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Company Introduction Daewoong Pharmaceutical Affiliate relationship DNCompany (DNC) Founded in 1945, became a listed company in Korea 7 Companies over the world ( China, Vietnam, Thailand, Philippines, Indonesia, Japan) Founded in 2001 An affiliate of Daewoong Pharm., Korea s leading Pharmaceutical company 5 R&D centers over the world ( Korea, 2 in China, India and USA) Specialized in manufacturing and selling cosmetics, filler, toxin and other derma and plastic surgery related products. 2
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1. Company info 4
2. Strategy & Organization 5
2. Strategy & Organization 6
3. Core competitive power- Sales Hospitals 252 MRs Clinics 467 MRs Total 719MRs 7
3. Core competitive power- Global network 8
3. Core competitive power - Partnership 9
4. Compliance Program Ethical management Company with Validated Compliance 10
5. Global Network Global R&D centers 11
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1. Company Information Derma & Plastic Surgery Network Company More than 4,000 accounts in Dermatology & Plastic Surgery clinics in South Korea Strong relationship with Korean Academic Society MRs cover 3,200 Derma & P/S accounts national-wide Worldwide Partnership 2017 2016 Jan Received First Domestic Brand Award in Korea for 3 consecutive years and in China for 2 consecutive years 2015 2014 Oct Easydew Domestic Home Shopping Jun Easydew launched in HONG KONG SASA for more than 70 stores 2013 Nov Perfecta awarded 2015 premium brand prize for female consumers in the filler market Sep TEOSYAL launched (Only for Korean Market) Dec DANAE (HA filler) launched Dec NABOTA (Botulinum toxin Type A) launched Jan Easydew EX launched 2012 Apr DNCannula launched Mar DW-PDT launched Feb Facetem(CA filler) launched 2011 Nov EGF Gel form & hair tonic launched 2009 Aug Exclusive distributorship contract of Perfectha for Asian market. 2008 Apr Esthemed launched 2006 Jul Easydew launched 2005 Sep Cellisys launched 2001 Dec DNC Co., Ltd. Founded 2000 Apr Deawoong Pharmaceuticals Derma & Plastic Surgery Team formed 13
2. Strategy & Organization 14
3. Performance(Revenue and sales) 57 62 40 35 33.7 30 25 21.6 20 15 10 11.7 9.5 15.5 16.8 5 0 2009 2010 2011 2012 2013 2014 2015 2016 15
3. Performance(Revenue and sales) Medicines, 31% Etc, 5 Filler, 29% Cosmetics, 20% Botulinum Toxin, 15% 16
4. Core competitive power - Sales P/S clinics Dermatology G/P clinics Total 3200 accounts As of 2Q. 2014 17
4. Core competency - Sales DNC guarantees WIN-WIN business with you based on our extensive know-how and success stories from global networks. Doctor to Doctor Have chance to share Knowledge and Know-how of Filler / Toxin injection and Complications with Korean Doctors Grand Launching Symposium DNC provides support for successfully entering new overseas markets with various experience. Binding Program DNC provides opportunities for networking and sharing knowledge and experiences among accomplished doctors in the country and from abroad. 18
4. Core competitive power- Partnership 19
4. Core competency - Partnership 20
5. Why DNC? 40 30 20 10 21.6 15.5 16.8 11.7 9.5 33.7 No. 1 Position in Aesthetics Company, providing total solution from manufacturing to marketing services 0 2009 2010 2011 2012 2013 2014 CAGR :24 % for last 6years Aesthetic Market was increased 10% annually 5 R&D centers 5 Branches Over 20 partners in 30 countries 21
3 rd DNC Product 22
1. DNC Aesthetic Portfolio Pipe-lines Contouring Wrinkle Skin Care Acne Filler (only for Korea) (only for Asia) Toxin Cosmetics Lifting thread 23
2. Filler(HA) Type : HA Reticulated gel Biphasic + Monophasic Technology : Rotation and Revolution (R 2 Technology) World First, 2 in 1 Hyaluronic Acid Filler R Square technology - combines the advantages of Monophasic and Biphasic Non-free HA - strong maintaining volume, no swelling High Satisfaction - containing lidocaine, reduced pain Ease of Injection - TSK s Ultra Thin Wall Needle 24
2. Filler(HA) Type : HA Reticulated gel, Biphasic + Monophasic Technology : Rotation and Revolution (R 2 Technogy) Storage : 2 to 30 [Protected against sun and freezing] Danae Original Danae Line Danae Contour HA concentration Injection Depth Cross Linking Agent Mono : Bi (%) Duration 20mg/ml 20mg/ml 20mg/ml Superficial Deep Dermis Subcutaneous BDDE BDDE BDDE 50 : 50 (%) 40 : 60 (%) 30 : 70 (%) 6~9 months 9~12 months 12~15 months Needle Supplied [TSK Ultra Thin Wall] 1*30G 1*27G [TSK Ultra Thin Wall] 2*27G [TSK Ultra Thin Wall] 1*22G 1*27G Syringe Volume 1*1ml 1*1ml 2*1ml (2 syringe) 25
2. Filler(HA) Type : HA Reticulated gel_biphasic Technology : E-BRID The Latest Generation of Biphasic Hyaluronic Acid Filler 50,000 Doctors using PERFECTHA 71 Countries where PERFECTHA is sold 2.5Millions of PERFCTHA syringes sold worldwide since 2007 Duration of action in 18 months of PERFECTHA Subskin 0.001% of adverse events reported since 2007 to January 2014. 1% of cross-linking agent used 26
2. Filler(HA) Type : HA Reticulated gel_biphasic Technology : E-BRID Storage : 2 to 30 [Protected against sun and freezing] Perfectha Complement Perfectha Derm Perfectha Deep Perfectha Subskin HA concentration Injection Depth Cross Linking Agent Number of Particles/ml Duration 20mg/ml 20mg/ml 20mg/ml 20mg/ml Superficial dermis Mid dermis Deep dermis subq layer BDDE BDDE BDDE BDDE 180,000(180,000) 90,000(90,000) 8,000(8,000) 6,000(2,000) 4~6months 6~12months 8~12months 12~18months Needle Supplied Syringe Volume 2*30G 2*30G 2*27G 1*0.8ml 1*1ml 1*1ml 1*22G Needle 1*22G Cannula 1ml*3syringes or 3ml*1 27
2. Filler(CaHA) Obtained USA patent on porosity of Apatite (US703 7867-1) Using Apatite same with Bongros (Synthetic bone) approved by US FDA Type : Lattice-pore structure Collagen Stimulator of Calcium Hydroxyl apatite Filler Collagen stimulator Superior modeling and volume - Increased viscoelasticity by Highest 700 thousand Dalton gel carrier Ease of injection Superior Duration by Lattice-pore structure - Slow & Shell degradation Research apatite technology for 20 years 20 different patents on Apatite in Korea 28
2. Filler(CaHA) 20 different patents on Apatite Obtained USA patent on porosity of Apatite (US703 7867-1) Using Apatite same with Bongros (Synthetic bone) approved by US FDA Type : Lattice-pore structure Contents Simulator Gel-carrier Beads size Injection depth Packaging Calcium hydroxyl apatite microsphere Polymer gel carrier(carboxymethyl cellulose sodium, Glycerin, Water) 25μm ~45μm (Average 30μm ) Deep dermis Prefilled syringe / PET tray / Out-box 0.8cc*2syn/1.5cc Syringe volume Storage Biocompatible, nontoxic, nonirritating, non-antigenic, not required, sensitivity testing Room temperature CE Approval 29
3. Botulinum Toxin PRO s CHOICE FDA IND 1) Approval Registered our product strain in NCBI 2) Patented Technology - Promote Bio technology Industry for 30 years Reduced Impurity - High Purity (>99%) Overseas Expansion - 50 countries export contract 1) IND : Investigation New Drug 2) NCBI : National Center for Biotechnology Information 30
3. Botulinum Toxin Appearance ph Bacterial endotoxin Moisture Potency Specification White or off-white lyophilized powder 6.0± 0.5 Less than 10 EU/vial Less than 3% 80~125% High purity (>98%) Safer than competitor - Proved safe even if twice more doses taken compared to competitor - Accurate localization of clinical effect Identity Solubility Foreign insoluble matter Insoluble particulate matter Not loss in weight and dead Dissolved in 10~60 seconds Transparent and no foreign matter 10um<6000ea/container 25um<600ea/container More stable The reconstituted solution can be stored for up to 48hours in case of refrigerated storage condition FDA IND Approval / Recorded World class product / Registered our product strain in NCBI 31
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5. Medical Cosmetics - Portfolio - Post-laser Care - Intensive Moisturizer - Containing DW-EGF * For hospitals/clinics/plastic surgeries - CPRS Core Care - Skin Regeneration by DW-EGF - Sensitive Skin Care * For General Consumers Cosmetics - DW-EGF Cream - DW-EGF Cream Limited - DW-EGF Cream Premium - DW-EGF Dermal Needle Program * For home-shopping - Wrinkle Reducing - Elasticity Increasing - Containing DW-EGF * Online Shopping& Duty-Free - Cosmeceutical + Naturalism - Wrinkle Care - Purify + Revitalize + Brighten * Online Shopping& Duty-Free 34
Medical Cosmetics 5. Medical Cosmetics EGF by DAEWOONG Wound Healing Wrinkle Reduction Wound healing effect B&A photos with Easydew products &Laser treatment Clinical trials for Wrinkle reduction Wrinkle Improvement results 0 week 4 weeks 0 week 4 weeks Enhanced Skin Density < ref. data Asan Medical Center > < tested by Derma Pro > < tested by Derma Pro > 35
5. Medical Cosmetics EASYDEW(EX) 36
5. Medical Cosmetics EASYDEW(Daily) To improve skin problems fundamentally by 4-step core care program(c-p-r-s) and DW-EGF which has a remarkable effect on skin regeneration 1 Cleansing The beginning step of skincare with the gentle and detailed removal of impurities 4 Sunscreen Step of maintaining healthy skin that is restored by protecting skin from UV rays. Moist Cleansing Whip Foam Ultra Shield Sun Cream Baby Smoothing Sun Lotion Waterproof Sun Cream Fresh Mild Sun Cream 2 Peeling 3 Return Removing dead skin cells is a preparation step to promote skin s absorption of core ingredients Step of returning to healthy skin condition with core ingredients Extra Mild Peeling Gel Double Hydra Toner Double Hydra Essence Double Hydra Cream Finish Allin-One Moisturizer After Soothing Gel Essential Barrier Mist 37
5. Medical Cosmetics EASYDEW Season 1 Limited Season 2 Easydew DW-EGF Cream & Toner Lotte Home Shopping + GS Home Shopping Total Number: Over 2.5 million Total Sales: KRW 20 billions No.1 Selling Product of Lotte TV Home shopping No.1 Repurchase Rate Easydew DW-EGF Limited Cream & Toner Easydew DW-EGF Premium Cream & Essence To improve the skin elasticity and hydration by enhancing the skin barrier To improve the elasticity as well as freckles and speckles due to intense UV rays in summer In-depth anti-aging care in dermis with patented ingredients 38
5. Medical Cosmetics EASYDEW To help DW-EGF penetrate into skin deeply through Derma Needle Program 3000 (D.N.P) Derma One Shot Ampoule 28ea + Derma 3000 Shot 4ea Derma 3000 Shot Roller 1ea The combination of the exclusive ingredient DW-EGF and the patented technology makes it possible to enjoy the premium, convenient and safe home care on the basis of professional MTS care 39
5. Medical Medical Cosmetics Cosmetics CELLISYS CELL INNOVATION SYSTEM BY CELLISYS 1. Daily Skin texture Care 7. Special Vitality Care Wrinkle Solution Skin Softener for moisturizing 2. Daily Skin Nourishing Care Concentrating Emulsion 5. Special treatment Care EGF Wrinkle 29 Activator EGF Intense Mask complex for skin s elasticity 3. Daily Skin Elasticity Care Concentrating Essence 4. Daily Eye Firming Care Eye Contour cream 6. Daily Revitalizing Care Wrinkle Solution cream 40
DNC s Aesthetic Portfolio DNC s 5. Medical Aesthetic Cosmetics Portfolio - ESTHEMED 24hr derma care system ESTHEMED Laboratories The Natural Cosmeceutical Brand, developed by 31 dermatologists Daily Pocket Masks Esthemed Gold Energy Cream Esthemed Miracle Spa Esthemed Water Magnet 41
THANK YOU For global inquires, please contact one of below. dncglobal@daewoong.co.kr 42