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(ENG) http://www.youtube.com/watch?v=niee2xju2yk#t=37 (ITA) https://www.youtube.com/watch?v=piqksa3zyqm

Mission and Network Istituto Italiano di Tecnologia is a Foundation that promotes excellence in fundamental and applied research, develops higher education in the area of science and technology and fosters the evolution of industry towards the forefront areas of technological innovation. Genova Central Research Lab 32.000 sqm, fully equipped, one of the largest single-site labs in Europe Machine Learning @ MIT Nanotech for brain @ Harvard Fondazione Istituto Italiano di Tecnologia 2

Scientific Plan Aimed at maximizing cross fertilization between disciplines, the scientific plan addresses some of the main trends that will impact the planet in the next decades, namely demographic shift, quality of life, and resource scarcity. To do so, scientific activity revolves around Robotics & Mechatronics, Neuroscience and Smart/Green Materials. Fondazione Istituto Italiano di Tecnologia 3

Governance Executive Committee Gabriele Galateri (Presidente), Roberto Cingolani (Direttore Scientifico), Giuseppe Pericu, Francesca Pasinelli, Alberto Sangiovanni Vincentelli. Scientific Committee Giorgio Margaritondo (EPFL, Switzerland) Chairman Lia Addadi (Weizmann Institute, Israel) Patrick Aebischer (EPFL, Switzerland) Adriano Aguzzi (University Hospital Zürich, Switzerland) Yasuhiko Arakawa (Tokyo University, Japan) Uri Banin (Hebrew University, Israel) Emilio Bizzi (MIT, USA) Martin Chalfie (Columbia University, USA) Kenji Doya (Okinawa Inst. of Science, Japan) Takeo Kanade (Carnegie Mellon University, USA) Oussama Khatib (Stanford University, USA) Arto Nurmikko (Brown University, USA) Michele Parrinello (ETH, Switzerland) Jean-Jeacques Slotine (MIT, USA) Board of Trustees Vittorio Grilli (Chairman) Fulvio Conti Adrienne Corboud Fumagalli Pietro Guindani Umberto Malesci Mauro Moretti Francesco Profumo Alberto Quadrio Curzio Giuseppe Recchi Lucrezia Reichlin Carlo Rosa Francesco Starace Vittorio Terzi Elena Zambon Gian Felice Rocca* Giuseppe Vita* * honorary members Fondazione Istituto Italiano di Tecnologia 4

People Headcount = 1400 Countries of origin 59% 41% Degree distribution MEDICINAL CHEMISTRY 2% BIOTECH 5% BIOCHEMISTRY 1% BIOLOGY 11% HUMANISTIC 10% PSYCHOLOGY 2% CHEMISTRY 12% PHYSICS 13% PHILOSOPHY 0,4% ENGINEERING 30% MATH 1% INDUSTRIAL DESIGN 0,2% IT 6% MATERIAL SCIENCE 1% MD 1% PHARMACOLOGY 1% 70 60 50 40 30 20 10 0 PhD * PostDoc * Team leader * Age (scientists) Average age 34 y Sen+Dir * 20 22 24 26 28 30 32 34 36 38 40 42 44 46 48 50 52 54 56 58 60 62 64 66 68 70 Fondazione Istituto Italiano di Tecnologia 5

Ranking Based on SCOPUS bibliometry referred to the 2006-2010 period, the SIR 2012 rankings confirm IIT positioning among the world s excellence of scientific research, evaluating the Foundation performance in the same range of the long established top institutions of the world. IIT % EXC High tech Caltech MIT Stanford Weizmann EPFL GaTech % EXC = % of works of an institution belonging to the top 10% most cited papers. % Q1 % Q1 = Ratio of publications that an institution publishes in the most influential scholarly journals of the world ANVUR Evaluation Agency of the Italian Ministry of Education and Research, ranked IIT no. 1 among the research institutions in Italy in its categories Fondazione Istituto Italiano di Tecnologia 6

Efficacia della ricerca Field-Weighted Citation Impact è un indice che registra il N di citazioni ricevute dalle pubblicazioni di un centro di ricerca in rapporto al numero medio di citazioni ricevute dalle pubblicazioni fatte quel settore da tutti i centri di ricerca del mondo (rif. www.scival.com). 3,00 Field-Weighted Citation Impact (SciVal/Scopus 2014) 2,50 2,00 1,50 1,00 IIT (average 2.06) MIT (average 2.45) EPFL (average 2.11) WEIZ (average 2.13) CNR (average 1.46) 0,50 0,00 2009 2010 2011 2012 2013 2014 Fondazione Istituto Italiano di Tecnologia 7

Performance Evaluation and Funding PERFORMANCE MONITORING: 1. Individual evaluation, on a yearly base, referred to assigned targets (Management by Objectives 20% of gross wage) 2. Departmental evaluation, every three years. Panel made of Chairman and selected members of Scientific Committee, plus international independent experts 3. Global evaluation: Evaluation Committee (external scientists and managers) FUNDING: M IIT is a Private Foundation, funded by the Italian Government, with annual budget of 95 million, and jointly supervised by the Italian Ministry of Finance and Ministry of Education In addition, IIT competes on international level for additional funding Funding on a competitive base from EU, National and International institutions and Industry Fondazione Istituto Italiano di Tecnologia 8

From Lab to Market RESEARCH INVENTION PATENT Proof of Principle Prototype Scale to industry std. Deliver to Market Select topic Write researc h report Determine research questions Validate Findings Design study Generate findings Collect data Analyze data The process is iterative and recursive; the driver of this phase is to capitalize on findings and know-how; These initial phases are dominated by research labs, normally without a market-oriented approach The idea is ready to be verified. A forecast of the target market and application must be provided; These phases are equally developed by researches and industry people, who become more and more relevant as the idea proceeds The work is focused on realizing a suitable prototype to be tested and prepared for the target market; Often times a set of additional patents can derive in connection with the introduction of an invention in a production cycle; In these phase the market players are the ones who take the lead. Product test; compliancy, security/safety; Market test and cost-return evaluation; Go/no-go for the launch The idea is out of the lab and begins its way to the market. Fondazione Istituto Italiano di Tecnologia 9

From Lab to Market RESEARCH effort / involvement RESEARCH INVENTION PATENT Proof of Principle Prototype Scale to industry std. Deliver to Market Select topic Write researc h report Determine research questions Validate Findings Design study Generate findings Collect data Analyze data The process is iterative and recursive; the driver of this phase is to capitalize on findings and know-how; These initial phases are dominated by research labs, normally without a market-oriented approach INDUSTRY effort / involvement The idea is ready to be verified. A forecast of the target market and application must be provided; These phases are equally developed by researches and industry people, who become more and more relevant as the idea proceeds The work is focused on realizing a suitable prototype to be tested and prepared for the target market; Often times a set of additional patents can derive in connection with the introduction of an invention in a production cycle; In these phase the market players are the ones who take the lead. Product test; compliancy, security/safety; Market test and cost-return evaluation; Go/no-go for the launch The idea is out of the lab and begins its way to the market. Fondazione Istituto Italiano di Tecnologia 10

Fondazione Istituto Italiano di Tecnologia 11 2008 2009 2010 2011 2012 2013 2014 2015 A dedicated team and over 1,0M invested in patent protection in 2015, looking into a growing trend. 11 18 23 33 40 62 65 109 98 162 122 146 173 been established. technology transfer. To this purpose, a dedicated Patent Office has IP protection is one key activity of IIT, being the starting point for 400 350 300 250 200 150 100 50 0 INVENTIONS PATENTS ACTIVE PORTFOLIO 234 298 361 Technology Transfer is part of the mission of IIT, and is realized through Feasibility studies and applied technology project developed together with industry players Joint Labs between IIT and Corporations/Firms Licensing of IIT technologies, based on know-how or patented technologies Creation of technology-based spin-off companies TT in practice

Spin Off s Name Topic 3Brain Med-Tech & Drug Discovery: HW & SW platform for in vitro response Circle Garage Robotics and ICT: wearable sensors network HiQ-Nano Smart Materials: High quality nano particles production Name Topic Biki Tech Drug Discovery: SW platform to design new drugs icub Robotics: intelligent interactive robotic solutions Rehab Tech Robotics and Healtcare: rehabilitation robotics CompAct Robotics: workforce support solutions Micro-turbine Clean Energy Harvesting: micro converter from fluid to electric power SEM+ Robotics and ICT: flexible tactile sensors Dual Cam Computer Vision: combined audio and video camera Ribes Technologies Energy and Smart Materials: roll-to-roll printed polymeric solar cells Optogenix Smart Materials & Neuroscience: production of patented probes for brain stimulation Artificial Retina Neuroscience and Smart Materials: biocompatible polymeric implant to repair blind retina vibe Computer Vision: customer behaviour analysis technology. Politronica Smart materials: nano-structured inks for printed electronics qbrobotics Robotics: robotic modules to be assembled Fondazione Istituto Italiano di Tecnologia 12

Research Fondazione Istituto Italiano di Tecnologia 13

Humanoid Robotic assistant www.icub.org http://www.youtube.com/ watch?v=zctwo2dpx8a http://www.youtube.com/ watch?v=ergfgf0uwuo http://www.youtube.com/ watch?v=jatebcsfp_m Fondazione Istituto Italiano di Tecnologia 14

sale price: 250K 28 robots distributed since 2008 about 3-4 icub s/year Fondazione Istituto Italiano di Tecnologia 15

Rehabilitation Robotics The INAIL-IIT joint lab is focused on developing robotic solutions for people rehabilitation https://youtu.be/zyrlst-xtec Developing active robotic prosthesis to allow amputees recovering a large portion of their movements, thus improving the quality of life and work Fondazione Istituto Italiano di Tecnologia 16

Coman and HyQ CoMan is a robotic platform focused on compliant behavior. It develops of a new set of mechanic joints and actuators, along with control logic to mimic humans HyQ is a robotic platform focused hydraulic actuation and a quadruped morphology. Torque and force control allow the robot deal with various situations, making it suitable for operations in hostile environment. http://www.youtube.com/watch?v=anwetzprtfe http://www.youtube.com/ watch?v=oxbyzxa25vc Fondazione Istituto Italiano di Tecnologia 17

DualCam: Seeing the Sound A real-time audio&video image provides enhanced information and timely automated response to observed events. https://www.youtube.com/wat ch?v=7lxsufflhkk Fondazione Istituto Italiano di Tecnologia 18

Smart Materials Combination of nanoparticles and polymers allows to change material properties A simple sponge becomes an OIL-WATER separator By treating the sponge surface with appropriate nanoparticles, the sponge absorbs oil (blue drop) dispersed in water, leaving the latter clean, on top of the hydrophobic surface Fondazione Istituto Italiano di Tecnologia 19

Paper treatments & encapsulation methods Fondazione Istituto Italiano di Tecnologia 20

Special wettability treatments Glass substrate response to water drops WCA ~ 60 Acrylic coating on glass: self cleaning effect and enhanced surface properties WCA ~ 60 Fondazione Istituto Italiano di Tecnologia 21

Green Plastic from vegetable waste Most of the plastics we use today are made up of non-degrading petroleum based resources. Lack of degradability and the closing of landfill sites as well as growing water and land pollution problems have led to serious global concern about plastics. Processed vegetables and cereals produce large amounts of waste rich in cellulose all over the world. Such waste was directly transformed into green plastics. From vegetable waste (e.g. cocoa) To Plastic with tunable mechanical properties COCOA RICE Softness of the paper after the treatment PARSLEY SPINACH Fondazione Istituto Italiano di Tecnologia 22

Corn Parsley Spinach Potatoes Tomato skin Fondazione Istituto Italiano di Tecnologia 23

Energy Harvesting Photocromatic polymers for window integrated solar cells Fondazione Istituto Italiano di Tecnologia 24

Ribes Tech film fotovoltaici mission is to become the leader suppliers of flexible, large scale, printed electronics, enabling the penetration of active parts in everyday objects (IOT). Electrode Interlayer Photoactiv Interl e layer Electr ayer ode PET 0.2 mm New low cost, highly adaptable energy sources Innovative organic photovoltaic cells Traditional printing processes Fondazione Istituto Italiano di Tecnologia 25

Micro Turbine This Spin-Off Company develops energy converters based on a microscale traditional turbine used in the energy industry Suitable application are energy production in remote infrastructure, converting fluid flows into electric power (SMART GRID, battery recharging, stand-alone energy back-up, ) AWARDS Fondazione Istituto Italiano di Tecnologia 26

Micro Energy Harvesting An artificial hair cell obtained by self-bending of a strained multilayer may be used as sensor or energy harvester in several applications: flow/pressure sensing in liquids and any fluid, hydrophones, prosthetics, scanning probes, biochemical sensing in liquids (water, oil, wine ) Artificial Hair Cells for flow sensing in AUV The readout system is both based on a m-strain gage, integrating a Wheatstone bridge, and/or a piezoelectric approach. The fabricated MEMS are water-proof by virtue of a conformal parylene coating and fabrication process allows for large scale production. Piezo MEMS based on aluminum nitride on Kapton substrates for energy harvesting applications Fondazione Istituto Italiano di Tecnologia 27

Your portable microscope mission is to provide everyone with the tools to explore the micro-world, through a family of innovative products in the field of microscopy, consumer electronics and micro-optics. Fondazione Istituto Italiano di Tecnologia 28

Nanochemistry labs Fondazione Istituto Italiano di Tecnologia 29

Fondazione Istituto Italiano di Tecnologia 30 50 nm 8 12 16 20 24 28 t(s) 20 25 T(C) 30 35 40 45 50 Amphiphilic polymer coated dimers Before Hyperthermia After Hyperthermia Magnetic Nanoparticles for Biomedical Applications

Nanodiagnostic for POC diagnostic Hybrid nano-sensors, combining nanomaterials with organic sensing elements, allow simplified detection (up to naked-eye), suitable for point-of-care diagnostics Fondazione Istituto Italiano di Tecnologia 31

In-vitro library of human tissue Bronchial Epithelium Cardiac Tissue Cardiac micro-muscle stroma Cancer Cells Cervix s epithelium Intestinal Villus: NUTRACEUTICS GUT Fondazione Istituto Italiano di Tecnologia 32

Graphene, the marvelous material Strongest Material 100 times tensile strength of steel - Young s modulus = 1 Tpa - Tensile strength = 80 Gpa Record Electronic Properties 60% higher conducibility than silver and copper; 1 million times the current density of copper - e - mobility 200 000 cm 2 /V s - Bulk resistivity = 10-6 Ωcm -1 Highest Thermal Conductivity 5 times that of copper, better than diamond - Thermal conductivity = 5000 W/mK Highest Surface Area Superior to active carbon - 2630 m 2 g -1 Optically Transparent Completely impermeable Fondazione Istituto Italiano di Tecnologia 33

On demand production Producing Graphene inks Fondazione Istituto Italiano di Tecnologia 34

mission is to conceive and create revolutionary materials to further improve everyday objects. DEVELOP SOLUTIONS Creare ricette per modificare i materiali convenzionali tramite introduzione di materiali 2D conferendogli caratteristiche uniche e innovative. PROVIDE MATERIALS Materiali 2D di altissima qualità e compositi contenenti materiali 2D. Produce high quality graphene and 2D crystals Create new composites New performance in manufacturing PA12 ABS EPS Fondazione Istituto Italiano di Tecnologia 35

Salvatore Majorana Istituto Italiano di Tecnologia Director of Technology Transfer Via Morego, 30 16163 Genova t: +39 010 71781 m: +39 366 6869345 salvatore.majorana@iit.it www.iit.it