Product Information Hair care: dermofeel P-30

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Product Information Hair care: Product features: - Natural hair- and skin-conditioner - Lowers combing forces of wet hair - Skin barrier protecting - Readily biodegradable - 100% naturally derived

The product: is able to adhere to the hair s cuticle and to take the place of the lipid layer that has been weakened by hair styling treatments and environmental stress. Like classical conditioning agents, it reduces the combing forces of wet hair. Additionally, it provides a conditioning effect on the skin where a refatting and protecting film is formed. Therefore, this is a natural alternative for the typical quaternised conditioning agents to develop well performing hair and skin care products. Characteristics - INCI: PCA Glyceryl Oleate - Appearance: Clear, amber-colored viscous liquid - 100% naturally derived, already ECOCERT/COSMOS approved and compliant with other standards for natural cosmetic, please contact us for further information - Readily biodegradable - Surfactant-like structure with amide group which gets a cationic character below ph 5,5 Hair care properties: - Mild conditioning agent - For shampoos, conditioners, and leave-on-products - Combing force reduction - Anti-static effect - No build up Skin care properties: - Refatting, skin barrier protecting - Film forming properties - Improves skin compatibility - For all kinds of skin cleansing products - Viscosity regulating - Improves foam characteristics - ph range: < 7,0 recommended ph for hair care: 4 5,5 Dosage Product Concept Dosage Shampoo/Leave in conditioner 0,5 1,0 % Rinse off hair treatments Max. 2,0 % Skin cleansing products 0,5 2 %

How to work with Manufacturing procedure (laboratory scale) for Surfactant based products: 1. Mix with concentrated surfactant phase and stir until completely dissolved. 2. Add remaining aqueous phase at the end of the process. 3. Note for viscosity adjustment: may have a thickening effect. 4. For best performance adjust ph to below 5,5. Hot or cold processing possible. Emulsions: Add to the oil phase and proceed as usual. Aqueous based concepts: has surface active properties as well as a lipophilic character. 1. Mix and other lipophilic substances with solubilizer, e.g. symbio solv XC or symbio solv clear. 2. Add water to this mixture. 3. If needed, add ethanol at the end. 4. Adjust ph to below 5,5. Formulation advice Boost efficacy Compatibility Combine with other natural conditioning agents (e.g. natural betain, lecithin, inulin, hydrolyzed wheat proteins, dermofeel sensolv). Adjust to recommended ph < 5,5. Robust to all kinds of ingredients. Incompatibility Alkaline medium (max ph 7). Application Ideas Perfectly suitable for for all leave on and rinse off hair care as well as skin cleansing products. For more formulation ideas visit us at: http://www.dr-straetmans.de/en/service/formulary.php

TEWL [g/m²] Proof of Performance Comparison of natural shampoos containing different hair conditioning agents Combing force reduction 10% 5% 0% -5% -10% -15% -20% -25% -30% -35% -40% 7% (measured on wet hair) 2% -5% -6% -34% -26% A: Natural cream shampoo (market product) B: Natural Shampoo (market product) C: Shampoo with quaternised Guar D: Shampoo with nat. betain E: Shampoo with hydrolyzed wheat protein F. Shampoo with dermofeel P-30 (0,5%) Samples A and B (certified natural shampoos) show a poor conditionig performance. Sample C (natural shampoo containing Guar Hydroxypropyl Trimonium Chloride) shows a reduction of combing forces. Samples D and E show poor conditioning performance. Sample F contains and provides a comparable combing force reduction than quarternised Guar in a natural shampoo base. TEWL values of skin after treatment with shower gel formulation 30 29,85 25 Skin barrier protection 20 15 10 10,41 9,93 9,91 13,41 8,4 16,33 Skin regeneration 9,45 8,73 5 0 untreated skin shower gel (placebo) shower gel with 1% dermofeel P-30 t0 = 10 min after washing t1 = 1h after washing t2 = 2h after washing The figure shows a series of transepidermal water loss (TEWL) measurements after standardised washing procedures on inside of the elbow with shower gel formulations (n=4). The addition of to the tested shower gel formulation lowers the increase of the TEWL caused by the washing procedure. It furthermore supports the skin regeneration.

Dermofeel_P-30_2015-01 Trade Information International Approval* Packaging Shelf life (stored in original container) EU, USA, Canada, China, Japan. 18 kg 36 months * Information is based on our best knowledge and reviewed for the most requested regions only. We recommend to check current regulatory requirements in individual target countries. For more information contact our regulatory department or refer to our regulatory status statement. For further information contact our Dr. Straetmans sales team: sales@dr-straetmans.de or your local representative.

Dr. Straetmans Worldwide Network http://www.dr-straetmans.de/en/company/distributors_abroad.php Disclaimer: The information above is believed to be accurate and represents the best information currently available to us. Dr. Straetmans makes no warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own determination on the suitability of the information for their particular purposes. In no way shall Dr. Straetmans be liable for any claims, losses, damages, lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising from the sale or use of this material. Dr. Straetmans GmbH Merkurring 90 D-22143 Hamburg Phone: +49 (0)40-669 356-0 Fax: +49 (0)40-669 356-310 email: info@dr-straetmans.de