Skin Active Texture Preservation Temporary version 04-07-2013
Active complex to stimulate skin hydration and improve its texture. Unichondrin ATP is an optimized mix between energetic and moisturizing molecules, that revitalize the skin: Rapid and intense hydration; Improvement of its texture in only one cycle of skin renewal. Stress and environmental factors Trans-epidermal water loss Degradation of the connective tissue Unichondrin ATP is an active complex consisting of chondroitin sulfate, an intense skin moisturizer; ATP, as energy source; hydrolyzed vegetable protein and butylene glycol. Dry and rough skin
Active complex to stimulate skin hydration and improve its texture. Unichondrin ATP is an optimized mix between energetic and moisturizing molecules, that revitalize the skin: Rapid and intense hydration; Improvement of its texture in only one cycle of skin renewal. Stress and environmental factors Unichondrin ATP Better regeneration of the connective tissue + - Chondroitin sulfate moisture retaining biopolymer that occurs in the connective tissue Adenosine Triphosphate cell energy for a long term effect Unichondrin ATP is an active complex consisting of chondroitin sulfate, an intense skin moisturizer; ATP, as energy source; hydrolyzed vegetable protein and butylene glycol. Improved texture and hydrated skin Hydrolyzed vegetable protein Stabilize ATP Reinforce the hydrating properties of chondroitin sulfate
Enhancement of skin texture (Clinical efficacy) Protocol: Unichondrin ATP was tested to enhance skin texture. This clinical study was run on 4 women (aged between 35 and 65), who applied either a placebo or the cream containing 2.5% of the product, twice a day, for 4 weeks on half of the face. Silicone replicas were then analyzed using computer aided image analysis. Result: Unichondrin ATP shows an overall enhancement of skin texture: -67% wrinkles decrease in number and -46% reduction of wrinkles depth, compared to placebo. % change vs T0 0-10 -20-30 -40-50 -60-70 Assessment of skin surface topography -35% -46% Average amplitude (RZ) -29% -67% Number of peaks (RN) -54% -58% Residual length (RS) -25% -42% Primary wrinkle (RT) -30% Placebo Unichondrin ATP - 2.5% -42% Roughness
Enhancement of skin texture (Clinical efficacy) Protocol: Unichondrin ATP was tested for its ability to enhance skin texture. This clinical study was run on 4 women (aged between 35 and 65), who applied on half of the face either a placebo or the cream containing 2.5% of the product, twice a day, for 4 weeks. 3-D representation of the silicone replicas were then analyzed done. Result: Unichondrin ATP shows an overall enhancement of skin texture, compared to placebo. 3-D representation 3-D representation with 2-D projection Digitized image analysis of silicone replicas Before Peaks Transitions Valleys After 4 weeks
Improvement of skin moisturization (Clinical efficacy) Protocol: Unichondrin ATP was tested for its ability to increase skin moisturization. This clinical study was run on 4 volunteers (aged of 43 & 44), who applied on their forearm a placebo and a cream containing 2.5% of the product, twice a day, for 29 days. Measurement were done using the electrical conductivity of the skin. Skin moisturization (% vs T0) 400 320 240 160 80 Measurement of skin moisture content +12% +62% Result: Unichondrin ATP increases skin moisturization by 62%, after 4 weeks of application, compared to placebo. 0 15 days 29 days Placebo Unichondrin ATP - 2.5%
TECHNICAL INFORMATION INCI: Origin: Preservation: Appearance: Solubility: Dosage: Processing: Regulatory status: Claims: Water, Butylene Glycol, Hydrolyzed Vegetable Protein, Adenosine Triphosphate, Sodium Chondroitin Sulfate Organic synthesis Preservative free Clear to slightly opalescent, brownish liquid Water-soluble 2.5% - 5% Can be incorporated in any formula in liquid form at ph below 6.5 and temperature below 45 C CN, JP, KR*, HK, AU, ASEAN, USA, CA, South-Am., Mid-East, EU Skin revitalization, skin texture enhancement, smoothing, moisturization SAFETY ASSESSMENT * Registration pending Ocular irritation: Skin irritation: Mutagenicity: Advanced Tissue Sciences Customer Testing - non irritant at 100% Closed epicutan patch test - non irritant at 20% Ames assay - OECD 471 - non mutagenic
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