RELAUNCH NEW FORMULA WITH PLANT STEM CELLS NEW DESIGN

RELAUNCH NEW FORMULA WITH PLANT STEM CELLS NEW DESIGN

50% are women 80% are men THE MOST COMMON PROBLEM: A research managed by an Italian group of Trichology has demonstrated that many people have hair loss problems:

Customers are looking for more developed products with guaranteed and tested effectiveness. An important market and in expansion. It is not by chance that the market of hair loss treatments is growing and becoming increasingly important in terms of value. It s 30% of hair treatments

Main CAUSES: Hormone unbalance (pregnancy, menopause) Causes linked to nutrition (lack of certain vitamins and minerals) Stress Disease or prolonged treatment with drugs Aggressive treatments (bleaching, excessive brushing) Age In women is manifested by a homogeneous thinning, while in men is concentrated in specific areas such as temples and neck.

Hair Science

Analysis of hair follicle hair follicle or root shaft Follicle is one of the most complex and specialized structure and needs big quantity of energy and an effective protective working of its cell activity. In particular, its activity is regulated by the dermal papilla and by extra cell matrix, fundamental for the building of new hair and to regulate growing cycle.

Life cycle Hair life is scanned by 3 precise cycles: Anagen(hair growth phase 70-85%). Hair grows per 2-6 years. Catagen(transition phase 1-2% of hair growing). Hair bulb divides the follicle from the dermal papilla, the follicle runs to the scalp and remains in this phase per 2-3 weeks. Telogen(rest phase -100 days). Hair remains anchored to the follicle, falls out to be substituted by new hair.

Hair wealth in a healthy individual A healthy individual has ± 100 000 hair follicles Each follicle is able to give life to many hair during the life time (±25 cycles) 25 cycles x 5 years(medium time of anagenphase) 125 years of guaranteed hair wealth

Hair wealth in an individual subject to alopecia Alopecia causes an alteration of the growth cycleof the follicle, that become shorter. hairis not able to reach normal length and thickness, becomes even more thin and delay the regrowth leaving the follicle empty. more is the number of empty follicles, hair depletes. Hair wealth consumes more rapidly

Altered Cycle NORMAL CYCLE ALTERATED CYCLE LOSS LOSS ANCHORING MINIATURIZATION FOLLICLE

Whydoeshair fallout? 3 important mechanisms can condition and alter the hair growing cycle causing a premature loss: HORMONAL EXTRA CELL MATRIX INFLAMMATIONS

Hormonal DHT shortens hair growing phase (Anagen phase shorter) Miniaturization of follicle Progressive production of finer hair HAIR LOSS

Effects of Matrix The dimensions of follicle are defined by: the volume of its dermal papilla the volume of the extra cell matrix A well dermal papilla produce good fibers of anchoring (as lamininand collagen typo IV) that support a good anchorage of hair in the surrounding tissue. If the renewal of ECM proteins is umproper, hair wears thin. Cycle after cycle, the follicle will become even more little since is miniaturized and fall off

Effect of inflammations Production of excessive free radicals Alteration of cell matrix Degradation of follicle HAIR LOSS

By Brelil laboratories A NEW HAIR LOSS TREATMENT AN INNOVATIVE TECHNOLOGY

An innovative technology to fight 3 main causes of hair loss. TOTAL HAIR DEFEND

with STEM CELLS Capixyl TM TOTAL HAIR DEFEND

MINOXIDIL: is a vasodilator, the most popular and most used, it helps to promote hair growth by increasing blood flow. Not suitable for people with blood pressure problems, requires an application 2 times a day. anni 80-90 FINASTERIDE: acts on a hormonal level, it inhibits the enzyme that is to transform the TEST to DHT. It is a drug with proven efficacy but with contraindications. AMINEXIL: patented by l Oréal, it acts on premature aging of roots, moderating the hardening of collagen that covers the protective sheath, improving hair anchorage. Capixyl TM 2012 New molecule patented against hair loss

Capixyl: an unique combination, a new discover against hair loss Biochanin A is extracted from Red Clover. Potent inhibitor of the enzyme α-5 -Reductaseresponsible for the conversion of testosterone to DHT, harmful to the follicle. Acetyl Tetrapeptide 3 Biomimeticpolymer formed by 4 amino acids which stimulates the remodeling of sheath s tissues surrounding the follicle. It increases the size of hair follicle and improves the hair s anchoring, promotes the increase of hair density.

Focus on Stem Cells

What are they? They are generic cells no specialized, are able to reproduce to infinity and to ensure the renewal of the tissue in which they are. Human, animal or plant

Follicle s cells Present also into the scalp and hair follicle, if activates or stimulatedgive the start to a new hair life cycle. Ageing, internal and external stresses, can damage them, weakening their working.

Plant Stem Cells Our research has discovered that they contribute to activate the cells of hair follicle, stimulating their process of regeneration.

Plant Stem Cells Rich in active fundamental substances for the cell vitality as Vitamin C, minerals, Flavonoids, Polyphenols, Anthocyanins. Promote an optimal environment for the development of stem cells, stimulating their regeneration and then the hair renewal.

Extraordinary effectiveness Play a powerful action against free radicals Protect cellular DNA Increase cellular longevity of follicles Reduce inflammations of follicle

EFFECTIVENESS SCIENTIFICALLY TESTED

WITH DERMATOLOGICAL MONITORING

DIVISION OF MEDICINE UNIVERSITY OF PAVIA (ITALY)

VISIBLE EFFICACY 8 WEEKS BEST RESULTS 12 WEEKS

8 WEEKS of TREATMENT -57% lost hair during the washing Hair 2 times more resistant -75% itching of scalp Hair visibly softer and shiner -16% of sebumto the scalp -75% peeling of scalp

12 WEEKS of TREATMENT -59% lost hair during the washing Hair 2 times more resistant -75% itching of scalp hair visibly softer and shiner -21% of sebumto the scalp -85% peeling of scalp

The new anti hair loss programme TOTAL HAIR DEFEND

Adjuvant anti-hairloss with Capixyl and Stem Cells SHAMPOO Dermatologically tested anti hair loss shampoo: combats and prevents hair loss encouraging healthy re-growth and prepares the hair for the phial treatment. Directions for use: apply on wet hair and massage delicately. Rinse and reapply, and leave to set for 2/3 minutes before rinsing in plenty of water. Continue treatment for at least 2 months. B120073 SHAMPOO 200 ml B120072 SHAMPOO 750 ml plastic bottle with pump For the best results use with the Haircur Plant Stem Cell Anti Hair Loss Phials for an intensive treatment or with the Haircur Plant Stem Cell Serum for maintenance.

Adjuvant anti-hairloss with Capixyl and Stem Cells LOTION A FORMULA DESIGNED FOR ALL TYPES OF HAIR WOMEN AND MEN Application of 1 phial a day Suitable with all technical services Doesn t leave greasy effect Lotion slightly perfumed Refreshing action Dermo-balancing action Dermatologically tested Anti hair loss treatment, combats hair loss and encourages regrowth. Innovative technology based on: - Capixyl : fights the premature miniaturization of the hair follicles, prevents scalp inflammation, stimulates re-growth and increases the thickness of the hair fibre. -Plant stem cells: interacts with cellular DNA to encourage the regeneration of follicles, stimulating cell vitality and favours healthier and more vigorous hair growth. Directions for use: Apply daily on shampooed and towel-dried hair, distributing the contents carefully through the hair. Do not rinse. B120075 10 phials6 ml each B120076 40 phials6 ml each

Adjuvant anti-hairloss with Capixyl and Stem Cells SERUM B120074 SERUM 100 ml plastic bottle with spray pump Formulation with fortifying action Goes deep into the scalp thanks to the special spray pump Refreshing action Doesn t grease Texture pleasantly perfumed Dermatologically tested Innovative technology based on Plant Stem Cells that helps regenerate the hair bulb and Capixyl that combats scalp inflammation, stimulates re-growth and increases the thickness of the hair fibre. Directions for use: distribute the product on sections over the entire scalp using the special spray. Gently massage the scalp with flattened hands and then dry immediately. To optimize results we recommend that you use with the Haircur Plant Stem Cell Anti Hair Loss Shampoo.

The new anti hair loss programme THERAPY

The TREATMENT Apply with regularity the content of a phial every day (morning or evening), section by section on the scalp, on wet or dry hair. Do not rinse. For better results, we recommend to use in synergy Anti-hair loss Shampoo to clean hair that has a delicate action and prepare perfectly the scalp to the next phial treatment. FOR AN INTENSIVE TREATMENT 1 phiala day Per 12 weeks FOR A MAINTENANCE TREATMENT 1 or 2 phialsper week Per 8 weeks

Thanks for your time!