ALGISIUM. Skin restructuration anti-wrinkle MoiSturizer Body firming

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Skin restructuration anti-wrinkle oisturizer Body firing

the original silanol SILIcIU for SkIn restructuration Applications licium is an essential component of the skin. Indeed, by interacting with structure and elastic proteins within the dermis such as collagen fibers, elastin and proteoglycans, the silicium insures optimal skin organization and architecture. furthermore, many studies show that silicium is capable of stimulating skin cell metabolism for enhanced cell proliferation and activity e.g. collagen production, contraction ability ). However, with age the amount of silicium naturally present in the skin tends to decrease. As a result, an overall collapse of the skin architecture will happen, which will in turn induce skin metabolism slow down, inevitably leading to wrinkles. With the silanol technology, we replenish the natural pool of silicium hence allowing a complete skin restructuration for global benefits at all levels. Time lanol Wrinkles organic licium lanols is a family of compounds where all members share the same core of organic silicium. However, this silicium is prone to polymerization that will lead to a loss of activity. It is therefore mandatory to stabilize this organic silicium core in order to ensure an optimal activity. The silanol technology relies on exchangeable molecules to stabilize the organic silicium core and, with each different molecule chosen to stabilize this core, we have a different, more specialized silanol. the SILAnoL technology Organic silicium core IncI name: ETHYLSILAnOL AnnUROnATE Algisium, the original silanol StAbilizAtiOn Skin benefits is the father of the silanol family. Its organic silicium core is stabilized with alginic acid that has virtually no cosmetic benefits. All of s benefits therefore come from the organic silicium core only. Organic silicium core Increases skin cell proliferation Stimulates collagen production Improves cell communication Preserves skin hydration Stimulates lipolysis Prevents inflammation Prevents glycation. Protects skin cells from free radicals C H I N A I A N T C O P L A few specialized silanols Because all silanols have the same core of organic silicium, they also have all the benefits it provides. However, depending on which molecule the silicium core is stabilized with, we can have additional and specific benefits. AntI-AGInG Hyaluronic acid SoothInG - AntI InfLAAtIon Salicylic acid SLIInG SpeCiAlizAtiOn Cafeine Detailed scientific files are available on demand for each of these benefits. cosmetic applications Face care Body care EPIDEROSIL for strong anti-aging benefits in all skin compartments D.S.B. c for anti-aging benefits coupled with strong soothing benefits cafeisilane for anti-aging benefits coupled with strong slimming benefits Anti-aging Anti-wrinkle Eye contour. Hydration Anti-cellulite Slimming firming. Hydration

Skin restructuration for global benefits Skin restructuration for global benefits Because of aging, keratinocytes have a lower proliferation rate that slowly leads to an thinning and eventually weakens skin protection and reduce skin hydration because of an increased trans water loss. epideris better protection improves the number of proliferative keratinocytes in bright green) in human reconstructed. That leads to a thickening of the for a skin that will be better protected and better hydrated. better hydration Keratinocyte proliferation Keratinocyteproliferation ofof) ) Within the, Algisium improves keratinocyte proliferation Algisium restores cell communication 13 13 2 12 12 11 11 9 9 OSC Control eq. eq.algiu Keratinocytes have the ability to support fibroblast proliferation by secreting cytokines that will go from the through the DEJ and into the dermis where fibroblasts are located. With age, this cross-communication decreases and keratinocytes lose this ability to support fibroblast proliferation. That leads to a generalized impairment of skin architecture. better cohesion is capable of improving collagen VII in green) expression, one of the key constituent of the DEJ in human skin explants. This leads to an improved skin cohesion and skin cell communication. better cell communication 13 13 2 12 12 stimulates keratinocyte s ability to support fibroblast proliferation and therefore restores an optimal cell communication for global benefits. 11 11 9 9 OSC Control eq. eq.algiu Fibroblast proliferation Fibroblast proliferation ofof) ) The dermal epidermal junction DEJ) is the interface between both skin compartments. It is responsible for skin cohesion. With age, the DEJ becomes thinner and can be duplicated, hence leading to a loss of cohesion and a decreased cell communication. Collagen Vii proliferation expression Keratinocyte ofof) ) Within the DEJ, Algisium improves skin cohesion Within the dermis, Algisium improves collagen production Improved firmness improved elasticity Filled wrinkles Fibroblast number of ) DeRiS stimulates fibroblast number and activity. In the dermis, there will be more fibroblasts and each one of them will produce more collagen. This strong collagen booster effect leads to a firmer and more elastic skin. Wrinkles are filled and erased. Improved firmness Reduced cellulite leaner body stimulates adipocite ability to get rid of the fat by improving lipolysis. A treatment with improves three folds the amount of fat released by adipocytes. cellulite is strongly reduced, skin is firmer and eye bags are reduced. 15 5 ls cel ) ISIU ISIU ed S Ag fc ALG 1) ALG.1). 3 2 8 41 15 15 6 5 5 e d U IU ) lonne ) gegde s ISISIU SIIU ) GII S.5 G 1 ts alos)fcs a a occyytetse LG lassts ac ALLG 1) AL ) n o i b A A t atin ro la f1 1 1.5 kkeerra fibbrob1 i 165 6 F 4 2 ls ells cel dc ) SIU ung fcs) Age fcs LGI ) o Y A 2.5 2 1 Algisium improves skin architecture 3 3 released Fat excretion ) ofof) HYpODeRiS 15 Within the hypodermis, Algisium improves lipolysis With age, there are more and more adipocytes fat storing cells). This causes a fat accumulation leading for example to cellulite on the body and eye bags on the face. 96 2 Collagen production of ) With age, all metabolisms tend to slow down. In the dermis this results in a lower proliferation rate and a lower activity of fibroblasts.there are too few collagen fibers and the skin is flaccid and wrinkled. 93 2 2 163 2 2 sls ceelll ) ngc CSS) ouung ffc Y Yo 11 ISUIU ) GIGSI 3 ALAL3) Because of aging, the whole skin architecture is altered, and this is especially true within the dermis as the thick dark collagen bundles ) observed in a younger skin completely vanish. Because of the silicium ability to stimulate fibroblast combined with its affinity for collagen fibers, a treatment with leads to a complete reorganization of skin fibers for strong and long lasting rejuvenation effect. Aged TS Young Aged Aged OSc eq. 4 )

clinical tests: global benefits technical characteristics Global benefits for face care Realized under dermatological, this test was performed on 35 women aged 32 to 6. All volunteers received a facial treatment with twice a day for 28 days. benefits for and at all ages C H I N A I A N T C O P L Thanks to s restructuration properties, global benefits were observed for all skin parameters after only 14 days. The benefits achieved are even higher by the end of the treatment at 28 days. oisturizationimprovement ) 3 25 2 15 1 5 n s y e D14 D28 t Softness Luminosity Radiance General aspect At different age, different problems arise. Thanks to s global benefits, specific problems to all skin type is treated and solved. ature skin 5) Deep wrinkles Adult skin 4) Expression lines Young skin 3) Skin tone Before After AnALytIcAL coposition PhySIco-cheIcAL characteristics PreSerVAtIVeS onomethylsilanetriol.3 Including organic SILIcIU.9 annuronic acid.6 Water and preservative sqf) Limpid and colorless liquid. ph 5.. Density at 2 C 1.. iscible with water, alcohol and glycol. not miscible in oil. Different preservative systems are available in order to fit with your requirements. Please contact us for additional details about the available versions. Slimming and firming for body care fast and long lasting hydration tolerance And toxicity StUdIeS is perfectly tolerated. Tolerance and toxicity studies were performed using both in vitro cell culture and reconstructed ) and in vivo human volunteers) methods. Realized under dermatological, this test was performed on 1 women aged 25 to 35. All volunteers received a treatment with for ten weeks. Impressive slimming and firming benefits were observed by the end of the treatment. Ten volunteers aged 28 to 52 received a treatment with 6) and we measured skin hydration only minutes after a treatment. A dramatic improvement of skin hydration with a strong long lasting effect was measured. forulation Advised doses: 3 to 6. is not temperature sensitive. formula ph: 4 to 7. is not compatible with high concentrations of calcium salts, alcohol and glycols. cirtometry cm) -1-2 -3-4 -5 Waist Hip Thigh Knee -3.5-4.4-1.7 Placebo -.6 corneometry unit 9 8 7 6 5 2 after 2h Placebo 6) 37 after 6h 2 3 4 AVAILAbILItIeS is available in 5, 3 kg drums and 1 ton container IBc). Time min)

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