Material Safety Data Sheet NFPA HMIS Personal Protective Equipment 2 Health Hazard Fire Hazard 2 0 See Section 5. Section. Chemical Product and Company Identification Common Name/ Trade Name Manufacturer Commercial Name(s) Synonym Chemical Name Ketamine Hydrochloride SPECTRUM CHEMICAL MFG. CORP. 4422 S. SAN PEDRO STREET GARDENA, CA 90248 [2-(2-Chlorophenyl)-2-(methylamino)-cyclohexanone Hydrochloride] Ketamine Hydrochloride Catalog Number(s). CAS# RTECS TSCA CI# K068 867-66-9 GW400000 IN CASE OF EMERGENCY CHEMTREC (24hr) 800-424-9300 Page Number: TSCA 8(b) inventory: No products were found. Chemical Family Chemical Formula Supplier C3-H6-Cl-N-O. HCL SPECTRUM CHEMICAL MFG. CORP. 4422 S. SAN PEDRO STREET GARDENA, CA 90248 CALL (30) 56-8000 Section 2.Composition and Information on Ingredients Name CAS # Exposure Limits TWA (mg/m 3 ) STEL (mg/m 3 ) CEIL (mg/m 3 ) % by Weight ) Ketamine Hydrochloride 867-66-9 00 Toxicological Data on Ingredients Ketamine Hydrochloride: ORAL (LD50): Acute: 447 mg/kg [Rat]. 67 mg/kg [Mouse]. Section 3. Hazards Identification Potential Acute Health Effects Potential Chronic Health Effects Hazardous in case of skin contact (irritant, sensitizer), of eye contact (irritant), of ingestion, of inhalation (lung irritant). CARCINOGENIC EFFECTS: MUTAGENIC EFFECTS: TERATOGENIC EFFECTS: DEVELOPMENTAL TOXICITY: Classified Development toxin [POSSIBLE]. The substance is toxic to lungs, peripheral nervous system, cardiovascular system, upper respiratory tract. Repeated or prolonged exposure to the substance can produce target organs damage.
Ketamine Hydrochloride Page Number: 2 Section 4. First Aid Measures Eye Contact Skin Contact Serious Skin Contact Inhalation Check for and remove any contact lenses. Immediately flush eyes with running water for at least 5 minutes, keeping eyelids open. Cold water may be used. Do not use an eye ointment. Seek medical attention. After contact with skin, wash immediately with plenty of water. Gently and thoroughly wash the contaminated skin with running water and non-abrasive soap. Be particularly careful to clean folds, crevices, creases and groin. Cover the irritated skin with an emollient. If irritation persists, seek medical attention. Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate medical attention. Allow the victim to rest in a well ventilated area. Seek immediate medical attention. Serious Inhalation Ingestion Serious Ingestion Do not induce vomiting. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the toxic material was ingested; the absence of such signs, however, is not conclusive. Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek immediate medical attention. Section 5. Fire and Explosion Data Flammability of the Product Auto-Ignition Temperature Flash Points Flammable Limits Products of Combustion Fire Hazards in Presence of Various Substances Non-flammable. These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), halogenated compounds. Flammable in presence of open flames and sparks, of heat. Explosion Hazards in Presence of Various Substances Risks of explosion of the product in presence of mechanical impact: Risks of explosion of the product in presence of static discharge: Fire Fighting Media and Instructions Fire Hazards Explosion Hazards SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet. Section 6. Accidental Release Measures Small Spill Large Spill Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system.
Ketamine Hydrochloride Page Number: 3 Section 7. Handling and Storage Precautions Storage Keep locked up Do not ingest. Do not breathe gas/fumes/ vapour/spray. Wear suitable protective clothing In case of insufficient ventilation, wear suitable respiratory equipment If ingested, seek medical advice immediately and show the container or the label. Keep container tightly closed and in a well-ventilated place. Avoid contact with skin and eyes Carcinogenic, teratogenic or mutagenic materials should be stored in a separate locked safety storage cabinet or room. Section 8. Exposure Controls/Personal Protection Engineering Controls No special ventilation requirements. Personal Protection Personal Protection in Case of a Large Spill Exposure Limits Splash goggles. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Section 9. Physical and Chemical Properties Physical state and appearance Odor Molecular Weight ph (% soln/water) 274.2 g/mole Taste Color Colorless. Boiling Point Melting Point 262.5 C (504.5 F) Critical Temperature Specific Gravity Vapor Pressure Vapor Density Volatility Odor Threshold Water/Oil Dist. Coeff. Ionicity (in Water) Dispersion Properties Solubility Partially dispersed in hot water. Very slightly dispersed in cold water, methanol. Partially soluble in hot water. Very slightly soluble in cold water, methanol, n-octanol. Section 0. Stability and Data Stability Instability Temperature Conditions of Instability Incompatibility with various substances Corrosivity The product is stable. Slightly reactive to reactive with oxidizing agents. Non-corrosive in presence of glass.
Ketamine Hydrochloride Page Number: 4 Corrosivity Polymerization No. Section. Toxicological Information Routes of Entry Toxicity to Animals Chronic Effects on Humans Other Toxic Effects on Humans Toxicity to Animals Chronic Effects on Humans other Toxic Effects on Humans Absorbed through skin. Dermal contact. Eye contact. Inhalation. Ingestion. Acute oral toxicity (LD50): 447 mg/kg [Rat]. DEVELOPMENTAL TOXICITY: Classified Development toxin [POSSIBLE]. The substance is toxic to lungs, peripheral nervous system, cardiovascular system, upper respiratory tract. Hazardous in case of skin contact (irritant, sensitizer), of ingestion, of inhalation (lung irritant). Section 2. Ecological Information Ecotoxicity BOD5 and COD Products of Biodegradation Toxicity of the Products of Biodegradation the Products of Biodegradation Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise. The products of degradation are as toxic as the product itself. Section 3. Disposal Considerations Waste Disposal Section 4. Transport Information DOT Classification Identification Not a DOT controlled material (United States). Special Provisions for Transport DOT
Ketamine Hydrochloride Page Number: 5 Section 5. Other Regulatory Information and Pictograms Federal and State Regulations TSCA 8(b) inventory: No products were found. California Proposition 65 Warnings Other Regulations OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 90.200). Other Classifications WHMIS (Canada) DSCL (EEC) CLASS D-B: Material causing immediate and serious toxic effects (TOXIC). CLASS D-2A: Material causing other toxic effects (VERY TOXIC). R22- Harmful if swallowed. R36/37/38- Irritating to eyes, respiratory system and skin. R40- Possible risks of irreversible effects. HMIS (U.S.A.) Health Hazard Fire Hazard Personal Protection 2 0 h National Fire Protection Association (U.S.A.) Health 2 Flammability Specific hazard WHMIS (Canada) DSCL (Europe) TDG (Canada) ADR (Europe) Protective Equipment Gloves. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator when ventilation is inadequate.
Ketamine Hydrochloride Page Number: 6 Splash goggles. Section 6. Other Information MSDS Code References Other Special Considerations K3300 Validated by Sonia Owen on 8//2006. Verified by Sonia Owen. Printed 9/2/2006. CALL (30) 56-8000 Notice to Reader All chemicals may pose unknown hazards and should be used with caution. This Material Safety Data Sheet (MSDS) applies only to the material as packaged. If this product is combined with other materials, deteriorates, or becomes contaminated, it may pose hazards not mentioned in this MSDS. It shall be the user's responsibility to develop proper methods of handling and personal protection based on the actual conditions of use. While this MSDS is based on technical data judged to be reliable, Spectrum Quality Products, Inc. assumes no responsibility for the completeness or accuracy of the information contained herein.