Reinforcer of cutaneous shield Temporary version 04-07-2013
A multi-active ß-glucan complex for an immediate and long term protective effect. Uniglucan G-51 shields the skin against daily aggressions, by activating the immune system of the skin. It produces visible effects on: irritation roughness elasticity skin hydration Daily agressions: oxidative stress, UV, environmental pollution,... Dehydration of the skin Increase of skin roughness apparition of little cracks H CH 2 CH 2 CH 2 H H Structure of ß-glucan n Weakening of skin immune system risk of irritation Uniglucan G-51 is a concentrated polysaccharides substance based on purified natural yeast cell walls obtained using biotechnology.
A multi-active ß-glucan complex for an immediate and long term protective effect. Uniglucan G-51 shields the skin against daily aggressions, by activating the immune system of the skin. It produces visible effects on: irritation roughness elasticity skin hydration Daily agressions: oxidative stress, UV, environmental pollution,... Dehydration of the skin high water-binding capacity Decrease Increase of in skin roughness apparition of little cracks H CH 2 H CH 2 CH 2 Uniglucan G-51 is a concentrated polysaccharides substance based on purified natural yeast cell walls obtained using biotechnology. H Structure of ß-glucan n Weakening Stimulation of skin immune system risk of irritation Uniglucan G-51 The cutaneous shield is enhanced
Protection against irritation (clinical study) Protocol: A placebo and a cream containig 10% Uniglucan G-51 were tested for their ability to protect against irritation. Two protocols were used on each arm of 10 volunteers: a pretreatment (application once daily for 7 days) or a simultaneous treatment with the SLS* (0,5%) induced irritation. After 24h with a patch, skin surfaces were assessed. *SLS: Sodium Lauryl Sulfate Result: Uniglucan G-51 reduces skin irritation by an average of 56.5%, compared to placebo. It shows a protective and an irritation-inhibiting effect. Absolute difference from control 0-0,25-0,5-0,75-1 -1,25-1,5 Measurement of skin irritation Visually assessd on a scale of 0 to 4-57% Pre-treatment -56% Simultaneous treatment Placebo 10% Uniglucan G-51
Reduction of skin roughness (clincal study) Protocol: A placebo and a cream containig 10% Uniglucan G-51 were tested in a study on 10 women volunteers to evaluate skin roughness. A single application in the cheek region/lower eyelid was done. Laser profile measurements were made after 1, 2 and 8h. Result: Uniglucan G-51 shows an immediate smoothing effect: reduction of skin roughness up to -151% after 8h, compared to placebo. Rz (DIN) values (%) (mean surface roughness) 0-5 -10-15 -20-25 -30-35 Measurement of skin roughness Laser profilometry examination -82% -94% -151% After 1h After 2h After 8h Placebo 10% Uniglucan G-51
Long term improvement in skin elasticity (clincal study) Protocol: A placebo and a cream containig 5% Uniglucan G-51 were tested in a study on 5 women volunteers to evaluate skin elasticity. The products were applied twice daily, for 14 days on the inner side of the forearm. Skin firmness relative to day 1 (%) 35 30 25 20 15 10 5 Measurement of skin firmness Cutometer SEM 474 + 8% + 32 % Result: Uniglucan G-51 increases skin firmness by 32%, after 14 days. 0 After 14 days Placebo 5% Uniglucan G-51
Long term improvement in skin hydration (clincal study) Protocol: A placebo and a cream containig 5% Uniglucan G-51 were tested in a study on 5 women volunteers to evaluate skin moisture content. The products were applied twice daily, for 14 days on the inner side of the forearm. Result: Uniglucan G-51 increases skin hydration by respectively 16% and 28%, after 7 and 14 days. Skin hydration relative to day 1 (%) 35 30 25 20 15 10 5 0 Measurement of skin moisture content Corneometer CM 825 + 5% + 16 % After 7 days + 7% + 28 % After 14 days Placebo 5% Uniglucan G-51 %
TECHNICAL INFRMATIN INCI: rigin: Preservation: Appearance: Solubility: Dosage: Processing: Regulatory status: Claims: Water, Butylene Glycol, Yeast Polysaccharides Biotech & rganic synthesis Preservative free Brown pasty fluid Water-soluble 3% - 10% Can be added at the end of the formulation process under stirring or homogenizing or can be heated for a short time with the water phase of a formulation Formulate at ph between 5.0 and 8.0 and temperature below 80 C CN, JP, KR, HK, AU, ASEAN, USA, South-Am., Mid-East, EU Anti-irritation, smoothing, moisturizing SAFETY ASSESSMENT cular irritation: Skin irritation: Mutagenicity: Skinethic occular in vitro test - non irritant at 100% Closed epicutan patch test - non irritant at 50% Ames assay - ECD 471 - non mutagenic
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