SteMixx - Exclusive worldwide distributor : Contact: David Stark President AmStem International, Inc. (415)

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2 SteMixx - Exclusive worldwide distributor : Contact: David Stark President AmStem International, Inc. (415)

3 Why do I need SteMixx? As the process of aging occurs, elasticity declines, wrinkles increase, and the pigment in the skin changes because the number of stem cells in the human body decreases, as does the ability of the stem cells to divide. This product contains the HCSM (Human Stem Cell Conditioned Media) extracted from the umbilical cord blood. It helps to recover the function of the stem cell and vitalizes the stem cell of the skin. What is a stem cell? A stem cell is an undifferentiated cell that renews itself for long periods through cell division. It is the baby cell before developing into an adult cell that has characteristic shapes and specialized functions. When a stem cell divides, each new cell has the potential to either remain a stem cell or become another type of cell with a more specialized function. The skin, being the body s largest organ, has the most adult stem cells. Time and stress will diminish the skin s stem cells from their ability to renew and revitalize the skin. As a result, the skin loses its natural elasticity, and wrinkles form. How does SteMixx work? Using a scientifically balanced blend of dynamic Human Conditioned Stem Cell Media (HCSM) extract, naturallyoccurring stem cell protein solutions, and botanical flower extract ingredients, SteMixx provides the skin with vital nutritional supplements and makes it healthy, balanced, and rejuvenated in its ability to renew itself. Using the specially designed plunger applicators that waste almost nothing, SteMixx is applied to the face like any cream. Its soothing sustenance is rapidly absorbed into the thirsty skin, with effects you can see in a matter of days. SteMixx increases collagen secretion, and provides anti-inflammatory effects which provide important relaxation for the skin. All living things are relaxed when they are well-fed, and the skin s cells are no exception. SteMixx makes the skin nutritionally balanced, and provides it with a luxurious vacation from the stresses of survival in a harsh world. 1. Apply this product after cleansing. 2. Remove film from the back of individual packing of the special applicator. 3. Open the cap of the applicator. Please note when opening the cap, the contents disperse a small amount due to air pressure. 4. Press the plunger gently, and dispense a small amount of SteMixx onto the fingertips. 5. Apply evenly over the affected facial areas, and gently tap with fingertips. 6. Do not wash face or use other skin creams for 15 minutes. Storage & Additional Information 1. Each applicator of SteMixx contains approximately a two (2) day supply. You may use more or less as required. 2. This product consists of 5 individually sealed applicators. 3. This product does not contain antiseptic. 4. Store at room temperature, but refrigeration is recommended. Do not freeze. 5. After opening an applicator, please use within 3 days for best results.

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5 Wake up the cells that are sleeping in your skin! After the mid twenties the skin age starts aging and to get wrinkled because of the decrease of collagen, elastin, and the skin elastic. Also UV, stress and many other harmful materials causes pimples, liver spots, freckles, and makes rapid progress in skin aging. We would need an innovative care to keep up our skin health and skin age.

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7 Using dynamic Human cord/blood conditioned media extract, stem cell protein solution and natural flower Extract ingredients it provides the skin nutritional supplements and makes it nutritional balanced. Stemixx contains natural flower Extract ingredients and HCSM(human cord/blood cell conditioned media extract) which is registered in the ICID(International cosmetic ingredient Dictionary). stemixx protects the skin and has a lifting effect which makes the skin more elastic.

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9 Inviting a time travel for confident and elegant skin. After the mid twenties the skin age starts aging and to get wrinkled because of the decrease of collagen, elastin, and the skin elastic. Also UV, stress and many other harmful materials causes pimples, liver spots, freckles, and makes rapid progress in skin aging. We would need an innovative care to keep up our skin health and skin age.

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12 Introduction of histostem Histostem is the world's largest stem cell bank, which is concentrating on MLPC(multi-lineage progenitor cells) research. histostem is making a spurt on curing incurrable diseases and stem cell banking business. On 2003 histostem has proved it's superior technology by abstracting stem cells from human cord blood first in the world. Also retaining the technology of abstracting and proliferating the minimum existing stem cells from human cord blood. Business Model World s Largest Stem Cell Bank World s First Human stem cell therapy Mass-Production of Stem Cell HLA Technology Cell Therapy Health Care/ Anti-aging Skin Care/Cosmetics

13 Patents Registered & Pending Domestic (Korea) 1. Title : METHOD OF ISOLATING AND CULTURING MESENCHYMAL STEM CELL DERIVED FROM UMBILICAL CORD BLOOD 1) Patent No Title : METHOD OF ISOLATING AND CULTURING MESENCHYMAL STEM CELL DERIVED FROM CRYOPRESERVED UMBILICAL CORD BLOOD 1) Patent No Title : MIXING TECHNIQUE OF UMBRICAL CORD BLOODS WITHOUT IMMUNREACTION IN CASE OF MIXING BETWEEN MIXED UMBRICAL CORD BLOOD AND PERIPHERAL BLOOD 1) Patent No Title : CELL THERAPY OF SPINAL CORD INJURY WITH STEM CELL DERIVED FROM UMBILICAL CORD BLOOD 1) Patent No Title : TREATMENT OF BALDNESS WITH STEM CELL DERIVED FROM UMBILICAL CORD BLOOD 1) Patent No Title : COMPOSITION FOR CELL THERAPY OF AMYOTROPHIC LATERAL SCLEROSIS USING MANNITOL AND STEM CELL DERIVED FROM UMBILICAL CORD BLOOD 1) Patent No Title : A METHOD OF INDUCING MINIMALLY INVASIVE INJURY OF SPINAL CORD ON EXPERIMENTAL VERTEBRATE ANIMALS 1) Patent No Title : CULTURE MEDIUM COMPOSITION FOR IN VITRO PROLIFERATION OF MESENCHYMAL STEM CELL DERIVED FROM UMBILICAL CORD BLOOD COMPRISING SOY HYDROLISATE (Pending) 9. Title : COMPOSITION FOR CELL THERAPY OF LIVER CIRRHOSIS WITH STEM CELL DERIVED FROM HUMAN UMBILICAL CORD BLOOD (Pending) 10. Title : COMPOSITION INCLUDING CORD BLOOD MULTIPOTENT STEM CELL-DERIVED PROTEIN AND PROCESS FOR PREPARING THE SAME (Pending) 11. Title : PERCUTANEOUS INTRATHECAL TRANSPLANTATION OF STEM CELLS ON SPINAL CORD INJURED ANIMALS (Pending) 12. Title : STEM CELL TRANSPLANTATION METHOD AND COMPOSITION FOR CELL THERAPY WITH ENDOVASCULAR INTERVENTIONAL TECHNIQUES USING BASILAR ARTERY (Pending) 13. Title : PROCESS OF FRACTIONATING UMBILICAL CORD BLOOD WASTES AND CELL CULTURE MEDIA COMPOSITION COMPRISING THE FRACTION OBTAINED THEREFROM (Pending)

14 International 1. [U.S.A] Title : METHOD OF ISOLATING AND CULTURING MESENCHYMAL STEM CELL DERIVED FROM CRYOPRESERVED UMBILICAL CORD BLOOD 1) Patent No. 7,582,477 / 2) Registration date : September, 01, [EU] Title : METHOD OF ISOLATING AND CULTURING MESENCHYMAL STEM CELL DERIVED FROM UMBILICAL CORD BLOOD 1) Registration 3. Title : TREATMENT OF BALDNESS WITH STEM CELL DERIVED FROM UMBILICAL CORD BLOOD 1) Pending 4. Title : CELL THERAPY OF SPINAL CORD INJURY WITH STEM CELL DERIVED FROM UMBILICAL CORD BLOOD 1) Pending 5. [U.S.A] Title : METHOD OF ISOLATING AND CULTURING MESENCHYMAL STEM CELL DERIVED FROM CRYOPRESERVED UMBILICAL CORD BLOOD 1) Registration 6. [EU] Title : METHOD OF ISOLATING AND CULTURING MESENCHYMAL STEM CELL DERIVED FROM CRYOPRESERVED UMBILICAL CORD BLOOD 1) Registration

15 Histostem. People who keep the most beautiful thing. What is the most beautiful thing in the world? The answer is "life" that live and move gorgeously. However, numbers of people still dying out around the world because of the incurable diseases, in spite of the development of high-technology. Histostem is a company which starts with the biggest hope of human being, that everyone can have a healthy life without being worried about disease. Histostem, which has been concentrating on developing high technology of field of cord blood and stem cell, called a precious storage of new medicine as well as blood with miracle, achieved international authorization for cord bank first in Korea on August, 2002, and made world amazed with success on completely isolating stem cell of cord blood first in the world on May, 2003.We are operating Seoul cord bank, largest in the world, and Seoul Stem Cell Bank, established first in the world, and running for keeping life, the most beautiful in the world, and practicing the mind of real love. We will do our best to keep a single life which is precious, and to make this world healthier, for realization of vision of future. Thank you.

16 It is a water-soluble type ample containing protein originated from culture medium for stem cell from human cord blood, and the ingredient absorbed to skin makes tense. It is safe for skin without containing chemical antiseptic substance. It is good for the balance of skin by supplying nutrition with dynamic peptide originated from culture medium for stem cell from human cord blood and natural ingredient from plant. [Direction] 1. Apply this product after cleansing. 2. Remove film from the back of individual packing of the special applicator. 3. Open the cap of the applicator. Please note when opening the cap, the contents disperse a small amount due to air pressure. 4. Press the plunger gently, and dispense a small amount of SteMixx onto the fingertips. 5. Apply evenly over the affected facial areas, and gently tap with fingertips. 6. Do not wash face or use other skin creams for 15 minutes. [Volume] 1ml 5 ( 1 applicator for 2days ) - Each applicator of Stemixx contains approximately a two day supply. ( marked on applicator with lines) Distirbutor, sole Agency : Amstem Inc. USA Supplier : Histoste Co.,Ltd. Korea Manufacturer(OEM) : Hans Holdings Co., Ltd. Korea Made in Korea Customer Relations Office : (415) Homepage: