NEW HORIZONS IN DERMOCOSMETICS

NEW HORIZONS IN DERMOCOSMETICS Cosmetics treatment becomes therapy

Vandel is a partnership between doctors, pharmacists and communication experts. It offers scientific information to doctors, pharmacies and patients. It provides innovative formulations, the result of dermocosmetics research in laboratories where the opportunities offered by new materials and formulations, their safe use, packaging materials, and compatibility with the products are assessed. 2

MEDICAL BEAUTY WORKSOHPS Vandel organizes trainings for medical doctors, customers, pharmacists and wellness operators (MD). It also arranges workshops in esthetic medicine with the help of University expert speakers, doctors, pharmacists and communication experts. PRODUCTION AND SPECIFICATIONS CERTIFICATION OF COMPLIANCE WITH INTERNATIONAL STANDARDS Our flexibility in the production of specific formulations allows us to comply with the certifications required. We declared, to regard, currently do not use any derivative of pig or animal in general for our formulations used cosmetic dermatology. Our formulations are notified at the Italian Ministry of Health that we issue an identification code for each product and contain no preservatives skin irritants. SCIENTIFIC RESEARCH Vandel formulations are produced according to International regulations and can be an effective complement to a pharmaceutical therapy. The consumers needs and demands - object of exhaustive studies - have been thoroughly addressed. Practitioners and pharmacists are provided with highly effective formulations for solving skin problems. The safety and tolerability of our formulations is for us of primary importance: Vandel performs clinical trials with its formulations to address this aspect. Oxidative stress with free radicals - considered by the Scientific Community and leading manufacturers an accelerator of the aging processes of the skin - has also been addressed. CLINICAL TRIALS The use of cosmetic treatments can slow the dynamics of this aging process and meet the needs of those patients who demand a relaxed face and a glowing and tonic skin. The innovative Vandel formulations have a hydrating effect and promote a rapid relaxation of wrinkles and a rejuvenation of global tissue by stimulating the reactivity of the skin and promoting dermal tropism. The formulations are clinically tested in collaboration with Universities and clinics to guarantee their effectiveness and high tolerability for the skin. In particular at the Research Department of the Cosmetological Centre of the University of Ferrara. 3

DEEP MOISTURIZING VANDEL SKIN CREAM 50 ml. Soothing and normalizing factor, aging, altered by solar radiation (photoaging) and time (timeaging). MODE OF ACTION OF THE MAIN COMPONENTS OF VANDEL SKIN CREAM MANDELIC ACID: it s an alpha hydroxyl acid (AHA) with 8 carbon atoms, derived by hydrolysis of an extract of bitter almonds. It has a strong ability to penetrate the skin. It s widely used in cosmetology to promote the relaxation of wrinkles. It can be used unlike other acids adopted by dermatologists in all seasons because it is not photosensitizing. The treatments using mandelic acid may also be applied to photosensitive patients, without risk of hyperpigmentation. IALURONIC ACID: deep moisturizing, water reserve for skin. CARRAGEENAN: it s a film molecular sustained-release of long duration. It has high moisturizing and gives a pleasant touch to the treated area. And extracted from Chondrus crispus, also known as Irish seaweed. INDICATIONS: deep skin hydration, prevention and treatment of premature skin aging. Irritation from shaving. USE: apply VANDEL SKIN cream on the affected area and massage completely. Repeat application several times a day. Excellent as a base for makeup. SKIN CLEANSING NORMAL AND SENSITIVE VANDEL CLEANSING MILK 200 ml VANDEL CLEANSING MILK is a soothing formulation designed to complement treatment with Vandel Skin Cream. It s meets the needs of a sensitive skin, easily irritated and dehydrated. MODE OF ACTION OF THE MAIN COMPONENTS OF VANDEL CLEANSING MILK MANDELIC ACID: carries out repair and reactivation of cutaneous antiseptic properties. SHEA BUTTER: antioxidant and emollient useful for tropism and elasticity of the skin. SWEET ALMOND OIL: soothing activity and promoting tropism of the skin. VITAMINS A, E, H (BIOTIN): useful in the treatment of sensitive skin with excessive secretion of sebum. LINOLEIC ACID (VITAGENO F): keratolytic properties. USE: apply to wet face, massage and rinse. With a cotton swab dipped in cleansing the affected areas. Suitable for face and body, even in children. - Does not make irritation - Does not alter the barrier function of the skin 4

VANDEL BODY CREAM 150 ml SKIN FIRMING VANDEL BODY CREAM: innovative combination for treatment and prevention of skin aging. Used to treat breast firming. Adjuvant treatment in the cycle of skin renewal. VANDEL BODY CREAM reduces shaving frequency and skin irritation. MODE OF ACTION OF THE MAIN COMPONENTS OF VANDEL BODY CREAM THEOBROMA GRANDIFLORUM: rich in fatty acids (Omega 6, Omega 9), it absorbs water up to 419 % of its volume. It ensures optimal skin hydration by encouraging long-term processes of scarring and flaking. MANDELIC ACID is particularly active in skin repair. SHEA BUTTER: an emollient and antioxidant. It improves the firmness and elasticity of the skin. SWEET ALMOND OIL: unsaponifiable agent with natural soothing activity. CARRAGEENAN: molecular film with high moisturizing power, gives the treated area a pleasant and immediate tactile effect. Its activities include long-term sustained release. INDICATIONS: treatment skin aging, skin irritations after shaving, prolonged treatment of scars, breast firming. USE: Apply VANDEL BODY on the skin area and massage until completely absorbed. Repeat two or more times day. VANDEL ROSE CREAM 50 ml SKIN REDDENING VANDEL ROSE CREAM: a specific treatment for skin affected by rosacea and other forms of redness. It takes the extraordinary power of the spent grain wax and glycyrrhetic acid, providing a cortison-like activity. Reduce visibly every form of redness on the skin. VANDEL ROSE CREAM is an effective beauty treatment for the skin, moisturizing and soothing. It makes the skin toned and elastic and prevents signs of skin aging. MODE OF ACTION OF THE MAIN COMPONENTS OF VANDEL ROSE CREAM TITANIUM DIOXIDE ANATASE: sunscreen through refraction, absorption and reflection of sunlight. ACID GLYCYRRHETIC: cortisone-like activity without side effects usually related to the use of steroids. BISABOLOL: soothing and anti-reddening activity, it modulates inflammation. PALMITOYL TRIPEPTIDE-5: it stimulates the production of collagen, repairing damage to the extracellular matrix. SPENT GRAIN WAX: decongestant and on the surfaces of pericapillary areas. INDICATIONS: prevention and treatment of rosacea and aging, skin reddening. USE: apply VANDEL ROSE cream on the affected area, massage until completely absorbed. Repeat the application several times a day. Excellent as a base for makeup. No preservatives skin irritants 5

THE COSMETIC ALTERNATIVE TO BOTOX APPLICATIONS VANDEL LIFT CREAM 50 ml VANDEL LIFT CREAM: it favors cell turnover. It strengthens the skin s natural defenses. Ideal for daily care of sensitive skin. VANDEL LIFT Cream respects the skin balance, progressively renews the skin, removing the superficial layer altered, transmits to the skin hydration and elasticity. MODE OF ACTION OF THE MAIN COMPONENTS OF VANDEL LIFT CREAM The synergy of VANDEL LIFT CREAM promotes tissue growth, elasticity and skin tropism through the following components: DUNALIELLA SALINA, unicellular seaweed, it stimulates cellular levels of ATP (Adenosine triphosphate). PEPTIDES derived from snake venom, Tropidolaemus wagleri, muscle relaxant. PEPTIDE TRIAMMINOACIDIC for the stimulation of tissue growth (TGF-ß). INDICATIONS: anti-aging skin, before and after laser treatment, stimulation of the biological functions of the skin, especially in old age. USE: apply VANDEL LIFT Cream to the area (preferably moistened with distilled water) and massage until absorbed. Repeat two or more times a day. Excellent as a base for make up. FOR SKIN AND HAIR VANDEL ANFO 1 acid base cleanser 250 ml VANDEL ANFO 1 acid-base cleanser studied to protect skin and hair from mycosis, pool or gym for its preventive action of mycosis. It favors the physiological regulation and skin renewal and regulates transepidermal water loss (TEWL). It respect the balance between hydro-lipid film and natural moisturizing factor (NMF), reinforcing the protective function of the skin. MODE OF ACTION OF THE MAIN COMPONENTS OF VANDEL ANFO 1 CLEANSER SODIUM COCOYL GLUTAMATE: obtained from glutamic acid, it belongs to the category of acyl glutamates characterized by excellent skin tolerance and strong cleansing activity. UNDECYLENIC ACID: extracted from legumes. Effective in the prevention of superficial mycosis infection. SERICIN HYDROLYZED: silk protein with activity moisturizing and film-forming. Soothing and moisturizing the irritated scalp. INDICATIONS: Vandel Anfo 1 is indicated in the frequent washing of hair and body. Cleansing for normal and sensitive skin, pediatric and geriatric. Indicated in patients with allergic skin sensitive and intolerant. Ideal for use after sports activities in the pool or gym for its preventive action of mycosis and microbial diseases. USE: apply to wet area, rub and rinse. If necessary, repeat the operation several times a day. WARNING: Vandel Anfo 1 is indicated only for external use. Do not ingest. 6

V A N D E L P E E L S T R O N G 1 0 0 m l for 80-90 facial treatments DEEP TREATMENT FOR SKIN AGING VANDEL PEEL STRONG for professional use, balanced action, mixture of acids of natural origin. Composed of 25% trichloroacetic acid, the ph of the formulation between 1.6 and 2.0. INDICATIONS: Deep treatment for skin aging, hyperpigmentation, sebum control, acne, stimulation of skin cell turnover. WARNINGS: Do not apply on skin lesions, avoid contact with eyes and mucous membranes. USE: On the surface of the skin to be treated with a swab soaked by VANDEL CLEANSING MILK. Spread over the surface of the skin a veil of VANDEL PEEL STRONG, (with brush or sterile gauze). Wait 5-8 minutes before removing VANDEL PEEL STRONG with a swab soaked by VANDEL cleansing milk or water and baking soda (sol.1/10). Rinse with VANDEL CLEANSING MILK, then apply on the to skin VANDEL SKIN CREAM deep moisturizing. COMPOSITION: water, trichloroacetic acid, phytic acid, pyruvic acid, kojic acid, mandelic acid, tetrasodium edta. V A N D E L P E E L S O F T 1 0 0 m l for 80-90 facial treatments SOFT TREATMENT FOR SKIN AGING VANDEL PEEL is a formulation consists of a mixture of naturally derived acids. Acid quantitatively more this is the mandelic acid, contained 50%, the ph of the formulation is between 1.6 and 2.0. The formulation is completed with Resveratrol, Gluconolactone, Phytic acid, Lactic acid,tetrasodium EDTA. Do not apply on skin lesions, avoid contact with eyes and mucous membranes. Vandel peel is suitable for soft peeling treatment of aging skin, suffering from hyperpigmentation and scarring. The peeling is also indicated for patients who want to prevent the signs of aging skin and encourage cell turnover, Vandel peel also proved very effective in treating inflammatory acne. USE: On the surface of the skin to be treated with a swab soaked by VANDEL CLEANSING MILK. Spread over the surface of the skin a veil of VANDEL PEEL, (with a brush or sterile gauze). Wait 5-10 minutes before removing VANDEL PEEL with a swab soaked by VANDEL cleansing milk or water and baking soda (sol.1/10). Rinse with VANDEL CLEANSING MILK, apply on the skin VANDEL SKIN CREAM or VANDEL LIFT CREAM, moisturizing deep. VANDEL KIT KIT FOR PROFESSIONAL USE dermatological correction CONTENTS: VANDEL PEEL 100 ml: soft or strong peeling - VANDEL SKIN CREAM 50 ml - VANDEL CLEANSER MILK 200 ml - BRUSHES for peeling use. VANDEL KIT HOME USE consolidation results CONTENTS: VANDEL SKIN CREAM 50 ml - VANDEL CLEANSING MILK 200 ml - VANDEL ROSE CREAM 50 ml GENERAL BIBLIOGRAPHY: Merck Index, 11th Edition, 5599.- Corson, BB, Dodge, RA, Harris, SA; Yeaw, JS (1941). Scott JE, Presti D: Hyaluronan-mediated protective effect against cell damage caused by enzymatically produced hydroxyl radicals is dependent on hyaluronan molecular mass. Cell Biochemistry and Function 12: 281-288 (1994). Collins PS. Chemical face peeling. IN: Elson ML, ed. Evaluation and treatment of the aging Face. New York, NY: Spring-Verlag; 1995:51-52. Van Scott EJ, YU RJ. Alpha hydroxyacids: therapeutic potentials. Can J Dermatol 1989; 1: 2108-12. Berardesca E, Distante F, Vignoli GP et al. Alpha hydroxyacids modulate stratum corneum barrier function. Br J Dermatol 1997;137:934-8. Kobayashi T. and Yamada S.J. Dermatolog. Surg. Onc., Electrosurgery using insulated needles,basic studies.34 40,1987. Chess C, Journal of Cosmetic and Laser Therapy, 6: 86-90, 2004. Yang H, Protiva P, Cui B, Ma C, Baggett S, Hequet V, Mori S, Weinstein IB, Kennelly EJ (2003). New bioactive polyphenols from Theobroma grandiflorum ( cupuaçu ). J Nat Prod 66 (11): 1501-4. Foot Ankle Spec. 2008 Apr;1(2):93-6. A new concept in the topical treatment of onychomycosis with cyanoacrylate,undecylenic acid, and hydroquinone.rehder P, Nguyen TT. H.J. Draize, G.Woogard, H.O Calvery : Methods for the study of the irritation and toxicity of substances applied topically to the skin and mucous membranes J.Pharmacol.Exp.Ther., 82-337(1994). L.Celleno, A.Vasselli, M.V. Tolaini, A.Mastroianni and F. Macchia : Survey of tolerability and cosmetic acceptability of skin cleanser: methodology comparison.dermatological cosmetics, 45:p.17-50(1993) 7

Contact: Galleria dei Fonditori, 3-61122 Pesaro - Italy General Manager: Dr. Maurizio Pierpaolo Skype: pierpaolo.maurizio Telephone: 0039 0721 1835203 Fax: 0039 0721 1832175 Mobile: 0039 3920941569 E-Mail: info@vandel.it - p.maurizio@vandel.it www.vandel.it