Antiaging Treatments Natalia Jiménez. Hospital Universitario Ramón y Cajal Grupo de Dermatología Pedro Jaén
Background A statistically significant increase in the epidermis and papillary dermis thickness was seen after PRGF treatment (p < 0.001). Skin thickening was observed in all patients studied, being more intense in the group of patients with photodamage (p < 0.001). Intradermal PRGF infiltration appears to be an effective treatment for the photodamaged skin.
Endoret gel 100% Autologous and bioactive, stimulates the production of hyaluronic acid and collagen. Attenuates moderate wrinkles immediately, integrating itself in the tissues more naturally. Autologous filler
Clinical cases Clinical prospective study 10 patients Women, 50-65 years old 1 session of Endoret gel Clinical images, ultrasound examination, patient satisfaction, clinical improvement and side effects were registered.
Case 1-3D Images Periorbital wrinkles pre-treat. treatment 1 month 2 months 4 months
Results 10 patients, women 60,6 years Phototype: II: 60%, III: 40% 4 months follow-up Patient satisfaction (from -3 to +3): +2,6 Investigator improvement scale (from -3 to +3): +2,5 Adverse events were not reported. 2 cases: bruising. Dermal thickness improvement(average): 0 26 mm (periorbital), 0 29 mm (peribucal)
Daily clinical practice Combination with fractional laser (after Endoret gel) Other corporal areas: neck, neckline, hands, arms Good results in atrophic scars (acne, post steroid injections )
Daily clinical practice Good results in atrophic scars (acne, post steroid injections )
Conclusions 100% autologous treatment Safe; side effects risk: low Allows wrinkle reduction and facial volume reposition with natural results. Improves skin quality Trimestral treatment protocol More studies are needed (long term results)
Extra virgin olive oil Introduction Extra virgin olive oil contains an elevated concentrations of antioxidants (biophenols, vitamine E, squalene ). Recent publications: benefits in wound healing, areolar nursing dermatitis and radiodermitis prevention. Objectives: to determine the potential benefit on antiaging of extra virgin olive oil (Oleum +) topical treatment.
Extra virgin olive oil Materials and methods: Prospective, single-blind, patient-controlled, randomized study in 10 volunteers with mild to moderate skin photoaging on the back of their hands. Efficacy assessments: skin biopsy (pre/post treatment) and photographs (Reveal system; Canfield)
Conclusions Safety: excellent tolerance; no adverse events. Clinical improvement: 70% improvement; 30%: no changes were observed. Histology Increase in dermal thickness: 80% Increase in elastic fibers: 80% Increase in Langerhans cells: 90% (sunprotection effect?) Clinical and histologic data: extra virgin olive oil can be an effective and safe treatment against skin aging.
Objective Mechanism of action of cosmetic products is not often studied. The aim of this study: to determine the histological, immunohistochemical, and clinical changes of a new cosmetic formulation: IFC-CAF, WGC, and RetinSphere
Results. After treatment, a 26.3% improvement on epidermal thickness was detected and a significant increase on collagens I and III, elastin, and fibronectin fibers was achieved (pp < 0.05). A significant clinical improvement on the treated hand was obtained, compared to control hand.
Introduction Cutaneous changes linked to photoaging are currently treated with physical treatments, such as fractional laser, which may induce epidermal alteration. Objetive: To determine the efficacy and safety of a regenerative serum (Matricium", Laboratoire Bioderma, France) after laser procedure.
Results A superior quality of epidermal regeneration on the treated side compared to the placebo side. Superior and faster clinical improvement on static wrinkles on the hemiface on which the regenerative serum was used. After 60 days, a moderate to significant improvement of the skin on the treated side and a mild to moderate improvement on the placebo side was observed. Histological examinations: showed a superior thickness of epidermis and higher cellular proliferation rate (Ki67 markers) as well as a superior thickness of dermis with higher increase in elastin density with the regenerative serum compared to placebo.