis Pro-collagen Collagen type 1 Elastin Redensification Firmness Elasticity
Mechanism of action Subcutaneous tissue SREBP-1 Stimulation of lipogenesis NEFA Local fat accumulation Skin filling SREBP-1 sterol regulatory element binding proteins NEFA non-esterified fatty acids
In vitro Keratolytic effect and protection of the lower layers of the skin Human keratinocytes treated with 0.04% Exfo-Bio and incubated for 48 h % in relation to control -14% Transglutaminase Claudin-I 65%
Ex vivo Protection of the lower layers of the skin Human skin fragments treated with Exfo-Bio and incubated for 6 hours Control 0.04% Exfo-Bio claudin-i nucleus Increased cell adhesion in layers just below the stratum corneum
Ex vivo Keratolytic effect and cell renewal Human skin fragments treated with 3% Exfo-Bio and incubated for 72 hours Control Placebo 3% Exfo-Bio increase of 16% In relation to placebo Ki-67 Nucleus Stimulation of cell renewal and desquamation of the stratum corneum
Ex vivo Keratolytic effectand cell renewal Human skin fragments treated with Exfo-Bio and incubated for 6 hours Control 0,04% Exfo-Bio Increase the number of cells in epidermis
Gene expression in relation to control Exfo-Bio In vitro Skin firmness Human fibroblasts treated with Exfo-Bio and incubated for 48 hours 10,00 8,00 6,00 4,00 2,00 4,4 Pro-collagen 5,3 7,6 0,00 0,01% 0,02% 0,04%
Elastin Collagen type I Exfo-Bio Ex vivo Wrinkle filling and skin firmness Fragments of human skin treated with 3% Exfo-Bio and incubated for 72 hours Control Placebo 3% Exfo-Bio 175% * 62% * *in relation to placebo
Gene expression in relation to control % in relation to control Exfo-Bio In vitro Wrinkle filling Human adipocytes treated with Exfo-Bio and incubated for 48 hours 2,00 1,60 SREBP-1 1,6 1,6 1,7 Quantification of free fatty acids NEFA 0 0,01% 0,02% 0,04% 30% 1,20 0,80 0,40 0,00 0,01% 0,02% 0,04% -10-20 -30-40 -8,5-18,0-30,3 SREBP-1 sterol regulatory element binding proteins NEFA non-esterified fatty acids
In vivo Clinical efficacy Panel 35 volunteers from 35 until 55 years old Phototypes I to IV With signs of aging and wrinkles Application Face 2x a day For 28 days 3% of Exfo-Bio Evaluation From volunteers From dermatologist
In vivo Dermatologist evaluation (Improvement) Luminosity 24% Smothness 14% Moisturization 10% Eye wrinkles Firmness 7% 7% Fine wrinkles Skin whitening 3% 4%
In vivo Volunteer evaluation (Improvement) Smothness 94% Moisturization Wrinkles and expression lines Luminosity Tone and firmness 87% 84% 84% 81% Eye wrinkles 75% Skin whitening 69% Filling 63%
Benefits Gentle peeling through biological exfoliation Keratolytic effect/intelligent biological exfoliation when removing superficial dead cells and protecting the lower layers of the epidermis Increase of cell renewal in 16% Wrinkle-filling effect: stimulus of lipogenesis in up to 30% and extracellular matrix synthesis: collagen type 1 by 175% and elastin by 62% Improvement of the general characteristics of cutaneous micro-relief Younger skin, 94% softer, 84% more luminous and 81% firmer
Application Cream, gel, gel-cream and serum for mild exfoliation Stability and Compatibility Stable at ph 5-7 It can be heated up to 50ºC Water soluble Concentration of Use 1.0-5.0%
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