Dermal Fillers
Aesthetic Dermatology Vol. 4 Series Editor D.J. Goldberg New York, NY
Dermal Fillers Volume Editor D.J. Goldberg New York, NY 66 figures, 62 in color, and 7 tables, 2018 Basel Freiburg Paris London New York Chennai New Delhi Bangkok Beijing Shanghai Tokyo Kuala Lumpur Singapore Sydney
Dr. David J. Goldberg Director, Skin Laser and Surgery Specialists of New York and New Jersey New York, NY (USA) This book was generously supported by Library of Congress Cataloging-in-Publication Data Names: Goldberg, David J. (Dermatologist), editor. Title: Dermal fillers / volume editor, D.J. Goldberg. Other titles: Aesthetic dermatology (Series) ; v. 4. 2235-8609 Description: Basel ; New York : Karger, 2018. Series: Aesthetic dermatology, ISSN 2235-8609 ; vol. 4 Includes bibliographical references and indexes. Identifiers: LCCN 2017039083 ISBN 9783318061246 (hard cover : alk. paper) ISBN 9783318061253 (electronic version) Subjects: MESH: Dermal Fillers Face--surgery Injections, Subcutaneous Cosmetic Techniques Dermatologic Surgical Procedures Classification: LCC RD119.5.F33 NLM WE 705 DDC 617.5/2059--dc23 LC record available at https://lccn.loc.gov/2017039083 Bibliographic Indices. This publication is listed in bibliographic services, including Current Contents. Disclaimer. The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the book is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Drug Dosage. The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Copyright 2018 by S. Karger AG, P.O. Box, CH 4009 Basel (Switzerland) www.karger.com Printed on acid-free and non-aging paper (ISO 9706) ISSN 2235 8609 e-issn 2235 8595 ISBN 978 3 318 06124 6 e-isbn 978 3 318 06125 3
Contents VI Preface Goldberg, D.J. (New York, NY) 1 History of Fillers Narins, R.S. (New York, NY); Mariwalla, K. (West Islip, NY) 10 Anatomy for Facial Fillers: The Skin Surface and Beyond Sykes, J.; Allak, A. (Sacramento, CA); Palhazi, P. (Budapest); Cotofana, S. (Albany, NY) 27 Neocollagenesis Handler, M.Z.; Goldberg, D.J. (New York, NY) 36 Hyaluronic Acid in Dermal Fillers Goldie, K.; Voropai, D. (London) 47 Calcium Hydroxylapatite (Radiesse) Friedmann, D.P. (Austin, TX) 81 Safe and Effective Injection Technique Funt, D.K. (New York, NY) 105 Novel Use of Fillers (Chin, Nose, Hands) Marmur, E. (New York, NY) 119 Soft Tissue Augmentation in the US Nestor, M.S. (Aventura, FL/Miami, FL); Bass, A.M. (Aventura, FL); Gold, M.H. (Nashville, TN) 128 Complications of Cosmetic Fillers Grunebaum, L.D. (Miami, FL); Funt, D.K. (New York, NY) 141 Author Index 142 Subject Index Online supplementary material, https://www.karger.com/book/toc/276621 V
Preface It is now over 30 years since the initial bovine collagen dermal fillers became available. In the last 3 decades, a large variety of differentiated fillers have been introduced in the US and throughout the world. A book describing all the fillers available in Europe and Asia is not possible with the constant changes occurring almost monthly. Also, some potentially dangerous fillers have never reached the US because of strict FDA guidelines in the US. Therefore, this book will predominantly focus on dermal fillers available both in the US and in most of the world. The initial fillers were solely collagen-based products. They were FDA cleared, and predominantly used in the nasolabial folds. Today not only are there fillers made of a variety of substances, but numerous facial and non-facial areas can be treated using them. In addition, our understanding of dermal filler mechanisms of action has been revolutionized in recent decades. Initially thought to simply fill, some fillers also induce neocollagenesis after treatment, with the potential for further benefit after the initial fill. As expected, with increasing use of dermal fillers, more complications have been noted. Yet with better injection techniques and safety understanding, the incidence of complications has greatly decreased. In the initial chapters of the book, we will discuss the history of fillers, anatomy relative to filler injections, and filler-induced neocollagenesis. In subsequent chapters, we will discuss both hyaluronic acid and calcium hydroxyapatite fillers. The final chapters discuss the complications, injection techniques and safety, and novel use of fillers. E njoy. David J. Goldberg, New York, NY VI