Hydraconcept Skin is restructured and smooth
The power of a sweet patented combination Xylitylglucoside (and) Anhydroxylitol (and) Xylitol SEPPIC PATENT A visible action! 3D hydration for softer, smoother, restructured skin Skin shows visible differences: - Structures and reinforces the corneous layer - Effects are visible within 8 hours Improvement of cutaneous microrelief +30% Improvement of desquamation +25% Placebo AQUAXYL 3% Indispensable for hydration: All cutaneous moisturizing actors are boosted (lipids, proteins, polysaccharides, NMF) Immediate and long-term effect of cutaneous moisturizing Skin hydration 8H D15 D30 +6%* +5%* +11%* Improved cutaneous barrier effect (cellular cohesion) Reinforces the action of glycerin and erases its negative effects Water loss 8H D15 D30-3% -5% -14%* * p < 0,05 Protocol: Formula EU06925 with 3% AQUAXYL - 30 days of treatment - 2 daily applications on the legs - 25 Caucasian volunteers with extremely dry skin (<55UC) - Mark of microrelief - Measure normalization of desquamation, corneometry and transepidermal water loss
The power of a sweet patented combination Xylitylglucoside (and) Anhydroxylitol (and) Xylitol SEPPIC PATENT Unite two best-sellers Reinforced moisturizing: AQUAXYL + glycerin 1, a winning combination! AQUAXYL reinforces the moisturizing power of glycerin: Immediate and long-term cutaneous hydration (Corneometry) +30% of hydration all throughout treatment (AQUAXYL + glycerin vs glycerin alone) Short term Long term End of the treatment Remanent effect Skin shows visible differences: - Structures and reinforces the corneous layer - Effects are visible within 8 hours + AQUAXYL (1,5%) Hydratation ++ : AQUAXYL power 3H D14 D21 D24 D28 +46%* +51%* +56%* +37%* +23%* +29%* +30% LS +30%* +21% +23% % % of hydration improvement between Tx and T0 Indispensable for hydration: All cutaneous moisturizing actors are boosted (lipids, proteins, polysaccharides, NMF) D0 % % of hydration improvement between a formula containing 3% glycerin and a formula containing 3% glycerin + 1.5% of AQUAXYL D14 D21 D24 D28 1 Discovered in the 19 th century, glycerin is a traditional ingredient in beauty products. Its moisturizing and filmogenic properties are evident (about 40 % of moisturizers contain it) and is economically priced. However, extensive use can contribute to the skin s dehydration. Reinforces the action of glycerin and erases its negative effects AQUAXYL restores the integrity of stratum corneum and regulates the effects of glycerin: Protects the barrier function % of TEWL variation (D14 - D0) 3 2 1 0-1 -2-3 -4-5 -6 D14 Dehydration + AQUAXYL (1.5%) Protocol: Formula EU07333 at 3% glycerin + 1.5% AQUAXYL vs formula at 3% glycerin and vs. placebo - 21 days of treatment / 28 day follow-up of volunteers - 2 daily applications on the legs - 25 Caucasian volunteers with extremely dry skin / average age 38 years - Measure corneometry and transepidermal water loss * p < 0,05 LS p = 0,11
Hydraconcept CERAMIDES 1 & 2 / CHOLESTEROL Key lipids which make up the intercellular cement of the epidermis No effect of glycerin on the synthesis of CERAMIDES TRANSGLUTAMINASES Forms corneous layer: Builds the structural proteins between them CERAMIDES 1 & 2: +139% HMGCR: +61% 3hydroxy-3methylglutaryl-CoA reductase (enzyme involved in cholesterol synthesis) LORICRIN: +96% KALIKREIN-5: +111% KALIKREIN-7: +63% KERATIN: +122% TRANSGLUTAMINASE 1: +40% TRANSGLUTAMINASE 5: +126% LORICRIN Shielding effect: - Permeabilizes and increases resistance of corneous layer - Anchors inter-corneocyte lipids - 60% of the complete proteins of the corneous layer KALIKREIN Renews corneous layer: controls desquamation KERATIN Inter-cellular cohesion: structural proteins Cutaneous barrier against the risk of desquamation Optimized circulation of water and reserves NMF Groups of hygroscopic substances on the corneous layer: acts as sponge and soaks up water on the skin s surface CASPASE 14: +66% Enzyme involved in creating NMF (Natural Moisturizing Factor) TIGHT JUNCTIONS Still called waterproof junctions, they ensure the waterproof quality of the epidermis. They control the paracellular circulation and distribution of water HYALURONIC ACID High hygroscopic- powered Polysaccharide - Can hold up to 1000 times its weight in water - Part of the skin s biomechanical properties AQUAPORIN 3 Fosters trans-cellular exchange (water and glycerol circulation): membrane protein which forms pores Epidermic hyaluronic acid: +24% Dermic hyaluronic acid: +20% CLAUDINE 4: +123% CLAUDINE 5: +240% CLAUDINE 7: +75% Constituent proteins of tight junctions AQUAPORIN 3: +36%
Easily incorporated in all types of formulations, even cold processable. Does not impact the final color. Formulation tool box Full hydration cream - EU07333 A B C D Aqua/Water MONTANOV 202 LANOL 99 Coco Caprylate Caprate SEPIPLUS 400 AQUAXYL Glycerin Phenoxyethanol & Ethylhexylglycerin Phenylpropanol & Propanediol & Caprylylglycol & Tocopherol Citric Acid Up to 100% 5.00% 1 0.80% 1.00% 0.50% Up to H Strength & Hydration for skin EU06925 A B C D MONTANOV 68 MONTANOV 202 Cetearyl Octanoate Aqua/Water SIMULGEL EG AQUAXYL Parfum/Fragrance Preservative Preservative-free Non-ecotoxic 15.00% Up to 100% 1.00% 0.30% 0.50% Recommendation of use Can be added to skin care products for face and body with anti-aging and hydrating indications INCI Name: Xylitylglucoside (and) Anhydroxylitol (and) Xylitol Original structure derived from sugar: glucose and xylitol, from vegetable origin Recommended dosage: 1 to 3% Hydrosoluble, compatible with alcohols and glycols Transparent liquid ECOCERT: Raw material approved by ECOCERT GREENLIFE, in conformity with Ecocert natural and organic cosmetic standard CHINA China Compliant: All INCI names are listed on the IECIC list of June 2014 Natrue Approved: Raw materials certified according to Natrue standard Bio-Based Content: The renewable content is measured according to the «Association Chimie Du Vegetal» standard (ask us) Nota : The analytical specifications warranted are only those mentioned on the certificate of analysis supplied with each delivery of the product. Except as set forth above, SEPPIC* makes no warranties, whether express, implied of statutory, as to the product which is the subject of this document. Without limiting the generality, of the foregoing, SEPPIC* makes no warranty of merchantability of the product or of the fitness of the product for any particular purpose. Buyer assumes all risk and liability resulting from the use or sale of the product, whether singly or in combination with other goods. The information set forth herein is furnished free of charge and is based on technical data that SEPPIC* believes to be reliable. Its is intended for use by persons having technical skill and their own discretion and risk. Since conditions of use are outside SEPPIC* s control, SEPPIC* makes no warranties, express or implied, and assumes no liability in connection with any use of this information. Nothing herein Is to be taken as a license to operate under or a recommendation to infrige any patents. Air Liquide Healthcare is a world leader is medical gases, home healthcare, hygiene products and healthcare specialty ingredients. It aims to provide customers in the continuum of care from hospital to home with medical products, specialty ingredients and services that contribute to protecting vulnerable lives. *SEPPIC being: SEPPIC S.A. 22 Terrasse Bellini Paris La Défense 92806 Puteaux cedex - France Tel. + 33 (0)1 42 91 40 00 info.seppic@airliquide.com SEPPIC Castres Tel. + 33 (0)5 63 72 69 69 Head Office 75, quai d Orsay 75007 Paris 2016 SEPPIC SEPPIC is a subsidiary of the AIR LIQUIDE group SEPPIC Inc. USA Tel. + 1 973 882 5597 us.seppic@airliquide.com SEPPIC Japan Office JAPAN Tel. + 81 3 6414 6725 japan.seppic@airliquide.com SEPPIC Poland Office POLAND Tel. + 48 22 690 68 73 poland.seppic@airliquide.com SEPPIC Italia Srl ITALY Tel. + 39 02 38009110 italy.seppic@airliquide.com SEPPIC Brasil BRASIL Tel. + 55 11 3242 3911 brasil.seppic@airliquide.com SEPPIC Asia Singapore SINGAPORE Tel. + 65 6278 6711 singapore.seppic@airliquide.com SEPPIC Dubaï Office UNITED.ARAB.EMIRATES Tel. + 971 (4) 2395565 dubai.seppic@airliquide.com SEPPIC GmbH GERMANY Tel. + 49 (0)221-888824-20 germany.seppic@airliquide.com SEPPIC Colombia SAS COLOMBIA Tel. + 571 702 44 48 colombia.seppic@airliquide.com SEPPIC India INDIA Tel. + 91 22 61046464 india.seppic@airliquide.com SEPPIC China CHINA Tel. + 86 (21) 64 66 01 49 china.seppic@airliquide.com BiotechMarine Tel. + 33 (0)2 96 95 31 32 contact.biotechmarine@airliquide.com 7634/GB/01/May 2016 - Design: Gris Souris - Photo: Fotolia An affiliate of seppic.com