ingredients selector book 2010 Inspired by nature Realized by science Mibelle Biochemistry designs and develops innovative, high-quality actives based on naturally derived compounds and profound scientific know-how.
Anti-aging Skin rejuvenation 04 Photo-aging/Sun care 06 Experts 08 Antioxidant/Energizing 10 Hydration/Soothing 12 protection 14 Whitening 16 Hair 18 Anti-cellulite/Slimming 20 Natural Cosmetics 22
Anti-aging Skin rejuvenation 04 Activity Improvement of skin quality and radiance Name Characteristics ingredient Definition Looking for Ideas of application Carrier system components Preservative Alcohol-free PhytoCellTec Malus Domestica Plant stem cells for skin stem cells protection Protection of cell longevity Plant cell culture technology Delaying chronological aging Real rejuvenation Revolutionary anti-aging products Cosmeceuticals Swiss apple stem cells PE/ Sodium ben zoate* Happybelle- PE Phyto-Endorphins in a double vector system Well-being Radiance Collagen booster Neuro-cosmetics SPA treatments Happy skin products Monk s pepper berries extract (phyto-endorphins) Vitamins C and E Perfection Peptide P3 Biomimetic peeling to create a perfect skin Luminosity Even complexion Cell renewal Cosmeceuticals Daily peeling Radiance care Tripeptide (Hexanoyl-Arg-Ala- Nle-NH2 Acetate Salt) PE/no* Carrier system = Liposome, = Double vector system, = Nano-Emulsion, = Double Nano-Emulsion Preservative PE = Phenoxyethanol, * = 2 versions are available
05 Proven efficacy Benefits Stimulates collagen synthesis Anti-wrinkles firmness smoothness hydration Specific tests Use level in % Clinically tested on eye contour area Effect visible after only 1 month Preservativefree Up-regulates specific genes involved in delay of senescence, anti-oxidation and DNA damage correction Maintains the vitality of epidermal stem cells 2.0 5.0 Increases the feeling of well-being (consumer test) 1.0 2.0 Increases the turn-over of stratum corneum Smoothes the skin micro-relief (laser profilometry) the skin cohesion (scanning electron microscopy) 0.5 3.0 Proven efficacy in vitro test clinical study
Anti-aging Photo-aging/Sun care 06 Activity Prevent photo-aging, protect the skin against UV damage Name Characteristics ingredient Definition Looking for Ideas of application Carrier system components Preservative Alcohol-free PhytoCellTec Solar Vitis Protects epidermal stem cells against UV damage Protection of essential cells Plant cell culture technology Smart sun care Advanced stem cell cosmetics Grape stem cells Sodium benzoate GSP-T More than an antioxidant Broad protection against daily oxidative stress Stable combination of water- and oil-soluble antioxidants Cosmeceuticals Sensitive skin UV tolerance enhancer Swiss grape seed extract (procyanidins) Natural vitamin E Helioguard 365 Natural UVA-screening active to protect against photo-aging Daily UVA-protection DNA protection Face care Foundation Mycosporine-like amino acids (MAA) PE CM-Glucan Granulate AquaCacteen The repair and defense molecule Soothes and hydrates women and men s skin Protection Regeneration Calming Skin resistance booster for men Skin repairing Sensitive skin Skin defense enhancer Sensitive skin Baby care Sodium carboxymethyl beta-glucan from baker s yeast Organic opuntia ficus-indica stem extract no/pe* PE/no* Carrier system = Liposome, = Double vector system, = Nano-Emulsion, = Double Nano-Emulsion Preservative PE = Phenoxyethanol, * = 2 versions are available
07 Proven efficacy Benefits Anti-irritation activity Inhibits oxidation of skin lipids Anti-wrinkles firmness despite UV radiation hydration Specific tests Use level in % Clinically tested on eye contour area Inhibits lipidperoxidation Preservativefree Maintains the vitality of epidermal stem cells Protects epidermal stem cells against UV stress 0.4 1.0 Decreases the toxicity of oxidized squalene on cells Decreases UV-induced redness 0.5 2.5 Reduces UV-induced DNA damage Boosts SPF smoothness 1.0 5.0 cell renewal 0.02 0.1 Reduces redness 0.5 2.0 Proven efficacy in vitro test clinical study
Anti-aging Experts 08 Activity Focus on a specific corrective action Name Characteristics ingredient Definition Looking for Ideas of application Carrier system components Preservative Alcohol-free Lipobelle Soyaglycone Lift it up! Density Anti-gravity Lifting effect Collagen booster Re-plumping Multi-dimensional anti-aging Soy isoflavone aglycone (genistein) MAXnolia Fights skin inflamm aging Protection against chronic inflammation Eye contour formulations Skin prone to redness Magnolia officinalis bark extract Ameliox To fade away expression lines Wrinkle reduction Immediate smoothing Cosmeceuticals Anti-glycation Carnosine Silymarin Natural vitamin E PE/no* AstraForce Anti-aging especially for blemished skin Both anti-blemishes and anti-aging Clarity City products Skin texture enhancers Combination/oily skin Astragalus membranaceus root extract PE Carrier system = Liposome, = Double vector system, = Nano-Emulsion, = Double Nano-Emulsion Preservative PE = Phenoxyethanol, * = 2 versions are available
09 Proven efficacy Benefits regeneration Anti-wrinkles firmness skin thickness smoothness hydration Specific tests Use level in % Clinically tested on eye contour area Preservativefree Genistein stimulates collagen IV production The liposomal form increases the skin penetration of genistein Diminishes skin laxness and ptosis Makes the skin appear 5 years younger 1.0 5.0 Reduces redness on the face Decreases TEWL elasticity on the crow s feet 0.1 0.5 Reduces wrinkles both on crow s feet and forehead Visibly reduces lines and wrinkles (consumer test) 1.0 5.0 Inhibits lipase activity Reduces blemished skin signs 0.5 2.0 Proven efficacy in vitro test clinical study
Anti-aging Antioxidant/Energizing 10 Activity Revitalizing and nourishing Name Characteristics ingredient Definition Looking for Ideas of application Carrier system components Preservative Alcohol-free GSP-T More than an antioxidant Broad protection against daily oxidative stress Stable combination of water- and oil-soluble antioxidants Cosmeceuticals Protection against UV damage Swiss grape seed extract (procyanidins) Natural vitamin E NanoVit nc/oa Bioactive phyto-omegas 3,6,9 + 7 Healthier-looking skin Cell regeneration Pre/after sun products Sea buckthorn pulp oil Natural vitamin E Sodium benzoate /no* Nano- Lipobelle DN CoQ10 oa Nano- Lipobelle H-AECL Supersaturated CoQ10 double nano-emulsion The power snack for skin Vitality Collagen booster Mitochondrial cosmetics Nutrition Strengthening of skin barrier Metabolic activation Photo-aging prevention Coenzyme Q10 7 % Natural vitamin E 0.4 % Vitamin C 0.2 % Sensitive skin Vitamins (A, E, C) ester form Borage oil (rich in gamma linoleic acid) Benzoic acid NanoMax High performing antioxidant blend Antioxidant shield City products Daily care Coenzyme Q10 0.5 % Natural vitamin E 1 % Vitamin C 1 % Carrier system = Liposome, = Double vector system, = Nano-Emulsion, = Double Nano-Emulsion Preservative PE = Phenoxyethanol, * = 2 versions are available
11 Proven efficacy Benefits Stimulates collagen synthesis Inhibits lipid peroxidation Increases cell renewal Specific tests Use level in % 100 % natural Preservativefree Cumulative antioxidant activity Inhibits the glycation process Inhibits the COX-1 and COX-2 activity Immediate anti-redness effect 0.5 2.5 1.0 5.0 Protects mitochondrial DNA 1.0 5.0 1.0 5.0 1.0 5.0 Proven efficacy in vitro test clinical study
Hydration/Soothing 12 Activity Promote the homeostasis of the skin and bring comfort Name Characteristics ingredient Definition Looking for Ideas of application Carrier system components Preservative Alcohol-free AquaCacteen Trimoist KMF Soothes and hydrates women and men s skin 24h hydration and protection Calming Skin resistance booster for men 3-step moisturizer Anti-aging Sensitive skin After-shave products Baby care Sensitive skin Repair products Body care Organic opuntia ficus-indica stem extract CM-Glucan Granulate Lamellar lipids Humectants Carnosine PE/no* NanoCacao Lipobelle Glacier Poly-Fructol Femitim Deep comfort and relaxation 24h refreshing hydration with Swiss glacier water Adds value to all bath and hair products Especially for feminine hygiene Relaxation Good feeling Oil-soluble active Refreshment Long-lasting hydration Instant hydration Soft and fresh skin/hair Gentleness Well-feeling Anti-stress formulations Color cosmetics Wellness/SPA products Splashes SPA treatments Men s care Body care Hair care/styling Intimate hygiene Wipes products Cocoa bean lipophilic extract PE/no* Swiss glacier water * Polymer of fructose (inulin) Monk s pepper berries extract (phyto-endorphins) PE Carrier system = Liposome, = Double vector system, = Nano-Emulsion, = Double Nano-Emulsion Preservative PE = Phenoxyethanol, * = 2 versions are available
13 Proven efficacy Benefits Anti-irritation activity hydration Reduces redness smoothness firmness Specific tests Use level in % Tested in rinse-off application Preservativefree Soothes men skin after shaving 0.5 2.0 Protects against detergents Increases well-being and skin smoothness (consumer test) 1.0 5.0 Slows down muscle contraction (reversible effect) 3.0 5.0 Protects cells against heat stress Gives a refreshing feeling (consumer test) 1.0 5.0 0.1 5.0 Increases well-being feeling (consumer test) 0.5 3.0 Proven efficacy in vitro test clinical study
protection 14 Activity Boost the skin s self defense Name Characteristics ingredient Definition Looking for Ideas of application Carrier system components Preservative Alcohol-free Detoxophane Activates the skin s detoxification system Protection against pollutants Photo-aging prevention MelanoBronze Natural tanning activator Enhancement of natural skin tone CM-Glucan Granulate EpiCalmin TCM The repair and defense molecule Superdefense by Traditional Chinese Medicine Protection Regeneration Skin self-protection booster Both soothing and anti-aging City products Protection against environmental stress Foundation Pre-sun care Sun studio products Suntan booster Skin repairing Sensitive skin Skin defense enhancer Sensitive skin Wellness/SPA products TCM cosmetics Swiss garden cress sprout extract (sulforaphane) Monk s pepper berries extract (phyto-endorphins) Acetyl tyrosine Sodium carboxymethyl beta-glucan from baker s yeast Lonicera japonica flower extract Xanthium sibiricum fruit extract Cyperus rotundus root extract PE/no* no/pe* Sodium benzoate Carrier system = Liposome, = Double vector system, = Nano-Emulsion, = Double Nano-Emulsion Preservative PE = Phenoxyethanol, * = 2 versions are available
15 Proven efficacy Benefits Inhibits oxidation of skin lipids Anti-wrinkles firmness hydration cell renewal Specific tests Use level in % Clinically tested on eye contour area Preservativefree Protects against strong oxidizing components Stimulates the expression of natural antioxidants 0.5 3.0 Stimulates melanin synthesis Increases skin tanning with and without sun 1.0 5.0 Soothing activity Limits TEWL conse cutive to intense stress 0.02 0.1 Stimulates the skin s defense mechanisms against oxidative stress, inflammation and collagen degradation Reduces redness 2.0 5.0 Proven efficacy in vitro test clinical study
Whitening 16 Activity Skin lightening Name Characteristics ingredient Definition Looking for Ideas of application Carrier system components Preservative Alcohol-free SulforaWhite Phyto agent for visible whitening Exceptional brightening benefits Natural whitening active ingredient Delentigo The age spot solution Prevention and treatment of age spots Targeted whitening effect (lightens only pigmented areas) Evens skin tone Anti-aging with pigment disorder correction Whitening treatments Anti-aging with age spot correction Hand care products Skin luminosity Swiss organic garden cress sprout extract (sulforaphane) Swiss organic garden cress sprout extract (sulforaphane) Soy isoflavone aglycone (genistein) PE/no* PE NanoWhite Triple activity for skin brightening Even complexion Complete action on tyrosinase inhibition Lightening for every day Natural arbutin Glutathione Vitamin C Carrier system = Liposome, = Double vector system, = Nano-Emulsion, = Double Nano-Emulsion Preservative PE = Phenoxyethanol, * = 2 versions are available
17 Proven efficacy Benefits Inhibits melanin synthesis Inhibits a-msh activity Protects against strong oxidizing components Lightens the skin Depigments age spots Specific tests Use level in % Effect visible after only 1 month Preservativefree Inhibits the proteasome activity Efficient on both Caucasian and Asian skin type 2.0 5.0 Inhibits the proteasome activity Genistein stimulates collagen IV production Depigments selectively age spots without fading the neighboring normally pigmented area Lifts, firms, smoothes, hydrates the skin 4.0 6.0 Inhibits tyrosinase activity and activation 2.0 5.0 Proven efficacy in vitro test clinical study
Hair 18 Activity s which protect, take care and beautify hair Name Characteristics ingredient Definition Looking for Ideas of application Carrier system components Preservative Alcohol-free GSP-T Grape seed polyphenols for maximum hair protection Powerful radical scavenger Stable combination of water- and oil-soluble antioxidants Color protection All hair care products Outdoor formulations Anti-pollution hair care Protection against treatments Swiss grape seed extract (procyanidins) Natural vitamin E Nano- Lipobelle t-uv Cationic nano-emulsion of UV-filters Protection against daily environmental stress Sun protection Sun protection Coloured hair products UVA and UVB filters Nano- Lipobelle DN CoQ10 oa Hair growth with proven efficacy Hair growth stimulation Strength and vitality Anti-aging for scalp and hair Metabolic activation SPA treatments Anti-aging products Coenzyme Q10 Natural vitamin E Vitamin C Benzoic acid Lipobelle S100/PA Cationic liposomal panthenol for hydration Repair Hair shine Makes combing easier Repair Daily shampoos, conditioners, sprays D-panthenol Carrier system = Liposome, = Double vector system, = Nano-Emulsion, = Double Nano-Emulsion Preservative PE = Phenoxyethanol, * = 2 versions are available
19 Proven efficacy Benefits Increases proliferation of human follicle dermal papilla Stimulates hair growth Reduces coloured hair fading Soothing effect Specific tests Use level in % Suitable for rinse-off products Transparent aspect Inhibits lipidperoxidation Preservativefree Protects hair proteins against detergents, UV, hair-dryer and sea water the adsorption of tocopherol on hair Protective effect in both leave-on and rinse-off application 0.5 2.5 Increases the delivery of UV filters 1.0 5.0 Protects mitochondrial DNA 1.0 5.0 0.2 2.0 Proven efficacy in vitro test clinical study
Anti-cellulite/Slimming 20 Activity Slimming, firming and re-shaping Name Characteristics ingredient Definition Looking for Ideas of application Carrier system components Preservative Alcohol-free AmaraShape Iso-Slim Complex High performance in body shaping Pro slimming anti cellulite Body contouring Thermogenic activity Lipolytic activity Anti-orange peel Multi-targeted slimming activity Lipid breakdown trigger Fitness body care Re-sculpting body care SPA treatments SPA treatments Refining skin body care Anti-aging Caffeine Bitter orange extract (synephrine) Soy isoflavone aglycone (genistein) Caffeine Carnitine Spirulina platensis algae extract PE/no* PE/no* Carrier system = Liposome, = Double vector system, = Nano-Emulsion, = Double Nano-Emulsion Preservative PE = Phenoxyethanol, * = 2 versions are available
21 Proven efficacy Benefits firmness smoothness Specific tests Use level in % Effective after only 6 weeks Preservativefree Abdominal girth reduction: 2.5 cm 1.0 3.0 Genistein inhibits the adipogenesis process Genistein stimulates collagen IV production Degree of cellulite: 37 % (clinical score) Thigh girth: 3.8 cm Elasticity: +57 % 1.0 5.0 Proven efficacy in vitro test clinical study
Natural cosmetics 22 Activity ingredients complying with Ecocert Name Characteristics ingredient Definition Category Preservative AquaCacteen nc Soothes and hydrates women and men s care Hydration/Soothing no EpiCalmin TCM Superdefense by Traditional Chinese Medicine Hydration/Soothing Sodium benzoate NanoVit nc Bioactive phyto-omegas 3,6,9+7 Antioxidant/ Energizing no NanoVit oa Bioactive phyto-omegas 3,6,9+7 Antioxidant/ Energizing Sodium benzoate Lipobelle Glacier 24h refreshing hydration with Swiss glacier water Hydration/Soothing no Noriguard nc Natural UVA-screening active to protect against photo-aging Anti-aging/Sun care Sodium benzoate Femitim Especially for feminine hygiene Hydration/Soothing no Carrier system = Liposome, = Double vector system, = Nano-Emulsion, = Double Nano-Emulsion Preservative PE = Phenoxyethanol, * = 2 versions are available, ** = Total of natural origin: chemically + physically processed natural origin ingredients, *** = Raw material certified by Ecocert Greenlife according to the Ecocert Standard for Natural and Organic Cosmetics available at www.ecocert.com/cosmetics
23 Proven efficacy Ecocert information In vitro test Clinical study Use level in % Ecocert approved Ecocert certified*** Total of natural origin** % Plant % Organic % Synthetic % Preservativefree 0.5 2 99.84 99.84 0.16 2 5 99.70 24 0.30 1 5 100 15 1 5 99.95 15 0.05 1 5 99.94 6 0.06 2 10 99.70 0.30 0.5 3 100 7.23 Proven efficacy in vitro test clinical study
Mibelle AG Biochemistry, Bolimattstrasse 1, 5033 Buchs/Switzerland Phone +41 62 836 17 31, info@mibellebiochemistry.com, www.mibellebiochemistry.com The information contained in this publication is provided in good faith and is based on our current knowledge. No legally binding promise or warranty regarding the suitability of our products for any specific use is made. Claim ideas are offered solely for your consideration, investigation and verification. Mibelle Biochemistry will not assume any expressed or implied liability in connection with any use of this information.