Breakthrough in Anti-Aging Skin Care Technology

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Breakthrough in Anti-Aging Skin Care Technology Environ Skin Care Launches the New C-Quence Line Environ first launched the Ionzyme C-Quence skin care products in 1997. Since that time, Dr. Des Fernandes, founder and medical director, continued his research and clinical studies to provide the most advanced skin care products. With state of the art technology and the inclusion of more effective chirally correct ingredients, Environ has formulated an improved Ionzyme C-Quence range. It enriches the skin with an exciting combination of powerful polypeptides, antioxidants, vitamins, ceramides, and green tea thereby introducing a new dimension to skin care. The revolutionary cocktail of active antiaging ingredients is truly extraordinary. This improved range is the most efficacious and luxurious Environ home treatment available. It will help speed up the restoration of the skin cells resulting in a more youthful and healthy complexion. No expense has been spared in the research and production of this improved formulae for C-Quence 1, 2, 3 & 4. Each level of these unique formulae assists in: Enriching and protecting the skin Refining the surface of the skin Reducing the uneven tone of blemishes, dark pigmented areas and scarring Thickening of the upper layer of the skin and normalization of the skin cells Enhancing the appearance of the skin texture Improving moisturization Firming the skin and smoothing wrinkles and fine lines All the Gels contain many powerful ingredients for the most effective results: The Anti-aging vitamin A in the formula helps slow down the visible signs of premature aging. It leaves the skin feeling revitalized and looking younger and healthier with a radiant glow. Ascorbyl tetraisopalmitate, a state of the art oil soluble form of vitamin C, Spring Special Free Trial Size New C-Quence Purchase either Hydrating Oil Capsules or C-Boost plus any cleanser, and receive a free trial size of New C-Quence, a $25 value, while supplies last. Quantities are limited. New C-Quence Orders Please be advised that you may start placing orders for the new improved C-Quence 1, 2 and the C-Quence Cream in June. Please remember, if your client is currently on C-Quence 2, they must step down to C-Quence 1 in the new C-Quence range. Also, clients who are currently on C-Quence 3 must step down to C-Quence 2. is incorporated into the formula. It is more stable than the water-soluble forms often used in cosmetics. This vitamin C is a powerful antioxidant that assists in the prevention of UV-induced cell damage. This also helps to increase collagen production and decrease pigmentation. Continued on reverse.

New C-Quence Line continued from front. Vitamin E, an extremely effective oil soluble antioxidant, quenches free radicals thus enhancing the effects of the skin s natural sun protectors. It protects collagen and assists in making the skin look younger. Lycopene is incorporated into the formulae and is used as an antioxidant to assist in slowing down the process of the visible signs of aging. It is extremely powerful and is 100 times more effective than vitamin E and twice as powerful as Beta-Carotene. It protects the skin against damage caused by the high energy blue light. Matrixyl (Palmitoyl Pentapeptide-3) is a synthetic combination of five natural amino acids, which when compared to Retinol, acts just as effectively but has the advantage of not inducing skin irritations or reactions. Dermaxyl TM (Palmitoyl Oligopeptide) rehydrates the skin and assists in the reduction of sun damaged cells. It helps plump up the skin thereby reducing the depth of wrinkles and fine lines, and giving the skin a smoother appearance. Dermaxyl is a combination of six natural amino acids which are found in the body and therefore not likely to cause any allergic reactions. Pure Epigallocatechin Gallate, the active ingredient in Green Tea, is possibly the most powerful antioxidant available. It assists in reducing the appearance of sun damage. Rosemary extract is another powerful antioxidant. Soya Bean Oil provides an essential fatty acid which assists with skin hydration. Ceramide 2 helps to plump up the skin and enhances moisturization thereby reducing skin dryness. The new formula C-Quence Gels come in 4 strengths with progressively stronger concentrations of vitamins A and C. It is recommended, for the most beneficial effect on the skin, to follow the path from the mildest to the strongest through the four strengths. It is not recommended for problematic or acne prone skin. Because of the increased active vitamins in the new improved C-Quence formulae, it is advisable that clients currently using the original C-Quence 3 and 2 should step down to the new C-Quence 2 and 1 respectively, until their skin acclimatizes to the new, advanced formulation. C-Quence 4 is recommended for those who are able to tolerate maximum concentrations of vitamins. It should only be used by those whose skin has acclimatized to C-Quence 3 or the Intensive Retinol series. C-QUENCE CRÈME is a new, improved moisturizing cream formulated to be used with C-Quence Gels to complete the full Ionzyme home care treatment. It is rich in highly effective antioxidants including vitamin C, vitamin E and Rosemary extract to assist in protecting the skin against UV radiation. It nourishes and moisturizes to maintain a healthy skin. This new formula also contains Lutein, a lipophilic carotenoid extracted from marigolds and which gives the cream its yellowish coloring. Lutein is an antioxidant that filters out the harmful high-energy blue light that is present in our everyday environment. It also significantly reduces free radical activity. The new formula contains an ingredient called Cyancobalamin (Vitamin B12), which is an essential co-enzyme that is destroyed by sunlight. Replacement therefore is necessary to help promote the growth of healthy skin cells. Other effective ingredients include pure Epigallocatechin Gallate, the active ingredient in Green Tea, which is possibly the most powerful antioxidant available. It assists in reducing the appearance of sun damage. Soya Bean Oil provides an essential fatty acid, which assists with skin hydration. Squalane is a plant-derived emollient that helps improve the elasticity of the skin. This new formula assists in: New cell growth to firm the skin and reduce the appearance of fine lines and wrinkles. Protection against free radical activity. Reduction of signs of photo aging induced by UV rays. Filtration of and protection against the harmful effects of high energy blue light that is found in our everyday environment. Improvement of skin hydration The new C-Quence Gels and Crème are packaged in 35 ml airless pump bottles with side windows for easy level identification. The attractive cobalt blue packaging protects the active vitamins in the C-Quence formula. All the products are preservative free and do not contain a sunscreen. They are manufactured each week under the most sterile conditions with gentle loving care in our own factory to ensure that the client receives the freshest products possible. The product must be used within six weeks of opening for maximum efficacy of the vitamins. The new C-Quence line will be available in the United States in June. For details and a free sample (if not included with an order, shipping is charged), please call (508) 539 8900.

Mineral Oil Fact vs. Myth Several Environ pre-cleansers incorporate a specially formulated, highly refined mineral oil. Although mineral oil has been despised for a very long time, it has proven to be one of the safest oils that can be applied to human skin. It is the preferred oil for use on babies to protect them from aggressive chemicals, and no one has ever had reason to doubt that the popular baby oils are in fact safe. The reason why mineral oil becomes essential in anti-comedogenic products is because oil is required to dissolve the waxes that make up the comedone. Highly refined pharmaceutical grade mineral oil is particularly useful from that point of view. It is also one of the safest ingredients that we can use (the main constituent of baby oils), and recently the FDA has recognized that mineral oil in contra-distinction to other petro-chemicals, does not need any legislations and special bottle tops to prevent ingestion by children. As you know, it has also been used as a mild laxative in children for many years. Mineral oil has been thoroughly investigated and it has been shown that when one uses highly refined mineral oil then it is extremely unlikely that it will cause skin reactions. Dr. Kligman and also Dr. Fulton have recommended its use for many years. When commenting on mineral oil containing products, the CTFA stated that They have a demonstrated safety record. Billions of these products have been safely used by many millions of consumers for many years. Even Cosmetic Cop now recognizes highly refined mineral oil as an extremely efficacious ingredient in skin care technology especially in treating oily skin. Environ s pre-cleansers are superb at helping to pull sebum out of pores with the use of botanical oils as well as mineral oil. Combined with Environ s Claytech Masque, this unique duo has proven to be an exceptional regime to rid the skin of excess oil and waxes without over drying and triggering the over production of oil. The cosmetic industry used to denigrate mineral oil as being crude and not plant derived. In fact mineral oil is a natural and highly refined extract of plants something people easily lose sight of! Continued on reverse. Product of the Month EssentiA Forte Environ s Proactive EssentiA has been available for a number of years. It is renowned for its moisturizing effect and is currently used mostly on the body. It is a very fine oil containing high doses of vitamins A and E. It is excellent for dry skin conditions and is particularly recommended for sun damaged areas of the body. Environ now brings you Intensive EssentiA Forte, a stronger formulation than the current EssentiA. It helps to normalize the skin and promote the production of collagen and elastin to a greater degree. Because of the increased strength of the ingredients, however, it must only be used by clients who are acclimatized to the Proactive EssentiA. It is also indicated for people who have had medical needling.

Mineral Oil continued from front. There is no carcinogenic potential in highly refined mineral oil. It is safe and innocuous enough to actually be instilled into the eyes to prevent mucosa from drying up without causing any problems. The advantages of mineral oil are: 1. It is a solvent for sebum and can melt the inspissated, dry sebum that may clog the ducts of the sebaceous glands. As a result the ducts are cleared and sebum can drain. Blackheads are dissolved away and white heads disappear. Since this is one of the important stages in the development of acne, the chances for a breakout are reduced. 2. The solvent activity also helps to remove oily debris from the surface of the skin. The skin is, therefore, cleaned quite thoroughly but extremely gently. 3. Mineral oil also temporarily liquifies the glue between the cells of the horny layer and is postulated to actually improve penetration of active agents by allowing the actives to move more easily through the glue and enter the inter-cellular fluid. That means that the active ingredient can then more easily get to the layers where the effects can be expressed on the keratinocytes and the fibroblasts. 4. The oily quality of mineral oil is light enough not to be a cosmetic problem and also can still act as a seal to minimize trans-epidermal water loss. That means that the skin becomes better hydrated. This is of particular value in dry atmospheres. Chirality and Environ Environ Skin Care Products are Chirally Correct Several skin care companies have started to advertise themselves as chirally correct as if this is a new discovery. Environ has been using chirally correct molecules for over fifteen years. Environ only uses molecules that can be effectively and safely used in the body. The skin, the body s largest organ, has millions of receptors that control whether or not a molecule can be accepted and used effectively by the body. Most biomolecules, including skin care ingredients, are chiral. This means they have a left and a right chemical orientation, much like our hands (chiral, pronounced ki-rul, is Greek for hands). Chiral molecules, like our hands, are identical mirror images of each other, some of these fit into the skin s receptors while others do not. Usually only one of the mirror images is good for your skin, so it is necessary to use chirally correct molecules when formulating effective products. Environ has been doing this since its inception. Environ Price Restructuring We would like to thank you for your support over the past year. Environ Skin Care continues to grow in the USA thanks to your continued confidence in our products. It is now one of the fastest growing, medically based skin care lines in the country. The response to the products by patients, physicians and skin care professionals has been overwhelming. Environ Skin Care and have always made the utmost effort to avoid a price increase. We recognize price increases can have a disruptive effect if not handled properly. For the past eighteen months has managed to maintain pricing in spite of the dramatically falling dollar and increased costs. With the changing US economy and the strengthening of foreign currencies relative to a weakened dollar, we have to institute a price increase on products as research, ingredients, manufacturing and distribution costs have risen. This is only the second increase in eight years. plans to delay implementing a price increase until May 1, 2005. We will continue to absorb the increased costs on your behalf until this date. This provides you with lead time before any changes take effect. Feel free to purchase as much of any product as you wish prior to the price increase taking effect. All orders at the old prices must be received prior to May 1, 2005. Effective May 1, 2005, most treatment products will increase between 5% and 10% while many popular products (e.g. cleansers) will increase 5% or less. A comparative price analysis of Environ products in the U.S. demonstrates our line is reasonably, fairly and competitively priced in relation to other clinical lines both nationally and internationally. As we have demonstrated over the past eight years, we will endeavor to avoid any further changes for as long into the future as is possible without ever compromising the quality and innovation of our unique products. We value our relationship with you. Please call us at (508) 539 8900 if you have any questions.

Plastic Surgery and Environ By Dr. Des Fernandes Vitamin A When doing plastic, cosmetic or reconstructive surgery one wants to make the best scars possible. No matter where the scar is placed, it will heal better if the skin growth cycle is fast. It will also heal better if the mechanisms to make collagen are activated. Vitamin A does exactly that, which is why I started to use vitamin A on scars in 1976/7. I also learned then that one can avoid or minimize keloids by using retinoic acid. At that time I believed that only retinoic acid could do this and I put all my breast surgery, abdominoplasty, face lift patients on this to use on the area just before and for a few weeks after surgery. I also noticed that people with oily facial skin benefited from this. People with oily facial and nose skin make awful scars and I discovered that if the people use retinoic acid for about three months prior to surgery, then the oil gland activity is reduced and the skin becomes smoother. The resultant scars are better. I extended the use to people who had keloids. Before doing an intralesional excision of a keloid, I made the patients use retin-a for at least three months. I believe that is why I never saw a keloid in a scar except for two patients: one patient who had such a bad keloid tendency that he even had keloids on his palms! I managed to give him smaller keloids in my subsequent surgery, but he never got the keloids as big as they had been before. Interestingly enough I am now treating his son because he feels that I am the only one who knows how to manage keloids. In the beginning I thought that only retinoic acid could do this. After I started work with retinyl palmitate in 1987/8, I also started to use it for scars and I believe that retinyl palmitate or acetate is the best one to use because one hardly ever gets people who default in using it. A major problem I found is that people would react to the retinoic acid and then stop using it, so that when they came for their surgery, they had not used it. With retinyl acetate/palmitate this does not happen. I had the patients use EssentiA oil on their bodies in the areas where I would be making the scars. Of course, I also taped up my scars for about three months and some people say that is the real reason why the scars were better. I believe taping plus vitamin A is the best solution. Vitamin C Now it turns out that vitamin C may have a very important part to play in the treatment of keloids. One patient of mine had his ears fixed at the university and then came to me with grotesquely large keloids. I put him on vitamin A and did an intralesional excision and over the following few years he grew a keloid which was not large but could still be seen. I told him that we should not do anything more. He came across my name a few years ago on a keloid chat line and contacted me again and begged for more surgery. We used vitamin A on the skin and also Masque Crystal applied daily to the area of the keloid. He did this for three months post-operatively and never developed a keloid. Another patient who had breast surgery developed a hypertrophic scar on her breast even though she generally makes invisible scars. We had not prepared her skin because I knew she makes such good scars. The hypertrophic scars responded to Masque Crystal applied under occlusion of plastic. It caused a peel-like affect to the area but the scars flattened and the red disappeared. As a standard post-operative care for face lifts, I believe that the C-Quence 3 Continued on reverse.

Plastic Surgery continued from front. is probably the finest that we can offer. Not only will the scars mature well but the facial skin will get a younger appearance. Peeling The Environ peels have special advantage because they are mild and yet can be converted into heavier peels by either layering them thicker, or by leaving them on for a longer time. I found that if one does a mild peel to a scar within a day or two of surgery, then the scar settles down faster and looks more mature. I once was visited by a famous Japanese plastic surgeon, Dr. Yukio Shirakabe, and he was with me when I was seeing a patient who had had a face lift. I showed him the scars and then he asked the patient when she had had her surgery. He was very surprised to hear that it was about 10 days before. The scars looked like six months scars, he said. I apply the TCA cream 5% to the scar for about 10 minutes and do this on the second day after surgery, and every day or two afterwards when they come in for their normal follow-up. I now also use the 5% TCA PamGel and it works just as well. TCA (and I imagine AHAs) clean up infections because they kill the bacteria. Bacteria have no resistance to acid and so one does not have to worry about what type of bacteria one is dealing with. I have been consulted on two occasions by dermatologists to help them with awful infections of the face. They both had large septic areas in the dangerous triangle of the face near the nose, and had been on numerous antibiotics and were not responding. The abscesses were draining. I applied the TCA cream 5% and left it on until the edges of the abscess frosted. Both of these men told me that about 20 minutes later the pain in their face subsided. One patient was so bad that I had asked him to come back in the evening for another treatment, and by then the edema was showing signs of dissipating. I treated the abscess again and then had him in for daily treatments. Within about four days his dangerous signs had disappeared and the abscess stopped draining, and he healed despite not being on any additional antibiotic. In fact he stopped using the antibiotic after about two days. He healed without a major scar. I have also used peeling for horrible fungal toe or finger nail infections. Takes time about two months but then so do the very expensive antifungals. I am considering writing a paper about this, but...time!!! Of course peeling is great for acne but only if the person is using vitamin A at the same time. Then one can push the vitamin A dose higher and control the acne with peeling. Iontophoresis and Sonophoresis I believe we have a very powerful tool here for treating scars, and also for making skin look younger and getting the best effects from cosmetic plastic surgery. For everyone doing a face-lift, I recommend a series of about 24 iontophoresis treatments done either twice a week or once a week, or at the worst on alternative weeks. The Masque Crystal and the vitamin A gel are the usual agents used. However, Serum C-Quel should not be forgotten in those people with less sun-damage. Acne scars can be treated better by iontophoresis of vitamin A gel. This we have shown to give better results than resorting to dermabrasion. If dermabrasion has recently been done then a course of these treatments should give healthier skin and a better result: a major point that should be kept in mind. We have done intensive iontophoresis for dense post-burn scars and we have been able to flatten the scars and make them less ugly. In summary, every plastic surgery patient should use the Proactive or Ionzyme series. Where we want more intensive effects then we use iontophoresis and sonophoresis. If the skin is infected, then mild peeling has an important role to play, e.g. acne. It may also help to get skin looking better, though once one has treated the surface roughness, then the iontophoresis will give better results. The combination of mild peeling on a fresh scar and vitamin A and C, I believe, gives the best possible scars.