Doctors Recommended Therapeutic Moisturizer for Clinics & Hospitals

Doctors Recommended Therapeutic Moisturizer for Clinics & Hospitals NEOPHARM, A GLOBAL LEADER IN SKIN SCIENCE

CONTENTS ZEROID IS ZEROID TECHNOLOGY INSIDE MLE Multi-Lamellar Emulsion Defensamide ADfence-P TM ZEROID PRODUCT RANGE SOOTHING INTENSIVE UREA+SILICONE DERMA-NEWAL PIMPROVE CLINICAL SAFETY MANUFACTURING & DISTRIBUTING

ZEROID IS Defensamide Therapeutic moisturizers for basic skin care in skin diseases Product Information Therapeutic moisturizer for basic skin care for barrier disturbed skin Especially efficacious for atopic dermatitis, sensitive skin, psoriasis and also oily & combination skin Sales Channel Exclusively sold in Hospitals, Clinics and Houses for elderly people Mainly sold by recommendation of Doctors or Nurses Products Classification Therapeutic moisturizer for skin barrier improvement: Cosmetics Adjunctive therapeutic moisturizer for skin diseases: Medical devices ll ZERO+STEROID

ZEROID TECHNOLOGY INSIDE Ceramide is a key component in stratum corneum, intercellular lipid, together with cholesterol and free fatty acid. NeoPharm s patented helps to build the Multi-Lamellar Structure of the intercellular lipid. Skin cell Natural Ceramide Exists in human skin lipid Main component of skin barrier function 50% of skin lipid Brick and Mortar model of stratum corneum by Prof. Peter M. Elias(UCSF, USA) Intercellular lipid Excellent alternatives - To build the Multi Lamellar Structure - Safe & effective Patent (*USP 6221371/ JP 4408960) Published in Journal of Investigative Dermatology (2003) Registered in REACH Origin: Synthetic INCI Name: Myristoyl/Palmitoyl Oxostearamide/Arachamide MEA Topical moisturizer with pseudoceramide (PC-9S) expresses lamellar structure similar to SC intercellular lipids. <J Invest Dermatol 2003; 121: 794-801> Topical moisturizer with lamellar structure (MLE ) has beneficial effect on AD(Atopic Dermatitis). <Ann Dermatol 2003; 15: 133-138>

ZEROID TECHNOLOGY INSIDE PSOREX LOTION MLE Multi-Lamellar Emulsion MLE, ideal solution for skin barrier recovery. It mimics the same three-dimensional structure that your skin barrier has. Skin lipid-identical lamellar structure Improves and reinforces the skin barrier Intensive and prolonged skin moisturization Skin Lipid Components Ceramide Cholesterol Free Fatty Acid MLE in ZEROID Components Cholesterol/Phytosterol Stearic Acid Without skin irritation and sensitization Ideal for dry and sensitive skin Patent - Pseudoceramides, and dermatologic external preparations containing the same: US6221371, JP4408960 - Multi-lamellar emulsion for stabilizing skin useful substance and skin care preparation thereof: TW248369, CN01116162, JP3887182 - Multi-lamellar emulsion(mle ) for stabilizing dermatologically useful ingredients and external base preparations for general skin diseases utilizing the same : EP1370241 Patent pending - Composition for skin external application : PCT/KR2013/011019

ZEROID TECHNOLOGY INSIDE PSOREX LOTION MLE Multi-Lamellar Emulsion MLE, ideal solution for skin barrier recovery. It mimics the same three-dimensional structure that your skin barrier has. ZEROID SOOTHING CREAM UNDER CROSS-POLARIZED MICROCOPE ZEROID INTENSIVE CREAM UNDER CROSS-POLARIZED MICROCOPE MLE containing ZEROID clearly showed perfect Maltese cross structure, as a representation of lamellar structure under cross-polarized microscope. MLE - Internationally acknowledged confidence

PSOREX ZEROID LOTION TECHNOLOGY INSIDE Defensamide Novel ingredient for skin barrier function. Anti-microbial peptide(amp) in human plays very important role in natural defense system. Defensamide stimulates the production of AMPs in skin, and improves and reinforces skin barrier function and defense system. Origin: Natural amino acid derivative INCI Name: Methyl Caprooyl Tyrosinate Defensamide Prevents colonization of S. aures in OXA-induced model. Number of S. aures (arrow) bound to SC was observed in biopsy samples after Gram staining. Significant increase ins. aures in SC was observed in oxazolone treated skin (b), compared with normal skin (a). Topical treatment of either desonide (topical steroid) (c) or Defensamide (d) significantly reduced the number of S. aures (e).

ZEROID TECHNOLOGY INSIDE PSOREX LOTION ADfence-P TM Focusing on the proteases / anti-proteases balance for skin s health, NeoPharm introduces a new cosmetic ingredient for comedone prevention through sebum control. It functions by inhibiting the action of the Protease-activated receptor (PAR)-2 in the skin. ADfence-P TM helps decrease the sebum formation in the skin and as a result aids in preventing comedone formation. Clinical improvements of acne related parameters by ADfence-P TM Containing Moisturizer The clinical efficacy of ADfence-P TM was evaluated using 22 subjects with facial acne. The skin conditions of the participants were recorded prior to the start of the study, then after 2 weeks into the study and finally, after 4 weeks of using 0.1% ADfence-P TM. Subjective evaluation of the efficacy of ADfence-P TM Containing Moisturizer Origin: Synthetic INCI Name: Methylbenzyl Methylbenzimidazole Piperidinylmethanone Significant improvments in the comedones and papules were observed and also a decrease in the level of sebum output was noted at the conclusion of the 4 week study.

ZEROID PRODUCT RANGE SOOTHING DERMA-NEWAL Daily skin care for Normal to Sensitive & Dry and Eczema, Psoriasis and Itchiness Ideal for skin barrier restoration Mild Care for Sensitive & Dry Skin Revitalizing skin care for After various treatment such as Laser/Peeling and Microdermabrasion Prompt skin renewal care Strong Protection after Laser/Peeling Treatment INTENSIVE PIMPROVE Daily skin care for Very Sensitive & Dry and Eczema, Psoriasis and Itchiness Perfect for skin barrier restoration Intensive Care for Severe Dry & Disordered Skin Right solution for Acne-prone skin Immediate skin improvement Excellent Anti-inflammation & Soothing Optimal Care for Oily & Combination Skin UREA+SILICONE Concentrated skin care for Dry & Cracked skin. Especially for hand, elbow and foot Strong skin softening & increasing hydration Five professional range 10SKU are available Protection & Hydration for Dry & Cracked Skin

ZEROID SOOTHING ZEROID Foaming Cleanser is a gentle foam type cleanser without alcohol, perfume, and preservatives to minimize irritation from disordered skins such as dry, sensitive, and atopic skin. It is no needs to use a hand towel or a bath sponge to make bubbles. It provides rich bubble by itself. Just use hands with the foam. It is allowed to reduce the skin irritations caused by the towel or bath sponge for the sensitive and disordered skin. In addition, it helps to adjust skin to physiological ph 5.5. The hygienic formula of ZEROID Foaming Cleanser washes and soothers the skins suffered from bacteria, so your skin looks and feels it s healthy best. ZEROID Foaming Cleanser 240ml Recommended Retail Price US$24.00 Non Drying / PH Balanced / No Volatile Alcohols or Dyes / Fragrance Free / Paraben Free Hypoallergenic Directions : Make foams on your hands and massage the face, the body or the scalp smoothly. Then, rinse thoroughly with water.

ZEROID SOOTHING ZEROID Soothing Lotion 200ml & Cream 80ml ZEROID Intensive Lotion & Cream provide prompt moisturizing and prolonged moisturization on your skin with enriched (Myristoyl/palmitoyl oxostearamide/arachamide MEA) and squalene. It is very effective for the care of severely dried and disordered skin conditions that are not easily curable by ordinary moisturizers. ZEROID Soothing Lotion 200ml Recommended Retail Price US$30.00 ZEROID Soothing Cream 80ml Recommended Retail Price US$27.00 No Perfume, Colorant, Ethanol and Preservative Hypoallergenic ZEROID soothing Lotion & Cream are skin barrier repair moisturizer with patented MLE formula for the daily care of dry & sensitive and disordered skin conditions. With an intercellular lipid lamellar structure, it gives prompt and effective protection and restores the skin barrier function. Also, it helps to adjust skin to physiological ph 5.5. Defensamide (Methyl caprooyl tryosinate), the unique soothing ingredient of NeoPharm, relieves the inflammatory symptoms from skin disorders. Directions : Apply several times onto dry, sensitive, or disordered skin daily or as needed. MLE Defensamide

ZEROID INTENSIVE 50% more Active Ingredients than ZEROID Soothing Lotion & Cream ZEROID Intensive Lotion 200ml & Cream 80ml ZEROID Intensive Lotion & Cream provide prompt moisturizing and prolonged moisturization on your skin with enriched (Myristoyl/palmitoyl oxostearamide/arachamide MEA) and squalene. It is very effective for the care of severely dried and disordered skin conditions that are not easily curable by ordinary moisturizers. ZEROID Intensive Lotion 200ml Recommended Retail Price US$36.00 ZEROID Intensive Cream 80ml Recommended Retail Price US$30.00 No Perfume, Colorant, Ethanol and Preservative Hypoallergenic MLE Defensamide ZEROID Intensive Lotion & Cream are skin barrier repair moisturizer with patented MLE formula for the daily care of dry & sensitive and disordered skin conditions. With an intercellular lipid lamellar structure, it gives prompt and effective protection and restores the skin barrier function. Also, it helps to adjust skin to physiological ph 5.5. Enriched Defensamide (Methyl caprooyl tyrosinate), the unique soothing ingredient of NeoPharm, relieves the inflammatory symptoms of skin disorders effectively by increasing AMPs(antimicrobial peptides) expression in skin. Moreover, it accelerates skin barrier recovery. Directions : Apply several times onto the dry or disordered skin daily or as needed.

ZEROID UREA+SILICONE ZEROID Urea 5% Silicone Cream 70ml ZEROID Urea 5% Silicone Cream 70ml is suitable for the very dry and cracked skin. This kinds of skin lacks skin s own moisturizing factors: over 50% less urea-content than in normal skin. Also, the skin barrier function is disturbed by a reduced formation of lipids, especially ceramide. Urea, a component of urine, widely used in cosmetics, has good water-binding and exfoliating functions but also can cause inflammation when used larger concentration. Mixed formulation of urea and silicone minimize the side effects of urea only formulation. Also Silicone has a great silky texture with effective keratin care and long-lasting moisturizing functions. ZEROID Urea 5% Silicone Cream 70ml Recommended Retail Price US$32.00 No Colorant, Ethanol, PEG, Mineral Oil and Paraben Hypoallergenic MLE Defensamide Urea 5% +Silicone The unique formulation of MLE with silicone supports the skin barrier function tightly and makes the skin silky smooth and urea absorbs moisture in the skin. The combination of special ingredients including Defensamide (Methyl caprooyl tryosinate) supports the normalization of the malfunctioning skin barrier and helps improve the skin s protective role. The ph value of 5.5 supports the barrier function of your skin to safeguard against the penetration of harmful environmental influences. As an added benefit, this cream contains no colorant, ethanol, mineral oil, PEG and paraben. Directions : Apply several times onto the dry or irritated skin such as hand, elbow and body daily or as needed. For the best results, continue to use even after skin has returned to its normal appearance to help maintain a healthy condition.

ZEROID DERMA-NEWAL ZEROID Derma-Newal Cream 40ml ZEROID Derma-Newal Cream 40ml contains a trio of unique ingredients, Dexphantenol(5%), Niacinamide(1%) and Defensamide (0.1%).This special blend of ingredients quickly calms irritation, relieves itching and soothes hot, reddened skin that is a result of various harsh treatments. This cream is ideal for hypersensitive skin. It is particularly effective and soothing for skin that has experienced laser/peeling or microdermabrasion treatments ZEROID Derma-Newal Cream 40ml Recommended Retail Price US$40.00 No Colorant, Ethanol, PEG and Paraben Dermatologist-tested Hypoallergenic MLE Defensamide 7-Active Ingredients This cream also helps encourage the skin s natural revitalizing process with Centella Asiatica Extract, Palmitoyl pentapeptide-4, Tocopheryl acetate and Tocotrienols which are known as super antioxidants. Moreover, the Defensamide (Methyl caprooyl tryosinate) helps strengthen the skin s natural defense system and MLE helps restore the skin s protective moisture barrier system. As an added benefit, this soothing, calming cream contains no dyes, volatile alcohols, PEG or paraben. Perfect for use on hypersensitive skin since all of the most common irritants have been eliminated. Directions : Apply to affected areas several times daily follow with either ZEROID Soothing Cream or ZEROID Intensive Cream for the better results. Can be used as often as needed. For the best results, continue to use even after skin has returned to its normal appearance to help maintain a healthy condition.

ZEROID DERMA-NEWAL ZEROID Derma-Newal Sun Block SPF50+ PA+++ 50ml This sun-block cream is suitable for sensitive or disordered skin from laser/peeling of microdermabrasion treatments. Treated with ZEROID Derma-Newal Cream 40ml & ZEROID Derma-Newal Sun Block SPF50+ PA+++ 50ml after IPL ZEROID Derma-Newal Sun Block SPF50+ PA+++ 50ml Recommended Retail Price US$32.00 No Perfume, Colorant, Mineral Oil, Talc and Paraben Dermatologist-tested Hypoallergenic MLE Defensamide All year-round usable for daily sun protection and outdoor activities. Unique ingredients of patented MLE & Defensamide (Methyl caprooyl tryosinate) powerfully helps soothe and revitalize the skin with Zinc Oxide, Phytosterols, Centella Asiatica Extract. As an added benefit, this sun-block cream contains no perfume, colorant, mineral oil, talc and paraben. Directions : All year-round. Apply evenly on the face, neck, and arms to be exposed to sunlight at the end of the skincare routine, as a make-up base, before going out side. Avoid eye area. In case of contact with eyes, rinse them immediately and thoroughly. This sun-block cream is ideal for hypersensitive skin. It is particularly effective and soothing for skin that has experienced laser/peeling or microdermabrasion treatments

ZEROID PIMPROVE ZEROID PIMPROVE Gel Cleanser 180ml is a gentle subacid gel type cleanser without Perfume, Colorant, Ethanol, Paraben, Phenoxyethanol, Mineral Oil, PG & PEG, Sulfate and Soap to minimize irritation from disordered skins such as sensitive, oily and combination skin. ZEROID PIMPROVE Gel Cleanser helps adjust skin to physiological ph 5.5 and its mild texture refreshes the face while efficient yet soothing ingredients lift and remove dirt, makeup, pollutants, and excess oils with natural surfactants ZEROID PIMPROVE Gel Cleanser 180ml Recommended Retail Price US$28.00 No Perfume, Colorant, Ethanol, Paraben, Phenoxyethanol, Mineral Oil, PG & PEG, Sulfate and Soap Non comedogenic-tested Hypoallergenic While Zinc PCA and Isopropyl methylphenol helps sooth skin trouble to return well balanced skin, Sodium lactate/sodium gluconate, D-panthenol and Ceramide(Myristoyl/palmitoyl oxostearamide/arachamide MEA) keeps long lasting moisturization. Directions : Make foams on your hands and massage face or the needed area. Then, rinse thoroughly with warm water.

ZEROID PIMPROVE ZEROID PIMPROVE Cream 60ml Recommended Retail Price US$30.00 No Perfume, Colorant, Ethanol, Paraben, Phenoxyethanol, Mineral Oil, PG & PEG, Diethanolamine and Benzyl Alcohol Non comedogenic-tested Hypoallergenic MLE Defensamide ADfence-P TM After 4 weeks Whitehead 31.6% Blackhead 13.8% Papules 38.3% Decreased ZEROID PIMPROVE Cream 60ml This dermotropic moisturizing cream for oily and combination skin quickly absorbed into skin without stickiness. Formulated without Perfume, Colorant, Ethanol, Paraben, Phenoxyethanol, Mineral Oil, PG & PEG, Diethanoloamine and Benzyl Alcohol to minimize chance of possible irritations to very sensitive skin. Zinc gluconate and ADfence-P TM (Methylbenzyl Methylbenzimidazole Piperidinylmethanone), a novel ingredient for comedone prevention through sebum control by inhibiting the action of Protease-activated receptor (PAR)-2 in the skin, help decrease the sebum formation and sooth troubled skin. While Patented MLE formula with an intercellular lipid lamellar structure gives prompt and effective protection and restores the skin barrier function, Defensamide (Methyl caprooyl tyrosinate) relieves the inflammatory symptoms of skin disorders effectively by increasing AMPs(antimicrobial peptides) expression in skin and accelerates skin barrier recovery as well. Directions : Apply to affected areas several times daily as needed. For the best results, continue to use even after skin has returned to its normal appearance to help maintain a healthy condition.

ZEROID CLINICAL SAFETY ALL PRODUCTS OF ZEROID PASSED SAFETY TESTS ZEROID FOAMING CLEANSER 50 HUMAN SUBJECT REPEATED INSULT PATCH TEST ZEROID SOOTHING LOTION 50 HUMAN SUBJECT REPEATED INSULT PATCH TEST ZEROID SOOTHING CREAM 50 HUMAN SUBJECT REPEATED INSULT PATCH TEST ZEROID INTENSIVE LOTION 50 HUMAN SUBJECT REPEATED INSULT PATCH TEST ZEROID INTENSIVE CREAM 50 HUMAN SUBJECT REPEATED INSULT PATCH TEST ZEROID UREA 5% SILICONE CREAM 50 HUMAN SUBJECT REPEATED INSULT PATCH TEST ZEROID DERMA-NEWAL CREAM 50 HUMAN SUBJECT REPEATED INSULT PATCH TEST ZEROID DERMA-NEWAL SUN BLOCK SPF50+ PA+++ 50 HUMAN SUBJECT REPEATED INSULT PATCH TEST COMEDOGENIC POTENTIAL ON HUMAN SUBJECTS ZEROID PIMPROVE GEL CLEANSER 50 HUMAN SUBJECT REPEATED INSULT PATCH TEST COMEDOGENIC POTENTIAL ON HUMAN SUBJECTS ZEROID PIMPROVE CREAM 50 HUMAN SUBJECT REPEATED INSULT PATCH TEST COMEDOGENIC POTENTIAL ON HUMAN SUBJECTS

ZEROID MANUFACTURING Therapeutic moisturizers for basic skin care in skin diseases is manufactured at NeoPharm under certified GMP conditions NeoPharm GMP site Location: Techno 2-ro,Yuseong-gu, Daejeon, Korea Established in 2008 Total area: 4,988m2 Products: Cosmetics, Pharmaceuticals, Medical Devices Certificates: ISO 9001 ISO 14001 Cosmetics GMP: ISO 22716 Pharmaceutical KGMP Pharmaceutical cgmp

ZEROID DISTRIBUTING Distribution of ZEROID Distribution channel focused on Department of Dermatology or Department of Pediatrics in University Hospitals Several General hospitals and major local clinics in main cities in Korea Exporting over 6 countries LITHUANIA RUSSIA JORDAN KOREA MALAYSIA SINGAPORE AUSTRALIA

CONFIDENTIAL AND PROPRIETARY INFORMATION UNDER LICENSE FROM NEOPHARM CO., LTD. THANK YOU contact overseas business department Daniel Lee daniel.lee@neopharmus.com Hayoung Shon hayoung@neopharmus.com Seul Lee ls@neopharmus.com www.neopharmus.com +82 70 7547 4750 Therapeutic moisturizers for basic skin care in skin diseases NEOPHARM, A GLOBAL LEADER IN SKIN SCIENCE