AMINAT -G PRESERVATIVE AND ACTIVE ANTIMICRBIAL FR CSMETICS INCI name: Glycerin and Ethyl Lauroyl Arginate HCl CMPSITIN AMINAT -G is based on a 20% solution of LAE (Ethyl lauroyl arginate monohydrochloride, E- 243) in glycerin. AMINAT -G is a multifunctional product that can be used by personal care formulators as a preservative in creams, lotions, body milks, hair conditioners and as an active compound in soaps, antidandruff shampoos, deodorants and oral care. Additionally, it can provide smoothness to skin and hair because of its cationic nature. AMINAT -G can be used in formulations certified ECCERT, CSMS and Natrue, thanks to the natural origin of glycerin and to LAE (molecule developed and synthesized by the Lamirsa Group) Active ingredient: N α -lauroyl-l-arginine, ethyl ester monohydrochloride (LAE ). Chemical structure: H 2 N NH NH (CH 2 ) 10 CH 3 Cl NH 2 CAS number: 60372-77 - 2 TECHNICAL DATA Physical-chemical properties Appearance Transparent to slightly opalescent liquid LAE content 20 ± 1% ph at 20 ºC (68ºF) 1% solution 4 ± 1 Viscosity at 20ºC (68ºF) (Brookfield RV, sp nº4, 20 rpm) 4000-6500 mpa s Density at 20ºC (68ºF) 1.22 ± 0.02 g/ml Solubility Soluble in water and totally soluble in ethanol
SPECTRUM F ACTIVITY AMINAT -G has a broad spectrum of antimicrobial activity covering bacteria, moulds and yeasts, as shown Table I. The activity of AMINAT -G is not ph dependent. Additional MIC values for other microorganisms are available upon request. Table I. Gram + Bacteria MIC* ppm Gram - Bacteria MIC*p pm Bacillus subtilis ATCC 6633 16 Staphylococcus aureus ATCC 6538 16 Micrococcus luteus ATCC 9631 64 Corynebacterium xerosis CECT 4160 16 Propionibacterium acnes ATCC 11827 16 Staphylococcus epidermis ATCC 1798 16 Streptococcus mutans ATCC 25175 64 Moulds/yeasts Citrobacter freundii ATCC 22636 256 Enterobacter aerogenes ATCC 13048 256 Enterobacter faecalis ATCC 27285 8 Chronobacter sakazakii ATCC 29544 160 Escherichia coli ATCC 8739 256 Klebsiella pneumoniae var pneumoniae 128 ATCC 4352 Proteus mirabilis CECT 170 256 Pseudomonas fluorescens ATCC 13413 80 Pseudomonas aeruginosa ATCC 9027 256 Serratia marcensesatcc 10759 256 MIC*ppm Aspergillus niger ATCC 14604 128 Aureobasidium pullulans ATCC 9348 128 Gliocladium virens ATCC 4645 256 Chaetomium globosum ATCC 6205 16 Penicillium chrysogenum ATCC 9480 256 Penicillium funiculosum CECT 2914 64 Candida albicans ATCC 10231 32 Rhodotorula rubra CECT 1158 64 Malassezia furfur ATCC 14521 64 Trycophyton mentagrophytes ATCC 18748 128 * MIC: Minimum Inhibitory Concentration. Expressed as AMINAT -G concentration (20% active ingredient).
FRMULATIN AMINAT -G is easy to incorporate into personal care formulations as it is a liquid. It may be added in the emulsion at any stage of the manufacturing process, in the aqueous phase, in the oil phase, during emulsification or after cooling. AMINAT -G can lose activity in systems with a high content of anionic surfactants or anionic thickeners such as carboxymethyl cellulose, xanthan gum, bentonite or carbomer. MAJR PTENCIAL APLICATINS Preservative for skin care products. Active ingredient for antiseptic hand wash products. Active ingredient for non-spray * deodorants and antiperspirants. Active ingredient for antidandruff hair care formulations. Active ingredient in oral care. Active ingredient in wet wipes. Preservative in hair and skin care products Microbiological studies have shown that AMINAT -G is an effective preservative in concentrations of 0.25-1% in all kinds of formulations without a large amount of anionic raw materials. - Shampoos - Hair conditioners - Sunscreens - Body milks - Make up removing liquids and milks - Facial products Due to its cationic surfactant properties, LAE provides additional smoothness to hair and skin and improves the skin natural defense against pathogens, besides an excellent formula preservation. Active ingredient in deodorant cosmetics AMINAT -G may be used as an active ingredient in non-spray deodorant cosmetic products with or without aluminum salts. Recommended application rate: From 0.5% to 4%.
Active ingredient in antidandruff formulations AMINAT -G can be used as an active ingredient in antidandruff shampoos and conditioners. In vivo tests demonstrate good activity, and AMINAT -G could be a green substitute of Znpyrithione. Recommended dosage: from 1% to 4% of AMINAT -G. Active ingredient in ral Care products AMINAT -G is a very effective antibacterial in mouthwashes. It shows a remarkable antiattachment effect for microbes on the tooth surface. The antiplaque effect of LAE is comparable to that of chlorhexidine digluconate. Recommended dosage: from 1% to 4% of AMINAT -G. LAE REGISTRATIN/APPRVAL Notified as new chemical compound for cosmetic products, according to the EU Directive 67/548 EEC. Regulation (EC) Nº 1907/2006 (REACH). Registration number: 01-0000018076-71-0000. Approval in the EU as a preservative for cosmetics in accordance with EU Directive 76/768 EEC of 1st February 2010 (Commission Directive 2010/3/EU) replaced by Regulation (EC) No 1223/2009 by amended by Regulation (EU) No 344/2013. 100% natural, certified by ECCERT. Derived 100% natural, certified by NaTrue. Considered safe for use as a preservative in mouthwashes at a maximum concentration of 0.15 % w/w (not to be used for children under 10 years old), according to Regulation (EU) 2016/1121 of 11 July 2016 amending Annex V to Regulation (EC) No 1223/2009 of the European Parliament and of the Council on cosmetic products. Specific maximum doses allowed for each particular application depending on countries are available upon request.
TXICITY AND LABELLING AMINAT -G is extremely mild for humans and for the environment, as Table II shows. Table II: Relevant toxicological and eco-toxicological data for LAE, the active ingredient of AMINAT -G. Acute dermal toxicity (rat, LD 50) (ECD 402)* > 2000 mg/kg b.w. Non toxic Skin irritation (ECD 404)* > 2000 mg/kg b.w. Non irritating Eye irritation (ECD 405)* Sensitization (GPMK-test) (ECD 406)* Biodegradation* (ECD 301B) Fish LC 50, 96 hours (ECD 203) Daphnia L(E)C 50, 48 hours (ECD 202) Algae (EC 50, 72 hours) (ECD 201) *Represented as an active ingredient (LAE ) Non irritating Non sensitizer 89% Readily biodegradable 118 mg/l 33 mg/l 2.3 mg/l No label is required concerning the environment PRESENTATIN AMINAT -G is available in 5, 25 and 1000 kg packaging. STRAGE AND SHELF LIFE We recommend to store between 4-30ºC or 39-86ºF. Avoid temperatures above 30ºC or 86ºF. Keep containers tightly closed in a dry, cool place, protected from exposure to direct sunlight. Under such conditions, the shelf life of the product is 18 months. The information contained in this bulletin cannot be taken as a basis of guarantee or liability. VEDEQSA is not responsible for the inappropriate use of this product. Revision: 04. Date: 27/10/2016.