L A N O L I N LANOLIN NATURE S ORIGINAL SKIN PROTECTION

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L A N O L I N A ND I TS D E RIVATI V ES T he N atu r al Cho i ce www.lanolin.de LANOLIN NATURE S ORIGINAL SKIN PROTECTION

OUTLINE NK Ingredients Singapore Lanolin and what it does Product range and how to use Lanolin Summary 14.11.2017 2

QUALITY THROUGHOUT Singapore Production Plant Most modern integrated lanolin, lanolin derivatives and cholesterol plant in the world Highest Purity Lowest pesticide level possible (below 0.2 ppm) Ultrarefined grade with free alcohol content below 3% (hypoallergenic) Low Peroxide Value reduced allergenic potential All natural No addition of stabilisers (BHT) necessary, still 2 year shelf live COSMOS and Natrue Without stabilisers (COSMOS certified). Hypoallergenic lanolin available. Lowest residual pesticide content. 14.11.2017 3

AT A GLANCE Specialised distributor for Lanolin and Derivatives Wealth of experience and knowledge Committed to highest level of quality Long-term and reliable partner Since 1968 Eichendorffstr. 37 D-60320 Frankfurt am Main Phone: +49 (0)69 561035 Fax: +49 (0)69 8518 www.lanolin.de info@lanolin.de 14.11.2017 4

OUR CERTIFICATES 14.11.2017 5

OUTLINE NK Ingredients Singapore Lanolin and what it does Product range and how to use Lanolin Summary 14.11.2017 6

WHAT IS LANOLIN? Lanolin is a semi-solid wax of sterols and aliphatic alcohols with medium- to long-chain fatty acids. Emollient - Emulsifier - Ointment Base 100% natural and renewable Proven over thousands of years Efficient Functional Safe Versatile 14.11.2017 7

THE SKIN BARRIER Source: https://www.otsuka.co.jp/en/health_illness/skin/01_mechanism.html Three layers of moisture protection in the Stratum corneum: Sebaceous lipids Extracellular lipids Natural Moisturizing Factor (NMF) 14.11.2017 8

LIPID COMPOSITION STRATUM CORNEUM Lipid type Sebaceous lipids Extracellular lipids Function Triglycerides 41.0% 16.5% Store and provide energy Wax ester* 25.0% Fatty acids* 16.4% 10.0% 15.0% Squalene 12.0% Moisturising and barrier function Moisturising and barrier function Moisturising and barrier function Cholesteryl ester* Cholesterol* 2.1% 1.4% 24.0% Moisturising and barrier function Ceramides 40.0% 50.0% Phospholipids 30.0% Skin protection and moisturisation Maintain metabolism and health Adapted from: Cui, L. et al. (2016). Advancements in the maintenance of skin barrier/skin lipid composition and the involvement of metabolic enzymes. Journal of Cosmetic Dermatology, 15(4), 549 558. *Found in Lanolin 14.11.2017 9

MODE OF ACTION 1. Lanolin penetrates throughout the entire Stratum corneum. Lanolin 2. Lanolin located in intercellular space forms spontaneously w/o emulsion with water. 3. Lanolin can penetrate to the interior of corneocytes. 4. Lanolin can become incorporated in the intercellular lipid bilayers. 14.11.2017 10

MODE OF ACTION 1. Lanolin penetrates throughout the entire Stratum corneum. Water 2. Lanolin located in intercellular space forms spontaneously w/o emulsion with water. 3. Lanolin can penetrate to the interior of corneocytes. 4. Lanolin can become incorporated in the intercellular lipid bilayers. 14.11.2017 11

MODE OF ACTION 1. Lanolin penetrates throughout the entire Stratum corneum. 2. Lanolin located in intercellular space forms spontaneously w/o emulsion with water. 3. Lanolin can penetrate to the interior of corneocytes. 4. Lanolin can become incorporated in the intercellular lipid bilayers. 14.11.2017 12

LANOLIN IN TOPICAL FORMULATIONS Lanolin is the ideal moisturizing lipid Similar composition to physiological skin lipids Increases water by binding it and not by occlusion Penetrates to Stratum granulosum* 32% reduction in transepithelial water loss* Almost 40% reduction in skin roughness in just 1 hour.** Functional W/O emulsifier (more than 200% water absorption) Suitable vehicle for active substances Adds structure and shine to semi-solid formulations Versatile Available in liquid, semi-solid and solid form Lanolin Alcohol with improved emulsifying properties Hydrophilic and hydrophobic derivatives * Clark, E. W., & Steel, I. (1993). Investigations into biomechanisms of moisturizing function of lanolin. J. Soc. Cosmet. Chem., 44, 181 195. ** I. Steel, Lanolin and Lanolin Derivatives, in: The Lanolin Book, 1999 14.11.2017 13

OUTLINE NK Ingredients Singapore Lanolin and what it does Product range and how to use Lanolin Summary 14.11.2017 14

PRODUCT FLOW DIAGRAM 14.11.2017 15

APPLICATION EXAMPLES Application Baby Creams & Lotions Day Creams & Lotions Hair Dyes Lipsticks & Lip Balm Pharmaceutical Creams & Lotions Sunscreen Wipes Product Lanolan EP ELP/ Lanolan Wax/ Lanolan Oil LP/ Lanowax/ Isopropyl Lanolate/ Liquid Absorption Base/ Cholesterol Lanolan/ Lanolan Wax/ Lanolan Oil LP/ Lanowax/ Hydr. Lanolin/ Isopropyl Lanolate/ PEG-Lanolin/ Base SE/ LLIP Lanowax/ PEG-Lanolin/ Cholesterol Lanolan/ Lanolan Wax/ Lanolan Oil LP/ Lanowax/ Hydr. Lanolin/ Isopropyl Lanolate/ ALAC Lanolan EP ELP/ Lanowax EP/ Cholesterol EP Lanolan / Lanolan Oil LP/ Lanolan Wax/ Lanowax/ Isopropyl Lanolate/ ALAC/ Base SE/ Liquid Absorption Base/ LLIP/ Cholesterol Lanolan/ Lanolan Oil LP/ Lanowax/ PEG-Lanolin/ ALAC/ LLIP Cleansers Leather Care Rust Preventive Lanolan/ Lanolan Oil LP/ PEG-Lanolin/ Lanowax/ Hydr. Lanolin/ Isopropyl Lanolate Woolgrease Fatty Acids/ Lanolin Fatty Acids/ Lanolan EP10/ Lanolan Oil Lanolin Fatty Acids/ Woolgrease Fatty Acids/ Lanolan EP10 14.11.2017 16

BENEFITS OF LANOLIN Natural, ph-ind. Emulsifier Replacement of Mineral Oils Emollient Active Ingredients Delivery Viscosity Control Dispersing Agent, e.g. for Pigments Moisturiser Wound Healing Water Resistance Stabiliser Superfatting Agent Texturiser Shine 14.11.2017 17

PRODUCTS Lanolan EP ELP Wool Fat Ph.Eur. LANOLIN (INCI) Applications Pharmaceutical Products High quality and natural cosmetics Creams, Ointments, Lotions, etc. Baby Care Features Pharmacopeia Quality Natrue and COSMOS EDQM Certificate Without BHT (by request) Lowest pesticide content Colour max. Gardner 10 Kosher and Halal Product Function Conc. Creams & Lotions Lipsticks & Lip Balm Soaps Sunscreen Emollient/Moisturiser, Ointment Base, Texturiser Emollient/Moisturiser, Shine, Dispersing Agent Superfatting Agent, Emollient/Moisturiser Water Resistance, Emollient/ Moisturiser, Vehicle for Actives 2%/5% to 10%/20% 5%/10% to 15%/20% 2% to 10%/ 15% 1%/2% to 10%/15% 14.11.2017 18

PRODUCTS Lanolan Oil Liquid Lanolin LANOLIN OIL (INCI) Applications Baby and sunscreen oils Liquid emulsions Fluid make-up Lip gloss/ stick Features Skin caring properties of lanolin in liquid form Natrue and COSMOS Lowest pesticide content Colour max. Gardner 9 Kosher and Halal Product Function Conc. Liquid Emulsions Lip Gloss Oils (Sunscreen, Baby) Emollient/Moisturiser, Viscosity Reduction Shine/Gloss, Emollient/Moisturiser, Adhesive Water Resistance, Emollient/Moisturiser, Vehicle for Actives 2%/5% to 10%/20% 1%/5% to 15%/20% 1%/2% to 10% 14.11.2017 19

PRODUCTS Lanolan Wax Deoiled Lanolin LANOLIN CERA (INCI) Applications Hair Styling Products High Viscosity Creams/ Body Butters Lipsticks Compact Powders Features Natrue COSMOS Without BHT (by request) High Melting Point Colour max. Gardner 7 Kosher and Halal Product Function Conc. Creams & Butters Hair Styling Lipsticks Texturiser, Emollient/Moisturiser, Emulsifier Texturiser, Moisturiser, Smoothness, Shine Texturiser, Adhesive 1%/2% to 10%/15% 1% to 5%/ 20% 1%/ 2% to 10%/ 30% 14.11.2017 20

PRODUCTS Lanowax EP/Cosm. (Wool Alcohol Ph.Eur.) LANOLIN ALCOHOL (INCI) Applications Pharmaceutical Products High quality and natural cosmetics Creams, Ointments, Lotions, etc. Baby Care Features Pharmacopeia Quality NATRUE ECOCERT EDQM Certificate of Suitability Without BHT (by request) Colour max. Gardner 10 Kosher and Halal Product Function Conc. Creams & Lotions Hair Dyes Soaps Emulsifier, Texturiser, Emollient/Moisturiser Dispersing Agent, Stabiliser Superfatting Agent, Emollient/Moisturiser 0.2%/0.5% to 5%/15% 0.1% to 1%/ 5% 0.1% to 1%/ 5% 14.11.2017 21

OUTLINE NK Ingredients Singapore Lanolin and what it does Product range and how to use Lanolin Summary 14.11.2017 22

SUMMARY NK Ingredients Singapore High quality/ purity lanolin and derivatives COSMOS, Natrue and EXCiPACT Lanolin 100% natural Emollient, moisturiser, emulsifier, texturiser Derivatives Use Lanolin Oil and Wax, Lanolin Alcohol and Fatty Acids, PEG-Lanolins,... Creams, lotions, hair dyes, lipsticks, sunscreen, wipes, 14.11.2017 23

L A N O L I N A ND I TS D E RIVATI V ES T he N atu r al Cho i ce www.lanolin.de THANK YOU Eichendorffstr. 37 D-60320 Frankfurt am Main Phone: +49 (0)69 561035 Fax: +49 (0)69 8518 www.lanolin.de info@lanolin.de