PHAR 434: PHARMACEUTICS IV Non-Sterile Practical
|
|
- Daniel Franklin
- 5 years ago
- Views:
Transcription
1 SEMISOLIDS PHAR 434: PHARMACEUTICS IV Non-Sterile Practical Topicals Suppositories Troches Bases: Every product has a base as its major component. The base defines the objective of the product its purpose. The drug is carried within the base, similar to the vehicle of a liquid. - Ex: Dry Skin Condition Oleaginous Base - Ex: Treatment of Acne Aqueous Base, or O/W Base Ointment Base Oleaginous, Absorption, W/O + Water, Water-Washable, O/W, Aqueous Suppository Base Fatty, W/O, PEG, Glycerinated Gelatin Troche Base Chewable (Glycerinated-Gelatin), Soft (PEG, Choco), Hard (Sugar) Ointment Water-Soluble Base O/W Gel OIL Non- Polar O L E A G I N O U S A Q U E O U S (Creams) WATER Polar Petrolatum Beeswax Aquaphor Semi-polar Glycols PEG, Polybase Hydrophilic Ointment Methylcellulose Contents Ointments and creams: Pages 1-2 Sticks: Pages 3-4 Lotion: Page 3 Suppositories: Pages 5-6 Troches: Pages 7-9 (1): TOPICALS Topical Bases: The ointment bases below are listed in order of decreasing hydrophobicity, increasing hydrophilicity Ointment Base Definition Levigating Agent Oleaginous Ex: Petroleum- pure hydrocarbon Greasy, non-washable, essentially pure oil They prevent moisture loss, occlusive! Mineral Oil Absorption Ex: Aquaphor, Aquabase W/O Ex: Eucerin Water-Washable Ex: Polyethylene Glycol (PEG) O/W Ex: Vanicream, Hydrophilic Ointment Aqueous Ex: Methylcellulose or carbomer gel Greasy, non-washable, with added surfactants but essentially no water (~W/O). Allows small quantities of aqueous solutions to be incorporated into ointment bases Moderately greasy, moderately washable. Involves water added to an absorption base Not greasy, water-washable, it is water-soluble Essentially aqueous, not greasy, and totally washable. It is a vanishing cream Pure hydrophilic. As water-soluble as it gets Mineral Oil Mineral Oil Propylene glycol or glycerin Glycerin Glycerin Levigating Agents: Levigating agents must be compatible with the ointment base when preparing creams, ointments, lotions, and sticks. Review the previous chart to find the appropriate levigating agent for your base. In general, mineral oil goes with our hydrophobic/oleaginous bases such as in Ointments, whereas glycerin goes with our hydrophilic/aqueous bases such as in creams or gels.
2 PREP: Ointments While ointment refers to any topical on the oil-water spectrum, ointment formulations specifically relate to the oil-soluble half of the spectrum. Ointments are generally applied to dry scaly skin. Ideal Base: Petrolatum Levigating Agent: Mineral Oil *Supporting Agent: Aquaphor (W/O+Surfactants) PREP: Cream Creams are on the aqueous half of the spectrum. They are usually applied to weeping or oozing surfaces. Ideal Base: Hydrophilic Ointment or- Polybase Levigating Agent: Glycerin Equipment Needed - Electronic Balance: Make sure you level your balance - Pill Tile: This is where you levigate your drug - If trituration is required Glass pestle and mortar - Rubber spatula This is used for the quantitative transfer, as well as removal from glass mortar - Ointment jar for the final product Ointment/Cream Procedure 1. Weigh your ingredients and label them. Do not leave powders laying around unmarked. a. Base b. Drug c. *Aquaphor if needed for Ointments. It may be needed to incorporate small quantities of aqueous solutions to ointment bases, such as urea. 2. Levigate your drug with an appropriate levigating agent on a pill tile a. Ointment product: Use mineral oil to levigate your drug on a pill tile i. *Exception: Water soluble drug Dissolve drug minimally in water, mix with aquaphor b. Cream product: Use glycerin to levigate your drug on a pill tile 3. Geometrically mix your base into your drug a. Look at your drug. How much is there. Mix an equal amount of your base to homogeneity on the pill tile. b. How much is there now? Mix an equal amount of your base to homogeneity on the pill tile. Continue. 4. Transfer your compounded product to an ointment jar a. If you get your jar greasy/wet/whatever, use isopropyl alcohol to wipe it down 5. Quality Check Quality Control: Color uniformity, Grittiness check, Weight/volume, appearance, odor, viscosity, particle size distribution, and texture, Field test = rub it on yourself as the grittiness check Counseling: For external use only, store in a cool dry place, keep tightly closed, keep out of reach of children, monitor for adverse/allergic reaction. Calculation Example Drug Source = Pure Drug Suppose we need 0.1mg/g of Drug Cream, total 2 Oz 1: How much drug do we need? 2 Oz = 60g 0.1mg/g * 60g = 6mg of drug is needed We cannot weigh 6mg on our electronic balance, but we can weigh 40mg. This is the least weighable quantity (LWQ)!"#$ &''('( -./01!"#$ 2: = à 67$ = 897$ )*+ -./01!"#$2!34#'5/ 897$ : So X = 266mg. Subtract the Batch Drug = 226mg diluent 3: Weigh 40mg drug, label. Weigh 226mg diluent, label. 4: Geometrically mix. If you need colored lactose, do it. 5: Weigh 40mg of your final product, it will have 6mg of your drug. Drug Source = Salt, or Commercial Product Ex: Caffeine Citrate Powder, the amount you weigh will not be the amount of caffeine you have. Must account for the molecular weight of citrate. Caffeine MW Caffeine Citrate MW = Total Caffeine Needed Caffeine Citrate to weigh Ex: Captopril 12.5mg tablets, the tablet weighs much more than 12.5mg. Must do a conversion! Assume Rx needs 30mg 1: Determine how many tablets you need: 30mg/12.5mg = 3 tablets 3 tablets has 37.5mg drug. We do not need all of it. 2: Find out how much 3 tablets actually weighs, lets pretend 120mg 37.5mg captopril 120mg total weight = 30mg captopril needed X triturated powder needed 3: Triturate and weigh out your powder. X = 96mg
3 PREP: Lotion A lotion is made by diluting your base with compatible diluent. Lotion are usually applied to rubbing areas with friction. Lotion formulations are characterized by viscosity, not polarity. Therefore, a lotion may be either oil-based or waterbased, and will be made to less viscous via dilution. - Hydrophobic Base (ie Aquaphor, Petrolatum): DILUTE with mineral oil - Hydrophilic Base (ie Methylcellulose): DILUTE with water or glycerin - For lotions we are diluting our base to the desired viscosity recall lotions are characterized by viscosity. So we will continue adding drops of mineral oil to petrolatum in the case of an oil-based lotion until we reach the desired viscosity. Lotion Procedure Methylcellulose formulation 1. Weigh your ingredients and label them - Methylcellulose (I recommend 2%) - Drug 2. Levigate/Dilute your Methycellulose with Glycerin (Add water?) 3. Levigate your drug with glycerin in a mortar 4. Geometrically add your base to your drug Ointment Base formulation 1. Weigh your ingredients and label them - Aquaphor - Drug 2. Dilute the Aquaphor with mineral oil 3. Levigate your drug with mineral oil in a mortar 4. Geometrically add your base to your drug Quality Control: Pourable (squeezable if in bottle), Qs volume, grittiness check Counseling: For external use only, shake well, store in a cool dry place, keep tightly closed, keep out of reach of children, monitor for adverse/allergic reaction. Stick dosage forms are made by adding thickening agents to the ointment base. You ll need to refer to a book to find the formula. PREP: Hydrophobic Stick Hydrophobic Stick Formulation: This product is compounded by melting hydrophobic ingredients on a water bath, adding drug and other ingredients after the wax has melted, and pouring into the stick device. Ingredients that are heat sensitive or volatile are added after melting of base ingredients to minimize ingredient loss. The benefits of the hydrophobic formulations include the formation of a barrier to prevent moisture loss - Hydrophobic Base (ie Petroleum) à Add Beeswax or high-melting point wax Hydrophobic Stick Procedure [Heat source, evaporating dish - Weigh your ingredients and label them. Do not leave powders laying around unmarked. o Base: Usually petrolatum o Emulsifying agent: Beeswax - excellent agent for emulsifying water-soluble components with the base o Thickening agent: Stearic acid? o Stearyl alcohol? o Drug - In class we used camphor, menthol - Combine and melt your hydrophobic ingredients on a heated water bath o This often includes Petrolatum, Stearic acid, stearyl alcohol, and beeswax - Remove from heat, add in your drug. Stir to dissolve until homogenous - While still warm, pour into application devices, slightly overfilling each tube. Try to work quickly and effectively - When the surface of the stick has hardened, add cap - Store devices upright for 24 hours until completely hardened. - Label, dispense, and counsel Quality Control: Allow remaining melted formulation to cool in small evaporating dish for thorough evaluation. Evaluate the cooled medicated sticks before dispensing. Counseling: For external use only, store in a cool dry place, keep tightly closed, keep out of reach of children, monitor for adverse/allergic reaction.
4 PREP: Hydrophilic Stick The most common example of a hydrophilic stick is deodorant. Similar to the hydrophobic stick, this product is compounded first by heating the ingredients until fully dissolved, adding the drug, pouring and cooling it in the application device. Be wary of ingredients that are heat sensitive, such as methyl salicylate, a common ingredient in the IcyHot stick. There are a few candidate bases, the one used in class involved propylene glycol and sodium stearate - Hydrophilic Base à Propylene Glycol + Sodium Stearate when heated and mixed forms a gel. - Hydrophilic Base (ie PEG) à Add Sodium Stearate Equipment needed Hot plate beaker water for boiling evaporating dish glass stirring rod And yea some other stuff. Check procedure Hydrophilic Stick Procedure - The following is a paraphrased protocol from Dr. Pluta s Semisolid lab - - Weigh/Measure your ingredients and label them. Do not leave powders laying around unmarked. o Base: In this case we will use Propylene glycol and Sodium Stearate o Drug o Since liquids are involved, knowing the density will be critical for determining appropriate content. o Ingredients: Methyl salicylate, menthol, sodium stearate, propylene glycol, purified water - Set up your evaporating dish on top of a boiling beaker-hot plate - Add propylene glycol and purified water to the already hot evaporating dish, mix using a stirring rod.. - Add sodium stearate to this mixture and mix thoroughly using a stirring rod. o Using a thermometer, make sure the temperature does not exceed 75º C. The goal is to have the sodium stearate completely dissolved/melted, which should occur between 55-70º C. - Once the sodium stearate is completely dissolved, remove the evaporating dish. If excessively hot, allow to cool until < 75ºC - Triturate menthol in a different evaporating dish to reduce particle size. - Add the crushed menthol to the sodium stearate/propylene glycol/water system and mix to dissolve. - Add methyl salicylate to the mixture, mix to dissolve o If your mixture is too hot, the methyl salicylate may burn and turn orange - Allow the preparation to cool, but before it hardens pour it into a 20g application stick o Retain excess for QC evaluation - After filling, place the application stick into the freezer for cooling and hardening - Cap the stick after hardening is underway or complete. - The finished stick should be solid and an opaque white. If orange, you fucked up. But you still have time, try again. Quality Control: Allow remaining melted formulation to cool in small evaporating dish for thorough evaluation. Evaluate the cooled medicated sticks before dispensing. Counseling: For external use only, store in a cool dry place, keep tightly closed, keep out of reach of children, monitor for adverse/allergic reaction.
5 (2): SUPPOSITORIES Suppositories can be very relaxing to make. Heating, casting, cooling Suppository Bases: Fatty, W/O, PEG, Glycerinated Gelatin Name Utility Pharmaceutics Yea what? Lubricant Polybase (Perrigo) Dissolve Inactive Water-soluble ointment base (PEG is another!) Used in suppositories. Mixture of MW polyethylene glycol and polysorbate Light Mineral Oil or Vegetable Oil Spray Fattyblend (Fagron) Melt Glycerinated- Gelatin Inactive Inactive Water-insoluble suppository base Hydrophilic base, suppository base Serves as the alternate suppository base of cocoa butter. Homogenous mixture of triglycerides Homogenous mixture of glycerin, gelatin, and water **Special mixing instructions, see end of this section Glycerin Light mineral oil or vegetable oil spray - Fatty: Oleaginous. Such as Cocoa Butter, or fattyblend. Designed to melt at body temperature - PEG: Specific Polyethylene Designed to dissolve at body temperature, such as vaginal suppositories - Glycerinated Gelatin: Aqueous. Has a laxative side effect, as glycerin is an irritant. Lubricating Agents: Suppository mold lubricants should be opposite polarity to the suppository formulation to facilitate the removal of the suppository from the mold. See procedure below for examples. Calculations - For the most part, we will be using solids, weighing them, and turning them into a product that has a set volume. Therefore, knowing the suppository mold volume is 2mL (rectal), determine the density of your base so you know how much of it to weigh for the full prep. Approach - (1) Determine the suppository base Base should be opposite polarity of the active drug - (2) Determine the appropriate lubricant Lubricant should be opposite polarity of the base. - (3) Determine the appropriate levigating agent Levigating agent should be same polarity as base. - (4) Determine the objective of the drug Will it be melting or dissolving? Is the drug heat sensitive? - (5) Is this a high drug dosage? A high drug dose is ³ 30% of the suppository weight or volume. In cases such as this, we will need to employ the double pour technique. Equipment needed: Suppository mold Pill tile Q-Tips Mineral Oil Glycerin Evaporating dishx2 Hot plate Beaker Water to boil Stirring rod Foil spatula High dose suppository Procedure [Double-Pour] - *Plan on making slightly extra to compensate for losses during the preparation. So if your Rx calls for 5 or 6 suppositories, lets fill that baby up and make 8. Just be sure to include this in your calculations. - Weigh your ingredients and label them. Do not leave powders laying around unmarked. o Drug o Base When weighing your base, weigh it in two separate halves. This is for the double-pour. - Lubricate the suppository mold with the appropriate lubricant. Use Q-tips to spread. Close mold & tighten screws o Fatty blend = Lubricant is Glycerin, because it is opposite polarity o Polybase/PEG = Lubricant is mineral oil, because it is opposite polarity - On a pill tile, Levigate your drug using the appropriate levigating agent and a spatula o Fatty blend = Levigating agent is mineral oil, because it is the same polarity o Polybase/PEG = Lubricant is glycerin, because it is the same polarity - Melt half of your base in an evaporating dish on a heated water bath - Add your drug into the melted base. This mixture has ALL of your drug and HALF of your base. Using stirring rod to disperse drug evenly. - Pour the melted blend into the 8 cavities in the suppository mold. None of the cavities should be completely filled. - Melt the 2 nd half of your base on another evaporating dish. Pour the melted base into your first evaporating dish this will serve as a rinsing step. - Pour, and overfill the half-filled suppository cavities with your melted base. Allow to cool and harden. - Remove the suppositories from the mold. Clean the mold, and re-lubricate with the appropriate lubricant - Melt the suppositories on a water bath. Using a stirring rod, melt to form a uniform mixture. - Pour the melted drug-base into the mold, fill at least the number of cavities you need to complete the Rx. - Wrap the suppositories in foil. Place them in a box, label, dispense, and counsel. Quality Control: Uniformity of weight and texture, physical appearance, odor. Review raw materials used for foreign particulates, expiration date, microbial contamination, and general suitability for use.
6 Low dose suppository Procedure [Single-pour] - *Plan on making slightly extra to compensate for losses during the preparation. So if your Rx calls for 5 or 6 suppositories, lets fill that baby up and make 8. Just be sure to include this in your calculations. o If the amount of required drug is small, it likely has no effect on the suppository volume and may be disregarded. It may be wise to calibrate your mold to determine the weight of the suppository formed in the mold. So make one. Let it cool. Weigh it. Boom you know. - Weigh your ingredients and label them. Do not leave powders laying around unmarked. o Drug o Base - Lubricate the suppository mold with the appropriate lubricant. Use Q-tips to spread. Close mold & tighten screws o Fatty blend = Lubricant is Glycerin, because it is opposite polarity o Polybase/PEG = Lubricant is mineral oil, because it is opposite polarity - On a pill tile, Levigate your drug using the appropriate levigating agent and a spatula o Fatty blend = Levigating agent is mineral oil, because it is the same polarity o Polybase/PEG = Lubricant is glycerin, because it is the same polarity - Melt your base in an evaporating dish on a heated water bath o This will require a steam bath if using glycerinated gelatin. See below at end of section. - Add your drug into the melted base. This mixture has ALL of your drug and ALL of your base. Using stirring rod to disperse drug evenly. - Pour the melted blend into the suppository mold. - Allow to cool and harden ~15-30 mins. - Remove the suppositories from the mold. Wrap the suppositories in foil. Place them in a box Label, dispense, and counsel. Quality Control: Uniformity of weight and texture, physical appearance, odor. Review raw materials used for foreign particulates, expiration date, microbial contamination, and general suitability for use. Counseling: Unwrap before using. Explain the route, it is not for eating. ***Glycerinated-Gelatin as your suppository base! Well you came to the right place - This one needs to be prepared a little differently. But have no fear, it not that much more difficult - Directions: Heat a water-glycerin mixture to ~80ºC on a steam bath (hotter than water bath) o Dissolve the gelatin in the water-glycerin mixture. Mix thoroughly with stirring rod Techniques - Double Pour for when you are unsure how much space your drug will take up. It s ok to not know some things. o The formulation is prepared by melting the vehicle, adding drug with mixing to half the vehicle amount o Pour vehicle+drug mixture into the mold cavities. When complete, there should be room in the cavities o Pour Qs our remaining additional suppository base (no drug) to overfill the cavity. Discard excess o Cool the mixture. Now re-melt it (we need the dosage to be uniform, not like candy corn) o Pour, cool, wrap, dispense. - Suppository Wrapping: Use 3x3 inch foil-square (Images of method featured below) o Place suppository in line with two corners of foil (along a diagonal) o Fold the bottom corner over the middle of the suppository o Fold one corner point over the end of the suppository o Fold the opposite corner point over end of the suppository o Roll the suppository over folded ends into remaining open foil o Dispense in box, remind patient to unwrap suppository before using
7 (3): TROCHES The objective of troches may be GI, Buccal, Chewable. They may be used for both local and systemic drug administration Ingredient Function Pharmaceutics Polybase (Perrigo) Inactive Ingredient. Base. Water-soluble ointment and suppository base. And I guess troche as well! SOFT troches. Polyethylene Glycol Aka PEG, or carbowax Inactive Ingredient. Base. SOFT troches Glycerinated Gelatin Inactive Ingredient. Base. Water-insoluble base for multiple dosage form. CHEWABLE gummy troches Bentonite Inactive. Suspending Agent, increases viscosity Sodium Saccharine Inactive. Sweetener Sweetness is 300x sucrose Acacia Citric Acid Monohydrate Inactive. Emulsifying and Suspending Agent. Increases viscosity Inactive. Tart flavoring Composition of aluminum oxide, silicon oxide, and other minerals Natural product of calcium, magnesium, and potassium salts of the saccharide arabic acid. Kool Aid Inactive. Flavoring Water-soluble. *Be wary of dye content. Chocolate (Wilton Candy Melts) Inactive. Flavoring. Chewable Designed for melting in water baths. *Be wary, made in factory with peanuts Used in SOFT troches Troche Lubricant Inactive. Lubricant Oleaginous Formulations: Use Glycerin Water-miscible formulations: Use light mineral oil or vegetable oil spray Dosage Form Type - Hard: Lozenges, Troches, Drops, Lollipop SUGAR BASE o Often contains solid syrups of sugars o Formulation Example: Drug, sugar, corn syrup, water o Purpose: Topical effects or for buccal absorption. Tonsillectomy, mouth ulcers - Soft: Pastilles WAX, PEG o PEG Formulations, potentially with chocolate o Formulation Example: Drug, PEG 1000, Sweetener o Purpose: Topical effects or for buccal absorption. - Chewable: Gummies GELATIN o Formulation Example: Drug, Gelatin, Glycerin, Water o Caution it does not look like medicine o Purpose: Chewed and swallowed for GI absorption Approach - (1) Determine the appropriate troche type Hard, Soft, Chewable. - (2) Determine the troche base Troche base should represent the objective of the troche - (3) Determine the appropriate lubricant Lubricant must be opposite polarity to the base. - (4) Calibrate your mold and calculations Don t forget to account for salt-drug versus base-drug weight Calibrating and Calculating Mold Size - Gummy Mold (clear plastic trays) o (1) Select desired mold/tray o (2) Fill a small graduated cylinder with water, preferably 10-20mL. o (3) Monitoring your before+after cylinder volume, pour water into the gummy cavities. You can either do 1 cavity, and hope it is an accurate fill and calculation Or you can try to fill 2 or 3 or 4 cavities with 20mL, divide by the # of cavities, to minimize error. ***The purpose of this is to determine the drug concentration your troche base will need to be so that the volume you pour into the mold will provide the desired dose of drug - Troche Mold (white plastic casettes) -- should be ~1gram/cavity o (1) On an electronic balance, tare a white plastic cassette. o (2) Using a dropper, instill water into a couple wells to capacity. Each well should be empty or full o (3) Reweigh the tray, We know the density of water is about 1g/mL. Depending how many wells you fill, calculate the average weight of each. Furthermore, you can determine the volume.
8 Chewable Troche Procedure - This is paraphrased from Dr. Pluta s caffeine gummy lab protocol- - *Formulation for this experiment: Jell-O, Unflavored gelatin, Glycerin, Purified water - *Mold should be calibrated prior to experiment. See previous page - Weigh/Measure your ingredients and label them. Do not leave powders laying around unmarked. o Base Gelatin ~will later be hydrated and glycerinated o Drug o Glycerin ~ The volume depends on our Rx and Calibrated mold size o Purified water ~ The volume depends on our Rx and Calibrated mold size - Add the measured water and glycerin to a large beaker. Heat on hot plate to ~80º F. - Sprinkle gelatin in slowly and evenly. Use a stirring rod to mix and help hydrate the gelatin - Sprinkle Jell-O in slowly and evenly into the large beaker. Mix to form a uniform dispersion. - Allow Jell-O and Knox gelatin to hydrate for approximately 10 minutes, mixing gently. - Heat beaker on hot plate to dissolve gelatin. It should take 10 minutes at 40% heat. Mix occasionally. Ex from class Jell-O: 42g Unflavored gelatin: 7.5g -packet Purified water: 60mL Glycerin: 20mL Glycerin: 20mL o The resulting solution should be clear, and the excessive foam should be removed via spoon - Add drug to the mixture. Stir gently to dissolve. If particles are evident, heat on hot plate as needed. Again remove the excessive foam with spoon - Fill the cavities with the drug-gelatin mixture. Either pour directly from the beaker or use a spoon. o Lubricant? We ve noticed over time it isn t needed, but you can if you want. Here use mineral oil. - Place the gummies in the freezer for minutes to solidify. - After gummies solidify, remove the gummies from the mold. Taste and expectorate (QC) - Packaging either wrap gummies if possible or bag them Quality Control: Weight, uniformity, appearance, odor, hardness, taste test. Counsel: Chew and swallow, Unwrap before using, Appears as candy, Keep out of reach of children. Watch the BUD. Soft Troche Procedure - Essentially copy-pasted from Pluta s Compounding Troches Non-sterile ppt- - *Plan on making slightly extra to account for losses. This is shown in the table above. *Calibrate mold. - Weigh/Measure your ingredients and label them. Do not leave powders laying around unmarked. o Base: Polybase + PEG1450 o Drug Drug A, needing to be dosed at 50mg/troche - Lubricate the troche mold with the appropriate lubricant o Polybase+PEG1450 are hydrophilic, so we want a hydrophobic lubricant à Mineral Oil - Prepare a hot water bath to melt base in an evaporating dish. - Cut up base into smaller pieces, and add o the evaporating dish. Stir to facilitate melting with glass stirring rod - On a pill tile, Reduce the particle size of our drug, either by intervention or using a mesh screen. Levigate o Levigating agent in this case will be glycerin - Once base is fully melted, add drug into the evaporating dish and mix until uniform with glass stirring rod o Putting the drug on the heat source is not standard protocol for all experiments. This depends on the heat sensitivity of the drug. If the drug is heat sensitive, simply remove the dish from heat, cool a bit, add drug - Pour melted mixture into troche mold, avoid overfilling. Allow to cool. - Once solidified, bend mold to loosen troches. You may tap the mold on the bench to release troches. - Wrap troches individually and dispense in box or vial Quality Control: Weight, uniformity, appearance, odor, hardness, taste test. Counseling: Unwrap troche before administration. Chew troche to prevent choking. Do not swallow hard or soft troches, allow to dissolve in mouth. Do not use drug once it is past beyond use date. Refrigerate if necessary. Keep away from kids
9 Chocolate Placebo Troche Notes on Compounding - Same as soft troche procedure. - Flavor may be added to the chocolate. - It is suggested to instill a few drops of mineral oil to the melted chocolate to facilitate pouring and spreading in molds. This is a similar concept to lotions being made less viscous by diluting with the levigating agent - When pouring chocolate, pour into the middle of the mold and spread into cavities using a rubber spatula. Ex: SOFT Troche (Adapted from Pluta s 25mg Calamine Troches) Drug K, 25mg Troches #12 - Drug? Calamine. The drug is calamine, it is insoluble. *Will need to levigate - Base: Water-soluble base Ideal base is opposite polarity to drug. - Lubricant: Mineral Oil Lubricant must be opposite polarity of the base. - Procedure: o Weigh Calamine, label. Weigh Polybase, label. Weigh PEG, label. Label troche mold o Lubricate troche mold with mineral oil. Do not over-lubricate o Levigate Calamine on pill tile with glycerin o Melt polybase and PEG in evaporating dish. Stir continuously, do not let burn. o Disperse calamine in melted PEG-Polybase with mixing. o Fill 12 troche cavities with DrugA-Polybase-PEG mixture. o Do not cover, allow them to harden at room temperature. After cooling, remove troches from mold. Troches: Quality Control: Weight, uniformity, appearance, odor, hardness Ex: Chewable Troche (Adapted from Pluta s Glycerinated Gelatin Troches) Troches #12 - Drug? There is none. - Base: Glycerinated Gelatin Ideal base is opposite polarity to drug. - Lubricant: Mineral Oil Lubricant must be opposite polarity of the base. - Procedure: o Lubricate Mold with minimal drops of mineral oil, spread with a Q Tip o Weigh bentonite, label. Weigh sodium saccharin, label. Weigh acacia label. Weigh citric acid monohydrate, lavel. Weigh kool aid flavor, label. o Triturate measured powders together in a mortar and pestle to reduce particle size. o Weigh glycerin into evaporating dish on balance, label. o Add 1.5mL water o Troches: Quality Control: Weight, uniformity, appearance, odor, hardness
STAGES OF PHARMACEUTICAL MANUFACTURING
STAGES OF PHARMACEUTICAL MANUFACTURING API Finished Product API Primary Packaging Secondary Packaging Excipients Starting Materials (Chemicals) 1 PHARMACEUTICAL MANUFACTURING OF NORMAL DOSAGE FORMS 2 Dosage
More informationCHM111 Lab Physical Separations Grading Rubric
CHM111 Lab Physical Separations Grading Rubric Name Team Name Criteria Points possible Points earned Lab Performance Printed lab handout and rubric was brought to lab 3 Safety and proper waste disposal
More informationExperiment #3. Physical Separations Candy Chromatography
Experiment #3. Physical Separations Candy Chromatography Goals 1. To physically separate and identify dyes in candy by comparison to commercial food dyes using paper chromatography. 2. To become familiar
More informationIngredients Found At Natures Garden:
Ingredients Found At Natures Garden: BTMS 25 Emulsifier SILKY EMULSIFYING Wax EMULSIFYING Wax NF- Traditional POLYSORBATE 80 BEESWAX White Pastilles POLYSORBATE 20 Directions: If you have ever seen an
More informationChapters 18, 22 & 30 Viscosity-inducing Agents, Ointment Bases and Ointments, Creams, Gels, and Pastes
Chapters 18, 22 & 30 Viscosity-inducing Agents, Ointment Bases and Ointments, Creams, Gels, and Pastes Chapter 18 (Viscosity-inducing Agents) 1. What is Carbomer NF? 2. Carbomer is commonly referred to
More informationLIQUID SOAP INTRODUCTION
LIQUID SOAP The hygiene is important for people to keep clean and at the same time to avoid infections and other kind of diseases. This soap is used exclusively by hands. Objectives Drawing a simple of
More informationTopic: The Evaluation of Sunscreen Formulation and Effectiveness. National Science Education Standards: Science as inquiry/ Physical Science
Fellow: LaCrissia J. Bridges Teacher: Ms. Sandra Greene Theme Based Lesson Topic: The Evaluation of Sunscreen Formulation and Effectiveness National Science Education Standards: Science as inquiry/ Physical
More informationDemystifying Skin Care for Massage Therapists Chapter 5
1 Demystifying Skin Care for Massage Therapists Chapter 5 Created by Nina Howard, Founder and Master Trainer Adapted and Edited by Kathryn Myers, CEO Bellanina Insitute BELLANINA INSTITUTE for Skin and
More informationSENSOGEL 200 PRE-NEUTRALIZED, ACRYLAMIDE-FREE THICKENER FOR A FRESH, FEATHER-LITE SENSORY
SENSOGEL 200 PRE-NEUTRALIZED, ACRYLAMIDE-FREE THICKENER FOR A FRESH, FEATHER-LITE SENSORY 2 Cranberry Road, Unit A4 Parsippany, New Jersey 07054 Phone: 862-210-8344 Fax: 862-210-8336 Email: sales@applechem.com
More informationZinc Oxide Recipes. Sunscreen, Diaper Rash Cream, Deodorant, Soap and More!
10 Zinc Oxide Recipes lalune naturals Sunscreen, Diaper Rash Cream, Deodorant, Soap and More! DIY Sunscreen Making your own sunscreen doesn t have to be hard! This easy DIY sunscreen recipe can be made
More informationH O W T O M A K E Y O U R O W N L I P G L O S S
H O W T O M A K E Y O U R O W N L I P G L O S S 30 RECIPES TO ADD SHINE AND COLOR TO YOUR LIPS 2008 The Handcrafter s Companion. www.handcrafterscompanion.com 1 DISCLAIMER Please do not let children use
More informationSilicone Ingredients for Personal Care
Silicone Ingredients for Personal Care SF-600 SF-600B SF-600D SF-602A SF-607 SF-609 SF-6212 SF-6212N SF-606 Powder SF-6061 Powder SF-6081 Suspension SF-6082 Silicone Resin Elastomer Suspension (and) /Vinyldimethicone
More informationTopi-CLICK 140 Specifications
126mm 140 ml Topi-CLICK 140 Specifications Topi-CLICK 140: 140 ml, 0.50 ml per CLICK DESCRIPTION: The NEW Topi-CLICK 140 is an intelligently designed topical dosing device that overcomes the various limitations
More informationRheology Modifier Thickening Emulsifier Viscosity Controlling Agents
Rheology Modifier Thickening Emulsifier Viscosity Controlling Agents Sharing expertise around the world As a global manufacturer of cosmetic ingredients and functional fine chemicals, Hannong Chemicals
More informationUnit Introduction. Solutions, Mixtures, and Emulsions Vocabulary N A M E
Unit Introduction Vocabulary chemist a person who studies solids, liquids, and gases to solve problems chemistry the branch of science that identifies the substances that compose matter; the study of the
More informationThe NF contains monographs for six such polymers, carbomers 910, 934, 934P, 940, 941, and 1342.
GELS Gels Gels are semisolid preparations that contain small inorganic particles or large organic molecules interpenetrated by a liquid. The vehicle may be: Aqueous,hydroalcoholic, alcohol based or non
More informationCompounding Pharmacies Dosage Forms, Vehicles and Methods Robert P. Goldman, MD
3400-A Old Milton Pkwy Ste 360 Alpharetta GA 30005 770.475.0077 GeorgiaHormones.com Compounding Pharmacies Dosage Forms, Vehicles and Methods Robert P. Goldman, MD Introduction: Prior to the proliferation
More informationAmerican Cleaning Institute Development of Exposure Assessments Glossary of Functional Classes
American Cleaning Institute Development of Exposure Assessments Glossary of Functional Classes Abrasive: Abrasive ingredients are materials that are used to polish, buff, or scour away soils such as dirt
More informationThe solution contains isopropyl alcohol 50% v/v, propylene glycol, and water.
Cleocin T (clindamycin phosphate topical solution, USP) (clindamycin phosphate topical gel) (clindamycin phosphate topical lotion) For External Use DESCRIPTION CLEOCIN T Topical Solution and CLEOCIN T
More informationPERSONAL CARE. INNOVATIVE & NATURAL Functional ingredients based on sugar chemistry
PERSONAL CARE INNOVATIVE & NATURAL Functional ingredients based on sugar chemistry PERSONA INNOVATIVE & NATURAL Functional ingredients based on sugar chemistry L CARE Pack size Ecocert approved Ecocert
More informationThe Effects of Shear on Neutralized Carbomers in Aqueous Conditions
The Effects of Shear on Neutralized Carbomers in Aqueous Conditions Lyndel Speedy 18/07/2014 With thanks to Ensign Laboratories 1 Abstract Carbomer is the generic name for a class of high molecular weight
More informationWARNING. Not suitable for children under 8 years. For use. WARNING This set contains chemicals that may be harmful if EXPERIMENT MANUAL
EXPERIMENT MANUAL Please observe the safety information below, the advice for supervising adults on page, the safety rules on page, and the information about hazardous substances (chemicals) and their
More informationRepresented by: Integrity Ingredients Corporation
Represented by: Integrity Ingredients Corporation info@integrityingredientscorp.com (310) 782-0282 Represented by: Integrity Ingredients Corporation info@integrityingredientscorp.com (310) 782-0282 AMPHOTERIC
More informationPHARMACY PRACTICE I LAB PHCY 280L
College of Pharmacy and Nursing School of Pharmacy PHARMACY PRACTICE I LAB PHCY 280L Lab Manual Fall 2017/18 Faculty: Ms Beena Jimmy Lecturer, Pharmacy Practice Name: Student Id: 1 Learning Objectives
More informationPaper Chromatography and Steam Distillation EVERY STUDENT MUST BRING AT LEAST 3 ORANGES TO LAB FOR THIS EXPERIMENT! Equipment
Paper Chromatography and Steam Distillation EVERY STUDENT MUST BRING AT LEAST 3 ORANGES TO LAB FOR THIS EXPERIMENT! Equipment You will need a 600 ml beaker, a 50 ml graduated cylinder, 4 Expo Wet Erase
More informationMIGLYOL 840. Excellent light emollient. Alternative to IPM. INCI: Propylene Glycol Dicaprylate/Dicaprate. Excellent light and dry emollient
Excellent light emollient Excellent light and dry emollient Alternative to IPM 1. Description: MIGLYOL 840 is a propylene glycol diester of saturated plant fatty acids with chain lengths of C 8 and C 10.
More informationGeogard ULTRA Multifunctional specialty additive for cosmetics and toiletries.
Product Information Geogard ULTRA Multifunctional specialty additive for cosmetics and toiletries. I. Preservation Naturally-derived product Broad spectrum protection Globally accepted II. Moisturization
More informationISOLAN GPS Emulsifier for low viscous W/O lotions
ISOLAN GPS Emulsifier for low viscous W/O lotions PEG-free emulsifier based on vegetable raw materials Excellent emulsion stabilization properties even at low emulsifier concentrations (2-3 %) For the
More informationPO Box 5411 Arlington, TX SF A-348
SF A-348 PRODUCT DESCRIPTION SF A-348 organosilicone is a proprietary copolymer that represents a class of aminosilicone polyalkyleneoxide copolymers for hair conditioning. Conventional organomodified
More informationThis Sugaring Deluxe Bundle was designed to give you the best of two worlds and to prolong your smooth sugaring hair removal results.
This Sugaring Deluxe Bundle was designed to give you the best of two worlds and to prolong your smooth sugaring hair removal results. After all, exfoliation is the key to sugaring! Before and after care
More informationJBHomemade.com 2014
This Sugaring Starter kit was designed to give you the best of two worlds and to prolong your smooth sugaring hair removal results. After all, exfoliation is the key to sugaring! Before and after care
More informationItem/Package Details Size Item Bottle ph Shelf Life 1.0 oz/29.6 ml 1101 Lucite Matte Silver Pump months
B-Kleer 10 Lotion Use of mild to moderate acne. Gently exfoliates encrustation and acne pustules. Penetrates pores to eliminate most acne pimples. Reduces the severity of acne blemishes. Help prevent new
More informationMoisturizing Lotion with Laurest 1220 and Squalane
Moisturizing Lotion with Laurest 220 and Squalane In this formulation, Laurest 220 acts as an emollient, emulsifier, and antimicrobial agent. PHASE WT. % DI Water 78.20% Disodium EDTA 0.80% CARBOPOL 940
More informationCREAMS BATH SOAP SUBSTITUTES OINTMENT GEL ADDITIVES. NEW 500g. pump
CREAMS BATH ADDITIVES SOAP SUBSTITUTES OINTMENT GEL NEW NEW 500g pump The Zeroderma range of emollients offers similar products to leading brands with no compromise on patient care and cost s of up to
More informationCharacteristic of hydrophobically-modified hydroxypropyl methylcellulose, and application of hair cosmetics.
Characteristic of hydrophobically-modified hydroxypropyl methylcellulose, and application of hair cosmetics. Abstract : Hydrophobically-modified hydroxypropyl methylcellulose (HM-HPMC) is a thickener which
More informationVintage Pharmaceuticals, LLC
Vintage Pharmaceuticals, LLC MATERIAL SAFETY DATA SHEET 1. CHEMICAL PRODUCT AND ME Material Name: Lidocaine Hydrochloride Oral Topical Solution USP, 2% (Viscous) Item Number: 1392 Synonyms/Trade Names:
More informationPerformance is in our nature.
Performance is in our nature. 2 TECHNICAL BULLETIN USP-FCC Propanediol Making Beverages Better, Cheaper and Faster Abstract: USP-FCC propanediol is a bio-based polyol that adds a sweet, cool taste to beverages,
More informationDOWSIL 9040 Silicone Elastomer Blend
Technical Data Sheet FEATURES & BENEFITS Compatible with a variety of lipophilic active ingredients such as fragrances, sunscreens, vitamins, and vitamin derivatives Clear to slightly translucent crosslinked
More informationWashing Lotion. Art. no. 6964
Art. no. 6964 Washing Lotion Abena s Washing Lotion is mild and with effective cleansing properties for personal hygiene. A good alternative to traditional washing with water and soap. The Washing Lotion
More informationQuick Guide Unguator Technology - Competence from the Start
Quick Guide Unguator Technology - Competence from the Start Determinate mixing parameters, based on traditional pharmaceutical compounding: 1. Classification of the formulation according to its appropriate
More informationPRODUCT DEMONSTRATION BROCHURE
PRODUCT DEMONSTRATION BROCHURE 1 Fortune Delight is a concentrated herbal beverage based on the Philosophy of Regeneration. It promotes the body s natural cleansing effects and contains beneficial antioxidants.
More informationSpecialty Elastomers from Dow
Beauty and Personal Care Consumer Solutions Specialty Elasmers from Dow Table of Contents Elasmer Offerings at a Glance 2 Elasmer Suspensions 3 Elasmer Gels/Blends 4 Organic s 5 Elasmer Powders 6 Organic
More informationMaking Solid Body Lotion Bars by Yvonne Von Der Ahe
Making Solid Body Lotion Bars by Yvonne Von Der Ahe yvonderahe@charter.net "The secret of my health is applying honey inside and oil outside." - Democritus (460-370 BC), Greek philosopher and physician
More informationDesign, development and evaluation of solid dispersion incorporated transdermal gel of benzoyl peroxide
2016; 5(7): 13-18 ISSN: 2277-7695 TPI 2016; 5(7): 13-18 2016 TPI www.thepharmajournal.com Received: 01-05-2016 Accepted: 02-06-2016 Jitender Mor Rajinder Mann Bharti Chopra Design, development and evaluation
More informationProduct Information Gluconolactone and Sodium Benzoate (GSB)
The Soap Kitchen Unit 8 Caddsdown Industrial Park, Clovelly Road, Bideford, Devon EX39 3DX Tel: 01237 420872 (+44 (0)1237 420872) Email: info@thesoapkitchen.co.uk Product Information Gluconolactone and
More informationTable 6: Detailed Infection Prevention and Control Procedures for Tattooing and Micropigmentation. Use During Tattooing
FACT SHEET Table 6: Detailed Infection Prevention and Control Procedures for and Micropigmentation 1. Skin Preparation Spray bottle with a solution of soap and water Single use disposable razor The skin
More informationWhat is THIXCIN R? What is seeding? What is the benefit of using THIXCIN R in combination with BENTONE GEL in my formulation?
Questions & Answers Contents What is THIXCIN R? Where can THIXCIN R be used and what major benefits can be achieved? What is the preferred procedure for dispersing and activating THIXCIN R? What mixing
More informationFLORAESTERS CHEMISTRY
Bulletin 3 FLORAESTERS 60 FLORAESTERS CHEMISTRY Natural jojoba oil is actually not an oils but an array of oxidatively stable, liquid wax esters. The dominant molecular structure is a straight chain monoester
More informationDIY RECIPE COLLECTION
DIY RECIPE COLLECTION By Dawn Goehring Desert Naturals Essential Oils info@desertnaturals.me http://www.desertnaturals.me http://www.facebook.com/desertnaturals http://www.instagram.com/desertnaturals
More informationQuestions and answers on sodium laurilsulfate used as an excipient in medicinal products for human use
9 October 2017 EMA/CHMP/606830/2014 Committee for Human Medicinal Products (CHMP) Questions and answers on sodium laurilsulfate used as an excipient in medicinal products for human use Draft agreed by
More informationOrganic Bath & Beauty Recipes by The Coconut Mama No part of this publication shall be reproduced, transmitted, or sold in whole or in part in any
0 1 TABLE OF CONTENTS Disclaimer Page 2 Why DIY? Page 3 Ingredients Page 5 Whipped Body Butter Page 6 Sweet Honey & Lavender Lip Balm Page 7 Therapeutic Chest Rub Page 8 Soothing Bath Salts Page 9 Beautifying
More informationHealth & Beauty Solutions, Inc.
Health & Beauty Solutions, Inc. Providing essential delivery systems and ingredients for optimal skin care formulations. 2870 Forbs Avenue Hoffman Estates, IL 60192 p: 337.354.1044 f: 847.851.1318 www.amcolhpc.com
More informationBasic Deodorant Powder Formula (from Better Basics for the Home by Annie Berthold-Bond)
Shea Butter Soap (from Soothing Soaps by Sandy Maine) 2 cups glycerin soap base, melted in a double boiler 2 tbsp shea butter, melted separately Several drops of your favorite essential oil (optional)
More informationSection 1: Product & Company Identification
SAFETY DATA SHEET REVISION DATE: 07/19/2016 PRODUCT (KIT): PEDI IN A BOX Deluxe 4 Step Pedicure Cucumber Fresh with Cucumber Extract PACK SIZE: Sea Salt Soak (35g) / Sugar Scrub (15g) / Mud Masque (20g)
More informationWashing Lotion. Art. no. 6964
Art. no. 6964 Washing Lotion Abena s Washing Lotion is mild and with effective cleansing properties for personal hygiene. A good alternative to traditional washing with water and soap. The washing lotion
More informationAristoflex Velvet. Public. Clariant BU ICS Personal Care
Aristoflex Velvet Clariant BU ICS Personal Care 30.10.2013 2 Clariant, BU ICS Personal Care, 30.10.2013 Consumer Insights: Luxury wanted Consumers are looking for more from their everyday products Not
More informationMonopropylene Glycol. Pharmaceutical Grade. Kimiagaran Emrooz. Technical Data Sheet. Chemical Industries.
Monopropylene Glycol Pharmaceutical Grade Kimiagaran Emrooz Chemical Industries. Technical Data Sheet Propylene Glycol (MPG) Chemical Name: Propylene Glycol Trade Names: MPG/Pharmaceutical grade Introduction:
More informationIrwin Palefsky Cosmetech Laboratories Inc.
Irwin Palefsky Cosmetech Laboratories Inc. Irwin@cosmetech.com www.cosmetech.com The prevention or retardation of product deterioration caused by microorganisms from the time of production until the product
More informationMoisturizing Cream with Biopolysan 220B
Moisturizing Cream with Biopolysan 220B DI Water Disodium EDTA 0.20% Xanthan Gum 0.60% Glycerin 4.00% Grapeseed Oil 8.00% Jojoba Oil 5.00% Stearic Acid 3.00% Cetearyl Alcohol, Glyceryl Stearate, Sodium
More informationII. Moisturization Improves skin moisture content General Recognized as Safe (GRAS) ingredients by FDA (21 CFR 184) No animal testing, non GMO.
Lonza Ltd Muenchensteinerstrasse 38 CH-4002 Basel, Switzerland Tel +41 61 316 81 11 Fax +41 61 316 91 11 Product Information Geogard ULTRA Multifunctional specialty additive for cosmetics and toiletries,
More informationStudent Manual SO 3 N N N + Blue 1 Yellow 5 N N. Yellow 6 Red 40. Fig. 3. Reference dyes used in this experiment. - O 3 S - OOC
Student Manual Background How do you pick the foods you eat? The appearance of the food is a major deciding factor. For example, color can tell you whether a fruit is ripe or whether meat has spoiled.
More informationAMERIGEL BARRIER LOTION PRODUCT INFORMATION MSDS APPLICATION PROTOCOLS 07/01/13
AMERIGEL BARRIER LOTION PRODUCT INFORMATION MSDS APPLICATION PROTOCOLS 07/01/13 AMERIGEL BARRIER LOTION SUPERIOR SKIN PROTECTION Moisturizes, lubricates and soothes irritated, dry skin Excellent skin
More informationSurfactant Concentrate Iselux SLC
Surfactant Concentrate Iselux SLC INCI Name: Water (and) Sodium Lauroyl Methyl Isethionate (and) Sodium Lauroamphoacetate (and) Cocamide MIPA (and) Sodium Benzoate Iselux SLC is a concentrated surfactant
More informationWhat is BENTONE GEL IPM V? What is Isopropyl Myristate? Where can BENTONE GEL IPM V be used? What are the typical use levels?
Questions & Answers Contents What is BENTONE GEL IPM V? What is Isopropyl Myristate? What are the major application benefits? Where can BENTONE GEL IPM V be used? How do I incorporate this product into
More informationLuvigel EM. Technical Information. Thickener for the production of cosmetic products. = Registered trademark of BASF Aktiengesellschaft
Technical Information September 2007 Supersedes issue dated November 2006 Luvigel EM MEMKH 030701e-03/Page 1 of 10 = Registered trademark of BASF Aktiengesellschaft Thickener for the production of cosmetic
More informationMASSOCARE CONCENTRATES The easiest way to develop & manufacture Personal Care products
MASSOCARE Solutions for Success MASSOCARE CONCENTRATES The easiest way to develop & manufacture Personal Care products The MASSOCARE cosmetic ingredients are real solutions to the needs of the Personal
More informationAnti-ageing serum, anti-wrinkle action with bioencapsulated hyaluronic acid
LIPOHYAL Facial Care Anti-ageing serum, anti-wrinkle action with bioencapsulated hyaluronic acid High concentration of hyaluronic acid (HA). Great power of penetration, di usion and incorporation into
More information2. Mix the plant material with 5 ml of rubbing alcohol and let it soak for a few minutes. Swirl the container to mix it as you wait.
Spa Day Perfume 1. Grate, grind, or chop up about 1 teaspoon of plant material of your choice (e.g. nutmeg, citrus peel, cinnamon, cloves, scented leaves or flowers, and herbal teabags are all good sources
More informationStudent Manual SO 3 N N N + Blue 1 Yellow 5 N N. Yellow 6 Red 40. Fig. 3. Reference dyes used in this experiment. - O 3 S - OOC
Student Manual Background How do you pick the foods you eat? The appearance of the food is a major deciding factor. For example, color can tell you whether a fruit is ripe or whether meat has spoiled.
More informationMy introduction to Young Living
My introduction to Young Living A story of a new mom By: Agnes Tchoryk Ingredients to Avoid Mineral Oil, Petroleum Jelly, and Baby Oil Crude oil bi-product Block absorption of nutrients Found in baby shampoos,
More informationSpot-Cleaning Tips and Remedies
The best and most convenient way to remove spots and spills is to have your carpet serviced by an Aladdin Professional. However, the following tips and home remedies should help remove most spots and odors.
More informationGlo Germ Company. PO Box 189. Moab, Utah Safety Data Sheet (SDS) Revised July 3, 2018 Section 1: Identification
Glo Germ Company PO Box 189 Moab, Utah 84532 Safety Data Sheet (SDS) Revised July 3, 2018 Section 1: Identification GLO GERM LOTION BASE (GEL) AND SURFACE CLEANING DETECTION GEL Emergency & Information
More informationPowderfeel WR. One solution for multiple textures
Powderfeel WR One solution for multiple textures Powderfeel WR O/W emulsifi er based on pickering emulsion technology. It allows the development from sprayable formulas to high oil load butters, highly
More informationStandard Laboratory Practice for Consumer Applied Pet Stain and Odor Removal Chemical Evaluation on Pile Yarn Floor Coverings
P.O. Box 2048 Dalton Georgia 30722-2048 706.278.3176 carpet-rug.org CRI Test Method - 116 Technical Bulletin Standard Laboratory Practice for Consumer Applied Pet Stain and Odor Removal Chemical Evaluation
More informationFormulas from Voyageur Soap & Candle s Grand opening September 22, 2018 VOYAGEUR SOAP & CANDLE S GRAND OPENING FORMULAS SEPTEMBER 22, 2018
1 VOYAGEUR SOAP & CANDLE S GRAND OPENING FORMULAS SEPTEMBER 22, 2018 2 WHIPPED SHEA BUTTER... 3 WHIPPED SHEA BUTTER... 3 CREATING AN ORGANIC WHIPPED SHEA BUTTER... 4 CREATING A WHIPPED BUTTER SCRUB...
More informationProducts to recommend for the TREATMENT of Dry Eyes
Products to recommend for the TREATMENT of Dry Eyes Active ingredient: Polyethylene Glycol 400 0.4% Propylene Glycol 0.3% Systane Lubricating Eye drops & Unit dose vials For the temporary relief of burning
More informationPERSONAL CARE. INNOVATIVE & NATURAL Functional ingredients based on sugar chemistry
PERSONAL CARE INNOVATIVE & NATURAL Functional ingredients based on sugar chemistry PERSONAL CARE INNOVATIVE & NATURAL Functional ingredients based on sugar chemistry Pack size Ecocert approved Ecocert
More informationSubject Code: 0811 Model Answer Page No: 01/23
Subject Code: 0811 Model Answer Page No: 01/23 Important Instructions to examiners: 1) The answers should be examined by key words and not as word-to-word as given in the model answer scheme. 2) The model
More informationAvon Skin So Soft, Original Bath Oil Bonus-Size
Avon Skin So Soft, Original Bath Oil Bonus-Size Size: 25 fl. oz. America's favorite bath oil*, and sure to be yours, too! Moisturize your skin while you bathe. Skin So Soft Original Bath Oil is Jojoba
More informationPET Barrier Test PET- R- 02
PET Barrier Test PET- R- 02 The following protocol is designed to provide a procedure for identifying and quantifying residual amounts of three barrier materials, EVOH, MXD6 nylon, and epoxy diamine, in
More informationBIO 611 Polarity and Mixing Lab
Name: Date: Block: Introduction: BIO 611 Polarity and Mixing Lab When you mix two substances together, the first thing they do is decide whether or not they like each other. If they do, one will usually
More informationTEGO Carbomer 140 G TEGO Carbomer G
TEGO 140 G TEGO 141 1 G Convenient granulated viscosity adjusters and builders, emulsion stabilizers Granulated s with numerous advantages: lower dusting, easier to process, higher bulk density First s
More informationSAFETY DATA SHEETS. This SDS packet was issued with item:
SAFETY DATA SHEETS This SDS packet was issued with item: 078080905 The safety data sheets (SDS) in this packet apply to the individual products listed below. Please refer to invoice for specific item number(s).
More informationWOMEN'S Regaine EXTRA STRENGTH
WOMEN'S Regaine EXTRA STRENGTH MINOXIDIL 5% W/W TOPICAL FOAM Consumer Medicine Information Please read this booklet carefully. It will help you understand how to use Foam and what to expect from its use.
More informationChevron Material Safety Data Sheet
Chevron Material Safety Data Sheet DISCONTINUED - See Section 16. CHEVRON NL Gear Compound 150 CPS255053 Page 1 of 6 This Material Safety Data Sheet contains environmental, health and toxicology information
More informationHow to Use Guide. K o n j a c S p o n g e
How to Use Guide K o n j a c S p o n g e What is Konjac? The Japanese already use Konjac 1500 years. Combining these natural ingredients with its gentle texture, Konjac is not only establishing itself
More informationAMERIGEL CARE LOTION PRODUCT INFORMATION MSDS APPLICATION PROTOCOLS 07/01/13
AMERIGEL CARE LOTION PRODUCT INFORMATION MSDS APPLICATION PROTOCOLS 07/01/13 AMERIGEL CARE LOTION SUPERIOR SKIN CARE Restores lost moisture to fragile skin Promotes natural healing Protects and soothes
More informationSHEPROS. Baby Series BABY DISHWASHER - B-BD 001. Product Description:
BABY DISHWASHER - B-BD 001 Baby Dishwasher is a water based, low-foaming, non-skin irritating, biodegradable and environmentally friendly cleaner. It is made of powerful Nano Biotech Colloidal Micelles
More informationState of Kuwait Ministry of Health Infection Control Directorate SAFE INJECTION
State of Kuwait Ministry of Health Infection Control Directorate SAFE INJECTION May 2010 Contents I. Introduction II. Prevention strategies III. Best practices for injection A. General safety practices
More informationnames 1 inch + Black Vis-à-Vis Black Sharpie
Types of Covalent Compounds: Polar and Nonpolar If you ever had a piece of paper get wet, you ve noticed that the ink making up the lines of the paper or the ink from your carefully collected notes travel
More informationA natural, cost-efficient O/W emulsifier with excellent performance
Technical Information TEGO Care PSC 3 A natural, cost-efficient O/W emulsifier with excellent performance Intended use O/W emulsifier Benefits at a glance Completely based on natural raw materials Suitable
More informationWorléeAqua Nail - The simple Way to create outstanding water-based Nail Polishes
- The simple Way to create outstanding water-based Nail Polishes Product Range Product INCI Characteristics 100 200 Base Coat Top Coat Natural Remover Aqua, Polyacrylate-42, Dibutyl Sebacate, PPG-2 Methyl
More informationL A N O L I N LANOLIN NATURE S ORIGINAL SKIN PROTECTION
L A N O L I N A ND I TS D E RIVATI V ES T he N atu r al Cho i ce www.lanolin.de LANOLIN NATURE S ORIGINAL SKIN PROTECTION OUTLINE NK Ingredients Singapore Lanolin and what it does Product range and how
More informationState of the art ingredients fast friendly service
Product Information Geogard ULTRA Multifunctional specialty additive for cosmetics and toiletries. Description Geogard Ultra is accepted by ECOCERT as a preservative in certified organic cosmetics. As
More informationLaraCare A200 Your Multi-Functional Larch Tree Active
PersonalCare LaraCare A200 Your Multi-Functional Larch Tree Active INCI Name: Galactoarabinan SAP #: 179796 Key Product Attributes: Reduce Transepidermal Water Loss Reduce appearance of fine lines and
More informationDIAMOND FX FACE ART Water Based Make Up / Face Paint Products (Hydrocolors)
DIAMOND FX FACE ART Water Based Make Up / Face Paint Products (Hydrocolors) MATERIAL SAFETY DATA SHEET Diamond FX Face Art & FX products are manufactured in accordance with FDA and European Union guidelines.
More informationCosmetic Chemistry Developed for CWSE-ON 2010
Cosmetic Chemistry Developed for CWSE-ON 2010 Melanie Veltman & Rebecca Swabey 1 2 A Crazy Cosmetic Chemistry Vocabulary Game Fatty Acid: Points: Coal Tar: Points: Esters: Points: Boric Acid: Points: 3
More informationPetroleum Jelly / Vaseline General information and synonyms
Petroleum Jelly / Vaseline General information and synonyms COLOUR: Colour ranges from White to Yellow COMMON NAMES: Petrolatum, Petroleum Jelly, Vaseline, Soft Paraffin, Paraffin Jelly, Petroleum Vaseline
More informationPOST-PROCESSING YOUR 3D PRINTS
MAKERBOT EDUCATORS GUIDEBOOK GOING FURTHER: POST-PROCESSING GOING FURTHER POST-PROCESSING YOUR 3D PRINTS PAGE 160 SANDING YOUR 3D PRINTS 3D printing can bring your ideas to life, but sometimes your ideas
More informationSkin knows the difference
Skin knows the difference Cleanse Protect Treat Moisturize SECURA is a proven four-step preventive skin care system. SECURA products are formulated with high-quality ingredients that define the standard
More information